LATS1 (large tumor suppressor kinase 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: LATS1 (large tumor suppressor kinase 1) Homo sapiens
Analyze
Symbol: LATS1
Name: large tumor suppressor kinase 1
RGD ID: 1349703
HGNC Page HGNC
Description: Exhibits several functions, including ATP binding activity; estrogen receptor binding activity; and magnesium ion binding activity. Involved in several processes, including hippo signaling; regulation of cellular protein metabolic process; and regulation of signal transduction. Localizes to spindle pole.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: h-warts; large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6149,658,153 - 149,718,105 (-)EnsemblGRCh38hg38GRCh38
GRCh386149,658,153 - 149,718,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376149,979,289 - 150,039,237 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh376149,979,289 - 150,039,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366150,023,744 - 150,081,085 (-)NCBINCBI36hg18NCBI36
Build 346150,023,743 - 150,131,506NCBI
Celera6150,717,306 - 150,774,645 (-)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6147,545,928 - 147,605,163 (-)NCBIHuRef
CHM1_16150,243,964 - 150,304,031 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7743921   PMID:7829101   PMID:9988268   PMID:9988269   PMID:10518011   PMID:10831611   PMID:12372621   PMID:12379777   PMID:12477932   PMID:12624101   PMID:15122335   PMID:15144186  
PMID:15220930   PMID:15302935   PMID:15489334   PMID:15688006   PMID:15746036   PMID:16007220   PMID:16061636   PMID:16674920   PMID:17049657   PMID:17130845   PMID:17379520   PMID:17889669  
PMID:18158288   PMID:18328708   PMID:18413746   PMID:18640976   PMID:19739119   PMID:19799973   PMID:19927127   PMID:19962312   PMID:20048001   PMID:20303269   PMID:20407010   PMID:20412773  
PMID:20453000   PMID:20508983   PMID:20624913   PMID:20841485   PMID:20936779   PMID:21041411   PMID:21145461   PMID:21145499   PMID:21212414   PMID:21233212   PMID:21383157   PMID:21555462  
PMID:21822051   PMID:21832049   PMID:21873635   PMID:22078877   PMID:22195963   PMID:22623531   PMID:22641346   PMID:22863277   PMID:22909338   PMID:23230145   PMID:23564455   PMID:23573293  
PMID:23652010   PMID:23885148   PMID:24012335   PMID:24026096   PMID:24101513   PMID:24106267   PMID:24107629   PMID:24225952   PMID:24255178   PMID:24362629   PMID:24366813   PMID:24682284  
PMID:24682895   PMID:25023289   PMID:25026211   PMID:25041856   PMID:25044019   PMID:25127217   PMID:25218637   PMID:25270913   PMID:25283809   PMID:25362852   PMID:25393475   PMID:25416956  
PMID:25438054   PMID:25482410   PMID:25618271   PMID:25625370   PMID:25658096   PMID:25723520   PMID:25743838   PMID:25751139   PMID:25772246   PMID:25786116   PMID:25796446   PMID:25841306  
PMID:26045165   PMID:26116754   PMID:26496610   PMID:26638075   PMID:26840256   PMID:26921249   PMID:27325643   PMID:27684187   PMID:27786336   PMID:27847303   PMID:27886176   PMID:27973704  
PMID:28068668   PMID:28075055   PMID:28087714   PMID:28152516   PMID:28169360   PMID:28259899   PMID:28387539   PMID:28416659   PMID:28420424   PMID:28434174   PMID:28504812   PMID:28514442  
PMID:28718761   PMID:28720576   PMID:28754671   PMID:28893265   PMID:28926138   PMID:29183995   PMID:29362392   PMID:29437787   PMID:29438698   PMID:29507755   PMID:29513927   PMID:29730476  
PMID:29787761   PMID:29850494   PMID:29859193   PMID:29891922   PMID:29901195   PMID:29903769   PMID:30219064   PMID:30266805   PMID:30308519   PMID:30461308   PMID:30472188   PMID:30531839  
PMID:30671453   PMID:30718452   PMID:30863499   PMID:31091453   PMID:31419991   PMID:31569999   PMID:31578200   PMID:31605013   PMID:31619268   PMID:31827075   PMID:31831299   PMID:31848340  
PMID:32238586   PMID:32296183   PMID:32446383   PMID:32661924   PMID:32749848   PMID:33060197   PMID:33141042  


Genomics

Comparative Map Data
LATS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6149,658,153 - 149,718,105 (-)EnsemblGRCh38hg38GRCh38
GRCh386149,658,153 - 149,718,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376149,979,289 - 150,039,237 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh376149,979,289 - 150,039,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366150,023,744 - 150,081,085 (-)NCBINCBI36hg18NCBI36
Build 346150,023,743 - 150,131,506NCBI
Celera6150,717,306 - 150,774,645 (-)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6147,545,928 - 147,605,163 (-)NCBIHuRef
CHM1_16150,243,964 - 150,304,031 (-)NCBICHM1_1
Lats1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,556,964 - 7,592,225 (+)NCBIGRCm39mm39
GRCm38107,681,200 - 7,716,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,681,214 - 7,716,460 (+)EnsemblGRCm38mm10GRCm38
MGSCv37107,401,007 - 7,436,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv36107,371,399 - 7,403,706 (+)NCBImm8
Celera107,558,767 - 7,594,190 (+)NCBICelera
Cytogenetic Map10A1NCBI
Lats1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.212,160,411 - 2,193,640 (+)NCBI
Rnor_6.0 Ensembl11,784,078 - 1,817,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.011,784,078 - 1,817,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013,480,828 - 3,514,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,375,233 - 2,383,106 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1708,453 - 741,716 (+)NCBICelera
Cytogenetic Map1p13NCBI
Lats1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,559,657 - 11,611,660 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543911,559,655 - 11,611,287 (+)NCBIChiLan1.0ChiLan1.0
LATS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16152,182,394 - 152,239,276 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6152,182,394 - 152,239,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06147,476,913 - 147,533,491 (-)NCBIMhudiblu_PPA_v0panPan3
LATS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl140,260,064 - 40,457,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1140,430,096 - 40,475,193 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lats1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364892,607,114 - 2,649,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LATS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,274,970 - 16,320,619 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,274,955 - 16,320,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,600,766 - 18,633,991 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LATS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11321,901,153 - 21,966,227 (+)NCBI
ChlSab1.1 Ensembl1321,919,280 - 21,967,117 (+)Ensembl
Lats1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247858,356,238 - 8,405,877 (+)NCBI

Position Markers
SHGC-84591  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,998,401 - 149,998,599UniSTSGRCh37
Build 366150,040,094 - 150,040,292RGDNCBI36
Celera6150,733,656 - 150,733,854RGD
Cytogenetic Map6q25.1UniSTS
HuRef6147,565,039 - 147,565,237UniSTS
TNG Radiation Hybrid Map670570.0UniSTS
WIAF-1623  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,979,376 - 149,979,553UniSTSGRCh37
Build 366150,021,069 - 150,021,246RGDNCBI36
Celera6150,714,631 - 150,714,808RGD
Cytogenetic Map6q25.1UniSTS
HuRef6147,546,015 - 147,546,192UniSTS
GeneMap99-GB4 RH Map6596.81UniSTS
NCBI RH Map61598.0UniSTS
G17023  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,988,689 - 149,988,830UniSTSGRCh37
Build 366150,030,382 - 150,030,523RGDNCBI36
Celera6150,723,947 - 150,724,088RGD
Cytogenetic Map6q25.1UniSTS
HuRef6147,555,327 - 147,555,468UniSTS
LATS1__6377  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,981,894 - 149,982,800UniSTSGRCh37
Build 366150,023,587 - 150,024,493RGDNCBI36
Celera6150,717,149 - 150,718,056RGD
HuRef6147,548,533 - 147,549,439UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3084
Count of miRNA genes:1203
Interacting mature miRNAs:1507
Transcripts:ENST00000253339, ENST00000392273, ENST00000441107, ENST00000458696, ENST00000542720, ENST00000542747, ENST00000543571
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1286 1130 708 113 848 55 2516 640 1282 171 1104 1193 71 1 756 1517 4 1
Low 1153 1804 1018 511 1047 410 1841 1556 2452 247 356 420 104 448 1271 2 1
Below cutoff 57 56 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001350339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001350340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001350392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF104413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF164041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL358852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL583963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW021064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX276089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000253339   ⟹   ENSP00000253339
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,661,094 - 149,702,354 (-)Ensembl
RefSeq Acc Id: ENST00000392273   ⟹   ENSP00000444678
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,682,919 - 149,718,105 (-)Ensembl
RefSeq Acc Id: ENST00000441107   ⟹   ENSP00000403815
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,661,697 - 149,716,425 (-)Ensembl
RefSeq Acc Id: ENST00000458696   ⟹   ENSP00000441265
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,684,325 - 149,718,034 (-)Ensembl
RefSeq Acc Id: ENST00000542720   ⟹   ENSP00000444535
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,684,404 - 149,718,024 (-)Ensembl
RefSeq Acc Id: ENST00000542747
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,675,696 - 149,701,963 (-)Ensembl
RefSeq Acc Id: ENST00000543571   ⟹   ENSP00000437550
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,658,153 - 149,718,101 (-)Ensembl
RefSeq Acc Id: NM_001270519   ⟹   NP_001257448
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,682,914 - 149,718,101 (-)NCBI
GRCh376149,979,289 - 150,039,392 (-)NCBI
HuRef6147,545,928 - 147,605,163 (-)NCBI
CHM1_16150,268,730 - 150,304,031 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001350339   ⟹   NP_001337268
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,718,101 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001350340   ⟹   NP_001337269
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,718,101 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001350392   ⟹   NP_001337321
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,718,101 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004690   ⟹   NP_004681
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,718,101 (-)NCBI
GRCh376149,979,289 - 150,039,392 (-)NCBI
Build 366150,023,744 - 150,081,085 (-)NCBI Archive
HuRef6147,545,928 - 147,605,163 (-)NCBI
CHM1_16150,243,964 - 150,304,031 (-)NCBI
Sequence:
RefSeq Acc Id: NR_073033
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,716,425 (-)NCBI
GRCh376149,979,289 - 150,039,392 (-)NCBI
HuRef6147,545,928 - 147,605,163 (-)NCBI
CHM1_16150,243,964 - 150,302,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006715603   ⟹   XP_006715666
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,676,649 - 149,718,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011536252   ⟹   XP_011534554
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,664,137 - 149,718,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017011474   ⟹   XP_016866963
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,718,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017011477   ⟹   XP_016866966
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,664,136 - 149,718,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017011479   ⟹   XP_016866968
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,661,138 - 149,718,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017011480   ⟹   XP_016866969
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,717,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017011482   ⟹   XP_016866971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,681,461 - 149,718,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024446583   ⟹   XP_024302351
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,658,153 - 149,717,926 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004681   ⟸   NM_004690
- Peptide Label: isoform 1
- UniProtKB: O95835 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257448   ⟸   NM_001270519
- Peptide Label: isoform 2
- UniProtKB: O95835 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006715666   ⟸   XM_006715603
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011534554   ⟸   XM_011536252
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016866963   ⟸   XM_017011474
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016866969   ⟸   XM_017011480
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016866968   ⟸   XM_017011479
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016866966   ⟸   XM_017011477
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016866971   ⟸   XM_017011482
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: NP_001337321   ⟸   NM_001350392
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: NP_001337269   ⟸   NM_001350340
- Peptide Label: isoform 4
- Sequence:
RefSeq Acc Id: NP_001337268   ⟸   NM_001350339
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: XP_024302351   ⟸   XM_024446583
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000444535   ⟸   ENST00000542720
RefSeq Acc Id: ENSP00000253339   ⟸   ENST00000253339
RefSeq Acc Id: ENSP00000437550   ⟸   ENST00000543571
RefSeq Acc Id: ENSP00000403815   ⟸   ENST00000441107
RefSeq Acc Id: ENSP00000441265   ⟸   ENST00000458696
RefSeq Acc Id: ENSP00000444678   ⟸   ENST00000392273
Protein Domains
AGC-kinase C-terminal   Protein kinase   UBA

Promoters
RGD ID:7209403
Promoter ID:EPDNEW_H10447
Type:initiation region
Name:LATS1_1
Description:large tumor suppressor kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10448  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,718,082 - 149,718,142EPDNEW
RGD ID:7209405
Promoter ID:EPDNEW_H10448
Type:initiation region
Name:LATS1_2
Description:large tumor suppressor kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10447  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386149,718,262 - 149,718,322EPDNEW
RGD ID:6804055
Promoter ID:HG_KWN:55393
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000392273,   NM_004690,   OTTHUMT00000043923,   UC003QMW.2,   UC010KIG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 366150,080,659 - 150,081,159 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_004690.4(LATS1):c.2636G>A (p.Trp879Ter) single nucleotide variant Peritoneal mesothelioma [RCV000758178] Chr6:149676695 [GRCh38]
Chr6:149997831 [GRCh37]
Chr6:6q25.1
likely pathogenic
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27
pathogenic
GRCh38/hg38 6q24.3-25.1(chr6:146481119-151427629)x1 copy number loss See cases [RCV000051005] Chr6:146481119..151427629 [GRCh38]
Chr6:146802255..151748764 [GRCh37]
Chr6:146843948..151790457 [NCBI36]
Chr6:6q24.3-25.1
pathogenic
GRCh38/hg38 6q24.2-25.2(chr6:144932561-152985364)x1 copy number loss See cases [RCV000052206] Chr6:144932561..152985364 [GRCh38]
Chr6:145253697..153306499 [GRCh37]
Chr6:145295390..153348192 [NCBI36]
Chr6:6q24.2-25.2
pathogenic
GRCh38/hg38 6q24.3-25.1(chr6:147805119-150893715)x1 copy number loss See cases [RCV000135408] Chr6:147805119..150893715 [GRCh38]
Chr6:148126255..151214851 [GRCh37]
Chr6:148167948..151256544 [NCBI36]
Chr6:6q24.3-25.1
pathogenic
GRCh38/hg38 6q23.3-25.3(chr6:135358150-155455117)x3 copy number gain See cases [RCV000136826] Chr6:135358150..155455117 [GRCh38]
Chr6:135679288..155776251 [GRCh37]
Chr6:135720981..155817943 [NCBI36]
Chr6:6q23.3-25.3
pathogenic
GRCh38/hg38 6q24.3-25.1(chr6:147580351-150227963)x3 copy number gain See cases [RCV000138362] Chr6:147580351..150227963 [GRCh38]
Chr6:147901487..150549099 [GRCh37]
Chr6:147943180..150590792 [NCBI36]
Chr6:6q24.3-25.1
uncertain significance
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27
pathogenic
GRCh37/hg19 6q24.2-25.1(chr6:144075695-152337005)x1 copy number loss See cases [RCV000448815] Chr6:144075695..152337005 [GRCh37]
Chr6:6q24.2-25.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_004690.4(LATS1):c.2365G>C (p.Asp789His) single nucleotide variant Ependymoma [RCV000577865] Chr6:149680103 [GRCh38]
Chr6:150001239 [GRCh37]
Chr6:6q25.1
uncertain significance
GRCh37/hg19 6q24.1-25.1(chr6:139513020-150389231)x1 copy number loss See cases [RCV000510942] Chr6:139513020..150389231 [GRCh37]
Chr6:6q24.1-25.1
pathogenic
GRCh37/hg19 6q24.2-25.1(chr6:144947731-150266155)x1 copy number loss not provided [RCV000682729] Chr6:144947731..150266155 [GRCh37]
Chr6:6q24.2-25.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_004690.4(LATS1):c.610A>G (p.Ser204Gly) single nucleotide variant not provided [RCV000971534] Chr6:149684479 [GRCh38]
Chr6:150005615 [GRCh37]
Chr6:6q25.1
benign
GRCh37/hg19 6q24.3-25.1(chr6:148690764-150494873)x1 copy number loss See cases [RCV000790589] Chr6:148690764..150494873 [GRCh37]
Chr6:6q24.3-25.1
pathogenic
NM_004690.4(LATS1):c.2449G>A (p.Glu817Lys) single nucleotide variant Multiple myeloma [RCV000984108] Chr6:149680019 [GRCh38]
Chr6:150001155 [GRCh37]
Chr6:6q25.1
likely pathogenic
GRCh37/hg19 6q25.1-25.2(chr6:149431322-154120064)x1 copy number loss not provided [RCV001005856] Chr6:149431322..154120064 [GRCh37]
Chr6:6q25.1-25.2
pathogenic
GRCh37/hg19 6q24.3-25.3(chr6:148195086-160127254)x3 copy number gain not provided [RCV000846496] Chr6:148195086..160127254 [GRCh37]
Chr6:6q24.3-25.3
pathogenic
NM_004690.4(LATS1):c.1591C>T (p.Pro531Ser) single nucleotide variant not provided [RCV000893135] Chr6:149683498 [GRCh38]
Chr6:150004634 [GRCh37]
Chr6:6q25.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6514 AgrOrtholog
COSMIC LATS1 COSMIC
Ensembl Genes ENSG00000131023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000253339 UniProtKB/Swiss-Prot
  ENSP00000403815 UniProtKB/TrEMBL
  ENSP00000437550 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000441265 UniProtKB/TrEMBL
  ENSP00000444535 UniProtKB/TrEMBL
  ENSP00000444678 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000253339 UniProtKB/Swiss-Prot
  ENST00000392273 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000441107 UniProtKB/TrEMBL
  ENST00000458696 UniProtKB/TrEMBL
  ENST00000542720 UniProtKB/TrEMBL
  ENST00000543571 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000131023 GTEx
HGNC ID HGNC:6514 ENTREZGENE
Human Proteome Map LATS1 Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  LATS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LATS1_STKc UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  UBA-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9113 UniProtKB/Swiss-Prot
NCBI Gene 9113 ENTREZGENE
OMIM 603473 OMIM
PANTHER PTHR24356:SF138 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
PharmGKB PA30301 PharmGKB
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
UniProt H0YG09_HUMAN UniProtKB/TrEMBL
  LATS1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PJG3_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q6PKD0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-30 LATS1  large tumor suppressor kinase 1    LATS, large tumor suppressor, homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED