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Gene: SMARCA1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1) Homo sapiens
Symbol: SMARCA1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Description: Exhibits annealing helicase activity and transcription factor binding activity. Contributes to DNA-dependent ATPase activity and nucleosome-dependent ATPase activity. Involved in ATP-dependent chromatin remodeling; brain development; and positive regulation of transcription by RNA polymerase II. Localizes to the CERF complex; NURF complex; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP-dependent helicase SMARCA1; DKFZp686D1623; FLJ41547; global transcription activator homologous sequence; hSNF2L; ISWI; nucleosome-remodeling factor subunit SNF2L; NURF140; probable global transcription activator SNF2L1; SNF2-like 1; SNF2L; SNF2L1; SNF2LB; SNF2LT; sucrose nonfermenting 2-like protein 1; SWI; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1; SWI2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX129,446,501 - 129,523,500 (-)Ensembl
GRCh38X129,446,501 - 129,523,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X128,580,478 - 128,657,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,408,159 - 128,485,122 (-)NCBINCBI36hg18NCBI36
Build 34X128,306,012 - 128,382,976NCBI
CeleraX128,969,174 - 129,046,159 (-)NCBI
Cytogenetic MapXq25-q26.1NCBI
HuRefX117,987,239 - 118,059,634 (-)NCBIHuRef
CHM1_1X128,491,871 - 128,568,846 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SMARCA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350342
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.