DCD (dermcidin) - Rat Genome Database

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Gene: DCD (dermcidin) Homo sapiens
Analyze
Symbol: DCD
Name: dermcidin
RGD ID: 1349389
HGNC Page HGNC:14669
Description: Enables lipid binding activity and monoatomic anion channel activity. Involved in defense response to other organism and inorganic anion transport. Located in extracellular space and membrane. Is extrinsic component of membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AIDD; DCD-1; diffusible survival/evasion peptide; DSEP; HCAP; MGC71930; PIF; preproteolysin; proteolysis inducing factor; survival promoting peptide
RGD Orthologs
Mouse
Chinchilla
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,644,589 - 54,648,365 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1254,644,589 - 54,648,493 (-)EnsemblGRCh38hg38GRCh38
GRCh371255,038,373 - 55,042,149 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,324,642 - 53,328,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 341253,324,698 - 53,328,413NCBI
Celera1254,690,262 - 54,694,036 (-)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1252,076,981 - 52,080,755 (-)NCBIHuRef
CHM1_11255,005,101 - 55,008,875 (-)NCBICHM1_1
T2T-CHM13v2.01254,611,207 - 54,614,982 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8602222   PMID:9139670   PMID:9736629   PMID:10833321   PMID:11694882   PMID:12429208   PMID:12477932   PMID:12953101   PMID:14978112   PMID:15174051   PMID:15340161   PMID:15342556  
PMID:15355918   PMID:15489334   PMID:15670776   PMID:15944307   PMID:16142329   PMID:16196087   PMID:16354654   PMID:16685272   PMID:17207965   PMID:17353931   PMID:17373842   PMID:17448443  
PMID:17620599   PMID:17626247   PMID:18058718   PMID:18372903   PMID:18403914   PMID:18594538   PMID:18599487   PMID:18714373   PMID:18781797   PMID:19020323   PMID:19056867   PMID:19380743  
PMID:19394292   PMID:19670153   PMID:19703016   PMID:19720844   PMID:19833888   PMID:20020773   PMID:20510021   PMID:20571754   PMID:20809104   PMID:20837461   PMID:20889853   PMID:21139048  
PMID:21145461   PMID:21319273   PMID:21397687   PMID:21565611   PMID:21642987   PMID:21873635   PMID:21988832   PMID:22262861   PMID:22588119   PMID:22658674   PMID:23376485   PMID:23398456  
PMID:23426625   PMID:23455922   PMID:23686814   PMID:23824909   PMID:23979707   PMID:24562771   PMID:24969620   PMID:24981860   PMID:25055737   PMID:25324306   PMID:25331947   PMID:25416956  
PMID:25673161   PMID:25879571   PMID:25921289   PMID:25963833   PMID:26170170   PMID:26693507   PMID:26718508   PMID:26725010   PMID:26777405   PMID:26944449   PMID:26972000   PMID:27217568  
PMID:27392853   PMID:27432908   PMID:27462432   PMID:27545878   PMID:27591049   PMID:27609421   PMID:27650261   PMID:28515276   PMID:28685749   PMID:28888369   PMID:28977666   PMID:29053956  
PMID:29128334   PMID:29178343   PMID:29180619   PMID:29298432   PMID:29467282   PMID:29478914   PMID:29507755   PMID:29549164   PMID:29563501   PMID:29676528   PMID:29735542   PMID:29777862  
PMID:29844126   PMID:29845934   PMID:29859926   PMID:29969578   PMID:30226544   PMID:30258100   PMID:30309841   PMID:30413534   PMID:30463107   PMID:30575818   PMID:30734678   PMID:30737378  
PMID:30745168   PMID:30836988   PMID:30948266   PMID:30997501   PMID:31010829   PMID:31091453   PMID:31115649   PMID:31180492   PMID:31253590   PMID:31267705   PMID:31273033   PMID:31300519  
PMID:31324722   PMID:31406141   PMID:31436131   PMID:31586073   PMID:31669268   PMID:31950832   PMID:31952546   PMID:32120844   PMID:32129710   PMID:32176739   PMID:32296183   PMID:32355176  
PMID:32398829   PMID:32552912   PMID:32572027   PMID:32614325   PMID:32687490   PMID:32807901   PMID:32905556   PMID:32908313   PMID:32913203   PMID:32929329   PMID:32989256   PMID:33005030  
PMID:33194618   PMID:33239621   PMID:33644029   PMID:33742100   PMID:33838681   PMID:33981001   PMID:34185411   PMID:34431227   PMID:34445801   PMID:34728620   PMID:35013218   PMID:35124280  
PMID:35256949   PMID:35271311   PMID:35474131   PMID:35546148   PMID:35583604   PMID:35652658   PMID:35831895   PMID:35864588   PMID:35896951   PMID:35944360   PMID:36057605   PMID:36114006  
PMID:36147463   PMID:36180891   PMID:36199071   PMID:36215168   PMID:36243803   PMID:36244648   PMID:36307841   PMID:36339263   PMID:36373674   PMID:36414381   PMID:36424410   PMID:36490346  
PMID:36517590   PMID:36526897   PMID:36574265   PMID:36604567   PMID:36610398   PMID:36636478   PMID:37689310   PMID:37827155   PMID:38113892   PMID:38172120  


Genomics

Comparative Map Data
DCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,644,589 - 54,648,365 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1254,644,589 - 54,648,493 (-)EnsemblGRCh38hg38GRCh38
GRCh371255,038,373 - 55,042,149 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,324,642 - 53,328,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 341253,324,698 - 53,328,413NCBI
Celera1254,690,262 - 54,694,036 (-)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1252,076,981 - 52,080,755 (-)NCBIHuRef
CHM1_11255,005,101 - 55,008,875 (-)NCBICHM1_1
T2T-CHM13v2.01254,611,207 - 54,614,982 (-)NCBIT2T-CHM13v2.0
A930009A15Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,399,555 - 115,418,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10115,405,891 - 115,418,353 (+)EnsemblGRCm39 Ensembl
GRCm3810115,569,986 - 115,582,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,569,986 - 115,582,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710115,007,042 - 115,019,510 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610114,974,096 - 114,986,558 (+)NCBIMGSCv36mm8
Celera10117,500,535 - 117,512,691 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
Dcd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554581,875,244 - 1,879,434 (-)NCBIChiLan1.0ChiLan1.0
DCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21039,526,381 - 39,530,591 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11239,523,150 - 39,527,334 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01234,099,063 - 34,102,968 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11234,826,958 - 34,830,859 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1234,826,958 - 34,830,859 (+)Ensemblpanpan1.1panPan2
DCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,760,466 - 50,765,369 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037195,272,017 - 195,276,034 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DCD
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q13.13-13.3(chr12:53420606-56202942)x3 copy number gain See cases [RCV000141435] Chr12:53420606..56202942 [GRCh38]
Chr12:53814390..56596726 [GRCh37]
Chr12:52100657..54882993 [NCBI36]
Chr12:12q13.13-13.3		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_053283.4(DCD):c.211G>A (p.Asp71Asn) single nucleotide variant not provided [RCV000973150] Chr12:54645251 [GRCh38]
Chr12:55039035 [GRCh37]
Chr12:12q13.2		 benign
NM_053283.4(DCD):c.72C>T (p.Ala24=) single nucleotide variant not provided [RCV000897772] Chr12:54647146 [GRCh38]
Chr12:55040930 [GRCh37]
Chr12:12q13.2		 likely benign
NM_053283.4(DCD):c.280G>A (p.Val94Met) single nucleotide variant Inborn genetic diseases [RCV003241217] Chr12:54645182 [GRCh38]
Chr12:55038966 [GRCh37]
Chr12:12q13.2		 uncertain significance
NM_053283.4(DCD):c.326T>C (p.Val109Ala) single nucleotide variant Inborn genetic diseases [RCV002728268] Chr12:54644720 [GRCh38]
Chr12:55038504 [GRCh37]
Chr12:12q13.2		 uncertain significance
NM_053283.4(DCD):c.89C>T (p.Ser30Leu) single nucleotide variant Inborn genetic diseases [RCV002640912] Chr12:54647129 [GRCh38]
Chr12:55040913 [GRCh37]
Chr12:12q13.2		 uncertain significance
NM_053283.4(DCD):c.241G>A (p.Gly81Arg) single nucleotide variant Inborn genetic diseases [RCV002769433] Chr12:54645221 [GRCh38]
Chr12:55039005 [GRCh37]
Chr12:12q13.2		 uncertain significance
NM_053283.4(DCD):c.295G>A (p.Val99Ile) single nucleotide variant Inborn genetic diseases [RCV002940581] Chr12:54644751 [GRCh38]
Chr12:55038535 [GRCh37]
Chr12:12q13.2		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:170
Interacting mature miRNAs:171
Transcripts:ENST00000293371, ENST00000456047, ENST00000546807
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 1 743 19 467
Medium 11 11 6 2 2 2 499 6 10 4 9 27 218
Low 718 1126 385 89 296 46 1495 707 893 27 406 424 43 608 1069
Below cutoff 1003 1389 627 180 653 112 1130 1095 1728 119 558 527 68 464 861

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000293371   ⟹   ENSP00000293371
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1254,644,589 - 54,648,365 (-)Ensembl
RefSeq Acc Id: ENST00000456047   ⟹   ENSP00000406773
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1254,644,630 - 54,648,493 (-)Ensembl
RefSeq Acc Id: ENST00000546807   ⟹   ENSP00000450415
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1254,644,630 - 54,648,493 (-)Ensembl
RefSeq Acc Id: NM_001300854   ⟹   NP_001287783
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381254,644,589 - 54,648,365 (-)NCBI
CHM1_11255,005,101 - 55,009,003 (-)NCBI
T2T-CHM13v2.01254,611,207 - 54,614,982 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053283   ⟹   NP_444513
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381254,644,589 - 54,648,365 (-)NCBI
GRCh371255,038,375 - 55,042,277 (-)NCBI
Build 361253,324,642 - 53,328,416 (-)NCBI Archive
HuRef1252,076,981 - 52,080,755 (-)ENTREZGENE
CHM1_11255,005,101 - 55,009,003 (-)NCBI
T2T-CHM13v2.01254,611,207 - 54,614,982 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_444513   ⟸   NM_053283
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P58461 (UniProtKB/Swiss-Prot),   A5JHP3 (UniProtKB/Swiss-Prot),   A5JHP2 (UniProtKB/Swiss-Prot),   Q53YJ2 (UniProtKB/Swiss-Prot),   P81605 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001287783   ⟸   NM_001300854
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P81605 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000293371   ⟸   ENST00000293371
RefSeq Acc Id: ENSP00000450415   ⟸   ENST00000546807
RefSeq Acc Id: ENSP00000406773   ⟸   ENST00000456047

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81605-F1-model_v2 AlphaFold P81605 1-110 view protein structure

Promoters
RGD ID:7224277
Promoter ID:EPDNEW_H17884
Type:multiple initiation site
Name:DCD_1
Description:dermcidin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381254,648,362 - 54,648,422EPDNEW

Additional Information

Database Acc Id Source(s)
COSMIC DCD COSMIC
Ensembl Genes ENSG00000161634 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000293371 ENTREZGENE
  ENST00000293371.11 UniProtKB/Swiss-Prot
  ENST00000456047 ENTREZGENE
  ENST00000456047.2 UniProtKB/Swiss-Prot
  ENST00000546807.5 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.580 UniProtKB/Swiss-Prot
GTEx ENSG00000161634 GTEx
HGNC ID HGNC:14669 ENTREZGENE
Human Proteome Map DCD Human Proteome Map
InterPro Dermcidin UniProtKB/Swiss-Prot
  Dermcidin/Lacritin UniProtKB/Swiss-Prot
KEGG Report hsa:117159 UniProtKB/Swiss-Prot
NCBI Gene 117159 ENTREZGENE
OMIM 606634 OMIM
PANTHER PTHR40711 UniProtKB/Swiss-Prot
  PTHR40711:SF1 UniProtKB/Swiss-Prot
Pfam Dermcidin UniProtKB/Swiss-Prot
PharmGKB PA27171 PharmGKB
UniProt A5JHP2 ENTREZGENE
  A5JHP3 ENTREZGENE
  DCD_HUMAN UniProtKB/Swiss-Prot
  P58461 ENTREZGENE
  P81605 ENTREZGENE
  Q53YJ2 ENTREZGENE
UniProt Secondary A5JHP2 UniProtKB/Swiss-Prot
  A5JHP3 UniProtKB/Swiss-Prot
  P58461 UniProtKB/Swiss-Prot
  Q53YJ2 UniProtKB/Swiss-Prot