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Gene: HLA-DRB5 (major histocompatibility complex, class II, DR beta 5) Homo sapiens
Symbol: HLA-DRB5
Name: major histocompatibility complex, class II, DR beta 5
Description: Predicted to have peptide antigen binding activity. Predicted to be involved in T cell receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; and interferon-gamma-mediated signaling pathway. Localizes to late endosome membrane and lysosomal membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DR beta-5; DR-9; DR2-beta-2; DR9; dw2; FLJ76359; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA-DRB; human leucocyte antigen DRB5; leukocyte antigen class II; MHC class I antigen; MHC class II antigen DRB1*9; MHC class II antigen DRB5; MHC class II HLA beta chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl632,517,353 - 32,530,287 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,517,343 - 32,530,316 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,485,151 - 32,498,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,593,129 - 32,605,984 (-)NCBINCBI36hg18NCBI36
Build 34632,593,133 - 32,605,984NCBI
Cytogenetic Map6p21.32NCBI
CHM1_1632,487,629 - 32,500,484 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HLA-DRB5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350012
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.