Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | PCYOX1 | Human | (+)-schisandrin B | multiple interactions | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PCYOX1 mRNA] | CTD | PMID:31150632 | PCYOX1 | Human | 1,2-dimethylhydrazine | multiple interactions | ISO | Pcyox1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PCYOX1 mRNA | CTD | PMID:22206623 | PCYOX1 | Human | 1,2-dimethylhydrazine | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PCYOX1 mRNA | CTD | PMID:22206623 | PCYOX1 | Human | 17alpha-ethynylestradiol | increases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of PCYOX1 mRNA | CTD | PMID:29097150 | PCYOX1 | Human | 17beta-estradiol | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of PCYOX1 mRNA | CTD | PMID:32145629 | PCYOX1 | Human | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | PCYOX1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PCYOX1 mRNA | CTD | PMID:21570461 | PCYOX1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PCYOX1 mRNA | CTD | PMID:33387578 | PCYOX1 | Human | 2,4,6-tribromophenol | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | PCYOX1 | Human | 2,6-dinitrotoluene | affects expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of PCYOX1 mRNA | CTD | PMID:21346803 | PCYOX1 | Human | 3,3',5,5'-tetrabromobisphenol A | decreases expression | EXP | | 6480464 | tetrabromobisphenol A results in decreased expression of PCYOX1 protein | CTD | PMID:31675489 | PCYOX1 | Human | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PCYOX1 mRNA | CTD | PMID:20188158 | PCYOX1 | Human | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | Pcyox1 (Mus musculus) | 6480464 | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PCYOX1 mRNA | CTD | PMID:24848799 | PCYOX1 | Human | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PCYOX1 mRNA | CTD | PMID:28628672 | PCYOX1 | Human | 4,4'-diaminodiphenylmethane | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of PCYOX1 mRNA | CTD | PMID:18648102 | PCYOX1 | Human | 4,4'-sulfonyldiphenol | affects methylation | ISO | Pcyox1 (Mus musculus) | 6480464 | bisphenol S affects the methylation of PCYOX1 gene | CTD | PMID:31683443 | PCYOX1 | Human | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of PCYOX1 protein | CTD | PMID:34186270 | PCYOX1 | Human | 4-hydroxynon-2-enal | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in increased expression of PCYOX1 mRNA | CTD | PMID:19191707 | PCYOX1 | Human | acetamide | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of PCYOX1 mRNA | CTD | PMID:31881176 | PCYOX1 | Human | aconitine | increases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Aconitine results in increased expression of PCYOX1 protein | CTD | PMID:33236894 | PCYOX1 | Human | afimoxifene | increases expression | EXP | | 6480464 | afimoxifene results in increased expression of PCYOX1 mRNA | CTD | PMID:16849584 | PCYOX1 | Human | aflatoxin B1 | affects expression | EXP | | 6480464 | Aflatoxin B1 affects the expression of PCYOX1 protein | CTD | PMID:20106945 | PCYOX1 | Human | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of PCYOX1 mRNA | CTD | PMID:27153756 | PCYOX1 | Human | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of PCYOX1 mRNA | CTD | PMID:33167477 | PCYOX1 | Human | amitrole | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of PCYOX1 mRNA | CTD | PMID:38685447 | PCYOX1 | Human | ammonium chloride | affects expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of PCYOX1 mRNA | CTD | PMID:16483693 | PCYOX1 | Human | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of PCYOX1 mRNA | CTD | PMID:33212167 | PCYOX1 | Human | Aroclor 1254 | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PCYOX1 mRNA | CTD | PMID:23650126 | PCYOX1 | Human | benzene | affects expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Benzene affects the expression of PCYOX1 mRNA | CTD | PMID:15878777 | PCYOX1 | Human | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of PCYOX1 intron | CTD | PMID:30157460 | PCYOX1 | Human | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of PCYOX1 promoter | CTD | PMID:27901495 | PCYOX1 | Human | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:20018196 | PCYOX1 | Human | benzo[a]pyrene diol epoxide I | increases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:20382639 and PMID:26238291 | PCYOX1 | Human | bisphenol A | increases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PCYOX1 mRNA | CTD | PMID:25181051 more ... | PCYOX1 | Human | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PCYOX1 protein | CTD | PMID:34186270 | PCYOX1 | Human | bisphenol A | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of PCYOX1 mRNA | CTD | PMID:32145629 | PCYOX1 | Human | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PCYOX1 mRNA and bisphenol A results in increased expression of PCYOX1 protein | CTD | PMID:29275510 and PMID:37567409 | PCYOX1 | Human | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PCYOX1 mRNA | CTD | PMID:30903817 | PCYOX1 | Human | bisphenol A | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PCYOX1 mRNA | CTD | PMID:28628672 | PCYOX1 | Human | Bisphenol B | increases expression | EXP | | 6480464 | bisphenol B results in increased expression of PCYOX1 protein | CTD | PMID:34186270 | PCYOX1 | Human | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of PCYOX1 protein | CTD | PMID:34186270 | PCYOX1 | Human | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of PCYOX1 mRNA | CTD | PMID:26079696 | PCYOX1 | Human | cannabidiol | decreases expression | EXP | | 6480464 | Cannabidiol results in decreased expression of PCYOX1 mRNA | CTD | PMID:33244087 | PCYOX1 | Human | carbon nanotube | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of PCYOX1 mRNA | CTD | PMID:25620056 | PCYOX1 | Human | cisplatin | multiple interactions | EXP | | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PCYOX1 mRNA | CTD | PMID:27392435 | PCYOX1 | Human | copper(II) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of PCYOX1 mRNA | CTD | PMID:19549813 | PCYOX1 | Human | coumarin | increases phosphorylation | EXP | | 6480464 | coumarin results in increased phosphorylation of PCYOX1 protein | CTD | PMID:35688186 | PCYOX1 | Human | crocidolite asbestos | affects expression | EXP | | 6480464 | Asbestos and Crocidolite affects the expression of PCYOX1 mRNA | CTD | PMID:17331233 | PCYOX1 | Human | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PCYOX1 mRNA | CTD | PMID:20106945 more ... | PCYOX1 | Human | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of PCYOX1 protein | CTD | PMID:31675489 | PCYOX1 | Human | dexamethasone | multiple interactions | ISO | Pcyox1 (Mus musculus) | 6480464 | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PCYOX1 mRNA | CTD | PMID:24848799 | PCYOX1 | Human | dexamethasone | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PCYOX1 mRNA | CTD | PMID:28628672 | PCYOX1 | Human | Dibutyl phosphate | affects expression | EXP | | 6480464 | di-n-butylphosphoric acid affects the expression of PCYOX1 mRNA | CTD | PMID:37042841 | PCYOX1 | Human | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of PCYOX1 mRNA | CTD | PMID:29803840 | PCYOX1 | Human | epoxiconazole | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of PCYOX1 mRNA | CTD | PMID:35436446 | PCYOX1 | Human | ethanol | multiple interactions | ISO | Pcyox1 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of PCYOX1 mRNA | CTD | PMID:30319688 | PCYOX1 | Human | flutamide | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of PCYOX1 mRNA | CTD | PMID:24793618 | PCYOX1 | Human | folic acid | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PCYOX1 mRNA | CTD | PMID:25629700 | PCYOX1 | Human | folic acid | multiple interactions | ISO | Pcyox1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PCYOX1 mRNA | CTD | PMID:22206623 | PCYOX1 | Human | gentamycin | increases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PCYOX1 mRNA | CTD | PMID:22061828 | PCYOX1 | Human | gentamycin | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of PCYOX1 mRNA | CTD | PMID:33387578 | PCYOX1 | Human | indometacin | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PCYOX1 mRNA | CTD | PMID:28628672 | PCYOX1 | Human | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of PCYOX1 protein | CTD | PMID:32959892 | PCYOX1 | Human | lead diacetate | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | lead acetate results in decreased expression of PCYOX1 mRNA | CTD | PMID:21829687 | PCYOX1 | Human | lipopolysaccharide | decreases expression | EXP | | 6480464 | Lipopolysaccharides results in decreased expression of PCYOX1 mRNA | CTD | PMID:35811015 | PCYOX1 | Human | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PCYOX1 mRNA | CTD | PMID:35811015 | PCYOX1 | Human | methapyrilene | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of PCYOX1 mRNA | CTD | PMID:30467583 | PCYOX1 | Human | methotrexate | increases expression | EXP | | 6480464 | Methotrexate results in increased expression of PCYOX1 mRNA | CTD | PMID:17400583 | PCYOX1 | Human | methoxychlor | affects methylation | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of PCYOX1 gene | CTD | PMID:35440735 | PCYOX1 | Human | N-methyl-4-phenylpyridinium | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of PCYOX1 protein | CTD | PMID:26558463 | PCYOX1 | Human | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of PCYOX1 mRNA | CTD | PMID:23195993 | PCYOX1 | Human | paracetamol | affects expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PCYOX1 mRNA | CTD | PMID:17562736 | PCYOX1 | Human | paracetamol | increases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of PCYOX1 mRNA | CTD | PMID:33387578 | PCYOX1 | Human | paraquat | affects expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Paraquat affects the expression of PCYOX1 mRNA | CTD | PMID:16854511 | PCYOX1 | Human | perfluorononanoic acid | decreases expression | EXP | | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of PCYOX1 mRNA | CTD | PMID:32588087 | PCYOX1 | Human | phenytoin | increases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Phenytoin results in increased expression of PCYOX1 mRNA | CTD | PMID:20345932 | PCYOX1 | Human | pirinixic acid | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PCYOX1 mRNA | CTD | PMID:18445702 | PCYOX1 | Human | pirinixic acid | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PCYOX1 mRNA | CTD | PMID:17426115 more ... | PCYOX1 | Human | potassium dichromate | increases expression | EXP | | 6480464 | Potassium Dichromate results in increased expression of PCYOX1 protein | CTD | PMID:23718831 | PCYOX1 | Human | rimonabant | affects expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Rimonabant affects the expression of PCYOX1 mRNA | CTD | PMID:19030233 | PCYOX1 | Human | rimonabant | multiple interactions | ISO | Pcyox1 (Mus musculus) | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PCYOX1 mRNA] | CTD | PMID:19030233 | PCYOX1 | Human | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PCYOX1 mRNA | CTD | PMID:35811015 | PCYOX1 | Human | SB 431542 | multiple interactions | EXP | | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of PCYOX1 protein | CTD | PMID:37664457 | PCYOX1 | Human | silicon dioxide | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of PCYOX1 mRNA | CTD | PMID:19073995 | PCYOX1 | Human | silicon dioxide | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of PCYOX1 mRNA | CTD | PMID:23221170 | PCYOX1 | Human | sodium arsenite | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of PCYOX1 protein | CTD | PMID:29044176 | PCYOX1 | Human | sodium arsenite | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of PCYOX1 mRNA | CTD | PMID:37682722 | PCYOX1 | Human | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of PCYOX1 mRNA | CTD | PMID:38568856 | PCYOX1 | Human | temozolomide | decreases expression | EXP | | 6480464 | Temozolomide results in decreased expression of PCYOX1 mRNA | CTD | PMID:31758290 | PCYOX1 | Human | tert-butyl hydroperoxide | decreases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in decreased expression of PCYOX1 mRNA | CTD | PMID:15336504 | PCYOX1 | Human | testosterone enanthate | affects expression | EXP | | 6480464 | testosterone enanthate affects the expression of PCYOX1 mRNA | CTD | PMID:17440010 | PCYOX1 | Human | tetrachloromethane | multiple interactions | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PCYOX1 mRNA] | CTD | PMID:31150632 | PCYOX1 | Human | tetrachloromethane | decreases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of PCYOX1 mRNA | CTD | PMID:31919559 | PCYOX1 | Human | tetrachloromethane | decreases expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of PCYOX1 mRNA | CTD | PMID:31150632 | PCYOX1 | Human | thiram | decreases expression | EXP | | 6480464 | Thiram results in decreased expression of PCYOX1 mRNA | CTD | PMID:38568856 | PCYOX1 | Human | tributylstannane | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | tributyltin results in increased expression of PCYOX1 mRNA | CTD | PMID:24848799 | PCYOX1 | Human | trichostatin A | affects expression | EXP | | 6480464 | trichostatin A affects the expression of PCYOX1 mRNA | CTD | PMID:28542535 | PCYOX1 | Human | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of PCYOX1 mRNA | CTD | PMID:37042841 | PCYOX1 | Human | triphenyl phosphate | affects expression | ISO | Pcyox1 (Rattus norvegicus) | 6480464 | triphenyl phosphate affects the expression of PCYOX1 mRNA | CTD | PMID:30589522 | PCYOX1 | Human | triptonide | increases expression | ISO | Pcyox1 (Mus musculus) | 6480464 | triptonide results in increased expression of PCYOX1 mRNA | CTD | PMID:33045310 | PCYOX1 | Human | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of PCYOX1 mRNA | CTD | PMID:19101580 | PCYOX1 | Human | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of PCYOX1 mRNA | CTD | PMID:25979313 | PCYOX1 | Human | zinc atom | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of PCYOX1 mRNA | CTD | PMID:22171008 | PCYOX1 | Human | zinc(0) | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of PCYOX1 mRNA | CTD | PMID:22171008 | PCYOX1 | Human | zoledronic acid | increases expression | EXP | | 6480464 | zoledronic acid results in increased expression of PCYOX1 mRNA | CTD | PMID:20977926 | |