OR1E3 (olfactory receptor family 1 subfamily E member 3) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: OR1E3 (olfactory receptor family 1 subfamily E member 3) Homo sapiens
Analyze
Symbol: OR1E3
Name: olfactory receptor family 1 subfamily E member 3
RGD ID: 1351004
HGNC Page HGNC
Description: Predicted to have olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to localize to integral component of membrane and plasma membrane.
Type: pseudo
RefSeq Status: INFERRED
Also known as: olfactory receptor 17-210; olfactory receptor 1E3; olfactory receptor family 1 subfamily E member 3 (gene/pseudogene); olfactory receptor OR17-7; olfactory receptor, family 1, subfamily E, member 3 pseudogene; OLFR 17-210; OR17-210; OR1E3P; seven transmembrane helices olfactory receptor
RGD Orthologs
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl173,116,427 - 3,117,374 (+)EnsemblGRCh38hg38GRCh38
GRCh38173,116,593 - 3,117,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37173,019,721 - 3,020,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36172,966,471 - 2,967,418 (+)NCBINCBI36hg18NCBI36
Celera173,037,943 - 3,038,890 (+)NCBI
Cytogenetic Map17p13.3NCBI
HuRef172,911,974 - 2,912,921 (+)NCBIHuRef
CHM1_1173,028,575 - 3,029,522 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8004088   PMID:10673334   PMID:12023980   PMID:12379593   PMID:15741602   PMID:18802787   PMID:21873635  


Genomics

Comparative Map Data
OR1E3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl173,116,427 - 3,117,374 (+)EnsemblGRCh38hg38GRCh38
GRCh38173,116,593 - 3,117,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37173,019,721 - 3,020,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36172,966,471 - 2,967,418 (+)NCBINCBI36hg18NCBI36
Celera173,037,943 - 3,038,890 (+)NCBI
Cytogenetic Map17p13.3NCBI
HuRef172,911,974 - 2,912,921 (+)NCBIHuRef
CHM1_1173,028,575 - 3,029,522 (+)NCBICHM1_1
Olfr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,285,902 - 73,290,321 (-)NCBIGRCm39mm39
GRCm381173,395,076 - 73,399,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,393,010 - 73,399,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,208,578 - 73,212,997 (-)NCBIGRCm37mm9NCBIm37
MGSCv361173,211,271 - 73,212,215 (-)NCBImm8
Celera1180,932,019 - 80,936,438 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1145.33NCBI
LOC100994685
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1173,106,073 - 3,107,092 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0173,106,036 - 3,108,000 (+)NCBIMhudiblu_PPA_v0panPan3
LOC103242145
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,742,796 - 2,744,392 (-)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:99
Interacting mature miRNAs:99
Transcripts:ENST00000270133, ENST00000575608
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 3 1 3 1
Below cutoff 97 109 57 17 89 5 180 75 282 8 282 56 12 43 130

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_002151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001348201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF399437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF546363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP290396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000575608
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl173,116,427 - 3,117,374 (+)Ensembl
RefSeq Acc Id: NM_001348201   ⟹   NP_001335130
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38173,116,593 - 3,117,457 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001335130 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC99555 (Get FASTA)   NCBI Sequence Viewer  
  Q8WZA6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001335130   ⟸   NM_001348201
- Sequence:
Protein Domains
G_PROTEIN_RECEP_F1_2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17p13.3-13.2(chr17:198748-3436345)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053386]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053386]|See cases [RCV000053386] Chr17:198748..3436345 [GRCh38]
Chr17:50690..3339639 [GRCh37]
Chr17:48539..3286389 [NCBI36]
Chr17:17p13.3-13.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8191 AgrOrtholog
COSMIC OR1E3 COSMIC
Ensembl Genes ENSG00000142163 Ensembl
GTEx ENSG00000142163 GTEx
HGNC ID HGNC:8191 ENTREZGENE
Human Proteome Map OR1E3 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8389 UniProtKB/TrEMBL
NCBI Gene 8389 ENTREZGENE
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32064 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt OR1E3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9UM77_HUMAN UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-11 OR1E3  olfactory receptor family 1 subfamily E member 3  OR1E3  olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)  Symbol and/or name change 19259463 PROVISIONAL
2015-12-15 OR1E3  olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)  OR1E3  olfactory receptor, family 1, subfamily E, member 3 (gene/pseudogene)  Symbol and/or name change 5135510 APPROVED