RTN3 (reticulon 3) - Rat Genome Database

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Gene: RTN3 (reticulon 3) Homo sapiens
Analyze
Symbol: RTN3
Name: reticulon 3
RGD ID: 1349287
HGNC Page HGNC
Description: Involved in endoplasmic reticulum tubular network formation and negative regulation of amyloid-beta formation. Located in Golgi apparatus and endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ASY interacting protein; ASYIP; HAP; homolog of ASY protein; isoforme III; isoforme VI; neuroendocrine-specific protein-like 2; neuroendocrine-specific protein-like II; NSP-like protein 2; NSP-like protein II; NSPL2; NSPLII; reticulon-3; RTN3-A1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100418882   RTN3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1163,681,446 - 63,759,891 (+)EnsemblGRCh38hg38GRCh38
GRCh381163,681,315 - 63,759,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371163,448,922 - 63,527,363 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,205,498 - 63,283,939 (+)NCBINCBI36hg18NCBI36
Build 341163,205,497 - 63,283,937NCBI
Celera1160,773,986 - 60,853,237 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1159,778,651 - 59,857,054 (+)NCBIHuRef
CHM1_11163,331,936 - 63,410,394 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:8125298   PMID:10331947   PMID:12054434   PMID:12477932   PMID:12811824   PMID:12832288   PMID:12873973   PMID:14702039   PMID:14986927   PMID:15117958   PMID:15286784   PMID:15350194  
PMID:15489334   PMID:15560370   PMID:15799019   PMID:15946766   PMID:16054885   PMID:16189514   PMID:16303743   PMID:16847569   PMID:16965550   PMID:16979658   PMID:17031492   PMID:17081983  
PMID:17182608   PMID:17191123   PMID:17379544   PMID:17699523   PMID:18029348   PMID:18779370   PMID:18854154   PMID:19284479   PMID:19364499   PMID:19386906   PMID:19405102   PMID:19521671  
PMID:19669607   PMID:19730683   PMID:20374499   PMID:20379614   PMID:20717916   PMID:21044950   PMID:21964562   PMID:21976701   PMID:22190034   PMID:22742855   PMID:22939629   PMID:23376485  
PMID:23407961   PMID:24262037   PMID:24623722   PMID:24898729   PMID:25319692   PMID:25416956   PMID:25612671   PMID:26164948   PMID:26272612   PMID:26344197   PMID:26496610   PMID:26638075  
PMID:26673895   PMID:26871637   PMID:27070582   PMID:27107014   PMID:28298427   PMID:28495747   PMID:28514442   PMID:28551625   PMID:28611215   PMID:28617241   PMID:28733667   PMID:29117863  
PMID:29180619   PMID:29356939   PMID:29716941   PMID:29756473   PMID:29892012   PMID:30561431   PMID:30575818   PMID:30948266   PMID:31006538   PMID:31056421   PMID:31073040   PMID:31091453  
PMID:31176671   PMID:31515488   PMID:32031713   PMID:32296183   PMID:32620754   PMID:32788342   PMID:32807901   PMID:32877691   PMID:32941510   PMID:33434526   PMID:33924890   PMID:33957083  
PMID:34079125  


Genomics

Comparative Map Data
RTN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1163,681,446 - 63,759,891 (+)EnsemblGRCh38hg38GRCh38
GRCh381163,681,315 - 63,759,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371163,448,922 - 63,527,363 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,205,498 - 63,283,939 (+)NCBINCBI36hg18NCBI36
Build 341163,205,497 - 63,283,937NCBI
Celera1160,773,986 - 60,853,237 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1159,778,651 - 59,857,054 (+)NCBIHuRef
CHM1_11163,331,936 - 63,410,394 (+)NCBICHM1_1
Rtn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,403,260 - 7,460,656 (-)NCBIGRCm39mm39
GRCm39 Ensembl197,403,266 - 7,460,646 (-)Ensembl
GRCm38197,425,895 - 7,483,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,425,901 - 7,483,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,500,391 - 7,557,779 (-)NCBIGRCm37mm9NCBIm37
MGSCv36197,492,945 - 7,550,333 (-)NCBImm8
Celera197,197,649 - 7,254,911 (-)NCBICelera
Cytogenetic Map19ANCBI
Rtn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21204,612,675 - 204,669,212 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1222,677,365 - 222,734,241 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01222,677,359 - 222,734,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01229,664,608 - 229,721,539 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41210,109,534 - 210,166,035 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11210,267,963 - 210,324,465 (-)NCBI
Celera1202,144,880 - 202,201,397 (-)NCBICelera
Cytogenetic Map1q43NCBI
Rtn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542221,289,652 - 21,358,865 (-)NCBIChiLan1.0ChiLan1.0
RTN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11162,391,284 - 62,468,595 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,391,284 - 62,468,595 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01159,039,313 - 59,117,572 (+)NCBIMhudiblu_PPA_v0panPan3
RTN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,239,893 - 53,298,020 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,239,914 - 53,297,984 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,847,678 - 51,905,278 (-)NCBI
ROS_Cfam_1.01854,286,179 - 54,343,796 (-)NCBI
UMICH_Zoey_3.11853,387,735 - 53,445,261 (-)NCBI
UNSW_CanFamBas_1.01852,963,486 - 53,020,402 (-)NCBI
UU_Cfam_GSD_1.01853,749,031 - 53,806,406 (-)NCBI
Rtn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,922,051 - 8,987,765 (-)NCBI
SpeTri2.0NW_0049365995,364,406 - 5,430,076 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.128,291,750 - 8,354,920 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.227,558,481 - 7,714,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RTN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,485,943 - 10,559,725 (-)NCBI
Vero_WHO_p1.0NW_023666038107,829,967 - 107,904,046 (-)NCBI
Rtn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476722,498,849 - 22,558,990 (-)NCBI

Position Markers
D7S2862  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,527,431 - 63,527,637UniSTSGRCh37
Build 361163,284,007 - 63,284,213RGDNCBI36
Celera1160,853,305 - 60,853,511RGD
Cytogenetic Map11q13UniSTS
HuRef1159,857,122 - 59,857,328UniSTS
Stanford-G3 RH Map112759.0UniSTS
GeneMap99-GB4 RH Map11228.98UniSTS
GeneMap99-G3 RH Map112759.0UniSTS
D11S4400  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,450,666 - 63,450,918UniSTSGRCh37
Build 361163,207,242 - 63,207,494RGDNCBI36
Celera1160,775,730 - 60,775,982RGD
Cytogenetic Map11q13UniSTS
HuRef1159,780,405 - 59,780,657UniSTS
Whitehead-RH Map11327.1UniSTS
Whitehead-YAC Contig Map11 UniSTS
NCBI RH Map11563.0UniSTS
RH91589  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,526,252 - 63,526,409UniSTSGRCh37
Build 361163,282,828 - 63,282,985RGDNCBI36
Celera1160,852,127 - 60,852,284RGD
Cytogenetic Map11q13UniSTS
HuRef1159,855,944 - 59,856,101UniSTS
GeneMap99-GB4 RH Map11228.98UniSTS
D11S2837  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,510,098 - 63,510,207UniSTSGRCh37
Build 361163,266,674 - 63,266,783RGDNCBI36
Celera1160,835,972 - 60,836,081RGD
Cytogenetic Map11q13UniSTS
HuRef1159,839,787 - 59,839,896UniSTS
SHGC-132011  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377137,598,470 - 137,598,743UniSTSGRCh37
GRCh371163,527,419 - 63,527,692UniSTSGRCh37
Build 367137,249,010 - 137,249,283RGDNCBI36
Celera1160,853,293 - 60,853,566UniSTS
Celera7132,337,444 - 132,337,717RGD
Cytogenetic Map7q34UniSTS
Cytogenetic Map11q13UniSTS
HuRef1159,857,110 - 59,857,383UniSTS
HuRef7131,906,298 - 131,906,571UniSTS
CRA_TCAGchr7v27136,943,855 - 136,944,128UniSTS
TNG Radiation Hybrid Map760758.0UniSTS
D3S4219  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,485,574 - 63,485,710UniSTSGRCh37
Build 361163,242,150 - 63,242,286RGDNCBI36
Celera1160,811,444 - 60,811,580RGD
Cytogenetic Map11q13UniSTS
HuRef1159,815,254 - 59,815,390UniSTS
TNG Radiation Hybrid Map1128271.0UniSTS
Stanford-G3 RH Map112782.0UniSTS
NCBI RH Map11563.0UniSTS
GeneMap99-G3 RH Map112782.0UniSTS
D11S2301E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,525,961 - 63,526,167UniSTSGRCh37
GRCh374146,297,692 - 146,297,909UniSTSGRCh37
Build 364146,517,142 - 146,517,359RGDNCBI36
Celera4143,625,228 - 143,625,445RGD
Celera1160,851,836 - 60,852,042UniSTS
Cytogenetic Map4q31.21UniSTS
Cytogenetic Map11q13UniSTS
HuRef1159,855,653 - 59,855,859UniSTS
HuRef4142,029,130 - 142,029,349UniSTS
GeneMap99-GB4 RH Map11228.98UniSTS
D11S4017  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,507,293 - 63,507,471UniSTSGRCh37
Build 361163,263,869 - 63,264,047RGDNCBI36
Celera1160,833,167 - 60,833,345RGD
Cytogenetic Map11q13UniSTS
HuRef1159,836,981 - 59,837,159UniSTS
Whitehead-RH Map11314.4UniSTS
Whitehead-YAC Contig Map11 UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4969
Count of miRNA genes:841
Interacting mature miRNAs:940
Transcripts:ENST00000338850, ENST00000339997, ENST00000341307, ENST00000354497, ENST00000356000, ENST00000377819, ENST00000536011, ENST00000537981, ENST00000538995, ENST00000540798, ENST00000542238, ENST00000543123, ENST00000543552, ENST00000545432
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 2
Medium 2439 2782 1682 589 1918 430 4348 2006 3731 410 1457 1613 175 1 1204 2779 6 2
Low 209 44 35 33 35 9 191 2 9 1 9
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001265589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001265590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001265591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_049750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_049751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF119297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP006289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY427821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY750848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC118550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC118628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ754316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ754322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS051431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000338850
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,539 - 63,714,166 (+)Ensembl
RefSeq Acc Id: ENST00000339997   ⟹   ENSP00000344106
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,483 - 63,759,891 (+)Ensembl
RefSeq Acc Id: ENST00000341307   ⟹   ENSP00000340903
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,446 - 63,759,882 (+)Ensembl
RefSeq Acc Id: ENST00000354497   ⟹   ENSP00000346492
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,573 - 63,759,089 (+)Ensembl
RefSeq Acc Id: ENST00000356000   ⟹   ENSP00000348279
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,450 - 63,759,891 (+)Ensembl
RefSeq Acc Id: ENST00000377819   ⟹   ENSP00000367050
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,500 - 63,759,882 (+)Ensembl
RefSeq Acc Id: ENST00000536011   ⟹   ENSP00000440960
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,500 - 63,758,543 (+)Ensembl
RefSeq Acc Id: ENST00000537981   ⟹   ENSP00000440874
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,500 - 63,759,885 (+)Ensembl
RefSeq Acc Id: ENST00000538995
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,474 - 63,714,479 (+)Ensembl
RefSeq Acc Id: ENST00000540798   ⟹   ENSP00000442733
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,496 - 63,758,421 (+)Ensembl
RefSeq Acc Id: ENST00000542238   ⟹   ENSP00000437971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,458 - 63,752,634 (+)Ensembl
RefSeq Acc Id: ENST00000543123
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,500 - 63,750,423 (+)Ensembl
RefSeq Acc Id: ENST00000543552   ⟹   ENSP00000442080
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,500 - 63,719,197 (+)Ensembl
RefSeq Acc Id: ENST00000545432   ⟹   ENSP00000441614
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1163,681,500 - 63,719,189 (+)Ensembl
RefSeq Acc Id: NM_001265589   ⟹   NP_001252518
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)NCBI
HuRef1159,778,651 - 59,857,054 (+)NCBI
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001265590   ⟹   NP_001252519
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)NCBI
HuRef1159,778,651 - 59,857,054 (+)NCBI
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001265591   ⟹   NP_001252520
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)NCBI
HuRef1159,778,651 - 59,857,054 (+)NCBI
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006054   ⟹   NP_006045
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)ENTREZGENE
Build 361163,205,498 - 63,283,934 (+)NCBI Archive
HuRef1159,778,651 - 59,857,054 (+)ENTREZGENE
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NM_201428   ⟹   NP_958831
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)ENTREZGENE
Build 361163,205,498 - 63,283,939 (+)NCBI Archive
HuRef1159,778,651 - 59,857,054 (+)ENTREZGENE
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NM_201429   ⟹   NP_958832
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,450 - 63,759,891 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)ENTREZGENE
Build 361163,205,498 - 63,283,939 (+)NCBI Archive
HuRef1159,778,651 - 59,857,054 (+)ENTREZGENE
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NM_201430   ⟹   NP_958833
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)ENTREZGENE
Build 361163,205,498 - 63,283,939 (+)NCBI Archive
HuRef1159,778,651 - 59,857,054 (+)ENTREZGENE
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NR_049750
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)NCBI
HuRef1159,778,651 - 59,857,054 (+)NCBI
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: NR_049751
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,759,882 (+)NCBI
GRCh371163,448,922 - 63,527,363 (+)NCBI
HuRef1159,778,651 - 59,857,054 (+)NCBI
CHM1_11163,331,936 - 63,410,394 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011544730   ⟹   XP_011543032
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,360 - 63,759,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011544731   ⟹   XP_011543033
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,315 - 63,759,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017017091   ⟹   XP_016872580
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,360 - 63,748,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017017092   ⟹   XP_016872581
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,360 - 63,726,622 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001252518 (Get FASTA)   NCBI Sequence Viewer  
  NP_001252519 (Get FASTA)   NCBI Sequence Viewer  
  NP_001252520 (Get FASTA)   NCBI Sequence Viewer  
  NP_006045 (Get FASTA)   NCBI Sequence Viewer  
  NP_958831 (Get FASTA)   NCBI Sequence Viewer  
  NP_958832 (Get FASTA)   NCBI Sequence Viewer  
  NP_958833 (Get FASTA)   NCBI Sequence Viewer  
  XP_011543032 (Get FASTA)   NCBI Sequence Viewer  
  XP_011543033 (Get FASTA)   NCBI Sequence Viewer  
  XP_016872580 (Get FASTA)   NCBI Sequence Viewer  
  XP_016872581 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC99319 (Get FASTA)   NCBI Sequence Viewer  
  AAD20951 (Get FASTA)   NCBI Sequence Viewer  
  AAD26810 (Get FASTA)   NCBI Sequence Viewer  
  AAH00634 (Get FASTA)   NCBI Sequence Viewer  
  AAH00865 (Get FASTA)   NCBI Sequence Viewer  
  AAH10556 (Get FASTA)   NCBI Sequence Viewer  
  AAH11394 (Get FASTA)   NCBI Sequence Viewer  
  AAH22993 (Get FASTA)   NCBI Sequence Viewer  
  AAI00823 (Get FASTA)   NCBI Sequence Viewer  
  AAI00824 (Get FASTA)   NCBI Sequence Viewer  
  AAI05982 (Get FASTA)   NCBI Sequence Viewer  
  AAI05983 (Get FASTA)   NCBI Sequence Viewer  
  AAI18551 (Get FASTA)   NCBI Sequence Viewer  
  AAI18629 (Get FASTA)   NCBI Sequence Viewer  
  AAR02474 (Get FASTA)   NCBI Sequence Viewer  
  AAU81930 (Get FASTA)   NCBI Sequence Viewer  
  BAD93008 (Get FASTA)   NCBI Sequence Viewer  
  BAD96618 (Get FASTA)   NCBI Sequence Viewer  
  BAG52134 (Get FASTA)   NCBI Sequence Viewer  
  BAH12044 (Get FASTA)   NCBI Sequence Viewer  
  BAH12097 (Get FASTA)   NCBI Sequence Viewer  
  BAH12179 (Get FASTA)   NCBI Sequence Viewer  
  BAH12606 (Get FASTA)   NCBI Sequence Viewer  
  BAH12607 (Get FASTA)   NCBI Sequence Viewer  
  BAH14104 (Get FASTA)   NCBI Sequence Viewer  
  CAF32494 (Get FASTA)   NCBI Sequence Viewer  
  CAF32497 (Get FASTA)   NCBI Sequence Viewer  
  CAI72209 (Get FASTA)   NCBI Sequence Viewer  
  DAA01930 (Get FASTA)   NCBI Sequence Viewer  
  DAA01931 (Get FASTA)   NCBI Sequence Viewer  
  DAA01941 (Get FASTA)   NCBI Sequence Viewer  
  DAA01942 (Get FASTA)   NCBI Sequence Viewer  
  DAA01943 (Get FASTA)   NCBI Sequence Viewer  
  EAW74164 (Get FASTA)   NCBI Sequence Viewer  
  EAW74165 (Get FASTA)   NCBI Sequence Viewer  
  EAW74166 (Get FASTA)   NCBI Sequence Viewer  
  EAW74167 (Get FASTA)   NCBI Sequence Viewer  
  EAW74168 (Get FASTA)   NCBI Sequence Viewer  
  EAW74169 (Get FASTA)   NCBI Sequence Viewer  
  EAW74170 (Get FASTA)   NCBI Sequence Viewer  
  O95197 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_958832   ⟸   NM_201429
- Peptide Label: isoform c
- UniProtKB: O95197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_958831   ⟸   NM_201428
- Peptide Label: isoform b
- UniProtKB: O95197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_958833   ⟸   NM_201430
- Peptide Label: isoform d
- UniProtKB: O95197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_006045   ⟸   NM_006054
- Peptide Label: isoform a
- UniProtKB: O95197 (UniProtKB/Swiss-Prot),   A0A024R5C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001252518   ⟸   NM_001265589
- Peptide Label: isoform e
- UniProtKB: O95197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001252519   ⟸   NM_001265590
- Peptide Label: isoform f
- UniProtKB: O95197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001252520   ⟸   NM_001265591
- Peptide Label: isoform g
- UniProtKB: O95197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011543032   ⟸   XM_011544730
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011543033   ⟸   XM_011544731
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016872580   ⟸   XM_017017091
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016872581   ⟸   XM_017017092
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000437971   ⟸   ENST00000542238
RefSeq Acc Id: ENSP00000442080   ⟸   ENST00000543552
RefSeq Acc Id: ENSP00000441614   ⟸   ENST00000545432
RefSeq Acc Id: ENSP00000367050   ⟸   ENST00000377819
RefSeq Acc Id: ENSP00000344106   ⟸   ENST00000339997
RefSeq Acc Id: ENSP00000440960   ⟸   ENST00000536011
RefSeq Acc Id: ENSP00000440874   ⟸   ENST00000537981
RefSeq Acc Id: ENSP00000346492   ⟸   ENST00000354497
RefSeq Acc Id: ENSP00000340903   ⟸   ENST00000341307
RefSeq Acc Id: ENSP00000348279   ⟸   ENST00000356000
RefSeq Acc Id: ENSP00000442733   ⟸   ENST00000540798
Protein Domains
Reticulon

Promoters
RGD ID:6789338
Promoter ID:HG_KWN:13170
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000338850,   NM_201428,   NM_201429,   NM_201430,   UC001NXO.1,   UC001NXQ.1,   UC009YOV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,205,261 - 63,205,761 (+)MPROMDB
RGD ID:6852730
Promoter ID:EP74178
Type:initiation region
Name:HS_RTN3
Description:Reticulon 3.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,205,548 - 63,205,608EPD
RGD ID:7220783
Promoter ID:EPDNEW_H16137
Type:initiation region
Name:RTN3_1
Description:reticulon 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,681,500 - 63,681,560EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_201428.2(RTN3):c.829C>A (p.Pro277Thr) single nucleotide variant Malignant melanoma [RCV000069580] Chr11:63719388 [GRCh38]
Chr11:63486860 [GRCh37]
Chr11:63243436 [NCBI36]
Chr11:11q13.1
not provided
NM_201428.2(RTN3):c.830C>T (p.Pro277Leu) single nucleotide variant Malignant melanoma [RCV000069581] Chr11:63719389 [GRCh38]
Chr11:63486861 [GRCh37]
Chr11:63243437 [NCBI36]
Chr11:11q13.1
not provided
GRCh38/hg38 11q12.3-13.1(chr11:62893226-64335043)x1 copy number loss See cases [RCV000140879] Chr11:62893226..64335043 [GRCh38]
Chr11:62660698..64102515 [GRCh37]
Chr11:62417274..63859091 [NCBI36]
Chr11:11q12.3-13.1
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.1(chr11:63410966-63525778)x3 copy number gain not provided [RCV000750074] Chr11:63410966..63525778 [GRCh37]
Chr11:11q13.1
benign
NM_001265589.2(RTN3):c.177A>C (p.Val59=) single nucleotide variant not provided [RCV000891650] Chr11:63704885 [GRCh38]
Chr11:63472357 [GRCh37]
Chr11:11q13.1
benign
NM_001265589.2(RTN3):c.1808C>T (p.Pro603Leu) single nucleotide variant not provided [RCV000886223] Chr11:63720310 [GRCh38]
Chr11:63487782 [GRCh37]
Chr11:11q13.1
benign
NM_001265589.2(RTN3):c.30C>T (p.Ser10=) single nucleotide variant not provided [RCV000957663] Chr11:63681666 [GRCh38]
Chr11:63449138 [GRCh37]
Chr11:11q13.1
benign
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Epilepsy, familial temporal lobe, 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10469 AgrOrtholog
COSMIC RTN3 COSMIC
Ensembl Genes ENSG00000133318 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000340903 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000344106 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000346492 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000348279 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000367050 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000437971 UniProtKB/TrEMBL
  ENSP00000440874 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000440960 UniProtKB/TrEMBL
  ENSP00000441614 UniProtKB/TrEMBL
  ENSP00000442080 UniProtKB/TrEMBL
  ENSP00000442733 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000339997 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000341307 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000354497 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000356000 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000377819 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000536011 UniProtKB/TrEMBL
  ENST00000537981 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000540798 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000542238 UniProtKB/TrEMBL
  ENST00000543552 UniProtKB/TrEMBL
  ENST00000545432 UniProtKB/TrEMBL
GTEx ENSG00000133318 GTEx
HGNC ID HGNC:10469 ENTREZGENE
Human Proteome Map RTN3 Human Proteome Map
InterPro Reticulon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10313 UniProtKB/Swiss-Prot
NCBI Gene 10313 ENTREZGENE
OMIM 604249 OMIM
Pfam Reticulon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34882 PharmGKB
PROSITE RETICULON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R5C4 ENTREZGENE, UniProtKB/TrEMBL
  B7Z4M1_HUMAN UniProtKB/TrEMBL
  F5GWG7_HUMAN UniProtKB/TrEMBL
  F5H617_HUMAN UniProtKB/TrEMBL
  F5H891_HUMAN UniProtKB/TrEMBL
  O95197 ENTREZGENE
  Q7RTN4_HUMAN UniProtKB/TrEMBL
  RTN3_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B3KQS2 UniProtKB/Swiss-Prot
  B7Z308 UniProtKB/Swiss-Prot
  B7Z4M0 UniProtKB/Swiss-Prot
  F5H774 UniProtKB/Swiss-Prot
  Q147U9 UniProtKB/Swiss-Prot
  Q496K2 UniProtKB/Swiss-Prot
  Q53GN3 UniProtKB/Swiss-Prot
  Q59EP0 UniProtKB/Swiss-Prot
  Q5UEP2 UniProtKB/Swiss-Prot
  Q6T930 UniProtKB/Swiss-Prot
  Q7RTM7 UniProtKB/Swiss-Prot
  Q7RTM8 UniProtKB/Swiss-Prot
  Q7RTN3 UniProtKB/Swiss-Prot