NR4A3 (nuclear receptor subfamily 4 group A member 3) - Rat Genome Database

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Gene: NR4A3 (nuclear receptor subfamily 4 group A member 3) Homo sapiens
Analyze
Symbol: NR4A3
Name: nuclear receptor subfamily 4 group A member 3
RGD ID: 1348747
HGNC Page HGNC
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and protein kinase binding activity. Involved in several processes, including positive regulation of monocyte aggregation; positive regulation of vascular associated smooth muscle cell migration; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be part of chromatin and transcription regulator complex. Predicted to be active in nucleus. Implicated in extraskeletal myxoid chondrosarcoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CHN; chondrosarcoma, extraskeletal myxoid, fused to EWS; CSMF; MINOR; mitogen induced nuclear orphan receptor; mitogen-induced nuclear orphan receptor; neuron derived orphan receptor; neuron-derived orphan receptor 1; NOR1; nuclear hormone receptor NOR-1; nuclear receptor subfamily 4, group A, member 3; TEC; translocated in extraskeletal chondrosarcoma
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl999,821,855 - 99,866,891 (+)EnsemblGRCh38hg38GRCh38
GRCh38999,821,885 - 99,866,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379102,584,167 - 102,629,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,623,958 - 101,668,994 (+)NCBINCBI36hg18NCBI36
Build 34999,668,563 - 99,708,728NCBI
Celera973,097,532 - 73,142,572 (+)NCBI
Cytogenetic Map9q31.1NCBI
HuRef972,183,339 - 72,228,487 (+)NCBIHuRef
CHM1_19102,730,616 - 102,775,645 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(R)-mevalonic acid  (EXP)
1,2,4-trimethylbenzene  (ISO)
15-acetyldeoxynivalenol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
astemizole  (ISO)
atrazine  (EXP)
azathioprine  (EXP)
bathocuproine disulfonic acid  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
Calcimycin  (ISO)
cannabidiol  (ISO)
carbonyl sulfide  (ISO)
chlordecone  (ISO)
cisplatin  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dieldrin  (EXP)
dipentyl phthalate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
gemcitabine  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
graphite  (ISO)
haloperidol  (ISO)
hydrogen cyanide  (ISO)
ionomycin  (EXP)
kainic acid  (ISO)
ketamine  (ISO)
L-ascorbic acid  (EXP)
leflunomide  (EXP)
LY294002  (EXP)
melphalan  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
milrinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalenes  (ISO)
nickel atom  (EXP)
ozone  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenformin  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium chromate  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
raloxifene  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP)
sodium aurothiomalate  (EXP)
Soman  (ISO)
styrene  (ISO)
sulforaphane  (EXP)
tamoxifen  (EXP)
titanium dioxide  (ISO)
torcetrapib  (EXP)
Tributyltin oxide  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
Y-27632  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
animal organ regeneration  (IEA,ISO)
axon guidance  (ISO)
cellular respiration  (ISS)
cellular response to catecholamine stimulus  (ISS)
cellular response to corticotropin-releasing hormone stimulus  (IBA,ISS)
cellular response to leptin stimulus  (ISS)
common myeloid progenitor cell proliferation  (ISS)
energy homeostasis  (ISS)
fat cell differentiation  (ISS)
gastrulation  (ISS)
hippocampus development  (ISO)
inner ear morphogenesis  (ISO)
intracellular receptor signaling pathway  (IEA)
mast cell degranulation  (ISS)
mesoderm formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of hydrogen peroxide-induced neuron death  (ISS)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of transcription by RNA polymerase II  (ISS)
neuromuscular process controlling balance  (ISO)
platelet-derived growth factor receptor signaling pathway  (IDA)
positive regulation of cardiac muscle hypertrophy  (ISS)
positive regulation of cell cycle  (ISO)
positive regulation of epithelial cell proliferation  (ISS)
positive regulation of fatty acid oxidation  (ISS)
positive regulation of feeding behavior  (ISS)
positive regulation of glucose transmembrane transport  (IDA)
positive regulation of leukocyte apoptotic process  (ISO)
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway  (ISS)
positive regulation of mast cell cytokine production  (ISS)
positive regulation of monocyte aggregation  (IMP)
positive regulation of smooth muscle cell proliferation  (ISS)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IGI)
positive regulation of vascular associated smooth muscle cell proliferation  (IGI)
pyruvate oxidation  (ISS)
regulation of smooth muscle cell proliferation  (IDA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of type B pancreatic cell proliferation  (ISS)
response to hydrogen peroxide  (ISO)
response to peptide hormone  (ISO)
semicircular canal morphogenesis  (ISO)
steroid hormone mediated signaling pathway  (IEA)
vestibular reflex  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:7811288   PMID:8570200   PMID:8614405   PMID:8634690   PMID:8809112   PMID:9573341   PMID:10359536   PMID:10602519   PMID:11156374   PMID:11173923   PMID:12049818   PMID:12543801  
PMID:14525795   PMID:14962944   PMID:15164053   PMID:15262426   PMID:15523651   PMID:15604093   PMID:15949808   PMID:15964844   PMID:16223362   PMID:16873729   PMID:16945922   PMID:17515897  
PMID:17596136   PMID:17981763   PMID:18325999   PMID:19274049   PMID:19321449   PMID:19336002   PMID:19682370   PMID:19720740   PMID:19727524   PMID:19775727   PMID:20411565   PMID:20558821  
PMID:20659174   PMID:20668010   PMID:21621845   PMID:21725049   PMID:21752397   PMID:21873635   PMID:21873782   PMID:22143616   PMID:22569967   PMID:22581839   PMID:22789442   PMID:23064961  
PMID:23247046   PMID:23390133   PMID:23462179   PMID:23554459   PMID:23588370   PMID:24005216   PMID:24022864   PMID:24626568   PMID:24630523   PMID:24657653   PMID:24788728   PMID:24806827  
PMID:25089663   PMID:25118646   PMID:25199433   PMID:25410408   PMID:25449536   PMID:25536180   PMID:25809189   PMID:25844690   PMID:25852083   PMID:25917081   PMID:25941992   PMID:26096603  
PMID:26600038   PMID:26634653   PMID:27159982   PMID:27166283   PMID:27181368   PMID:27528092   PMID:27697661   PMID:27891591   PMID:28232113   PMID:28249774   PMID:28249906   PMID:28637666  
PMID:28666984   PMID:28791396   PMID:28808448   PMID:29180619   PMID:29377304   PMID:29507755   PMID:29695901   PMID:30076719   PMID:30096407   PMID:30227111   PMID:30455429   PMID:30664630  
PMID:30696767   PMID:31020999   PMID:31094928   PMID:31182584   PMID:31183633   PMID:31209222   PMID:31701670   PMID:31936632   PMID:31985010   PMID:32125766   PMID:32241159   PMID:32296183  
PMID:32323598   PMID:32341238   PMID:32393512   PMID:32809265   PMID:33163142   PMID:33221345   PMID:33241311   PMID:34248958   PMID:34383980  


Genomics

Comparative Map Data
NR4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl999,821,855 - 99,866,891 (+)EnsemblGRCh38hg38GRCh38
GRCh38999,821,885 - 99,866,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379102,584,167 - 102,629,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,623,958 - 101,668,994 (+)NCBINCBI36hg18NCBI36
Build 34999,668,563 - 99,708,728NCBI
Celera973,097,532 - 73,142,572 (+)NCBI
Cytogenetic Map9q31.1NCBI
HuRef972,183,339 - 72,228,487 (+)NCBIHuRef
CHM1_19102,730,616 - 102,775,645 (+)NCBICHM1_1
Nr4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,045,098 - 48,086,446 (+)NCBIGRCm39mm39
GRCm39 Ensembl448,045,153 - 48,086,447 (+)Ensembl
GRCm38448,045,078 - 48,086,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37448,064,120 - 48,096,224 (+)NCBIGRCm37mm9NCBIm37
MGSCv36448,072,348 - 48,104,452 (+)NCBImm8
Celera448,073,263 - 48,105,416 (+)NCBICelera
Cytogenetic Map4B1NCBI
Nr4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)Ensembl
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Celera565,193,786 - 65,233,628 (-)NCBICelera
Cytogenetic Map5q22NCBI
Nr4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541925,779,178 - 25,818,706 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541925,779,368 - 25,817,445 (-)NCBIChiLan1.0ChiLan1.0
NR4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1999,028,151 - 99,049,949 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0970,907,056 - 70,950,221 (+)NCBIMhudiblu_PPA_v0panPan3
NR4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,806,506 - 56,846,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,812,804 - 56,847,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1155,238,295 - 55,278,535 (+)NCBI
ROS_Cfam_1.01157,915,798 - 57,956,020 (+)NCBI
UMICH_Zoey_3.11156,420,068 - 56,460,272 (+)NCBI
UNSW_CanFamBas_1.01156,444,924 - 56,485,181 (+)NCBI
UU_Cfam_GSD_1.01157,144,349 - 57,184,553 (+)NCBI
Nr4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,704,489 - 171,743,204 (+)NCBI
SpeTri2.0NW_0049365248,252,321 - 8,290,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1241,569,905 - 241,611,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11241,569,867 - 241,611,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,813,286 - 269,852,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11239,568,085 - 39,611,704 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1239,567,852 - 39,606,837 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660352,937,605 - 2,981,244 (+)NCBIVero_WHO_p1.0
Nr4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248251,098,915 - 1,141,373 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH78307  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379102,628,921 - 102,629,084UniSTSGRCh37
Build 369101,668,742 - 101,668,905RGDNCBI36
Celera973,142,320 - 73,142,483RGD
Cytogenetic Map9q22UniSTS
HuRef972,228,235 - 72,228,398UniSTS
GeneMap99-GB4 RH Map9325.85UniSTS
NCBI RH Map9858.6UniSTS
STS-X89894  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379102,596,000 - 102,596,190UniSTSGRCh37
Build 369101,635,821 - 101,636,011RGDNCBI36
Celera973,109,395 - 73,109,585RGD
Cytogenetic Map9q22UniSTS
HuRef972,195,320 - 72,195,510UniSTS
GeneMap99-GB4 RH Map9323.13UniSTS
RH93279  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379102,594,302 - 102,594,383UniSTSGRCh37
Build 369101,634,123 - 101,634,204RGDNCBI36
Celera973,107,697 - 73,107,778RGD
Cytogenetic Map9q22UniSTS
HuRef972,193,622 - 72,193,703UniSTS
GeneMap99-GB4 RH Map9323.13UniSTS
PMC133552P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379102,590,708 - 102,591,137UniSTSGRCh37
Build 369101,630,529 - 101,630,958RGDNCBI36
Celera973,104,103 - 73,104,532RGD
Cytogenetic Map9q22UniSTS
HuRef972,190,028 - 72,190,457UniSTS
NR4A3_2160  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379102,626,639 - 102,627,465UniSTSGRCh37
Build 369101,666,460 - 101,667,286RGDNCBI36
Celera973,140,035 - 73,140,864RGD
HuRef972,225,950 - 72,226,779UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR10Bhsa-miR-10b-5pMirtarbaseexternal_infoReporter assayNon-Functional MTI21642433
MIR10Bhsa-miR-10b-5pTarbaseexternal_infoReporter GeneNEGATIVE

Predicted Target Of
Summary Value
Count of predictions:1943
Count of miRNA genes:805
Interacting mature miRNAs:998
Transcripts:ENST00000330847, ENST00000338488, ENST00000395097
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 586 1310 503 30 92 24 1561 766 514 66 339 568 7 616 1307
Low 1595 1195 1043 395 1173 271 2524 1339 2822 266 1034 952 132 1 583 1426 4 1
Below cutoff 240 475 178 197 650 168 257 91 397 82 81 89 35 5 55 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK226108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL358937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D78579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000330847   ⟹   ENSP00000333122
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,826,727 - 99,866,891 (+)Ensembl
RefSeq Acc Id: ENST00000338488   ⟹   ENSP00000340301
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,821,855 - 99,834,059 (+)Ensembl
RefSeq Acc Id: ENST00000395097   ⟹   ENSP00000378531
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,821,885 - 99,866,891 (+)Ensembl
RefSeq Acc Id: ENST00000618101   ⟹   ENSP00000482027
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,821,855 - 99,866,891 (+)Ensembl
RefSeq Acc Id: NM_006981   ⟹   NP_008912
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38999,821,885 - 99,866,891 (+)NCBI
GRCh379102,584,137 - 102,629,173 (+)ENTREZGENE
GRCh379102,584,137 - 102,629,173 (+)NCBI
Build 369101,623,958 - 101,668,994 (+)NCBI Archive
HuRef972,183,339 - 72,228,487 (+)ENTREZGENE
CHM1_19102,730,616 - 102,775,645 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173199   ⟹   NP_775291
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38999,821,885 - 99,834,301 (+)NCBI
GRCh379102,584,137 - 102,629,173 (+)ENTREZGENE
Build 369101,623,958 - 101,636,162 (+)NCBI Archive
HuRef972,183,339 - 72,228,487 (+)ENTREZGENE
CHM1_19102,730,616 - 102,742,821 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173200   ⟹   NP_775292
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38999,821,885 - 99,866,891 (+)NCBI
GRCh379102,584,137 - 102,629,173 (+)NCBI
Build 369101,628,830 - 101,668,994 (+)NCBI Archive
HuRef972,183,339 - 72,228,487 (+)ENTREZGENE
CHM1_19102,730,616 - 102,775,645 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017015162   ⟹   XP_016870651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38999,826,808 - 99,866,893 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_775292   ⟸   NM_173200
- Peptide Label: isoform b
- UniProtKB: Q92570 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_008912   ⟸   NM_006981
- Peptide Label: isoform a
- UniProtKB: Q92570 (UniProtKB/Swiss-Prot),   A0A024R168 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_775291   ⟸   NM_173199
- Peptide Label: isoform c
- UniProtKB: Q92570 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016870651   ⟸   XM_017015162
- Peptide Label: isoform X1
- UniProtKB: Q92570 (UniProtKB/Swiss-Prot),   A0A024R168 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000333122   ⟸   ENST00000330847
RefSeq Acc Id: ENSP00000340301   ⟸   ENST00000338488
RefSeq Acc Id: ENSP00000482027   ⟸   ENST00000618101
RefSeq Acc Id: ENSP00000378531   ⟸   ENST00000395097
Protein Domains
NR LBD   Nuclear receptor   Rho-GAP

Promoters
RGD ID:7215659
Promoter ID:EPDNEW_H13576
Type:initiation region
Name:NR4A3_3
Description:nuclear receptor subfamily 4 group A member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13577  EPDNEW_H13578  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38999,821,580 - 99,821,640EPDNEW
RGD ID:7215661
Promoter ID:EPDNEW_H13577
Type:initiation region
Name:NR4A3_1
Description:nuclear receptor subfamily 4 group A member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13576  EPDNEW_H13578  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38999,821,885 - 99,821,945EPDNEW
RGD ID:7215663
Promoter ID:EPDNEW_H13578
Type:initiation region
Name:NR4A3_2
Description:nuclear receptor subfamily 4 group A member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13576  EPDNEW_H13577  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38999,821,988 - 99,822,048EPDNEW
RGD ID:6807932
Promoter ID:HG_KWN:64320
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000238459,   ENST00000395096,   ENST00000395097,   NM_006981,   NM_173199,   OTTHUMT00000055483,   UC004BAG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369101,623,181 - 101,624,317 (+)MPROMDB
RGD ID:6807933
Promoter ID:HG_KWN:64321
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   Lymphoblastoid
Transcripts:UC004BAH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369101,626,666 - 101,627,166 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000050315] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-31.1(chr9:99465640-100281736)x1 copy number loss See cases [RCV000051063] Chr9:99465640..100281736 [GRCh38]
Chr9:102227922..103044018 [GRCh37]
Chr9:101267743..102083839 [NCBI36]
Chr9:9q22.33-31.1
uncertain significance
GRCh38/hg38 9q22.33-33.1(chr9:99349916-115767475)x1 copy number loss See cases [RCV000052921] Chr9:99349916..115767475 [GRCh38]
Chr9:102112198..118529754 [GRCh37]
Chr9:101152019..117569575 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9q22.33-31.1(chr9:99465640-100394582)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052885]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052885]|See cases [RCV000052885] Chr9:99465640..100394582 [GRCh38]
Chr9:102227922..103156864 [GRCh37]
Chr9:101267743..102196685 [NCBI36]
Chr9:9q22.33-31.1
uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.1-32(chr9:88522292-113687796)x3 copy number gain See cases [RCV000053752] Chr9:88522292..113687796 [GRCh38]
Chr9:91137207..116450076 [GRCh37]
Chr9:90327027..115489897 [NCBI36]
Chr9:9q22.1-32
pathogenic
GRCh38/hg38 9q22.32-31.2(chr9:94184266-106730550)x3 copy number gain See cases [RCV000053774] Chr9:94184266..106730550 [GRCh38]
Chr9:96946548..109492831 [GRCh37]
Chr9:95986369..108532652 [NCBI36]
Chr9:9q22.32-31.2
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.32-31.3(chr9:95061030-108695569)x1 copy number loss See cases [RCV000134375] Chr9:95061030..108695569 [GRCh38]
Chr9:97823312..111457849 [GRCh37]
Chr9:96863133..110497670 [NCBI36]
Chr9:9q22.32-31.3
pathogenic
GRCh38/hg38 9q21.11-31.2(chr9:68420430-106579493)x3 copy number gain See cases [RCV000136788] Chr9:68420430..106579493 [GRCh38]
Chr9:71130848..109341774 [GRCh37]
Chr9:70225166..108381595 [NCBI36]
Chr9:9q21.11-31.2
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-31.3(chr9:99024205-109947890)x1 copy number loss See cases [RCV000138281] Chr9:99024205..109947890 [GRCh38]
Chr9:101786487..112710170 [GRCh37]
Chr9:100826308..111749991 [NCBI36]
Chr9:9q22.33-31.3
pathogenic|likely pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000148264] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NC_000009.11:g.(?_102339410)_(109549354_?)del deletion Schizophrenia [RCV000416788] Chr9:102339410..109549354 [GRCh37]
Chr9:101379231..108589175 [NCBI36]
Chr9:9q22.33-31.2
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q22.32-31.1(chr9:97553176-102919383)x3 copy number gain See cases [RCV000510672] Chr9:97553176..102919383 [GRCh37]
Chr9:9q22.32-31.1
likely pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_006981.4(NR4A3):c.1455-8C>A single nucleotide variant not provided [RCV000940760] Chr9:99847429 [GRCh38]
Chr9:102609711 [GRCh37]
Chr9:9q31.1
likely benign
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic
GRCh37/hg19 9q22.31-31.2(chr9:96126075-108535272)x1 copy number loss See cases [RCV001194520] Chr9:96126075..108535272 [GRCh37]
Chr9:9q22.31-31.2
pathogenic
Single allele deletion Intellectual disability [RCV001293373] Chr9:97834573..107199088 [GRCh37]
Chr9:9q22.32-31.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7982 AgrOrtholog
COSMIC NR4A3 COSMIC
Ensembl Genes ENSG00000119508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000333122 UniProtKB/Swiss-Prot
  ENSP00000340301 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000378531 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000482027 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000330847 UniProtKB/Swiss-Prot
  ENST00000338488 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000395097 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000618101 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000119508 GTEx
HGNC ID HGNC:7982 ENTREZGENE
Human Proteome Map NR4A3 Human Proteome Map
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOR1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_orph_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8013 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8013 ENTREZGENE
OMIM 600542 OMIM
  612237 OMIM
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31763 PharmGKB
PRINTS NORNUCRECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEARECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R168 ENTREZGENE, UniProtKB/TrEMBL
  A0A1D8GZE0_HUMAN UniProtKB/TrEMBL
  NR4A3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2A3I7 UniProtKB/Swiss-Prot
  Q12935 UniProtKB/Swiss-Prot
  Q14979 UniProtKB/Swiss-Prot
  Q16420 UniProtKB/Swiss-Prot
  Q4VXA8 UniProtKB/Swiss-Prot
  Q4VXA9 UniProtKB/Swiss-Prot
  Q9UEK2 UniProtKB/Swiss-Prot
  Q9UEK3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 NR4A3  nuclear receptor subfamily 4 group A member 3    nuclear receptor subfamily 4, group A, member 3  Symbol and/or name change 5135510 APPROVED