MYG1 (MYG1 exonuclease) - Rat Genome Database

Name: MYG1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MYG1 (MYG1 exonuclease) Homo sapiens

Analyze

Symbol:

MYG1

Name:

MYG1 exonuclease

RGD ID:

1350875

HGNC Page

HGNC:17590

Description:

Predicted to enable nuclease activity. Predicted to act upstream of or within locomotory exploration behavior. Located in mitochondrion and nucleoplasm.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

C12orf10; chromosome 12 open reading frame 10; Gamm1; melanocyte proliferating gene 1; melanocyte related; MST024; MSTP024; MYG; UPF0160 protein MYG1, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Myg1 (melanocyte proliferating gene 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Myg1 (MYG1 exonuclease)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Myg1 (MYG1 exonuclease)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	MYG1 (MYG1 exonuclease)	NCBI	Ortholog
Canis lupus familiaris (dog):	MYG1 (MYG1 exonuclease)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Myg1 (MYG1 exonuclease)	NCBI	Ortholog
Sus scrofa (pig):	MYG1 (MYG1 exonuclease)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	MYG1 (MYG1 exonuclease)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Myg1 (MYG1 exonuclease)	NCBI	Ortholog
Other homologs ²
Sus scrofa (pig):	MYG1 (MYG1 exonuclease)	HGNC	Ensembl, OMA, OrthoDB, Panther, Treefam
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Myg1 (MYG1 exonuclease)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Myg1 (melanocyte proliferating gene 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	myg1 (melanocyte proliferating gene 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	CG11980	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C27H6.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YER156C	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	myg1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

MYG1P1

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	53,299,695 - 53,307,177 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	53,299,695 - 53,307,177 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	53,693,479 - 53,700,961 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	51,979,737 - 51,987,232 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	51,979,748 - 51,987,229	NCBI
Celera	12	53,342,755 - 53,350,242 (+)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	50,734,992 - 50,742,478 (+)	NCBI		HuRef
CHM1_1	12	53,659,909 - 53,667,402 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	53,265,406 - 53,272,879 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

triple-A syndrome (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

aconitine (ISO)

all-trans-retinoic acid (EXP)

aristolochic acid A (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (EXP)

chlordecone (ISO)

chlorpyrifos (ISO)

cocaine (ISO)

cyclosporin A (EXP)

decabromodiphenyl ether (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (EXP)

fenthion (ISO)

folic acid (ISO)

ivermectin (EXP)

methidathion (ISO)

nickel atom (ISO)

paracetamol (EXP,ISO)

propiconazole (ISO)

resveratrol (ISO)

SB 431542 (EXP)

tamoxifen (ISO)

thioacetamide (ISO)

triptonide (ISO)

tunicamycin (EXP)

urethane (EXP)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

locomotory exploration behavior (IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA)

mitochondrial matrix (IEA)

mitochondrion (IDA,IEA)

nucleolus (IEA)

nucleoplasm (IDA,IEA)

nucleus (IBA,IDA,IEA)

Molecular Function

hydrolase activity (IEA)

molecular_function (ND)

nuclease activity (IEA)

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15146197	PMID:15231748	PMID:16263121	PMID:16996721	PMID:17207965	PMID:18624398	PMID:19014353	PMID:20377893	PMID:21873635	PMID:22863883	PMID:22939629
PMID:23376485	PMID:23706493	PMID:25277244	PMID:25416956	PMID:26344197	PMID:26871637	PMID:30575818	PMID:31056398	PMID:31081026	PMID:31515488	PMID:32296183	PMID:32513696
PMID:32687490	PMID:32786267	PMID:32814053	PMID:33729478	PMID:33961781	PMID:35831314	PMID:35944360	PMID:35987950	PMID:36215168	PMID:37827155

Genomics

Comparative Map Data

MYG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	53,299,695 - 53,307,177 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	53,299,695 - 53,307,177 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	53,693,479 - 53,700,961 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	51,979,737 - 51,987,232 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	51,979,748 - 51,987,229	NCBI
Celera	12	53,342,755 - 53,350,242 (+)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	50,734,992 - 50,742,478 (+)	NCBI		HuRef
CHM1_1	12	53,659,909 - 53,667,402 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	53,265,406 - 53,272,879 (+)	NCBI		T2T-CHM13v2.0

Myg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	102,240,144 - 102,246,574 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	102,240,144 - 102,246,574 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	102,331,709 - 102,338,139 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	102,331,709 - 102,338,139 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	102,162,140 - 102,168,570 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	102,159,744 - 102,165,885 (+)	NCBI		MGSCv36	mm8
Celera	15	104,488,769 - 104,495,141 (+)	NCBI		Celera
Cytogenetic Map	15	F3	NCBI
cM Map	15	57.49	NCBI

Myg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	135,335,364 - 135,342,567 (+)	NCBI		GRCr8
mRatBN7.2	7	133,456,778 - 133,463,985 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	133,456,750 - 133,466,969 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	135,217,777 - 135,225,021 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	137,447,157 - 137,454,401 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	137,432,305 - 137,439,549 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	143,929,662 - 143,936,865 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	143,929,662 - 143,936,864 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	141,725,704 - 141,732,907 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	141,080,469 - 141,087,672 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	141,156,905 - 141,164,108 (+)	NCBI
Celera	7	129,890,186 - 129,897,389 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

Myg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	560,207 - 567,081 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	560,033 - 567,102 (+)	NCBI	ChiLan1.0	ChiLan1.0

MYG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	40,878,978 - 40,886,292 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	40,875,743 - 40,882,962 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	35,447,248 - 35,454,454 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	36,228,165 - 36,235,474 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	36,228,165 - 36,235,474 (-)	Ensembl	panpan1.1		panPan2

MYG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	1,900,360 - 1,905,946 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	1,900,360 - 1,905,931 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,343,336 - 44,348,921 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	1,904,821 - 1,910,407 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	1,885,025 - 1,910,810 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	1,923,155 - 1,928,712 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	1,908,056 - 1,913,641 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	44,744,034 - 44,749,620 (+)	NCBI		UU_Cfam_GSD_1.0

Myg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	62,575,564 - 62,581,240 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	10,581,797 - 10,589,250 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	10,583,552 - 10,589,266 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	18,517,001 - 18,525,877 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	18,516,947 - 18,526,069 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	18,952,686 - 18,961,606 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	49,403,574 - 49,424,193 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	196,643,964 - 196,651,681 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Myg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624904	1,412,049 - 1,419,365 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624904	1,412,664 - 1,419,398 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 12q13.13(chr12:53099658-53724525)x1	copy number loss	See cases [RCV000052811]	Chr12:53099658..53724525 [GRCh38] Chr12:53493442..54118309 [GRCh37] Chr12:51779709..52404576 [NCBI36] Chr12:12q13.13	pathogenic
GRCh38/hg38 12q13.13(chr12:53224024-54222450)x1	copy number loss	See cases [RCV000052812]	Chr12:53224024..54222450 [GRCh38] Chr12:53617808..54616234 [GRCh37] Chr12:51904075..52902501 [NCBI36] Chr12:12q13.13	pathogenic
GRCh38/hg38 12q13.13(chr12:52851850-53558824)x3	copy number gain	See cases [RCV000138030]	Chr12:52851850..53558824 [GRCh38] Chr12:53245634..53952608 [GRCh37] Chr12:51531901..52238875 [NCBI36] Chr12:12q13.13	likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3	copy number gain	See cases [RCV000139555]	Chr12:121271..133196807 [GRCh38] Chr12:282465..133773393 [GRCh37] Chr12:100698..132283466 [NCBI36] Chr12:12p13.33-q24.33	pathogenic
NC_000012.11:g.26370251_54361538inv	inversion	not specified [RCV000714265]	Chr12:26370251..54361538 [GRCh37] Chr12:12p12.1-q13.13	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3	copy number gain	See cases [RCV000258805]	Chr12:1..133851895 [GRCh37] Chr12:12p13.33-q24.33	pathogenic\|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3	copy number gain	See cases [RCV000510482]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)	copy number gain	See cases [RCV000511643]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3	copy number gain	not provided [RCV000750246]	Chr12:191619..133777645 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3	copy number gain	not provided [RCV000750253]	Chr12:621220..133779118 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12q13.13(chr12:53502510-54256094)x3	copy number gain	not specified [RCV003986989]	Chr12:53502510..54256094 [GRCh37] Chr12:12q13.13	uncertain significance
GRCh37/hg19 12q13.13(chr12:53583828-53922629)x3	copy number gain	not provided [RCV003484869]	Chr12:53583828..53922629 [GRCh37] Chr12:12q13.13	uncertain significance
NC_000012.12:g.53306793_53321761del	deletion	Glucocorticoid deficiency with achalasia [RCV000760142]	Chr12:53306793..53321761 [GRCh38] Chr12:12q13.13	pathogenic
GRCh37/hg19 12q13.13(chr12:53614278-53971802)x1	copy number loss	not provided [RCV001259613]	Chr12:53614278..53971802 [GRCh37] Chr12:12q13.13	likely pathogenic
GRCh37/hg19 12q13.13(chr12:53372321-53864490)x1	copy number loss	not provided [RCV001259614]	Chr12:53372321..53864490 [GRCh37] Chr12:12q13.13	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1596
Count of miRNA genes:	521
Interacting mature miRNAs:	571
Transcripts:	ENST00000267103, ENST00000547490, ENST00000547864, ENST00000548632, ENST00000548845, ENST00000549177, ENST00000549488, ENST00000550199, ENST00000551131, ENST00000551670
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

SHGC-31943

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	53,693,109 - 53,693,211	UniSTS	GRCh37
Build 36	12	51,979,376 - 51,979,478	RGD	NCBI36
Celera	12	53,342,395 - 53,342,497	RGD
Cytogenetic Map	12	q13	UniSTS
Cytogenetic Map	12	q12	UniSTS
HuRef	12	50,734,632 - 50,734,734	UniSTS
TNG Radiation Hybrid Map	12	25376.0	UniSTS
GeneMap99-G3 RH Map	12	1960.0	UniSTS

RH11320

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	53,700,560 - 53,700,942	UniSTS	GRCh37
Build 36	12	51,986,827 - 51,987,209	RGD	NCBI36
Celera	12	53,349,837 - 53,350,219	RGD
Cytogenetic Map	12	q13	UniSTS
HuRef	12	50,742,073 - 50,742,455	UniSTS
GeneMap99-GB4 RH Map	12	228.48	UniSTS

D12S1220E

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	53,701,356 - 53,701,446	UniSTS	GRCh37
Build 36	12	51,987,623 - 51,987,713	RGD	NCBI36
Celera	12	53,350,633 - 53,350,723	RGD
Cytogenetic Map	12	q13	UniSTS
HuRef	12	50,742,869 - 50,742,959	UniSTS

RH15738

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	53,700,792 - 53,700,929	UniSTS	GRCh37
Build 36	12	51,987,059 - 51,987,196	RGD	NCBI36
Celera	12	53,350,069 - 53,350,206	RGD
Cytogenetic Map	12	q13	UniSTS
HuRef	12	50,742,305 - 50,742,442	UniSTS
GeneMap99-GB4 RH Map	12	227.69	UniSTS
NCBI RH Map	12	441.1	UniSTS

D12S1190E

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	53,701,349 - 53,701,461	UniSTS	GRCh37
Build 36	12	51,987,616 - 51,987,728	RGD	NCBI36
Celera	12	53,350,626 - 53,350,738	RGD
Cytogenetic Map	12	q13	UniSTS
HuRef	12	50,742,862 - 50,742,974	UniSTS
GeneMap99-GB4 RH Map	12	228.58	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

2429

2858

1668

569

1912

411

4354

2099

3679

416

1447

1607

171

1204

2787

Low

133

Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_021640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA972697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC073611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF111805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF289485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK293449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC013956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC028904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC051871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM551107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CN308888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NTIA01000054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000267103 ⟹ ENSP00000267103

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,299,695 - 53,307,177 (+)	Ensembl

RefSeq Acc Id:

ENST00000547490

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,306,557 - 53,307,173 (+)	Ensembl

RefSeq Acc Id:

ENST00000547864 ⟹ ENSP00000455319

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,303,168 - 53,307,171 (+)	Ensembl

RefSeq Acc Id:

ENST00000548632 ⟹ ENSP00000450270

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,299,750 - 53,307,171 (+)	Ensembl

RefSeq Acc Id:

ENST00000548845

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,299,718 - 53,307,171 (+)	Ensembl

RefSeq Acc Id:

ENST00000549177

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,306,086 - 53,307,148 (+)	Ensembl

RefSeq Acc Id:

ENST00000549488 ⟹ ENSP00000448433

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,300,093 - 53,307,177 (+)	Ensembl

RefSeq Acc Id:

ENST00000550199

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,305,696 - 53,307,108 (+)	Ensembl

RefSeq Acc Id:

ENST00000551131

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,299,937 - 53,303,296 (+)	Ensembl

RefSeq Acc Id:

ENST00000551670

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	53,299,750 - 53,303,848 (+)	Ensembl

RefSeq Acc Id:

NM_021640 ⟹ NP_067653

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	53,299,695 - 53,307,177 (+)	NCBI
GRCh37	12	53,693,132 - 53,700,965 (+)	NCBI
Build 36	12	51,979,737 - 51,987,232 (+)	NCBI Archive
Celera	12	53,342,755 - 53,350,242 (+)	RGD
HuRef	12	50,734,992 - 50,742,478 (+)	RGD
CHM1_1	12	53,659,909 - 53,667,402 (+)	NCBI
T2T-CHM13v2.0	12	53,265,406 - 53,272,879 (+)	NCBI

Sequence:

show sequence

CTCTTCCGGGTCGGCGCTCCTGCCTCCCTGCAGGGAGCTGCTTATGGGACACCAATTCCTGCGC
GGCCTCTTAACGCTGCTGCTGCCGCCGCCACCCCTGTATACCCGGCACCGCATGCTCGGTCCAG
AGTCCGTCCCGCCCCCAAAACGATCCCGCAGCAAACTCATGGCACCGCCCCGAATCGGGACGCA
CAATGGCACCTTCCACTGCGACGAGGCACTGGCATGCGCACTGCTTCGCCTCCTGCCGGAGTAC
CGGGATGCAGAGATTGTGCGGACCCGGGATCCCGAAAAACTCGCTTCCTGTGACATCGTGGTGG
ACGTGGGGGGCGAGTACGACCCTCGGAGACACCGATATGACCATCACCAGAGGTCTTTCACAGA
GACCATGAGCTCCCTGTCCCCTGGGAAGCCGTGGCAGACCAAGCTGAGCAGTGCGGGACTCATC
TATCTGCACTTCGGGCACAAGCTGCTGGCCCAGTTGCTGGGCACTAGTGAAGAGGACAGCATGG
TGGGCACCCTCTATGACAAGATGTATGAGAACTTTGTGGAGGAGGTGGATGCTGTGGACAATGG
GATCTCCCAGTGGGCAGAGGGGGAGCCTCGATATGCACTGACCACTACCCTGAGTGCACGAGTT
GCTCGACTTAATCCTACCTGGAACCACCCCGACCAAGACACTGAGGCAGGGTTCAAGCGTGCAA
TGGATCTGGTTCAAGAGGAGTTTCTGCAGAGATTAGATTTCTACCAACACAGCTGGCTGCCAGC
CCGGGCCTTGGTGGAAGAGGCCCTTGCCCAGCGATTCCAGGTGGACCCAAGTGGAGAGATTGTG
GAACTGGCGAAAGGTGCATGTCCCTGGAAGGAGCATCTCTACCACCTGGAATCTGGGCTGTCCC
CTCCAGTGGCCATCTTCTTTGTTATCTACACTGACCAGGCTGGACAGTGGCGAATACAGTGTGT
GCCCAAGGAGCCCCACTCATTCCAAAGCCGGCTGCCCCTGCCAGAGCCATGGCGGGGTCTTCGG
GACGAGGCCCTGGACCAGGTCAGTGGGATCCCTGGCTGCATCTTCGTCCATGCAAGCGGCTTCA
CTGGCGGTCACCACACCCGAGAGGGTGCCTTGAGCATGGCCCGTGCCACCTTGGCCCAGCGCTC
ATACCTCCCACAAATCTCCTAGTCTAATAAAACCTTCCATCTCATACTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_067653	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG17847	(Get FASTA)	NCBI Sequence Viewer
	AAH13956	(Get FASTA)	NCBI Sequence Viewer
	AAH28904	(Get FASTA)	NCBI Sequence Viewer
	AAH51871	(Get FASTA)	NCBI Sequence Viewer
	AAL39007	(Get FASTA)	NCBI Sequence Viewer
	BAG56948	(Get FASTA)	NCBI Sequence Viewer
	EAW96687	(Get FASTA)	NCBI Sequence Viewer
	EAW96688	(Get FASTA)	NCBI Sequence Viewer
	EAW96689	(Get FASTA)	NCBI Sequence Viewer
	EAW96690	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000267103
	ENSP00000267103.5
	ENSP00000448433.1
	ENSP00000450270.1
	ENSP00000455319.1
	ENSP00000517432.1
GenBank Protein	Q9HB07	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_067653 ⟸ NM_021640
- Peptide Label:	precursor
- UniProtKB:	Q9HB07 (UniProtKB/Swiss-Prot), Q86UA3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGHQFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACAL LRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTK LSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEVDAVDNGISQWAEGEPRYALT TTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQV DPSGEIVELAKGACPWKEHLYHLESGLSPPVAIFFVIYTDQAGQWRIQCVPKEPHSFQSRLPLP EPWRGLRDEALDQVSGIPGCIFVHASGFIGGHHTREGALSMARATLAQRSYLPQIS hide sequence

RefSeq Acc Id:

ENSP00000267103 ⟸ ENST00000267103

RefSeq Acc Id:

ENSP00000455319 ⟸ ENST00000547864

RefSeq Acc Id:

ENSP00000450270 ⟸ ENST00000548632

RefSeq Acc Id:

ENSP00000448433 ⟸ ENST00000549488

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9HB07-F1-model_v2	AlphaFold	Q9HB07	1-376	view protein structure

Promoters

RGD ID:

6789722

Promoter ID:

HG_KWN:15753

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

NM_021640, UC001SCQ.2, UC009ZMX.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	12	51,979,594 - 51,980,094 (+)	MPROMDB

RGD ID:

7224097

Promoter ID:

EPDNEW_H17794

Type:

initiation region

Name:

C12orf10_2

Description:

chromosome 12 open reading frame 10

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H17795

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	53,299,409 - 53,299,469	EPDNEW

RGD ID:

7224107

Promoter ID:

EPDNEW_H17795

Type:

initiation region

Name:

C12orf10_1

Description:

chromosome 12 open reading frame 10

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H17794

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	53,299,695 - 53,299,755	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:17590	AgrOrtholog
COSMIC	MYG1	COSMIC
Ensembl Genes	ENSG00000139637	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000291835	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000267103	ENTREZGENE
	ENST00000267103.10	UniProtKB/Swiss-Prot
	ENST00000547864.1	UniProtKB/TrEMBL
	ENST00000548632.5	UniProtKB/TrEMBL
	ENST00000549488.5	UniProtKB/TrEMBL
	ENST00000708949.1	UniProtKB/Swiss-Prot
GTEx	ENSG00000139637	GTEx
	ENSG00000291835	GTEx
HGNC ID	HGNC:17590	ENTREZGENE
Human Proteome Map	MYG1	Human Proteome Map
InterPro	Met-dep_prot_hydro	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:60314	UniProtKB/Swiss-Prot
NCBI Gene	60314	ENTREZGENE
OMIM	611366	OMIM
PANTHER	MYG1 EXONUCLEASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11215	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	UPF0160	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F8VQQ3_HUMAN	UniProtKB/TrEMBL
	F8VR84_HUMAN	UniProtKB/TrEMBL
	H3BPH3_HUMAN	UniProtKB/TrEMBL
	MYG1_HUMAN	UniProtKB/Swiss-Prot
	Q86UA3	ENTREZGENE
	Q9HB07	ENTREZGENE
UniProt Secondary	Q86UA3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-01-21	MYG1	MYG1 exonuclease	C12orf10	chromosome 12 open reading frame 10	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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