GPR3 (G protein-coupled receptor 3) - Rat Genome Database

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Gene: GPR3 (G protein-coupled receptor 3) Homo sapiens
Analyze
Symbol: GPR3
Name: G protein-coupled receptor 3
RGD ID: 1350754
HGNC Page HGNC
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of meiotic cell cycle process involved in oocyte maturation; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within regulation of meiotic nuclear division. Predicted to be located in nuclear membrane. Predicted to be active in cytoplasm and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACCA; ACCA orphan receptor; adenylate cyclase constitutive activator; G-protein coupled receptor 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl127,392,622 - 27,395,814 (+)EnsemblGRCh38hg38GRCh38
GRCh38127,392,622 - 27,395,814 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,719,126 - 27,722,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,591,739 - 27,594,905 (+)NCBINCBI36hg18NCBI36
Build 34127,403,293 - 27,406,457NCBI
Celera126,116,440 - 26,119,606 (+)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,975,292 - 25,978,462 (+)NCBIHuRef
CHM1_1127,833,894 - 27,837,064 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7639700   PMID:7698767   PMID:7832990   PMID:7851889   PMID:8530049   PMID:12477932   PMID:12649592   PMID:15489334   PMID:15591206   PMID:16710414   PMID:17953967   PMID:19213921  
PMID:19322201   PMID:20158988   PMID:21873635   PMID:21988832   PMID:23732663   PMID:23826079   PMID:24069330   PMID:26186194   PMID:26455425   PMID:28514442   PMID:30038319   PMID:31516076  


Genomics

Comparative Map Data
GPR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl127,392,622 - 27,395,814 (+)EnsemblGRCh38hg38GRCh38
GRCh38127,392,622 - 27,395,814 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,719,126 - 27,722,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,591,739 - 27,594,905 (+)NCBINCBI36hg18NCBI36
Build 34127,403,293 - 27,406,457NCBI
Celera126,116,440 - 26,119,606 (+)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,975,292 - 25,978,462 (+)NCBIHuRef
CHM1_1127,833,894 - 27,837,064 (+)NCBICHM1_1
Gpr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,936,651 - 132,939,847 (-)NCBIGRCm39mm39
GRCm39 Ensembl4132,936,651 - 132,939,847 (-)Ensembl
GRCm384133,209,340 - 133,212,536 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,209,340 - 133,212,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv374132,765,255 - 132,768,451 (-)NCBIGRCm37mm9NCBIm37
MGSCv364132,481,416 - 132,484,583 (-)NCBImm8
Celera4131,374,420 - 131,377,613 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
Gpr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25145,411,500 - 145,414,621 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl5151,394,524 - 151,397,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05151,394,118 - 151,397,634 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05155,060,168 - 155,063,449 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,915,723 - 151,916,688 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,925,761 - 151,926,727 (+)NCBI
Celera5143,834,248 - 143,835,213 (-)NCBICelera
Cytogenetic Map5q36NCBI
Gpr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,648,470 - 6,651,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,648,470 - 6,651,938 (+)NCBIChiLan1.0ChiLan1.0
GPR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,702,003 - 27,705,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,703,180 - 27,704,172 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,654,198 - 26,657,421 (+)NCBIMhudiblu_PPA_v0panPan3
GPR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,882,127 - 72,885,369 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,883,183 - 72,884,175 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,459,125 - 69,462,341 (-)NCBI
ROS_Cfam_1.0273,443,788 - 73,447,004 (-)NCBI
UMICH_Zoey_3.1270,269,792 - 70,273,006 (-)NCBI
UNSW_CanFamBas_1.0271,281,278 - 71,284,494 (-)NCBI
UU_Cfam_GSD_1.0272,277,315 - 72,280,532 (-)NCBI
Gpr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,873,901 - 45,877,167 (+)NCBI
SpeTri2.0NW_00493647411,699,725 - 11,701,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,610,107 - 84,613,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,610,107 - 84,613,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,180,803 - 78,184,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,395,207 - 105,398,352 (-)NCBI
ChlSab1.1 Ensembl20105,396,228 - 105,397,220 (-)Ensembl
Vero_WHO_p1.0NW_02366603311,060,423 - 11,063,756 (+)NCBI
Gpr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476411,281,833 - 11,292,573 (+)NCBI

Position Markers
GPR3_2356  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,721,675 - 27,722,330UniSTSGRCh37
Build 36127,594,262 - 27,594,917RGDNCBI36
Celera126,118,963 - 26,119,618RGD
HuRef125,977,819 - 25,978,474UniSTS
RH70930  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,720,850 - 27,720,989UniSTSGRCh37
Build 36127,593,437 - 27,593,576RGDNCBI36
Celera126,118,138 - 26,118,277RGD
Cytogenetic Map1p36.1-p35UniSTS
HuRef125,976,994 - 25,977,133UniSTS
GeneMap99-GB4 RH Map194.1UniSTS
NCBI RH Map1142.5UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:497
Count of miRNA genes:396
Interacting mature miRNAs:415
Transcripts:ENST00000374024
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 39 53 127 2 26 2 215 23 285 17 45 136 30 1
Low 1503 1655 1099 223 864 120 2803 1039 3123 341 1052 1415 116 1073 1627 1
Below cutoff 888 1254 457 355 1018 301 1325 1116 323 60 349 60 56 101 1148 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000374024   ⟹   ENSP00000363136
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl127,392,622 - 27,395,814 (+)Ensembl
RefSeq Acc Id: NM_005281   ⟹   NP_005272
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,392,622 - 27,395,814 (+)NCBI
GRCh37127,719,148 - 27,722,318 (+)NCBI
Build 36127,591,739 - 27,594,905 (+)NCBI Archive
Celera126,116,440 - 26,119,606 (+)RGD
HuRef125,975,292 - 25,978,462 (+)NCBI
CHM1_1127,833,894 - 27,837,064 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005272   ⟸   NM_005281
- UniProtKB: P46089 (UniProtKB/Swiss-Prot),   F1DAM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000363136   ⟸   ENST00000374024
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6854684
Promoter ID:EPDNEW_H507
Type:initiation region
Name:GPR3_1
Description:G protein-coupled receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38127,392,624 - 27,392,684EPDNEW
RGD ID:6785679
Promoter ID:HG_KWN:1575
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000009522
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,590,996 - 27,591,867 (+)MPROMDB
RGD ID:6785680
Promoter ID:HG_KWN:1576
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562
Transcripts:UC009VSX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,593,169 - 27,593,669 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-35.2(chr1:26963045-32279045)x3 copy number gain See cases [RCV000051801] Chr1:26963045..32279045 [GRCh38]
Chr1:27289536..32744646 [GRCh37]
Chr1:27162123..32517233 [NCBI36]
Chr1:1p36.11-35.2
pathogenic
GRCh38/hg38 1p36.11-35.3(chr1:26807012-27685191)x1 copy number loss See cases [RCV000053799] Chr1:26807012..27685191 [GRCh38]
Chr1:27133503..28011702 [GRCh37]
Chr1:27006090..27884289 [NCBI36]
Chr1:1p36.11-35.3
pathogenic
GRCh38/hg38 1p36.11-35.3(chr1:26854636-27645829)x1 copy number loss See cases [RCV000137657] Chr1:26854636..27645829 [GRCh38]
Chr1:27181127..27972340 [GRCh37]
Chr1:27053714..27844927 [NCBI36]
Chr1:1p36.11-35.3
uncertain significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2
pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p36.11-35.3(chr1:27488298-28138628)x1 copy number loss See cases [RCV000447976] Chr1:27488298..28138628 [GRCh37]
Chr1:1p36.11-35.3
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4484 AgrOrtholog
COSMIC GPR3 COSMIC
Ensembl Genes ENSG00000181773 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000363136 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000374024 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000181773 GTEx
HGNC ID HGNC:4484 ENTREZGENE
Human Proteome Map GPR3 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR_3/6/12_orphan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2827 ENTREZGENE
OMIM 600241 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28872 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR3ORPHANR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPRORPHANR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1DAM5 ENTREZGENE, UniProtKB/TrEMBL
  GPR3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8K570 UniProtKB/Swiss-Prot