Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | increases expression | EXP | | 6480464 | epigallocatechin gallate results in increased expression of TULP4 mRNA | CTD | PMID:22079256 | (-)-epigallocatechin 3-gallate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TULP4 mRNA | CTD | PMID:22079256 | (1->4)-beta-D-glucan | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TULP4 mRNA | CTD | PMID:36331819 | 1,2-dichloroethane | decreases expression | ISO | Tulp4 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of TULP4 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Tulp4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TULP4 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of TULP4 mRNA] | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Tulp4 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of TULP4 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of TULP4 mRNA | CTD | PMID:29097150 | 17alpha-ethynylestradiol | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of TULP4 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TULP4 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of TULP4 mRNA | CTD | PMID:32145629 | 2,2',5,5'-tetrachlorobiphenyl | increases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:23829299 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TULP4 mRNA and AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TULP4 mRNA] | CTD | PMID:15034205 and PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TULP4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TULP4 mRNA | CTD | PMID:15034205 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tulp4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TULP4 mRNA | CTD | PMID:21570461 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TULP4 mRNA | CTD | PMID:28628672 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of TULP4 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | EXP | | 6480464 | aflatoxin B2 results in increased methylation of TULP4 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of TULP4 mRNA | CTD | PMID:23724009 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of TULP4 mRNA | CTD | PMID:33167477 | amphetamine | decreases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of TULP4 mRNA | CTD | PMID:30779732 | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of TULP4 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of TULP4 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of TULP4 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of TULP4 intron and Benzo(a)pyrene affects the methylation of TULP4 promoter | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of TULP4 mRNA | CTD | PMID:15034205 more ... | benzo[a]pyrene | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TULP4 mRNA and AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of TULP4 mRNA] | CTD | PMID:15034205 and PMID:27858113 | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:20018196 | benzo[b]fluoranthene | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TULP4 mRNA | CTD | PMID:27858113 | bisphenol A | decreases expression | ISO | Tulp4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of TULP4 mRNA | CTD | PMID:26063408 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of TULP4 gene | CTD | PMID:31601247 | bisphenol A | affects methylation | ISO | Tulp4 (Mus musculus) | 6480464 | bisphenol A affects the methylation of TULP4 promoter | CTD | PMID:27334623 | bisphenol A | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TULP4 mRNA | CTD | PMID:28628672 | bisphenol A | increases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of TULP4 mRNA | CTD | PMID:29097150 and PMID:30816183 | bisphenol A | increases methylation | ISO | Tulp4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of TULP4 gene | CTD | PMID:28505145 | bisphenol A | affects expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of TULP4 mRNA | CTD | PMID:25181051 and PMID:32145629 | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of TULP4 mRNA | CTD | PMID:26079696 | camptothecin | decreases expression | EXP | | 6480464 | Camptothecin results in decreased expression of TULP4 mRNA | CTD | PMID:33770205 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TULP4 gene] | CTD | PMID:28238834 | chlordecone | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | Chlordecone results in increased expression of TULP4 mRNA | CTD | PMID:33711761 | chloroprene | increases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Chloroprene results in increased expression of TULP4 mRNA | CTD | PMID:23125180 | chlorpyrifos | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of TULP4 mRNA | CTD | PMID:37019170 | chrysene | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TULP4 mRNA | CTD | PMID:27858113 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of TULP4 mRNA | CTD | PMID:27392435 | coumestrol | decreases expression | EXP | | 6480464 | Coumestrol results in decreased expression of TULP4 mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TULP4 mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in increased expression of TULP4 mRNA | CTD | PMID:29279043 | cyclosporin A | increases methylation | EXP | | 6480464 | Cyclosporine results in increased methylation of TULP4 promoter | CTD | PMID:27989131 | decabromodiphenyl ether | decreases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in decreased expression of TULP4 mRNA | CTD | PMID:23914054 | dexamethasone | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TULP4 mRNA | CTD | PMID:28628672 | dibenz[a,h]anthracene | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | dicrotophos | increases expression | EXP | | 6480464 | dicrotophos results in increased expression of TULP4 mRNA | CTD | PMID:28302478 | diuron | decreases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of TULP4 mRNA | CTD | PMID:25152437 | Enterolactone | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TULP4 mRNA | CTD | PMID:19167446 | epoxiconazole | decreases expression | ISO | Tulp4 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of TULP4 mRNA | CTD | PMID:35436446 | fenthion | decreases expression | ISO | Tulp4 (Mus musculus) | 6480464 | Fenthion results in decreased expression of TULP4 mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of TULP4 mRNA] | CTD | PMID:22206623 | FR900359 | affects phosphorylation | EXP | | 6480464 | FR900359 affects the phosphorylation of TULP4 protein | CTD | PMID:37730182 | geraniol | increases expression | EXP | | 6480464 | geraniol results in increased expression of TULP4 mRNA | CTD | PMID:27683099 | indometacin | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TULP4 mRNA | CTD | PMID:28628672 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of TULP4 mRNA | CTD | PMID:28988120 | menadione | affects expression | EXP | | 6480464 | Vitamin K 3 affects the expression of TULP4 mRNA | CTD | PMID:20044591 | mercury dichloride | decreases expression | EXP | | 6480464 | Mercuric Chloride results in decreased expression of TULP4 mRNA | CTD | PMID:27188386 | methidathion | decreases expression | ISO | Tulp4 (Mus musculus) | 6480464 | methidathion results in decreased expression of TULP4 mRNA | CTD | PMID:34813904 | N-nitrosodiethylamine | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TULP4 gene | CTD | PMID:23968726 | nitrofen | decreases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | nitrofen results in decreased expression of TULP4 mRNA | CTD | PMID:33484710 | panobinostat | increases expression | EXP | | 6480464 | Panobinostat results in increased expression of TULP4 mRNA | CTD | PMID:33770205 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of TULP4 mRNA | CTD | PMID:29067470 | perfluorohexanesulfonic acid | decreases expression | ISO | Tulp4 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of TULP4 mRNA | CTD | PMID:37995155 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TULP4 mRNA | CTD | PMID:36331819 | piperonyl butoxide | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TULP4 gene | CTD | PMID:23968726 | pirinixic acid | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | PPARA protein affects the reaction [pirinixic acid results in increased expression of TULP4 mRNA] | CTD | PMID:21318169 | pirinixic acid | increases expression | ISO | Tulp4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of TULP4 mRNA | CTD | PMID:21318169 | potassium chromate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TULP4 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | EXP | | 6480464 | potassium chromate(VI) results in decreased expression of TULP4 mRNA | CTD | PMID:22079256 | tamoxifen | affects expression | ISO | Tulp4 (Mus musculus) | 6480464 | Tamoxifen affects the expression of TULP4 mRNA | CTD | PMID:17555576 | tetrachloromethane | affects expression | ISO | Tulp4 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of TULP4 mRNA | CTD | PMID:17484886 | tetraphene | multiple interactions | ISO | Tulp4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TULP4 mRNA | CTD | PMID:27858113 | thioacetamide | increases expression | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of TULP4 mRNA | CTD | PMID:34492290 | urethane | increases expression | EXP | | 6480464 | Urethane results in increased expression of TULP4 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of TULP4 gene | CTD | PMID:29154799 | valproic acid | affects splicing | ISO | Tulp4 (Rattus norvegicus) | 6480464 | Valproic Acid affects the splicing of TULP4 mRNA | CTD | PMID:29427782 | vincristine | increases expression | EXP | | 6480464 | Vincristine results in increased expression of TULP4 mRNA | CTD | PMID:23649840 | vorinostat | decreases expression | EXP | | 6480464 | vorinostat results in decreased expression of TULP4 mRNA | CTD | PMID:27188386 | |