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Gene: HLA-DMB (major histocompatibility complex, class II, DM beta) Homo sapiens
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Symbol: HLA-DMB
Name: major histocompatibility complex, class II, DM beta
Description: Exhibits MHC class II protein complex binding activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Localizes to MHC class II protein complex and intracellular membrane-bounded organelle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: class II histocompatibility antigen, M beta chain; D6S221E; HLA class II histocompatibility antigen, DM beta chain; MHC class II antigen DMB; MHC class II antigen HLA-DM beta chain; MHC class II HLA-DMB; really interesting new gene 7 protein; RING7
Orthologs:
Mus musculus (house mouse) : H2-DMb2 (histocompatibility 2, class II, locus Mb2)  MGI  Alliance
Rattus norvegicus (Norway rat) : RT1-DMb (RT1 class II, locus DMb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102023521 (HLA class II histocompatibility antigen, DM beta chain)
Pan paniscus (bonobo/pygmy chimpanzee) : MHC-DMB (HLA class II histocompatibility antigen, DM beta chain)
Canis lupus familiaris (dog) : DLA-DMB (major histocompatibility complex, class II, DM beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101959667 (HLA class II histocompatibility antigen, DM beta chain)
Sus scrofa (pig) : SLA-DMB (MHC class II, DM beta)
Chlorocebus sabaeus (African green monkey) : MHC-DMB (major histocompatibility complex, class II, DM beta)
Heterocephalus glaber (naked mole-rat) : LOC101701356 (HLA class II histocompatibility antigen, DM beta chain)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl632,934,629 - 32,941,028 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,934,636 - 32,941,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,902,406 - 32,908,847 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,010,393 - 33,016,795 (-)NCBINCBI36hg18NCBI36
Build 34633,010,392 - 33,016,795NCBI
Celera634,451,309 - 34,457,750 (-)NCBI
Cytogenetic Map6p21.32NCBI
HuRef632,644,839 - 32,651,376 (-)NCBIHuRef
CHM1_1632,903,201 - 32,909,642 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HLA-DMB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349438
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.