MIR30B (microRNA 30b) - Rat Genome Database

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Gene: MIR30B (microRNA 30b) Homo sapiens
Analyze
Symbol: MIR30B
Name: microRNA 30b
RGD ID: 1349241
HGNC Page HGNC
Description: Predicted to be involved in several processes, including cellular hyperosmotic salinity response; cellular response to lipopolysaccharide; and long-term synaptic potentiation. Biomarker of colorectal cancer.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-30b; MIRN30B
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8134,800,520 - 134,800,607 (-)EnsemblGRCh38hg38GRCh38
GRCh388134,800,520 - 134,800,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378135,812,763 - 135,812,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368135,881,944 - 135,882,031 (-)NCBINCBI36hg18NCBI36
Celera8131,985,504 - 131,985,591 (-)NCBI
Cytogenetic Map8q24.22NCBI
HuRef8131,128,460 - 131,128,547 (-)NCBIHuRef
CHM1_18135,854,881 - 135,854,968 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:17604727   PMID:17616659   PMID:20347265   PMID:20889907   PMID:21037258   PMID:21741600   PMID:22387553   PMID:22647547   PMID:22880027   PMID:22902743  
PMID:22964638   PMID:23086751   PMID:23249809   PMID:23893664   PMID:23968872   PMID:24067935   PMID:24129493   PMID:24199710   PMID:24593661   PMID:24913034   PMID:25170877   PMID:25596505  
PMID:25601927   PMID:25703910   PMID:25990241   PMID:26263983   PMID:26309359   PMID:26367486   PMID:26646931   PMID:26653555   PMID:26898246   PMID:27084450   PMID:27333771   PMID:27450007  
PMID:27464494   PMID:27611009   PMID:27683042   PMID:28120942   PMID:28179587   PMID:28189678   PMID:28259953   PMID:28273636   PMID:28536082   PMID:28550683   PMID:28798470   PMID:28905195  
PMID:28977001   PMID:29080678   PMID:29155108   PMID:29297231   PMID:29534579   PMID:29772430   PMID:30154547   PMID:30365113   PMID:30522932   PMID:30600796   PMID:31002820   PMID:31093946  
PMID:31358876   PMID:31447008   PMID:31607036   PMID:31768184   PMID:31839047   PMID:31861407   PMID:31888645   PMID:31926547   PMID:32112903   PMID:32299444   PMID:32336754   PMID:32420372  
PMID:32576349   PMID:32626942   PMID:32643523   PMID:33360521   PMID:33383483   PMID:33667194  


Genomics

Comparative Map Data
MIR30B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8134,800,520 - 134,800,607 (-)EnsemblGRCh38hg38GRCh38
GRCh388134,800,520 - 134,800,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378135,812,763 - 135,812,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368135,881,944 - 135,882,031 (-)NCBINCBI36hg18NCBI36
Celera8131,985,504 - 131,985,591 (-)NCBI
Cytogenetic Map8q24.22NCBI
HuRef8131,128,460 - 131,128,547 (-)NCBIHuRef
CHM1_18135,854,881 - 135,854,968 (-)NCBICHM1_1
Mir30b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391568,209,264 - 68,209,359 (-)NCBIGRCm39mm39
GRCm39 Ensembl1568,209,264 - 68,209,359 (-)Ensembl
GRCm381568,337,415 - 68,337,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1568,337,415 - 68,337,510 (-)EnsemblGRCm38mm10GRCm38
MGSCv371568,168,977 - 68,169,072 (-)NCBIGRCm37mm9NCBIm37
Celera1569,853,459 - 69,853,554 (-)NCBICelera
Cytogenetic Map15D2NCBI
Mir30b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27100,132,589 - 100,132,675 (-)NCBI
Rnor_6.0 Ensembl7109,282,658 - 109,282,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07109,282,662 - 109,282,747 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera796,643,845 - 96,643,931 (-)NCBICelera
Cytogenetic Map7q34NCBI
MIR30B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11330,906,038 - 30,906,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1330,906,038 - 30,906,097 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1330,881,273 - 30,881,332 (-)NCBI
ROS_Cfam_1.01331,271,855 - 31,271,914 (-)NCBI
UMICH_Zoey_3.11330,991,393 - 30,991,452 (-)NCBI
UNSW_CanFamBas_1.01331,090,357 - 31,090,416 (-)NCBI
UU_Cfam_GSD_1.01331,440,586 - 31,440,645 (-)NCBI
MIR30B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl46,952,794 - 6,952,869 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.146,952,794 - 6,952,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.246,717,643 - 6,717,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
SOCS1hsa-miR-30b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22387553
SMAD1hsa-miR-30b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22253433
CCNE2hsa-miR-30b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22384020
CAThsa-miR-30b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22880027
KLHL28hsa-miR-30b-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
CAMKVhsa-miR-30b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
AP2A1hsa-miR-30b-5pTarbaseexternal_infoSequencingPOSITIVE
CASP3hsa-miR-30b-5pOncomiRDBexternal_infoNANA22964638
CCNE2hsa-miR-30b-5pOncomiRDBexternal_infoNANA22384020
BCL2L11hsa-miR-30b-5pOncomiRDBexternal_infoNANA22157681
GALNT7hsa-miR-30b-5pOncomiRDBexternal_infoNANA21741600
MYBhsa-miR-30b-5pOncomiRDBexternal_infoNANA21187425
UBE2Ihsa-miR-30b-5pOncomiRDBexternal_infoNANA20498642
RORChsa-miR-30b-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23359619
RNPS1hsa-miR-30b-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:80970
Count of gene targets:21874
Count of transcripts:53260
Interacting mature miRNAs:hsa-miR-30b-3p, hsa-miR-30b-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2
Low 21 4 25 15 79 15 26 4 14 26 32 45 2 2 3
Below cutoff 18 1 4 1 27 2 12 16 13 22 19 19 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384850
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8134,800,520 - 134,800,607 (-)Ensembl
RefSeq Acc Id: NR_029666
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388134,800,520 - 134,800,607 (-)NCBI
GRCh378135,812,763 - 135,812,850 (-)RGD
Celera8131,985,504 - 131,985,591 (-)RGD
HuRef8131,128,460 - 131,128,547 (-)ENTREZGENE
CHM1_18135,854,881 - 135,854,968 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:130115518-141228210)x3 copy number gain See cases [RCV000133621] Chr8:130115518..141228210 [GRCh38]
Chr8:131127764..142238309 [GRCh37]
Chr8:131196946..142307491 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.22(chr8:134189112-135015642)x3 copy number gain See cases [RCV000138082] Chr8:134189112..135015642 [GRCh38]
Chr8:135201355..136027885 [GRCh37]
Chr8:135270537..136097067 [NCBI36]
Chr8:8q24.22
likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.21-24.23(chr8:126626164-137169427)x1 copy number loss See cases [RCV000054306] Chr8:126626164..137169427 [GRCh38]
Chr8:127638409..138181670 [GRCh37]
Chr8:127707591..138250852 [NCBI36]
Chr8:8q24.21-24.23
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31625 AgrOrtholog
COSMIC MIR30B COSMIC
Ensembl Genes ENSG00000207582 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384850 ENTREZGENE
GTEx ENSG00000207582 GTEx
HGNC ID HGNC:31625 ENTREZGENE
Human Proteome Map MIR30B Human Proteome Map
miRBase MI0000441 ENTREZGENE
NCBI Gene 407030 ENTREZGENE
OMIM 619018 OMIM
PharmGKB PA164722642 PharmGKB
RNAcentral URS00002152A8 RNACentral
  URS00003426E6 RNACentral
  URS00005165DA RNACentral