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Gene: TBX18 (T-box transcription factor 18) Homo sapiens
Symbol: TBX18
Name: T-box transcription factor 18
Description: This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAKUT2; T-box 18; T-box protein 18; T-box transcription factor TBX18
Mus musculus (house mouse) : Tbx18 (T-box18)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tbx18 (T-box transcription factor 18)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbx18 (T-box transcription factor 18)
Pan paniscus (bonobo/pygmy chimpanzee) : TBX18 (T-box transcription factor 18)
Canis lupus familiaris (dog) : TBX18 (T-box transcription factor 18)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbx18 (T-box transcription factor 18)
Sus scrofa (pig) : TBX18 (T-box transcription factor 18)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38684,666,810 - 84,764,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37685,442,214 - 85,473,954 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36685,500,876 - 85,530,618 (-)NCBINCBI36hg18NCBI36
Build 34685,510,715 - 85,529,036NCBI
Celera685,871,383 - 85,901,128 (-)NCBI
Cytogenetic Map6q14.3NCBI
HuRef682,665,241 - 82,696,981 (-)NCBIHuRef
CHM1_1685,539,567 - 85,571,307 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TBX18
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350500
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.