MIR105-2 (microRNA 105-2) - Rat Genome Database

Name: MIR105-2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MIR105-2 (microRNA 105-2) Homo sapiens

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Symbol:

MIR105-2

Name:

microRNA 105-2

Description:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Type:

ncrna

RefSeq Status:

PROVISIONAL

Also known as:

mir-105-2; MIRN105-2

Orthologs:

Mus musculus (house mouse) : Mir105 (microRNA 105) MGI
Rattus norvegicus (Norway rat) : Mir105 (microRNA 105) Alliance
Canis lupus familiaris (dog) : MIR105B (microRNA mir-105b)
Sus scrofa (pig) : MIR105-2 (microRNA mir-105-2)

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38 Ensembl	X	152,394,412 - 152,394,492 (-)	Ensembl
GRCh38	X	152,394,412 - 152,394,492 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	X	151,562,884 - 151,562,964 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	151,313,539 - 151,313,619 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	X	151,809,689 - 151,809,769 (-)	NCBI
Cytogenetic Map	X	q28	NCBI
HuRef	X	140,416,730 - 140,416,810 (-)	NCBI		HuRef
CHM1_1	X	151,437,585 - 151,437,665 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

References - uncurated

Genomics

Comparative Map Data

miRNA Target Status

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	peripheral nervous system	zone of skin	large intestine	blood	breast	mucosa	stomach	brain	esophagus	pancreas	placenta	thyroid gland	lung	hematopoietic system	bone tissue
High
Medium
Low		2	1	3						1			3
Below cutoff	2	1	1		1	3	1	2	1	1	1	1	7	1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences

Clinical Variants

Additional Information

External Database Links

More on MIR105-2
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1350334
Created:	2005-03-08
Species:	Homo sapiens
Last Modified:	2019-12-25
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - ClinVar