OR4K3 (olfactory receptor family 4 subfamily K member 3 (gene/pseudogene)) - Rat Genome Database

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Gene: OR4K3 (olfactory receptor family 4 subfamily K member 3 (gene/pseudogene)) Homo sapiens
Analyze
Symbol: OR4K3
Name: olfactory receptor family 4 subfamily K member 3 (gene/pseudogene)
RGD ID: 1350165
HGNC Page HGNC:14731
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: olfactory receptor 4K3; olfactory receptor OR14-14; olfactory receptor, family 4, subfamily K, member 3 gene/pseudogene; olfactory receptor, family 4, subfamily k, member 3 pseudogene; OR14-10; OR4K3P
RGD Orthologs
Rat
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381419,868,197 - 19,869,173 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1419,868,197 - 19,869,143 (-)EnsemblGRCh38hg38GRCh38
GRCh371420,336,356 - 20,337,332 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,405,996 - 19,407,342 (-)NCBINCBI36Build 36hg18NCBI36
Celera14201,656 - 203,003 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14462,462 - 463,809 (-)NCBIHuRef
CHM1_11420,337,625 - 20,338,972 (-)NCBICHM1_1
T2T-CHM13v2.01414,067,651 - 14,068,628 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:12213199   PMID:12508121   PMID:12730696   PMID:14983052   PMID:21873635   PMID:23686814   PMID:33961781  


Genomics

Comparative Map Data
OR4K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381419,868,197 - 19,869,173 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1419,868,197 - 19,869,143 (-)EnsemblGRCh38hg38GRCh38
GRCh371420,336,356 - 20,337,332 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,405,996 - 19,407,342 (-)NCBINCBI36Build 36hg18NCBI36
Celera14201,656 - 203,003 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14462,462 - 463,809 (-)NCBIHuRef
CHM1_11420,337,625 - 20,338,972 (-)NCBICHM1_1
T2T-CHM13v2.01414,067,651 - 14,068,628 (-)NCBIT2T-CHM13v2.0
Or4k6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,902,657 - 25,909,662 (-)NCBIGRCr8
mRatBN7.21523,429,067 - 23,436,072 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,435,092 - 23,436,072 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,206,369 - 26,207,349 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,167,679 - 27,168,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,414,903 - 25,415,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,025,473 - 27,032,515 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,031,518 - 27,032,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01530,957,800 - 30,958,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41525,958,147 - 25,959,127 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11525,973,846 - 25,974,827 (-)NCBI
Celera1523,774,667 - 23,775,647 (-)NCBICelera
Cytogenetic Map15p14NCBI
LOC100980373
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21521,380,916 - 21,381,893 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11420,597,406 - 20,598,383 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v014746,577 - 747,548 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11418,810,870 - 18,812,409 (-)NCBIpanpan1.1PanPan1.1panPan2
OR4K6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13041,348 - 42,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3041,360 - 42,319 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha30421,204 - 422,163 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.030120,219 - 121,178 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl30120,219 - 121,178 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13080,381 - 81,340 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.030160,846 - 161,805 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.030214,618 - 215,577 (+)NCBIUU_Cfam_GSD_1.0
LOC101962928
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,053,404 - 77,054,383 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493687734,561 - 35,540 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100154725
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2784,113,029 - 84,113,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2(chr14:18658128-19967729)x1 copy number loss See cases [RCV000136157] Chr14:18658128..19967729 [GRCh38]
Chr14:19434605..20435888 [GRCh37]
Chr14:18504605..19505728 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:18600315-19946044)x3 copy number gain See cases [RCV000136168] Chr14:18600315..19946044 [GRCh38]
Chr14:19376792..20414203 [GRCh37]
Chr14:18446792..19484043 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:18600315-19967729)x1 copy number loss See cases [RCV000136184] Chr14:18600315..19967729 [GRCh38]
Chr14:19376792..20435888 [GRCh37]
Chr14:18446792..19505728 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:18698325-19967729)x1 copy number loss See cases [RCV000136219] Chr14:18698325..19967729 [GRCh38]
Chr14:19474802..20435888 [GRCh37]
Chr14:18544802..19505728 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:19735319-19941173)x3 copy number gain See cases [RCV000136318] Chr14:19735319..19941173 [GRCh38]
Chr14:20203478..20409332 [GRCh37]
Chr14:19273318..19479172 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:19617023-19967729)x1 copy number loss See cases [RCV000136329] Chr14:19617023..19967729 [GRCh38]
Chr14:20085860..20435888 [GRCh37]
Chr14:19155022..19505728 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:19735319-19952661)x3 copy number gain See cases [RCV000136368] Chr14:19735319..19952661 [GRCh38]
Chr14:20203478..20420820 [GRCh37]
Chr14:19273318..19490660 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:19730807-19997817)x3 copy number gain See cases [RCV000136460] Chr14:19730807..19997817 [GRCh38]
Chr14:20198966..20465976 [GRCh37]
Chr14:19268806..19535816 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:19785749-19938168)x1 copy number loss See cases [RCV000138469] Chr14:19785749..19938168 [GRCh38]
Chr14:20253908..20406327 [GRCh37]
Chr14:19323748..19476167 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:19749125-19938168)x3 copy number gain See cases [RCV000138749] Chr14:19749125..19938168 [GRCh38]
Chr14:20217284..20406327 [GRCh37]
Chr14:19287124..19476167 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:19734017-19938168)x1 copy number loss See cases [RCV000139547] Chr14:19734017..19938168 [GRCh38]
Chr14:20202176..20406327 [GRCh37]
Chr14:19272016..19476167 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:19749125-19938168)x1 copy number loss See cases [RCV000142893] Chr14:19749125..19938168 [GRCh38]
Chr14:20217284..20406327 [GRCh37]
Chr14:19287124..19476167 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:19755249-22741281)x1 copy number loss See cases [RCV000051483] Chr14:19755249..22741281 [GRCh38]
Chr14:20223408..23210490 [GRCh37]
Chr14:19293248..22280330 [NCBI36]
Chr14:14q11.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:64
Interacting mature miRNAs:65
Transcripts:ENST00000315936, ENST00000425829
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 3 4 1 2 1
Below cutoff 61 73 41 10 53 9 98 58 64 5 187 45 1 46 62

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000425829   ⟹   ENSP00000493291
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1419,868,197 - 19,869,143 (-)Ensembl
RefSeq Acc Id: NM_001348266   ⟹   NP_001335195
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01414,067,651 - 14,068,628 (-)NCBI
Sequence:
RefSeq Acc Id: NR_145507
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381419,868,197 - 19,869,173 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001335195 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK95056 (Get FASTA)   NCBI Sequence Viewer  
  ALI87500 (Get FASTA)   NCBI Sequence Viewer  
  Q96R72 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSP00000493291   ⟸   ENST00000425829
RefSeq Acc Id: NP_001335195   ⟸   NM_001348266
- UniProtKB: Q96R72 (UniProtKB/Swiss-Prot),   Q6IFA4 (UniProtKB/Swiss-Prot),   A0A126GVQ8 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96R72-F1-model_v2 AlphaFold Q96R72 1-315 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14731 AgrOrtholog
COSMIC OR4K3 COSMIC
Ensembl Genes ENSG00000176290 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000425829 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000176290 GTEx
HGNC ID HGNC:14731 ENTREZGENE
Human Proteome Map OR4K3 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 283617 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 4K3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32318 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A126GVQ8 ENTREZGENE, UniProtKB/TrEMBL
  OR4K3_HUMAN UniProtKB/Swiss-Prot
  Q6IFA4 ENTREZGENE
  Q96R72 ENTREZGENE
UniProt Secondary Q6IFA4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 OR4K3  olfactory receptor family 4 subfamily K member 3 (gene/pseudogene)    olfactory receptor, family 4, subfamily K, member 3 (gene/pseudogene)  Symbol and/or name change 5135510 APPROVED
2011-09-01 OR4K3  olfactory receptor, family 4, subfamily K, member 3 (gene/pseudogene)  OR4K3  olfactory receptor, family 4, subfamily K, member 3 (gene/pseudogene)  Symbol and/or name change 5135510 APPROVED