OR1E3 (olfactory receptor family 1 subfamily E member 3)

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Gene: OR1E3 (olfactory receptor family 1 subfamily E member 3) Homo sapiens

Analyze

Symbol:

OR1E3

Name:

olfactory receptor family 1 subfamily E member 3

RGD ID:

1351004

HGNC Page

HGNC

Description:

Predicted to have olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to localize to integral component of membrane and plasma membrane.

Type:

pseudo

RefSeq Status:

INFERRED

Also known as:

olfactory receptor 17-210; olfactory receptor 1E3; olfactory receptor family 1 subfamily E member 3 (gene/pseudogene); olfactory receptor OR17-7; olfactory receptor, family 1, subfamily E, member 3 pseudogene; OLFR 17-210; OR17-210; OR1E3P; seven transmembrane helices olfactory receptor

RGD Orthologs

Mouse

Bonobo

Green Monkey

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	3,116,427 - 3,117,374 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	3,116,593 - 3,117,457 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	3,019,721 - 3,020,668 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	2,966,471 - 2,967,418 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	17	3,037,943 - 3,038,890 (+)	NCBI
Cytogenetic Map	17	p13.3	NCBI
HuRef	17	2,911,974 - 2,912,921 (+)	NCBI		HuRef
CHM1_1	17	3,028,575 - 3,029,522 (+)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

antirheumatic drug (EXP)

methotrexate (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of smell (IEA)

G protein-coupled receptor signaling pathway (IEA)

Cellular Component

integral component of membrane (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

olfactory receptor activity (IBA)

References

References - curated


1.	GOA_HUMAN data from the GO Consortium
2.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8004088	PMID:10673334	PMID:12023980	PMID:12379593	PMID:15741602	PMID:18802787	PMID:21873635

Genomics

Comparative Map Data

OR1E3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	3,116,427 - 3,117,374 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	3,116,593 - 3,117,457 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	3,019,721 - 3,020,668 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	2,966,471 - 2,967,418 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	17	3,037,943 - 3,038,890 (+)	NCBI
Cytogenetic Map	17	p13.3	NCBI
HuRef	17	2,911,974 - 2,912,921 (+)	NCBI		HuRef
CHM1_1	17	3,028,575 - 3,029,522 (+)	NCBI		CHM1_1

Olfr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	73,285,902 - 73,290,321 (-)	NCBI	GRCm39		mm39
GRCm38	11	73,395,076 - 73,399,495 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	73,393,010 - 73,399,614 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	73,208,578 - 73,212,997 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	73,211,271 - 73,212,215 (-)	NCBI			mm8
Celera	11	80,932,019 - 80,936,438 (-)	NCBI		Celera
Cytogenetic Map	11	B4	NCBI
cM Map	11	45.33	NCBI

LOC100994685
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	3,106,073 - 3,107,092 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	17	3,106,036 - 3,108,000 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

LOC103242145
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	2,742,796 - 2,744,392 (-)	NCBI

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	126
Count of miRNA genes:	99
Interacting mature miRNAs:	99
Transcripts:	ENST00000270133, ENST00000575608
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

High

Medium

Low

Below cutoff

109

180

282

130

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_002151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001348201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF087929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF399437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF546363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KP290396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U04690	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U53583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000575608

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	17	3,116,427 - 3,117,374 (+)	Ensembl

RefSeq Acc Id:

NM_001348201 ⟹ NP_001335130

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	17	3,116,593 - 3,117,457 (+)	NCBI

Sequence:

show sequence

ATGCCTATGTATTTGTGTCTCAGCAACTTGTCCTTCTCTGACCTCTGCTTTTCCTCGGTCACAA
TGCCCAAATTGCTGCAGAACATGCAGAGCCAAAACCCATCCATCCCCTTTGCGGACTGCCTGGC
TCAGATGTACTTTCATCTGTTTTATGGAGTTCTGGAGAGCTTCCTCCTTGTGGTCATGGCTTAT
CACTGCTATGTGGCTATTTGCTTTCCTCTGCACTACACCACTATCATGAGCCCCAAGTGTTGCC
TTGGTCTGCTGACACTCTCCTGGCTGTTGACCACTGCCCATGCCACGTTGCACACCTTGCTTAT
GGCCAGGCTGTCCTTTTGTGCTGAGAATGTGATTCCTCACTTTTTCTGTGATACATCTACCTTG
TTGAAGCTGGCCTGCTCCAACACGCAAGTCAATGGGTGGGTGATGTTTTTCATGGGCGGGCTCA
TCCTTGTCATCCCATTCCTACTCCTCATCATGTCCTGTGCAAGAATCGTCTCCACCATCCTCAG
GGTCCCTTCCACTGGGGGCATCCAGAAGGCTTTCTCCACCTGTGGCCCCCACCTCTCTGTGGTG
TCTCTCTTCTATGGGACAATTATTGGTCTCTACTTGTGCCCATTGACGAATCATAACACTGTGA
AGGACACTGTCATGGCTGTGATGTACACTGGGGTGACCCACATGCTGAACCCCTTCATCTACAG
CCTGAGGAACAGAGACATGAGGGGGAACCCTGGGCAGAGTCTTCAGCACAAAGAAAATTTTTTT
GTCTTTAAAATAGTAATAGTTGGCATTTTACCGTTATTGAATTTAGTAGGTGTAGTAAAGTTGA
TAATGAAATATCACTCTAAATCAGTGGCTTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001335130	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC99555	(Get FASTA)	NCBI Sequence Viewer
	Q8WZA6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001335130 ⟸ NM_001348201

- Sequence:

show sequence

MPMYLCLSNLSFSDLCFSSVTMPKLLQNMQSQNPSIPFADCLAQMYFHLFYGVLESFLLVVMAY
HCYVAICFPLHYTTIMSPKCCLGLLTLSWLLTTAHATLHTLLMARLSFCAENVIPHFFCDTSTL
LKLACSNTQVNGWVMFFMGGLILVIPFLLLIMSCARIVSTILRVPSTGGIQKAFSTCGPHLSVV
SLFYGTIIGLYLCPLTNHNTVKDTVMAVMYTGVTHMLNPFIYSLRNRDMRGNPGQSLQHKENFF
VFKIVIVGILPLLNLVGVVKLIMKYHSKSVA

hide sequence

Protein Domains

G_PROTEIN_RECEP_F1_2

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 17p13.3-13.2(chr17:198748-3436345)x1	copy number loss	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053386]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053386]\|See cases [RCV000053386]	Chr17:198748..3436345 [GRCh38] Chr17:50690..3339639 [GRCh37] Chr17:48539..3286389 [NCBI36] Chr17:17p13.3-13.2	pathogenic

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:8191	AgrOrtholog
COSMIC	OR1E3	COSMIC
Ensembl Genes	ENSG00000142163	Ensembl
GTEx	ENSG00000142163	GTEx
HGNC ID	HGNC:8191	ENTREZGENE
Human Proteome Map	OR1E3	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Olfact_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:8389	UniProtKB/TrEMBL
NCBI Gene	8389	ENTREZGENE
Pfam	7tm_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA32064	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot
	OLFACTORYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	OR1E3_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9UM77_HUMAN	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-05-11	OR1E3	olfactory receptor family 1 subfamily E member 3	OR1E3	olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)	Symbol and/or name change	19259463	PROVISIONAL
2015-12-15	OR1E3	olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)	OR1E3	olfactory receptor, family 1, subfamily E, member 3 (gene/pseudogene)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)