MIR197 (microRNA 197) - Rat Genome Database

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Gene: MIR197 (microRNA 197) Homo sapiens
Analyze
Symbol: MIR197
Name: microRNA 197
RGD ID: 1348973
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: miR-197; MIRN197; miRNA197
RGD Orthologs
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1109,598,893 - 109,598,967 (+)EnsemblGRCh38hg38GRCh38
GRCh381109,598,893 - 109,598,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371110,141,515 - 110,141,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,943,037 - 109,943,111 (+)NCBINCBI36hg18NCBI36
Celera1108,410,814 - 108,410,888 (+)NCBI
Cytogenetic Map1p13.3NCBI
HuRef1108,034,026 - 108,034,100 (+)NCBIHuRef
CHM1_11110,256,436 - 110,256,510 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12554859   PMID:16381832   PMID:17604727   PMID:17616659   PMID:20167074   PMID:20889907   PMID:21037258   PMID:21435175   PMID:22351693   PMID:23139153   PMID:23710316   PMID:24123340  
PMID:24613834   PMID:25117314   PMID:25208211   PMID:25451482   PMID:25724519   PMID:25833695   PMID:25867273   PMID:25960207   PMID:25990270   PMID:26055341   PMID:26081814   PMID:26151540  
PMID:26199015   PMID:26311392   PMID:26352910   PMID:26581983   PMID:26646931   PMID:26720041   PMID:27035789   PMID:27223680   PMID:27320730   PMID:27631965   PMID:27716620   PMID:28259992  
PMID:29115517   PMID:29137688   PMID:29286108   PMID:29666324   PMID:29890998   PMID:30060954   PMID:30098551   PMID:30106114   PMID:30336044   PMID:30366080   PMID:30394668   PMID:30453289  
PMID:30548670   PMID:30836355   PMID:30841025   PMID:31001891   PMID:31081718   PMID:31127025   PMID:31694481   PMID:31797655   PMID:31864304   PMID:31926946   PMID:32027089   PMID:32081771  
PMID:32210729   PMID:32592202   PMID:32740683   PMID:32880393   PMID:32920929   PMID:32945345   PMID:33090399   PMID:33215222   PMID:33436947   PMID:34118139   PMID:34576006  


Genomics

Comparative Map Data
MIR197
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1109,598,893 - 109,598,967 (+)EnsemblGRCh38hg38GRCh38
GRCh381109,598,893 - 109,598,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371110,141,515 - 110,141,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,943,037 - 109,943,111 (+)NCBINCBI36hg18NCBI36
Celera1108,410,814 - 108,410,888 (+)NCBI
Cytogenetic Map1p13.3NCBI
HuRef1108,034,026 - 108,034,100 (+)NCBIHuRef
CHM1_11110,256,436 - 110,256,510 (+)NCBICHM1_1
MIR197
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,271,719 - 42,271,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,271,708 - 42,271,797 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha645,046,957 - 45,047,017 (-)NCBI
ROS_Cfam_1.0642,602,914 - 42,602,974 (-)NCBI
UMICH_Zoey_3.1642,335,531 - 42,335,591 (-)NCBI
UNSW_CanFamBas_1.0642,293,568 - 42,293,628 (-)NCBI
UU_Cfam_GSD_1.0642,728,751 - 42,728,811 (-)NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
TSPAN3hsa-miR-197-3pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)16822819
TSPAN3hsa-miR-197-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
PIPOXhsa-miR-197-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16822819
TUSC2hsa-miR-197-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19671678
NSUN5hsa-miR-197-3pMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//LucifFunctional MTI23139153
TUSC2hsa-miR-197-3pMirecordsexternal_infoNANA19671678
CXCL12hsa-miR-197-3pOncomiRDBexternal_infoNANA21343399
TUSC2hsa-miR-197-3pOncomiRDBexternal_infoNANA19671678

Predicted Targets
Summary Value
Count of predictions:47346
Count of gene targets:15218
Count of transcripts:33341
Interacting mature miRNAs:hsa-miR-197-3p, hsa-miR-197-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1109,598,893 - 109,598,967 (+)Ensembl
RefSeq Acc Id: NR_029583
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381109,598,893 - 109,598,967 (+)NCBI
GRCh371110,141,515 - 110,141,589 (+)RGD
Celera1108,410,814 - 108,410,888 (+)RGD
HuRef1108,034,026 - 108,034,100 (+)RGD
CHM1_11110,256,436 - 110,256,510 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p21.3-13.3(chr1:97410602-110670510)x1 copy number loss See cases [RCV000053877] Chr1:97410602..110670510 [GRCh38]
Chr1:97876158..111213132 [GRCh37]
Chr1:97648746..111014655 [NCBI36]
Chr1:1p21.3-13.3
pathogenic
GRCh38/hg38 1p21.2-13.2(chr1:101618097-111703028)x1 copy number loss See cases [RCV000053879] Chr1:101618097..111703028 [GRCh38]
Chr1:102083653..112245650 [GRCh37]
Chr1:101856241..112047173 [NCBI36]
Chr1:1p21.2-13.2
pathogenic
GRCh38/hg38 1p21.1-13.3(chr1:106074587-110144290)x1 copy number loss See cases [RCV000053881] Chr1:106074587..110144290 [GRCh38]
Chr1:106617209..110686912 [GRCh37]
Chr1:106418732..110488435 [NCBI36]
Chr1:1p21.1-13.3
pathogenic
GRCh38/hg38 1p13.3(chr1:108970247-109794222)x3 copy number gain See cases [RCV000138606] Chr1:108970247..109794222 [GRCh38]
Chr1:109512869..110336844 [GRCh37]
Chr1:109314392..110138367 [NCBI36]
Chr1:1p13.3
uncertain significance
GRCh38/hg38 1p21.1-12(chr1:104325484-119977655)x3 copy number gain See cases [RCV000142953] Chr1:104325484..119977655 [GRCh38]
Chr1:104868106..120471049 [GRCh37]
Chr1:104669629..120321801 [NCBI36]
Chr1:1p21.1-12
pathogenic
GRCh38/hg38 1p21.1-13.2(chr1:105468292-112190626)x1 copy number loss See cases [RCV000142760] Chr1:105468292..112190626 [GRCh38]
Chr1:106010914..112733248 [GRCh37]
Chr1:105812437..112534771 [NCBI36]
Chr1:1p21.1-13.2
pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p22.1-11.2(chr1:93837992-121343783)x3 copy number gain See cases [RCV000512354] Chr1:93837992..121343783 [GRCh37]
Chr1:1p22.1-11.2
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NC_000001.11:g.(?_103175204)_(111410059_?)del deletion Autistic disorder of childhood onset [RCV000754122] Chr1:103175204..111410059 [GRCh38]
Chr1:1p21.1-13.2
likely pathogenic
GRCh37/hg19 1p22.1-13.3(chr1:94054724-111671707)x3 copy number gain not provided [RCV000749068] Chr1:94054724..111671707 [GRCh37]
Chr1:1p22.1-13.3
pathogenic
Single allele deletion 1p13.3 deletion syndrome [RCV000786772] Chr1:107779092..111199205 [GRCh37]
Chr1:1p13.3
likely pathogenic
Single allele deletion not provided [RCV000844956] Chr1:108926313..111266497 [GRCh37]
Chr1:1p13.3
not provided
GRCh37/hg19 1p21.2-12(chr1:102021465-119737478) copy number loss Seizures [RCV001352640] Chr1:102021465..119737478 [GRCh37]
Chr1:1p21.2-12
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR197 COSMIC
Ensembl Genes ENSG00000284443 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384976 ENTREZGENE
GTEx ENSG00000284443 GTEx
HGNC ID HGNC:31569 ENTREZGENE
Human Proteome Map MIR197 Human Proteome Map
miRBase MI0000239 ENTREZGENE
NCBI Gene 406974 ENTREZGENE
OMIM 611189 OMIM
PharmGKB PA164722559 PharmGKB
RNAcentral URS00000F4AC3 RNACentral
  URS000020E2DD RNACentral
  URS000061E740 RNACentral