ETV3 (ETS variant transcription factor 3) - Rat Genome Database

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Gene: ETV3 (ETS variant transcription factor 3) Homo sapiens
Analyze
Symbol: ETV3
Name: ETS variant transcription factor 3
RGD ID: 1348851
HGNC Page HGNC:3492
Description: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bA110J1.4; ETS domain transcriptional repressor PE1; ETS translocation variant 3; ETS variant 3; ets variant gene 3, ETS family transcriptional repressor; FLJ79173; METS; mitogenic Ets transcriptional suppressor; PE-1; PE1
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,121,191 - 157,138,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,121,191 - 157,138,474 (-)EnsemblGRCh38hg38GRCh38
GRCh371157,090,983 - 157,108,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,369,600 - 155,374,801 (-)NCBINCBI36Build 36hg18NCBI36
Build 341153,916,050 - 153,921,250NCBI
Celera1130,165,650 - 130,179,574 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,452,734 - 128,466,660 (-)NCBIHuRef
CHM1_11158,490,846 - 158,504,773 (-)NCBICHM1_1
T2T-CHM13v2.01156,258,040 - 156,275,241 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8020980   PMID:8889548   PMID:12007404   PMID:12477932   PMID:14754893   PMID:15489334   PMID:16710414   PMID:17525531   PMID:18025162   PMID:18029348   PMID:18951430   PMID:18976975  
PMID:19274049   PMID:21150319   PMID:21244100   PMID:21832049   PMID:21873635   PMID:23329352   PMID:23455924   PMID:23667531   PMID:24999758   PMID:26186194   PMID:26673895   PMID:28027390  
PMID:28473536   PMID:28514442   PMID:29507755   PMID:29877893   PMID:31980649   PMID:33640491   PMID:33961781   PMID:34299191   PMID:35140242   PMID:35198878   PMID:35819319   PMID:36543959  


Genomics

Comparative Map Data
ETV3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,121,191 - 157,138,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,121,191 - 157,138,474 (-)EnsemblGRCh38hg38GRCh38
GRCh371157,090,983 - 157,108,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,369,600 - 155,374,801 (-)NCBINCBI36Build 36hg18NCBI36
Build 341153,916,050 - 153,921,250NCBI
Celera1130,165,650 - 130,179,574 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,452,734 - 128,466,660 (-)NCBIHuRef
CHM1_11158,490,846 - 158,504,773 (-)NCBICHM1_1
T2T-CHM13v2.01156,258,040 - 156,275,241 (-)NCBIT2T-CHM13v2.0
Etv3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,432,891 - 87,447,463 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,432,714 - 87,447,463 (+)EnsemblGRCm39 Ensembl
GRCm38387,525,577 - 87,540,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,525,407 - 87,540,156 (+)EnsemblGRCm38mm10GRCm38
MGSCv37387,329,500 - 87,344,078 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36387,611,525 - 87,625,522 (+)NCBIMGSCv36mm8
Celera387,558,676 - 87,573,235 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.19NCBI
Etv3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,263,389 - 175,278,217 (+)NCBIGRCr8
mRatBN7.22172,965,461 - 172,980,320 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2172,965,588 - 172,980,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,117,095 - 180,125,163 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,139,427 - 178,147,495 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,728,805 - 172,736,874 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02186,872,483 - 186,887,294 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2186,872,520 - 186,886,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,277,234 - 206,292,038 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42179,567,146 - 179,576,683 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12179,433,675 - 179,526,745 (+)NCBI
Celera2166,918,803 - 166,928,341 (+)NCBICelera
Cytogenetic Map2q34NCBI
LOC100993377
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2192,705,168 - 92,719,644 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,440,889 - 92,457,965 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,464,426 - 132,481,638 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,285,256 - 136,302,330 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,285,256 - 136,302,330 (-)Ensemblpanpan1.1panPan2
ETV3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1740,954,104 - 40,968,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl740,956,024 - 40,966,190 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,441,349 - 40,455,757 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0740,816,553 - 40,830,929 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl740,816,578 - 40,831,146 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,598,866 - 40,613,241 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,651,779 - 40,666,153 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0740,935,103 - 40,949,482 (+)NCBIUU_Cfam_GSD_1.0
Etv3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,204,235 - 27,219,001 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365806,237,701 - 6,247,231 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365806,234,038 - 6,249,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETV3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl492,964,941 - 92,979,122 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1492,964,808 - 92,979,129 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,424,237 - 101,436,974 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ETV3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1206,736,208 - 6,753,576 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl206,736,327 - 6,753,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,011,401 - 6,028,761 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Etv3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,217,433 - 2,232,305 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,218,766 - 2,232,395 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ETV3
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.1-23.3(chr1:156664483-160727411)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|See cases [RCV000051851] Chr1:156664483..160727411 [GRCh38]
Chr1:156634275..160697201 [GRCh37]
Chr1:154900899..158963825 [NCBI36]
Chr1:1q23.1-23.3		 pathogenic
GRCh38/hg38 1q21.3-23.1(chr1:154566501-157624084)x3 copy number gain See cases [RCV000139902] Chr1:154566501..157624084 [GRCh38]
Chr1:154538977..157593874 [GRCh37]
Chr1:152805601..155860498 [NCBI36]
Chr1:1q21.3-23.1		 pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
NM_001145312.3(ETV3):c.658A>T (p.Ile220Phe) single nucleotide variant Inborn genetic diseases [RCV003244643] Chr1:157125722 [GRCh38]
Chr1:157095514 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_001145312.3(ETV3):c.962G>A (p.Arg321His) single nucleotide variant Inborn genetic diseases [RCV003291221] Chr1:157125418 [GRCh38]
Chr1:157095210 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q22-23.1(chr1:155636337-158024499)x1 copy number loss not provided [RCV000684658] Chr1:155636337..158024499 [GRCh37]
Chr1:1q22-23.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NM_001145312.3(ETV3):c.619G>C (p.Asp207His) single nucleotide variant Inborn genetic diseases [RCV003261014] Chr1:157125761 [GRCh38]
Chr1:157095553 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.437C>T (p.Ala146Val) single nucleotide variant Inborn genetic diseases [RCV002905642] Chr1:157125943 [GRCh38]
Chr1:157095735 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.745G>T (p.Val249Phe) single nucleotide variant Inborn genetic diseases [RCV002776642] Chr1:157125635 [GRCh38]
Chr1:157095427 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.502C>T (p.Arg168Trp) single nucleotide variant Inborn genetic diseases [RCV002849046] Chr1:157125878 [GRCh38]
Chr1:157095670 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.717G>A (p.Met239Ile) single nucleotide variant Inborn genetic diseases [RCV002977327] Chr1:157125663 [GRCh38]
Chr1:157095455 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.1232C>G (p.Pro411Arg) single nucleotide variant Inborn genetic diseases [RCV002761966] Chr1:157125148 [GRCh38]
Chr1:157094940 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.232C>T (p.Arg78Cys) single nucleotide variant Inborn genetic diseases [RCV002980251] Chr1:157135523 [GRCh38]
Chr1:157105315 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.815C>T (p.Thr272Ile) single nucleotide variant Inborn genetic diseases [RCV002661772] Chr1:157125565 [GRCh38]
Chr1:157095357 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.659T>C (p.Ile220Thr) single nucleotide variant Inborn genetic diseases [RCV002982004] Chr1:157125721 [GRCh38]
Chr1:157095513 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.1177C>T (p.Leu393Phe) single nucleotide variant Inborn genetic diseases [RCV002745078] Chr1:157125203 [GRCh38]
Chr1:157094995 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.860G>A (p.Ser287Asn) single nucleotide variant Inborn genetic diseases [RCV002874503] Chr1:157125520 [GRCh38]
Chr1:157095312 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.817A>G (p.Ile273Val) single nucleotide variant Inborn genetic diseases [RCV002853666] Chr1:157125563 [GRCh38]
Chr1:157095355 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.607C>T (p.Arg203Cys) single nucleotide variant Inborn genetic diseases [RCV003008783] Chr1:157125773 [GRCh38]
Chr1:157095565 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.1439G>T (p.Trp480Leu) single nucleotide variant Inborn genetic diseases [RCV002940132] Chr1:157124941 [GRCh38]
Chr1:157094733 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.635G>A (p.Arg212Lys) single nucleotide variant Inborn genetic diseases [RCV003174044] Chr1:157125745 [GRCh38]
Chr1:157095537 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.82T>G (p.Ser28Ala) single nucleotide variant Inborn genetic diseases [RCV003174164] Chr1:157135673 [GRCh38]
Chr1:157105465 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_001145312.3(ETV3):c.764G>A (p.Arg255His) single nucleotide variant Inborn genetic diseases [RCV003208334] Chr1:157125616 [GRCh38]
Chr1:157095408 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q12-23.1(chr1:142535935-157648813)x3 copy number gain Chromosome 1q21.1 duplication syndrome [RCV003329522] Chr1:142535935..157648813 [GRCh37]
Chr1:1q12-23.1		 pathogenic
NM_001145312.3(ETV3):c.1178T>C (p.Leu393Pro) single nucleotide variant Inborn genetic diseases [RCV003370177] Chr1:157125202 [GRCh38]
Chr1:157094994 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q23.1(chr1:156996766-157144209)x1 copy number loss not provided [RCV003483922] Chr1:156996766..157144209 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q21.1-23.1(chr1:144368497-158992086)x3 copy number gain not specified [RCV003986717] Chr1:144368497..158992086 [GRCh37]
Chr1:1q21.1-23.1		 pathogenic
GRCh37/hg19 1q21.1-23.1(chr1:146577511-157155587)x3 copy number gain not specified [RCV003987261] Chr1:146577511..157155587 [GRCh37]
Chr1:1q21.1-23.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1758
Count of miRNA genes:964
Interacting mature miRNAs:1160
Transcripts:ENST00000326786, ENST00000368192, ENST00000460850
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S2332E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,095,587 - 157,095,661UniSTSGRCh37
Build 361155,362,211 - 155,362,285RGDNCBI36
Celera1130,166,778 - 130,166,852RGD
Cytogenetic Map1q21-q23UniSTS
HuRef1128,453,862 - 128,453,936UniSTS
ETV3_3364.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,102,934 - 157,103,716UniSTSGRCh37
Build 361155,369,558 - 155,370,340RGDNCBI36
Celera1130,174,125 - 130,174,907RGD
HuRef1128,461,209 - 128,461,991UniSTS
D1S3438  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37725,162,548 - 25,162,897UniSTSGRCh37
GRCh371157,098,881 - 157,099,242UniSTSGRCh37
Build 361155,365,505 - 155,365,866RGDNCBI36
Celera725,151,200 - 25,151,549UniSTS
Celera1130,170,072 - 130,170,433RGD
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map1q21-q23UniSTS
HuRef725,049,107 - 25,049,456UniSTS
CRA_TCAGchr7v2725,213,789 - 25,214,138UniSTS
GeneMap99-G3 RH Map7886.0UniSTS
RH17623  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,095,482 - 157,095,694UniSTSGRCh37
Build 361155,362,106 - 155,362,318RGDNCBI36
Celera1130,166,673 - 130,166,885RGD
Cytogenetic Map1q21-q23UniSTS
HuRef1128,453,757 - 128,453,969UniSTS
GeneMap99-GB4 RH Map1567.23UniSTS
NCBI RH Map11408.6UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 511 527 312 101 711 62 2341 143 418 155 957 947 53 617 1123 2
Low 1928 2449 1414 523 1226 403 2016 2053 3316 263 503 666 122 1 587 1665 4 2
Below cutoff 15 14 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000326786   ⟹   ENSP00000327316
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,133,145 - 157,138,474 (-)Ensembl
RefSeq Acc Id: ENST00000368192   ⟹   ENSP00000357175
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,121,191 - 157,138,395 (-)Ensembl
RefSeq Acc Id: ENST00000460850
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,135,092 - 157,138,335 (-)Ensembl
RefSeq Acc Id: NM_001145312   ⟹   NP_001138784
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,121,191 - 157,138,395 (-)NCBI
GRCh371157,094,459 - 157,108,383 (-)RGD
Celera1130,165,650 - 130,179,574 (-)RGD
HuRef1128,452,734 - 128,466,660 (-)ENTREZGENE
CHM1_11158,490,846 - 158,504,773 (-)NCBI
T2T-CHM13v2.01156,258,040 - 156,275,241 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005240   ⟹   NP_005231
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,133,145 - 157,138,395 (-)NCBI
GRCh371157,094,459 - 157,108,383 (-)RGD
Build 361155,369,600 - 155,374,801 (-)NCBI Archive
Celera1130,165,650 - 130,179,574 (-)RGD
HuRef1128,452,734 - 128,466,660 (-)ENTREZGENE
CHM1_11158,499,362 - 158,504,567 (-)NCBI
T2T-CHM13v2.01156,269,991 - 156,275,241 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006711210   ⟹   XP_006711273
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,121,191 - 157,138,395 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054335093   ⟹   XP_054191068
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01156,258,040 - 156,275,241 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001138784   ⟸   NM_001145312
- Peptide Label: isoform 1
- UniProtKB: Q8TAC8 (UniProtKB/Swiss-Prot),   B4E3M7 (UniProtKB/Swiss-Prot),   Q9BX30 (UniProtKB/Swiss-Prot),   P41162 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_005231   ⟸   NM_005240
- Peptide Label: isoform 2
- UniProtKB: P41162 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006711273   ⟸   XM_006711210
- Peptide Label: isoform X1
- UniProtKB: Q8TAC8 (UniProtKB/Swiss-Prot),   B4E3M7 (UniProtKB/Swiss-Prot),   Q9BX30 (UniProtKB/Swiss-Prot),   P41162 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000327316   ⟸   ENST00000326786
RefSeq Acc Id: ENSP00000357175   ⟸   ENST00000368192
RefSeq Acc Id: XP_054191068   ⟸   XM_054335093
- Peptide Label: isoform X1
- UniProtKB: Q8TAC8 (UniProtKB/Swiss-Prot),   P41162 (UniProtKB/Swiss-Prot),   B4E3M7 (UniProtKB/Swiss-Prot),   Q9BX30 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41162-F1-model_v2 AlphaFold P41162 1-512 view protein structure

Promoters
RGD ID:6785523
Promoter ID:HG_KWN:5599
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000082842,   OTTHUMT00000082843,   OTTHUMT00000099020
Position:
Human AssemblyChrPosition (strand)Source
Build 361155,374,811 - 155,375,367 (-)MPROMDB
RGD ID:6857652
Promoter ID:EPDNEW_H1991
Type:initiation region
Name:ETV3_1
Description:ETS variant 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,138,395 - 157,138,455EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3492 AgrOrtholog
COSMIC ETV3 COSMIC
Ensembl Genes ENSG00000117036 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000326786 ENTREZGENE
  ENST00000326786.4 UniProtKB/Swiss-Prot
  ENST00000368192 ENTREZGENE
  ENST00000368192.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
GTEx ENSG00000117036 GTEx
HGNC ID HGNC:3492 ENTREZGENE
Human Proteome Map ETV3 Human Proteome Map
InterPro Ets_dom UniProtKB/Swiss-Prot
  ETS_fam UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2117 UniProtKB/Swiss-Prot
NCBI Gene 2117 ENTREZGENE
OMIM 164873 OMIM
PANTHER ETS TRANSLOCATION VARIANT 3 UniProtKB/Swiss-Prot
  PTHR11849 UniProtKB/Swiss-Prot
Pfam Ets UniProtKB/Swiss-Prot
PharmGKB PA27906 PharmGKB
PRINTS ETSDOMAIN UniProtKB/Swiss-Prot
PROSITE ETS_DOMAIN_1 UniProtKB/Swiss-Prot
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot
SMART ETS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt B4E3M7 ENTREZGENE
  ETV3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8TAC8 ENTREZGENE
  Q9BX30 ENTREZGENE
UniProt Secondary B4E3M7 UniProtKB/Swiss-Prot
  Q8TAC8 UniProtKB/Swiss-Prot
  Q9BX30 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-12 ETV3  ETS variant transcription factor 3  ETV3  ETS variant 3  Symbol and/or name change 5135510 APPROVED
2016-02-29 ETV3  ETS variant 3    ets variant 3  Symbol and/or name change 5135510 APPROVED