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Gene: WAS (WASP actin nucleation promoting factor) Homo sapiens
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Symbol: WAS
Name: WASP actin nucleation promoting factor
Description: Exhibits SH3 domain binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including Cdc42 protein signal transduction; positive regulation of nucleobase-containing compound metabolic process; and regulation of actin filament organization. Localizes to several cellular components, including the actin filament; cytosol; and site of double-strand break. Implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: eczema-thrombocytopenia; IMD2; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); WASP; WASPA; Wiskott-Aldrich syndrome; wiskott-Aldrich syndrome protein
Orthologs:
Mus musculus (house mouse) : Was (Wiskott-Aldrich syndrome)  MGI  Alliance
Rattus norvegicus (Norway rat) : Was (WASP actin nucleation promoting factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Was (WASP actin nucleation promoting factor)
Pan paniscus (bonobo/pygmy chimpanzee) : WAS (WASP actin nucleation promoting factor)
Canis lupus familiaris (dog) : WAS (WASP actin nucleation promoting factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Was (WASP actin nucleation promoting factor)
Sus scrofa (pig) : WAS (WASP actin nucleation promoting factor)
Chlorocebus sabaeus (green monkey) : WAS (WASP actin nucleation promoting factor)
Heterocephalus glaber (naked mole-rat) : Was (WASP actin nucleation promoting factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX48,676,596 - 48,691,427 (+)Ensembl
GRCh38X48,683,753 - 48,691,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,542,186 - 48,549,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,427,153 - 48,434,759 (+)NCBINCBI36hg18NCBI36
Build 34X48,298,458 - 48,306,065NCBI
CeleraX53,114,189 - 53,121,821 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,204,599 - 46,212,234 (+)NCBIHuRef
CHM1_1X48,573,355 - 48,580,986 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on WAS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349471
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.