TRPC7 (transient receptor potential cation channel subfamily C member 7) - Rat Genome Database

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Gene: TRPC7 (transient receptor potential cation channel subfamily C member 7) Homo sapiens
Analyze
Symbol: TRPC7
Name: transient receptor potential cation channel subfamily C member 7
RGD ID: 1349355
HGNC Page HGNC:20754
Description: Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within calcium ion transport and manganese ion transport. Predicted to be located in membrane; nuclear envelope; and perinuclear region of cytoplasm. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Implicated in lung cancer.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hTRP7; likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7; putative capacitative calcium channel; short transient receptor potential channel 7; transient receptor potential cation channel, subfamily C, member 7; transient receptor protein 7; TRP-7; TRP7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,212,745 - 136,365,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,212,745 - 136,365,545 (-)EnsemblGRCh38hg38GRCh38
GRCh375135,548,433 - 135,701,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,577,022 - 135,720,974 (-)NCBINCBI36Build 36hg18NCBI36
Build 345135,577,021 - 135,720,972NCBI
Celera5131,673,736 - 131,825,919 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,737,474 - 130,889,316 (-)NCBIHuRef
CHM1_15134,981,614 - 135,133,762 (-)NCBICHM1_1
T2T-CHM13v2.05136,735,275 - 136,888,049 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Identification of TRPCs genetic variants that modify risk for lung cancer based on the pathway and two-stage study. Zhang Z, etal., Meta Gene. 2016 Jul 8;9:191-6. doi: 10.1016/j.mgene.2016.07.005. eCollection 2016 Sep.
Additional References at PubMed
PMID:11290752   PMID:11805119   PMID:12032305   PMID:12477932   PMID:15199065   PMID:15342342   PMID:15757897   PMID:15972814   PMID:16123040   PMID:16382100   PMID:16741513   PMID:17217055  
PMID:18021175   PMID:19240791   PMID:19812035   PMID:20379614   PMID:21402151   PMID:21873635   PMID:24470487   PMID:31755176   PMID:33961781  


Genomics

Comparative Map Data
TRPC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,212,745 - 136,365,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,212,745 - 136,365,545 (-)EnsemblGRCh38hg38GRCh38
GRCh375135,548,433 - 135,701,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,577,022 - 135,720,974 (-)NCBINCBI36Build 36hg18NCBI36
Build 345135,577,021 - 135,720,972NCBI
Celera5131,673,736 - 131,825,919 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,737,474 - 130,889,316 (-)NCBIHuRef
CHM1_15134,981,614 - 135,133,762 (-)NCBICHM1_1
T2T-CHM13v2.05136,735,275 - 136,888,049 (-)NCBIT2T-CHM13v2.0
Trpc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,920,911 - 57,043,778 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,920,926 - 57,043,806 (-)EnsemblGRCm39 Ensembl
GRCm381356,773,098 - 56,895,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,773,113 - 56,895,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv371356,874,469 - 56,996,949 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,782,730 - 56,905,210 (-)NCBIMGSCv36mm8
Celera1357,827,818 - 57,952,905 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.27NCBI
Trpc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,707,954 - 7,839,064 (+)NCBIGRCr8
mRatBN7.2177,708,911 - 7,833,435 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,709,583 - 7,833,435 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,728,782 - 7,851,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,261,227 - 9,383,024 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,725,168 - 7,847,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,134,267 - 8,280,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,135,251 - 8,279,515 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,316,554 - 10,456,609 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,660,133 - 13,781,358 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,749,821 - 13,771,093 (+)NCBI
Celera177,806,368 - 7,928,485 (+)NCBICelera
Cytogenetic Map17p14NCBI
Trpc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,261,421 - 31,416,108 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540831,260,767 - 31,408,852 (-)NCBIChiLan1.0ChiLan1.0
TRPC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,499,891 - 131,652,824 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,639,451 - 129,792,384 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,604,175 - 131,756,944 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,743,638 - 137,896,107 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,743,638 - 137,896,107 (-)Ensemblpanpan1.1panPan2
TRPC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11124,113,128 - 24,256,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,859,569 - 23,003,547 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,928,881 - 25,072,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,647,009 - 23,790,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,483,142 - 23,627,149 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01124,131,869 - 24,275,920 (-)NCBIUU_Cfam_GSD_1.0
Trpc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,274,159 - 124,418,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365973,298,984 - 3,443,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365973,298,968 - 3,470,863 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,373,189 - 138,510,728 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,373,972 - 138,502,280 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,969,145 - 144,151,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,957,128 - 39,098,615 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603438,814,605 - 38,955,676 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473310,703,428 - 10,900,054 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473310,703,295 - 10,900,206 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TRPC7
29 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:133401565-138437038)x1 copy number loss See cases [RCV000052114] Chr5:133401565..138437038 [GRCh38]
Chr5:132737257..137772727 [GRCh37]
Chr5:132765156..137800626 [NCBI36]
Chr5:5q31.1-31.2		 pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:135894042-137619032)x1 copy number loss See cases [RCV000052116] Chr5:135894042..137619032 [GRCh38]
Chr5:135229731..136954721 [GRCh37]
Chr5:135257630..136982620 [NCBI36]
Chr5:5q31.1-31.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3		 pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5q31.1(chr5:135395863-135680453)x3 copy number gain See cases [RCV000446642] Chr5:135395863..135680453 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q31.1(chr5:135699216-136189770)x3 copy number gain See cases [RCV000448164] Chr5:135699216..136189770 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5q31.1(chr5:135396615-135680453)x3 copy number gain See cases [RCV000448590] Chr5:135396615..135680453 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_020389.3(TRPC7):c.706G>A (p.Glu236Lys) single nucleotide variant Inborn genetic diseases [RCV003295942] Chr5:136356682 [GRCh38]
Chr5:135692370 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.615G>C (p.Glu205Asp) single nucleotide variant Inborn genetic diseases [RCV003262509] Chr5:136356773 [GRCh38]
Chr5:135692461 [GRCh37]
Chr5:5q31.1		 uncertain significance
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5q31.1-31.2(chr5:135699216-136201487)x3 copy number gain not provided [RCV000682598] Chr5:135699216..136201487 [GRCh37]
Chr5:5q31.1-31.2		 uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2		 likely pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
GRCh37/hg19 5q31.1(chr5:135499647-135588586)x1 copy number loss not provided [RCV001005737] Chr5:135499647..135588586 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.37C>T (p.Arg13Trp) single nucleotide variant Inborn genetic diseases [RCV003245519] Chr5:136357351 [GRCh38]
Chr5:135693039 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.2194C>T (p.Leu732Phe) single nucleotide variant Inborn genetic diseases [RCV002901047] Chr5:136226102 [GRCh38]
Chr5:135561790 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5q31.1(chr5:135699216-136197957)x3 copy number gain not provided [RCV001829063] Chr5:135699216..136197957 [GRCh37]
Chr5:5q31.1		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5q31.1-31.2(chr5:132031902-137623639) copy number loss not specified [RCV002053530] Chr5:132031902..137623639 [GRCh37]
Chr5:5q31.1-31.2		 pathogenic
GRCh37/hg19 5q31.1(chr5:135396615-135680453) copy number gain not specified [RCV002053532] Chr5:135396615..135680453 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.281C>T (p.Thr94Met) single nucleotide variant Inborn genetic diseases [RCV002729900] Chr5:136357107 [GRCh38]
Chr5:135692795 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.2564G>A (p.Arg855Lys) single nucleotide variant Inborn genetic diseases [RCV002777897] Chr5:136213460 [GRCh38]
Chr5:135549148 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.326C>T (p.Ala109Val) single nucleotide variant Inborn genetic diseases [RCV002691758] Chr5:136357062 [GRCh38]
Chr5:135692750 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.2357G>A (p.Arg786Gln) single nucleotide variant Inborn genetic diseases [RCV002931380] Chr5:136216262 [GRCh38]
Chr5:135551950 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1819G>A (p.Ala607Thr) single nucleotide variant Inborn genetic diseases [RCV002850798] Chr5:136247496 [GRCh38]
Chr5:135583184 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1465C>T (p.Arg489Cys) single nucleotide variant Inborn genetic diseases [RCV002896053] Chr5:136251763 [GRCh38]
Chr5:135587451 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1921G>A (p.Asp641Asn) single nucleotide variant Inborn genetic diseases [RCV002960421] Chr5:136231473 [GRCh38]
Chr5:135567161 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1381G>A (p.Glu461Lys) single nucleotide variant Inborn genetic diseases [RCV002669440] Chr5:136251847 [GRCh38]
Chr5:135587535 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1633G>A (p.Ala545Thr) single nucleotide variant Inborn genetic diseases [RCV003264939] Chr5:136247682 [GRCh38]
Chr5:135583370 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1814G>A (p.Arg605Gln) single nucleotide variant Inborn genetic diseases [RCV003340322] Chr5:136247501 [GRCh38]
Chr5:135583189 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1507G>A (p.Val503Met) single nucleotide variant Inborn genetic diseases [RCV003358566] Chr5:136251721 [GRCh38]
Chr5:135587409 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1226G>A (p.Arg409Gln) single nucleotide variant Inborn genetic diseases [RCV003367368] Chr5:136266339 [GRCh38]
Chr5:135602027 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.213C>A (p.Phe71Leu) single nucleotide variant Inborn genetic diseases [RCV003362168] Chr5:136357175 [GRCh38]
Chr5:135692863 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1814G>C (p.Arg605Pro) single nucleotide variant Inborn genetic diseases [RCV003385689] Chr5:136247501 [GRCh38]
Chr5:135583189 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.33G>T (p.Gln11His) single nucleotide variant Inborn genetic diseases [RCV003348313] Chr5:136357355 [GRCh38]
Chr5:135693043 [GRCh37]
Chr5:5q31.1		 uncertain significance
NM_020389.3(TRPC7):c.1971C>T (p.Asn657=) single nucleotide variant not provided [RCV003428612] Chr5:136231423 [GRCh38]
Chr5:135567111 [GRCh37]
Chr5:5q31.1		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3606
Count of miRNA genes:788
Interacting mature miRNAs:936
Transcripts:ENST00000352189, ENST00000355180, ENST00000378459, ENST00000426057, ENST00000502753, ENST00000503275, ENST00000509288, ENST00000513104, ENST00000514963
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D5S393  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375135,701,338 - 135,701,503UniSTSGRCh37
Build 365135,729,237 - 135,729,402RGDNCBI36
Celera5131,826,093 - 131,826,254RGD
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map5q31-q33UniSTS
Cytogenetic Map5q31.1UniSTS
HuRef5130,889,490 - 130,889,653UniSTS
Marshfield Genetic Map5140.72UniSTS
Marshfield Genetic Map5140.72RGD
Genethon Genetic Map5140.8UniSTS
Stanford-G3 RH Map55126.0UniSTS
GeneMap99-GB4 RH Map5516.68UniSTS
Whitehead-YAC Contig Map5 UniSTS
GeneMap99-G3 RH Map55214.0UniSTS
SHGC-105956  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375135,700,238 - 135,700,511UniSTSGRCh37
Build 365135,728,137 - 135,728,410RGDNCBI36
Celera5131,824,993 - 131,825,266RGD
Cytogenetic Map5q31.1UniSTS
HuRef5130,888,391 - 130,888,664UniSTS
TNG Radiation Hybrid Map562607.0UniSTS
SHGC-153363  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375135,609,762 - 135,610,060UniSTSGRCh37
Build 365135,637,661 - 135,637,959RGDNCBI36
Celera5131,734,534 - 131,734,832RGD
Cytogenetic Map5q31.1UniSTS
HuRef5130,798,255 - 130,798,553UniSTS
TNG Radiation Hybrid Map562423.0UniSTS
L28404  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375135,699,824 - 135,700,031UniSTSGRCh37
Build 365135,727,723 - 135,727,930RGDNCBI36
Celera5131,824,579 - 131,824,786RGD
Cytogenetic Map5q31.1UniSTS
HuRef5130,887,977 - 130,888,184UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 2 2 4
Low 9 2 203 4 5 4 20 413 107 398 7
Below cutoff 1432 758 395 100 364 78 1037 709 2168 178 262 249 23 181 711

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001167576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001167577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001376901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ272034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ421783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ549088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ549089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ549090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY167926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY167927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI826927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR002519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000352189   ⟹   ENSP00000330322
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5136,213,435 - 136,365,545 (-)Ensembl
RefSeq Acc Id: ENST00000378459   ⟹   ENSP00000367720
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5136,213,435 - 136,365,476 (-)Ensembl
RefSeq Acc Id: ENST00000502753   ⟹   ENSP00000424854
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5136,213,435 - 136,365,537 (-)Ensembl
RefSeq Acc Id: ENST00000503275   ⟹   ENSP00000421571
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5136,213,435 - 136,365,537 (-)Ensembl
RefSeq Acc Id: ENST00000509288
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5136,213,349 - 136,226,437 (-)Ensembl
RefSeq Acc Id: ENST00000513104   ⟹   ENSP00000426070
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5136,212,745 - 136,365,545 (-)Ensembl
RefSeq Acc Id: ENST00000514963   ⟹   ENSP00000426870
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5136,213,435 - 136,365,254 (-)Ensembl
RefSeq Acc Id: NM_001167576   ⟹   NP_001161048
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385136,212,745 - 136,365,545 (-)NCBI
GRCh375135,548,458 - 135,701,164 (-)NCBI
HuRef5130,737,474 - 130,889,316 (-)ENTREZGENE
CHM1_15134,981,614 - 135,133,762 (-)NCBI
T2T-CHM13v2.05136,735,275 - 136,888,049 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001167577   ⟹   NP_001161049
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385136,212,745 - 136,365,545 (-)NCBI
GRCh375135,548,458 - 135,701,164 (-)NCBI
HuRef5130,737,474 - 130,889,316 (-)ENTREZGENE
CHM1_15134,981,614 - 135,133,762 (-)NCBI
T2T-CHM13v2.05136,735,275 - 136,888,049 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001376901   ⟹   NP_001363830
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385136,212,745 - 136,365,545 (-)NCBI
T2T-CHM13v2.05136,735,275 - 136,888,049 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020389   ⟹   NP_065122
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385136,212,745 - 136,365,545 (-)NCBI
GRCh375135,548,458 - 135,701,164 (-)NCBI
Build 365135,577,022 - 135,720,974 (-)NCBI Archive
HuRef5130,737,474 - 130,889,316 (-)ENTREZGENE
CHM1_15134,981,614 - 135,133,762 (-)NCBI
T2T-CHM13v2.05136,735,275 - 136,888,049 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001161048   ⟸   NM_001167576
- Peptide Label: isoform 3
- UniProtKB: Q8IWP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001161049   ⟸   NM_001167577
- Peptide Label: isoform 2
- UniProtKB: Q8IWP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_065122   ⟸   NM_020389
- Peptide Label: isoform 1
- UniProtKB: Q70T26 (UniProtKB/Swiss-Prot),   F5H5U9 (UniProtKB/Swiss-Prot),   A1A4Z4 (UniProtKB/Swiss-Prot),   Q8IWP7 (UniProtKB/Swiss-Prot),   Q9HCX4 (UniProtKB/Swiss-Prot),   Q8WWL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001363830   ⟸   NM_001376901
- Peptide Label: isoform 4
- UniProtKB: H0Y9S0 (UniProtKB/TrEMBL),   Q70T25 (UniProtKB/TrEMBL),   Q8IWP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000424854   ⟸   ENST00000502753
RefSeq Acc Id: ENSP00000421571   ⟸   ENST00000503275
RefSeq Acc Id: ENSP00000367720   ⟸   ENST00000378459
RefSeq Acc Id: ENSP00000330322   ⟸   ENST00000352189
RefSeq Acc Id: ENSP00000426070   ⟸   ENST00000513104
RefSeq Acc Id: ENSP00000426870   ⟸   ENST00000514963
Protein Domains
Transient receptor ion channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HCX4-F1-model_v2 AlphaFold Q9HCX4 1-862 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:20754 AgrOrtholog
COSMIC TRPC7 COSMIC
Ensembl Genes ENSG00000069018 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000352189 ENTREZGENE
  ENST00000352189.8 UniProtKB/Swiss-Prot
  ENST00000378459 ENTREZGENE
  ENST00000378459.7 UniProtKB/Swiss-Prot
  ENST00000502753 ENTREZGENE
  ENST00000502753.4 UniProtKB/TrEMBL
  ENST00000503275.6 UniProtKB/TrEMBL
  ENST00000513104 ENTREZGENE
  ENST00000513104.6 UniProtKB/Swiss-Prot
  ENST00000514963.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000069018 GTEx
HGNC ID HGNC:20754 ENTREZGENE
Human Proteome Map TRPC7 Human Proteome Map
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC7_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:57113 UniProtKB/Swiss-Prot
NCBI Gene 57113 ENTREZGENE
PANTHER PTHR10117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10117:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164742693 PharmGKB
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPCHANNEL7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1A4Z4 ENTREZGENE
  A1A4Z5_HUMAN UniProtKB/TrEMBL
  F5H5U9 ENTREZGENE
  H0Y9S0 ENTREZGENE
  Q70T24_HUMAN UniProtKB/TrEMBL
  Q70T25 ENTREZGENE, UniProtKB/TrEMBL
  Q70T26 ENTREZGENE
  Q8IWP7 ENTREZGENE
  Q8IWP8 ENTREZGENE, UniProtKB/TrEMBL
  Q8WWL3 ENTREZGENE, UniProtKB/TrEMBL
  Q9HCX4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A1A4Z4 UniProtKB/Swiss-Prot
  F5H5U9 UniProtKB/Swiss-Prot
  H0Y8N3 UniProtKB/TrEMBL
  H0Y9S0 UniProtKB/TrEMBL
  H0YAE7 UniProtKB/TrEMBL
  Q70T26 UniProtKB/Swiss-Prot
  Q8IWP7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 TRPC7  transient receptor potential cation channel subfamily C member 7    transient receptor potential cation channel, subfamily C, member 7  Symbol and/or name change 5135510 APPROVED