HTR1E (5-hydroxytryptamine receptor 1E) - Rat Genome Database

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Gene: HTR1E (5-hydroxytryptamine receptor 1E) Homo sapiens
Analyze
Symbol: HTR1E
Name: 5-hydroxytryptamine receptor 1E
RGD ID: 1350220
HGNC Page HGNC:5291
Description: Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-1E; 5-HT1E; 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled; S31; serotonin receptor 1E
RGD Orthologs
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38686,937,528 - 87,016,679 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl686,937,528 - 87,016,679 (+)EnsemblGRCh38hg38GRCh38
GRCh37687,647,246 - 87,726,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36687,704,129 - 87,783,116 (+)NCBINCBI36Build 36hg18NCBI36
Build 34687,704,128 - 87,783,115NCBI
Celera688,065,796 - 88,145,153 (+)NCBICelera
Cytogenetic Map6q14.3NCBI
HuRef684,863,632 - 84,942,983 (+)NCBIHuRef
CHM1_1687,744,419 - 87,824,174 (+)NCBICHM1_1
T2T-CHM13v2.0688,146,245 - 88,225,391 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IBA)
plasma membrane  (IBA,IEA,IMP,TAS)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1513320   PMID:1608964   PMID:1733778   PMID:2834384   PMID:8001977   PMID:9316030   PMID:10391209   PMID:12477932   PMID:12627464   PMID:14574404   PMID:15489334   PMID:17353931  
PMID:18079067   PMID:18240029   PMID:18577758   PMID:18821565   PMID:18937842   PMID:19058789   PMID:19086053   PMID:19156168   PMID:19455600   PMID:21422162   PMID:21873635   PMID:25416956  
PMID:26186194   PMID:28514442   PMID:32814053   PMID:33961781   PMID:34093864   PMID:34966948  


Genomics

Comparative Map Data
HTR1E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38686,937,528 - 87,016,679 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl686,937,528 - 87,016,679 (+)EnsemblGRCh38hg38GRCh38
GRCh37687,647,246 - 87,726,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36687,704,129 - 87,783,116 (+)NCBINCBI36Build 36hg18NCBI36
Build 34687,704,128 - 87,783,115NCBI
Celera688,065,796 - 88,145,153 (+)NCBICelera
Cytogenetic Map6q14.3NCBI
HuRef684,863,632 - 84,942,983 (+)NCBIHuRef
CHM1_1687,744,419 - 87,824,174 (+)NCBICHM1_1
T2T-CHM13v2.0688,146,245 - 88,225,391 (+)NCBIT2T-CHM13v2.0
Htr1e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541114,025,196 - 14,026,281 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541113,955,905 - 14,026,555 (+)NCBIChiLan1.0ChiLan1.0
HTR1E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25107,014,359 - 107,097,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16104,908,312 - 104,990,527 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0684,810,961 - 84,889,170 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1688,162,240 - 88,163,764 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl688,162,424 - 88,163,521 (+)Ensemblpanpan1.1panPan2
HTR1E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11246,459,899 - 46,557,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1246,270,675 - 46,363,075 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01247,233,636 - 47,327,902 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1247,244,335 - 47,327,888 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11246,557,642 - 46,650,100 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01246,487,299 - 46,579,785 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01246,673,991 - 46,768,334 (+)NCBIUU_Cfam_GSD_1.0
Htr1e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494681,638,006 - 81,718,820 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365104,753,341 - 4,832,844 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365104,753,341 - 4,833,255 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR1E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl155,408,112 - 55,497,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1155,407,853 - 55,498,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2161,986,346 - 62,072,356 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR1E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11311,412,150 - 11,504,462 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1311,503,013 - 11,504,110 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040187,603,462 - 187,697,461 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr1e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247997,364,840 - 7,456,458 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247997,364,722 - 7,456,843 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HTR1E
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q14.1-16.1(chr6:82569098-93753476)x1 copy number loss See cases [RCV000052192] Chr6:82569098..93753476 [GRCh38]
Chr6:83278815..94463194 [GRCh37]
Chr6:83335534..94519915 [NCBI36]
Chr6:6q14.1-16.1		 pathogenic
NM_000865.2(HTR1E):c.876C>T (p.Ile292=) single nucleotide variant Malignant melanoma [RCV000067489] Chr6:87016210 [GRCh38]
Chr6:87725928 [GRCh37]
Chr6:87782647 [NCBI36]
Chr6:6q14.3		 not provided
NM_000865.2(HTR1E):c.799C>T (p.Pro267Ser) single nucleotide variant Malignant melanoma [RCV000061495] Chr6:87016133 [GRCh38]
Chr6:87725851 [GRCh37]
Chr6:87782570 [NCBI36]
Chr6:6q14.3		 not provided
NM_000865.2(HTR1E):c.-186+23473C>G single nucleotide variant Lung cancer [RCV000097241] Chr6:86961296 [GRCh38]
Chr6:87671014 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6q14.1-16.1(chr6:78911022-98909173)x1 copy number loss See cases [RCV002292710] Chr6:78911022..98909173 [GRCh37]
Chr6:6q14.1-16.1		 uncertain significance
GRCh38/hg38 6q14.2-16.1(chr6:83838303-98822313)x1 copy number loss See cases [RCV000135773] Chr6:83838303..98822313 [GRCh38]
Chr6:84548022..99270189 [GRCh37]
Chr6:84604741..99376910 [NCBI36]
Chr6:6q14.2-16.1		 pathogenic
GRCh38/hg38 6q14.3-16.1(chr6:85804273-93189258)x1 copy number loss See cases [RCV000135450] Chr6:85804273..93189258 [GRCh38]
Chr6:86513991..93898976 [GRCh37]
Chr6:86570710..93955697 [NCBI36]
Chr6:6q14.3-16.1		 pathogenic
GRCh38/hg38 6q14.3-15(chr6:86259565-87312972)x3 copy number gain See cases [RCV000135950] Chr6:86259565..87312972 [GRCh38]
Chr6:86969283..88022690 [GRCh37]
Chr6:87026002..88079409 [NCBI36]
Chr6:6q14.3-15		 uncertain significance
GRCh38/hg38 6q14.3-15(chr6:85370716-90669793)x1 copy number loss See cases [RCV000136757] Chr6:85370716..90669793 [GRCh38]
Chr6:86080434..91379512 [GRCh37]
Chr6:86137153..91436233 [NCBI36]
Chr6:6q14.3-15		 pathogenic
GRCh38/hg38 6q14.3-15(chr6:84926864-87365441)x1 copy number loss See cases [RCV000137766] Chr6:84926864..87365441 [GRCh38]
Chr6:85636582..88075159 [GRCh37]
Chr6:85693301..88131878 [NCBI36]
Chr6:6q14.3-15		 likely pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1		 pathogenic
GRCh38/hg38 6q14.1-16.1(chr6:75926199-92710793)x1 copy number loss See cases [RCV000143505] Chr6:75926199..92710793 [GRCh38]
Chr6:76635916..93420511 [GRCh37]
Chr6:76692636..93477232 [NCBI36]
Chr6:6q14.1-16.1		 pathogenic
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31		 pathogenic
GRCh37/hg19 6q14.3(chr6:87650323-87870024)x3 copy number gain See cases [RCV000446007] Chr6:87650323..87870024 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q14.3(chr6:86967785-87992594)x3 copy number gain See cases [RCV000510510] Chr6:86967785..87992594 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6q14.3(chr6:86910282-87954977)x3 copy number gain See cases [RCV000511616] Chr6:86910282..87954977 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6q14.1-16.1(chr6:81261418-97796269)x3 copy number gain not provided [RCV000682688] Chr6:81261418..97796269 [GRCh37]
Chr6:6q14.1-16.1		 pathogenic
Single allele deletion not provided [RCV000677932] Chr6:83319012..91907669 [GRCh37]
Chr6:6q14.1-15		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_000865.3(HTR1E):c.570G>A (p.Ala190=) single nucleotide variant not provided [RCV000902226] Chr6:87015904 [GRCh38]
Chr6:87725622 [GRCh37]
Chr6:6q14.3		 benign
NM_000865.3(HTR1E):c.800C>A (p.Pro267His) single nucleotide variant not provided [RCV000897356] Chr6:87016134 [GRCh38]
Chr6:87725852 [GRCh37]
Chr6:6q14.3		 likely benign
NM_000865.3(HTR1E):c.336C>T (p.His112=) single nucleotide variant not provided [RCV000895057] Chr6:87015670 [GRCh38]
Chr6:87725388 [GRCh37]
Chr6:6q14.3		 likely benign
GRCh37/hg19 6q14.3-15(chr6:86024761-90023713)x1 copy number loss not provided [RCV001005826] Chr6:86024761..90023713 [GRCh37]
Chr6:6q14.3-15		 pathogenic
GRCh37/hg19 6q14.3-16.1(chr6:87627836-93698486)x1 copy number loss not provided [RCV000848967] Chr6:87627836..93698486 [GRCh37]
Chr6:6q14.3-16.1		 uncertain significance
GRCh37/hg19 6q14.3(chr6:87561324-87920197)x3 copy number gain not provided [RCV000849200] Chr6:87561324..87920197 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6q14.3(chr6:87565438-87920197)x3 copy number gain not provided [RCV000846366] Chr6:87565438..87920197 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6q14.3(chr6:87724126-87800047)x1 copy number loss not provided [RCV001005828] Chr6:87724126..87800047 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6q14.3(chr6:87564055-87921049)x3 copy number gain not provided [RCV001005827] Chr6:87564055..87921049 [GRCh37]
Chr6:6q14.3		 likely benign
GRCh37/hg19 6q14.3(chr6:86702329-87861145)x3 copy number gain not provided [RCV000847476] Chr6:86702329..87861145 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.419C>T (p.Ala140Val) single nucleotide variant Inborn genetic diseases [RCV003270163] Chr6:87015753 [GRCh38]
Chr6:87725471 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.755C>G (p.Pro252Arg) single nucleotide variant Inborn genetic diseases [RCV003251198] Chr6:87016089 [GRCh38]
Chr6:87725807 [GRCh37]
Chr6:6q14.3		 uncertain significance
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687) copy number loss not specified [RCV002053595] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31		 pathogenic
GRCh37/hg19 6q12-16.1(chr6:69938252-94379210) copy number gain not specified [RCV002053581] Chr6:69938252..94379210 [GRCh37]
Chr6:6q12-16.1		 pathogenic
GRCh37/hg19 6q14.1-15(chr6:83141523-88023466)x1 copy number loss not provided [RCV001829074] Chr6:83141523..88023466 [GRCh37]
Chr6:6q14.1-15		 pathogenic
GRCh37/hg19 6q14.3-15(chr6:86098133-88663964)x3 copy number gain not provided [RCV002474634] Chr6:86098133..88663964 [GRCh37]
Chr6:6q14.3-15		 uncertain significance
NM_000865.3(HTR1E):c.55A>G (p.Ile19Val) single nucleotide variant Inborn genetic diseases [RCV002771801] Chr6:87015389 [GRCh38]
Chr6:87725107 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.887T>C (p.Ile296Thr) single nucleotide variant Inborn genetic diseases [RCV002771904] Chr6:87016221 [GRCh38]
Chr6:87725939 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.961G>A (p.Val321Met) single nucleotide variant Inborn genetic diseases [RCV002776644] Chr6:87016295 [GRCh38]
Chr6:87726013 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.391G>A (p.Ala131Thr) single nucleotide variant Inborn genetic diseases [RCV002925756] Chr6:87015725 [GRCh38]
Chr6:87725443 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.799C>G (p.Pro267Ala) single nucleotide variant Inborn genetic diseases [RCV002921482] Chr6:87016133 [GRCh38]
Chr6:87725851 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.836A>G (p.Gln279Arg) single nucleotide variant Inborn genetic diseases [RCV003205534] Chr6:87016170 [GRCh38]
Chr6:87725888 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.243C>G (p.Ile81Met) single nucleotide variant Inborn genetic diseases [RCV003370503] Chr6:87015577 [GRCh38]
Chr6:87725295 [GRCh37]
Chr6:6q14.3		 likely benign
NM_000865.3(HTR1E):c.724T>C (p.Phe242Leu) single nucleotide variant Inborn genetic diseases [RCV003365159] Chr6:87016058 [GRCh38]
Chr6:87725776 [GRCh37]
Chr6:6q14.3		 uncertain significance
NM_000865.3(HTR1E):c.611G>A (p.Arg204Gln) single nucleotide variant Inborn genetic diseases [RCV003368879] Chr6:87015945 [GRCh38]
Chr6:87725663 [GRCh37]
Chr6:6q14.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:86
Interacting mature miRNAs:88
Transcripts:ENST00000305344
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-80936  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,659,702 - 87,659,973UniSTSGRCh37
Build 36687,716,421 - 87,716,692RGDNCBI36
Celera688,078,474 - 88,078,745RGD
Cytogenetic Map6q14-q15UniSTS
Cytogenetic Map6q15UniSTS
HuRef684,876,310 - 84,876,581UniSTS
TNG Radiation Hybrid Map641385.0UniSTS
GDB:435478  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,725,126 - 87,725,709UniSTSGRCh37
Build 36687,781,845 - 87,782,428RGDNCBI36
Celera688,143,882 - 88,144,465RGD
Cytogenetic Map6q14-q15UniSTS
HuRef684,941,712 - 84,942,295UniSTS
GDB:435482  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,725,677 - 87,726,066UniSTSGRCh37
Build 36687,782,396 - 87,782,785RGDNCBI36
Celera688,144,433 - 88,144,822RGD
Cytogenetic Map6q14-q15UniSTS
HuRef684,942,263 - 84,942,652UniSTS
D6S2061  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,726,151 - 87,726,248UniSTSGRCh37
Build 36687,782,870 - 87,782,967RGDNCBI36
Celera688,144,907 - 88,145,004RGD
Cytogenetic Map6q14-q15UniSTS
HuRef684,942,737 - 84,942,834UniSTS
TNG Radiation Hybrid Map641393.0UniSTS
GeneMap99-G3 RH Map64060.0UniSTS
G15845  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,726,175 - 87,726,331UniSTSGRCh37
Build 36687,782,894 - 87,783,050RGDNCBI36
Celera688,144,931 - 88,145,087RGD
Cytogenetic Map6q14-q15UniSTS
HuRef684,942,761 - 84,942,917UniSTS
WI-18995  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,726,150 - 87,726,349UniSTSGRCh37
Build 36687,782,869 - 87,783,068RGDNCBI36
Celera688,144,906 - 88,145,105RGD
Cytogenetic Map6q14-q15UniSTS
HuRef684,942,736 - 84,942,935UniSTS
GeneMap99-GB4 RH Map6384.23UniSTS
Whitehead-RH Map6586.2UniSTS
RH46696  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,726,186 - 87,726,333UniSTSGRCh37
Build 36687,782,905 - 87,783,052RGDNCBI36
Celera688,144,942 - 88,145,089RGD
Cytogenetic Map6q14-q15UniSTS
HuRef684,942,772 - 84,942,919UniSTS
GeneMap99-GB4 RH Map6382.65UniSTS
NCBI RH Map61183.2UniSTS
AFM296tf1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,662,157 - 87,662,392UniSTSGRCh37
Build 36687,718,876 - 87,719,111RGDNCBI36
Celera688,080,929 - 88,081,164RGD
Cytogenetic Map6q14-q15UniSTS
HuRef684,878,765 - 84,879,000UniSTS
Whitehead-RH Map6565.8UniSTS
Whitehead-YAC Contig Map6 UniSTS
UniSTS:481920  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,725,011 - 87,726,200UniSTSGRCh37
Celera688,143,767 - 88,144,956UniSTS
HuRef684,941,597 - 84,942,786UniSTS
UniSTS:489680  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37687,724,888 - 87,726,333UniSTSGRCh37
Celera688,143,644 - 88,145,089UniSTS
HuRef684,941,474 - 84,942,919UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 13 3 26 2
Low 663 1 261 3 4 3 78 400 2137 20 630 273 1 1 22
Below cutoff 1102 290 708 38 163 21 1158 550 1010 36 361 533 19 106 661

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000305344   ⟹   ENSP00000307766
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl686,937,528 - 87,016,679 (+)Ensembl
RefSeq Acc Id: NM_000865   ⟹   NP_000856
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38686,937,528 - 87,016,679 (+)NCBI
GRCh37687,647,024 - 87,726,397 (+)ENTREZGENE
Build 36687,704,129 - 87,783,116 (+)NCBI Archive
HuRef684,863,632 - 84,942,983 (+)ENTREZGENE
CHM1_1687,744,419 - 87,824,174 (+)NCBI
T2T-CHM13v2.0688,146,245 - 88,225,391 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535789   ⟹   XP_011534091
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38686,937,528 - 87,016,679 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054355315   ⟹   XP_054211290
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0688,146,344 - 88,225,391 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_000856   ⟸   NM_000865
- UniProtKB: E1P503 (UniProtKB/Swiss-Prot),   Q9P1Y1 (UniProtKB/Swiss-Prot),   P28566 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534091   ⟸   XM_011535789
- Peptide Label: isoform X1
- UniProtKB: E1P503 (UniProtKB/Swiss-Prot),   Q9P1Y1 (UniProtKB/Swiss-Prot),   P28566 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000307766   ⟸   ENST00000305344
RefSeq Acc Id: XP_054211290   ⟸   XM_054355315
- Peptide Label: isoform X1
- UniProtKB: P28566 (UniProtKB/Swiss-Prot),   E1P503 (UniProtKB/Swiss-Prot),   Q9P1Y1 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28566-F1-model_v2 AlphaFold P28566 1-365 view protein structure

Promoters
RGD ID:7208635
Promoter ID:EPDNEW_H10063
Type:initiation region
Name:HTR1E_1
Description:5-hydroxytryptamine receptor 1E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10064  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38686,937,297 - 86,937,357EPDNEW
RGD ID:7208637
Promoter ID:EPDNEW_H10064
Type:initiation region
Name:HTR1E_2
Description:5-hydroxytryptamine receptor 1E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10063  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38686,937,541 - 86,937,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5291 AgrOrtholog
COSMIC HTR1E COSMIC
Ensembl Genes ENSG00000168830 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000305344 ENTREZGENE
  ENST00000305344.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
GTEx ENSG00000168830 GTEx
HGNC ID HGNC:5291 ENTREZGENE
Human Proteome Map HTR1E Human Proteome Map
InterPro 5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report hsa:3354 UniProtKB/Swiss-Prot
NCBI Gene 3354 ENTREZGENE
OMIM 182132 OMIM
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR24247:SF33 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA29552 PharmGKB
PRINTS 5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT1E_HUMAN UniProtKB/Swiss-Prot
  E1P503 ENTREZGENE
  P28566 ENTREZGENE
  Q9P1Y1 ENTREZGENE
UniProt Secondary E1P503 UniProtKB/Swiss-Prot
  Q9P1Y1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 HTR1E  5-hydroxytryptamine receptor 1E    5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled  Symbol and/or name change 5135510 APPROVED
2012-02-14 HTR1E  5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled  HTR1E  5-hydroxytryptamine (serotonin) receptor 1E  Symbol and/or name change 5135510 APPROVED