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Gene: HMGB3 (high mobility group box 3) Homo sapiens
Symbol: HMGB3
Name: high mobility group box 3
Description: Exhibits RNA binding activity. Predicted to be involved in several processes, including DNA geometric change; positive regulation of innate immune response; and positive regulation of transcription by RNA polymerase II. Predicted to localize to the cytoplasm and nuclear chromatin. Implicated in microphthalmia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: high mobility group protein 2a; high mobility group protein 4; high mobility group protein B3; high-mobility group (nonhistone chromosomal) protein 4; high-mobility group box 3; HMG-2a; HMG-4; HMG2A; HMG4; MCOPS13; MGC90319; non-histone chromosomal protein
Mus musculus (house mouse) : Hmgb3 (high mobility group box 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hmgb3 (high mobility group box 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgb3 (high mobility group box 3)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGB3 (high mobility group box 3)
Canis lupus familiaris (dog) : HMGB3 (high mobility group box 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgb3 (high mobility group box 3)
Sus scrofa (pig) : HMGB3 (high mobility group box 3)
Heterocephalus glaber (naked mole-rat) : Hmgb3 (high mobility group box 3)
more info ...
Related Pseudogenes: HMGB3P1   HMGB3P10   HMGB3P11   HMGB3P12   HMGB3P13   HMGB3P14   HMGB3P15   HMGB3P16   HMGB3P17   HMGB3P18   HMGB3P19   HMGB3P2   HMGB3P20   HMGB3P21   HMGB3P22   HMGB3P23   HMGB3P24   HMGB3P25   HMGB3P26   HMGB3P27   HMGB3P28   HMGB3P29   HMGB3P3   HMGB3P30   HMGB3P31   HMGB3P32   HMGB3P4   HMGB3P5   HMGB3P7   HMGB3P8   HMGB3P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX150,980,509 - 150,990,771 (+)Ensembl
GRCh38X150,980,507 - 150,990,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X150,149,056 - 150,159,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X149,902,421 - 149,909,906 (+)NCBINCBI36hg18NCBI36
Build 34X149,822,336 - 149,827,902NCBI
CeleraX150,399,636 - 150,407,102 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX139,013,654 - 139,018,732 (+)NCBIHuRef
CHM1_1X150,023,365 - 150,033,552 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HMGB3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350742
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.