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Gene: GSDME (gasdermin E) Homo sapiens
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Symbol: GSDME
Name: gasdermin E
Description: Exhibits cardiolipin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of intracellular signal transduction; and pyroptosis. Localizes to the cytosol and plasma membrane. Implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deafness, autosomal dominant 5; DFNA5; DFNA5, deafness associated tumor suppressor; gasdermin-E; ICERE-1; inversely correlated with estrogen receptor expression 1; non-syndromic hearing impairment protein 5; nonsyndromic hearing impairment protein
Orthologs:
Mus musculus (house mouse) : Gsdme (gasdermin E)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gsdme (gasdermin E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsdme (gasdermin E)
Pan paniscus (bonobo/pygmy chimpanzee) : GSDME (gasdermin E)
Canis lupus familiaris (dog) : GSDME (gasdermin E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsdme (gasdermin E)
Sus scrofa (pig) : GSDME (gasdermin E)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl724,698,355 - 24,757,940 (-)Ensembl
GRCh38724,698,355 - 24,762,235 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37724,737,974 - 24,797,639 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,704,499 - 24,764,164 (-)NCBINCBI36hg18NCBI36
Build 34724,511,214 - 24,570,603NCBI
Celera724,726,449 - 24,786,103 (-)NCBI
Cytogenetic Map7p15.3NCBI
HuRef724,622,538 - 24,682,209 (-)NCBIHuRef
CHM1_1724,739,537 - 24,799,201 (-)NCBICHM1_1
CRA_TCAGchr7v2724,789,534 - 24,849,193 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GSDME
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349553
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.