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Gene: BTLA (B and T lymphocyte associated) Homo sapiens
Symbol: BTLA
Name: B and T lymphocyte associated
Description: Predicted to have signaling receptor activity. Predicted to be involved in immune response-regulating cell surface receptor signaling pathway; negative regulation of B cell proliferation; and negative regulation of alpha-beta T cell proliferation. Predicted to localize to external side of plasma membrane and integral component of plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA1; CD272; FLJ16065; MGC129743
Mus musculus (house mouse) : Btla (B and T lymphocyte associated)  MGI  Alliance
Rattus norvegicus (Norway rat) : Btla (B and T lymphocyte associated)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btla (B and T lymphocyte associated)
Pan paniscus (bonobo/pygmy chimpanzee) : BTLA (B and T lymphocyte associated)
Canis lupus familiaris (dog) : BTLA (B and T lymphocyte associated)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btla (B and T lymphocyte associated)
Sus scrofa (pig) : BTLA (B and T lymphocyte associated)
Chlorocebus sabaeus (African green monkey) : BTLA (B and T lymphocyte associated)
Heterocephalus glaber (naked mole-rat) : Btla (B and T lymphocyte associated)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3112,463,966 - 112,499,472 (-)EnsemblGRCh38hg38GRCh38
GRCh383112,463,030 - 112,499,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373112,182,813 - 112,218,438 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363113,665,503 - 113,701,098 (-)NCBINCBI36hg18NCBI36
Build 343113,667,463 - 113,701,066NCBI
Celera3110,591,487 - 110,627,086 (-)NCBI
Cytogenetic Map3q13.2NCBI
HuRef3109,566,845 - 109,602,503 (-)NCBIHuRef
CHM1_13112,146,758 - 112,182,356 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on BTLA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350737
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.