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Gene: KDM5C (lysine demethylase 5C) Homo sapiens
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Symbol: KDM5C
Name: lysine demethylase 5C
Description: Exhibits histone demethylase activity (H3-K4 specific) and zinc ion binding activity. Involved in histone H3-K4 demethylation. Localizes to the cytosol and nucleoplasm. Implicated in syndromic X-linked intellectual disability Claes-Jensen type. Biomarker of Huntington's disease and breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DXS1272E; histone demethylase JARID1C; JARID1C; JmjC domain-containing protein SMCX; jumonji, AT rich interactive domain 1C; Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; lysine (K)-specific demethylase 5C; lysine-specific demethylase 5C; mental retardation, X-linked 13; MRX13; MRXJ; MRXSCJ; MRXSJ; selected cDNA on X; SMCX; Smcx homolog, X chromosome; Smcy homolog, X-linked; smcy homolog, x-linked (mouse); XE169
Orthologs:
Mus musculus (house mouse) : Kdm5c (lysine (K)-specific demethylase 5C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm5c (lysine demethylase 5C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm5c (lysine demethylase 5C)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM5C (lysine demethylase 5C)
Canis lupus familiaris (dog) : KDM5C (lysine demethylase 5C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm5c (lysine demethylase 5C)
Sus scrofa (pig) : KDM5C (lysine demethylase 5C)
Chlorocebus sabaeus (green monkey) : KDM5C (lysine demethylase 5C)
Heterocephalus glaber (naked mole-rat) : Kdm5c (lysine demethylase 5C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX53,191,321 - 53,225,422 (-)Ensembl
GRCh38X53,176,277 - 53,225,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,220,503 - 53,254,604 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,237,378 - 53,271,329 (-)NCBINCBI36hg18NCBI36
Build 34X53,104,473 - 53,137,625NCBI
CeleraX57,049,741 - 57,083,840 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX50,285,660 - 50,319,741 (-)NCBIHuRef
CHM1_1X53,210,762 - 53,244,827 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KDM5C
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349337
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.