CMKLR1 (chemerin chemokine-like receptor 1) - Rat Genome Database

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Gene: CMKLR1 (chemerin chemokine-like receptor 1) Homo sapiens
Analyze
Symbol: CMKLR1
Name: chemerin chemokine-like receptor 1
RGD ID: 1348723
HGNC Page HGNC:2121
Description: Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chemerin receptor; chemerin-like receptor 1; CHEMERINR; chemokine receptor-like 1; chemokine-like receptor 1; ChemR23; DEZ; ERV1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; MGC126105; MGC126106; orphan G-protein coupled receptor, Dez; resolvin E1 receptor; RVER1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,288,046 - 108,339,311 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,288,044 - 108,339,317 (-)EnsemblGRCh38hg38GRCh38
GRCh3712108,681,823 - 108,733,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,209,477 - 107,257,212 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412107,187,813 - 107,235,553NCBI
Celera12108,351,249 - 108,402,507 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12105,746,498 - 105,797,979 (-)NCBIHuRef
CHM1_112108,647,879 - 108,699,141 (-)NCBICHM1_1
T2T-CHM13v2.012108,256,268 - 108,307,509 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA,NAS)
plasma membrane  (IBA,IDA,IEA,TAS)

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8976386   PMID:9144535   PMID:9425281   PMID:9603476   PMID:12477932   PMID:14530373   PMID:14702039   PMID:14759258   PMID:15342556   PMID:15489334   PMID:15753205   PMID:16344560  
PMID:16904155   PMID:17339491   PMID:17558413   PMID:18564921   PMID:18976975   PMID:19168032   PMID:19443732   PMID:19906641   PMID:20044979   PMID:20237496   PMID:20379614   PMID:20921899  
PMID:20932654   PMID:21192818   PMID:21346723   PMID:21483023   PMID:21715684   PMID:21873635   PMID:21959042   PMID:22610747   PMID:22688191   PMID:22768214   PMID:22842622   PMID:23469143  
PMID:23495698   PMID:23904282   PMID:23999103   PMID:24659779   PMID:24689495   PMID:24709693   PMID:24779513   PMID:24927181   PMID:25030943   PMID:25079809   PMID:25121101   PMID:25539827  
PMID:25627894   PMID:25637017   PMID:26628300   PMID:26972253   PMID:27092781   PMID:27239101   PMID:27548138   PMID:27716822   PMID:27742615   PMID:27792688   PMID:27860453   PMID:28120562  
PMID:29146976   PMID:29430984   PMID:29556954   PMID:29717200   PMID:29853566   PMID:30304526   PMID:30784180   PMID:30804218   PMID:31370263   PMID:31926977   PMID:32506925   PMID:32526705  
PMID:33003572   PMID:33081030   PMID:33508012   PMID:33849519   PMID:33961781   PMID:33980047   PMID:34169422   PMID:34339312   PMID:34605770   PMID:34946244   PMID:36156768   PMID:36881626  
PMID:37153997   PMID:37186779   PMID:37539056  


Genomics

Comparative Map Data
CMKLR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,288,046 - 108,339,311 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,288,044 - 108,339,317 (-)EnsemblGRCh38hg38GRCh38
GRCh3712108,681,823 - 108,733,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,209,477 - 107,257,212 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412107,187,813 - 107,235,553NCBI
Celera12108,351,249 - 108,402,507 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12105,746,498 - 105,797,979 (-)NCBIHuRef
CHM1_112108,647,879 - 108,699,141 (-)NCBICHM1_1
T2T-CHM13v2.012108,256,268 - 108,307,509 (-)NCBIT2T-CHM13v2.0
Cmklr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,750,415 - 113,792,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,750,415 - 113,788,487 (-)EnsemblGRCm39 Ensembl
GRCm385113,612,355 - 113,650,475 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,612,354 - 113,650,426 (-)EnsemblGRCm38mm10GRCm38
MGSCv375114,062,364 - 114,100,399 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365113,873,360 - 113,911,389 (-)NCBIMGSCv36mm8
Celera5110,714,182 - 110,752,271 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
Cmklr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,634,929 - 48,687,833 (+)NCBIGRCr8
mRatBN7.21242,974,462 - 43,027,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,974,410 - 43,028,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,186,820 - 44,191,095 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,800,395 - 44,804,670 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,860,934 - 43,865,209 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,743,556 - 48,796,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,789,261 - 48,793,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,531,209 - 50,584,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41244,056,527 - 44,061,043 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,921,991 - 43,923,110 (+)NCBI
Celera1244,621,019 - 44,625,349 (+)NCBICelera
Cytogenetic Map12q16NCBI
Cmklr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554559,589,822 - 9,590,937 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554559,587,421 - 9,638,602 (-)NCBIChiLan1.0ChiLan1.0
CMKLR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210116,348,281 - 116,399,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112116,347,528 - 116,395,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012105,859,702 - 105,911,010 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112109,256,329 - 109,307,526 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,260,130 - 109,261,271 (-)Ensemblpanpan1.1panPan2
CMKLR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,487,700 - 18,539,678 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,532,479 - 18,533,576 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,254,935 - 17,309,701 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02618,836,295 - 18,888,040 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,836,443 - 18,884,494 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,467,315 - 17,495,005 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,824,230 - 18,875,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,845,535 - 18,897,317 (+)NCBIUU_Cfam_GSD_1.0
Cmklr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118145,171,728 - 145,175,406 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936769302,391 - 304,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CMKLR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1442,420,177 - 42,468,058 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11442,420,166 - 42,468,080 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,964,240 - 44,977,991 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21445,116,776 - 45,118,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q21.1NCBI
CMKLR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111103,484,422 - 103,536,273 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037141,555,941 - 141,609,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cmklr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474711,553,268 - 11,601,105 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CMKLR1
29 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.3-24.13(chr12:105234677-112194686)x1 copy number loss See cases [RCV000050807] Chr12:105234677..112194686 [GRCh38]
Chr12:105628455..112632490 [GRCh37]
Chr12:104152585..111116873 [NCBI36]
Chr12:12q23.3-24.13		 pathogenic
GRCh38/hg38 12q23.1-23.3(chr12:100670616-108583607)x1 copy number loss See cases [RCV000051320] Chr12:100670616..108583607 [GRCh38]
Chr12:101064394..108977383 [GRCh37]
Chr12:99588525..107501512 [NCBI36]
Chr12:12q23.1-23.3		 pathogenic
NM_001142343.1(CMKLR1):c.-74+8140G>C single nucleotide variant Lung cancer [RCV000110580] Chr12:108321855 [GRCh38]
Chr12:108715632 [GRCh37]
Chr12:12q23.3		 uncertain significance
GRCh38/hg38 12q23.3-24.11(chr12:105644967-108994840)x1 copy number loss See cases [RCV000138537] Chr12:105644967..108994840 [GRCh38]
Chr12:106038745..109432645 [GRCh37]
Chr12:104562875..107917026 [NCBI36]
Chr12:12q23.3-24.11		 uncertain significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12q23.3-24.11(chr12:107197584-109830564)x1 copy number loss not provided [RCV001270637] Chr12:107197584..109830564 [GRCh37]
Chr12:12q23.3-24.11		 uncertain significance
GRCh37/hg19 12q23.2-24.11(chr12:103044333-111639805)x1 copy number loss See cases [RCV000445832] Chr12:103044333..111639805 [GRCh37]
Chr12:12q23.2-24.11		 likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_001142343.2(CMKLR1):c.913G>C (p.Ala305Pro) single nucleotide variant Inborn genetic diseases [RCV003257523] Chr12:108292050 [GRCh38]
Chr12:108685827 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.605C>T (p.Ser202Leu) single nucleotide variant Inborn genetic diseases [RCV003255070] Chr12:108292358 [GRCh38]
Chr12:108686135 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.768G>C (p.Lys256Asn) single nucleotide variant Inborn genetic diseases [RCV003276794] Chr12:108292195 [GRCh38]
Chr12:108685972 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.331A>G (p.Met111Val) single nucleotide variant Inborn genetic diseases [RCV003265156] Chr12:108292632 [GRCh38]
Chr12:108686409 [GRCh37]
Chr12:12q23.3		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_001142343.2(CMKLR1):c.867G>T (p.Met289Ile) single nucleotide variant not provided [RCV000879567] Chr12:108292096 [GRCh38]
Chr12:108685873 [GRCh37]
Chr12:12q23.3		 benign
NM_001142343.2(CMKLR1):c.607T>A (p.Trp203Arg) single nucleotide variant Inborn genetic diseases [RCV003249696] Chr12:108292356 [GRCh38]
Chr12:108686133 [GRCh37]
Chr12:12q23.3		 uncertain significance
GRCh37/hg19 12q23.3-24.12(chr12:106498814-112252906)x1 copy number loss not provided [RCV001259630] Chr12:106498814..112252906 [GRCh37]
Chr12:12q23.3-24.12		 pathogenic
GRCh37/hg19 12q23.3-24.12(chr12:104230462-111984801)x1 copy number loss not provided [RCV001834231] Chr12:104230462..111984801 [GRCh37]
Chr12:12q23.3-24.12		 pathogenic
GRCh37/hg19 12q23.2-24.11(chr12:103044333-111639805) copy number loss not specified [RCV002053016] Chr12:103044333..111639805 [GRCh37]
Chr12:12q23.2-24.11		 likely pathogenic
NM_001142343.2(CMKLR1):c.157C>T (p.Leu53Phe) single nucleotide variant Inborn genetic diseases [RCV003260492] Chr12:108292806 [GRCh38]
Chr12:108686583 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.378C>A (p.Ser126Arg) single nucleotide variant Inborn genetic diseases [RCV003258443] Chr12:108292585 [GRCh38]
Chr12:108686362 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.582C>G (p.Ser194Arg) single nucleotide variant Inborn genetic diseases [RCV003287458] Chr12:108292381 [GRCh38]
Chr12:108686158 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.1007A>G (p.Asn336Ser) single nucleotide variant Inborn genetic diseases [RCV002905890] Chr12:108291956 [GRCh38]
Chr12:108685733 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.595G>A (p.Gly199Arg) single nucleotide variant Inborn genetic diseases [RCV002859303] Chr12:108292368 [GRCh38]
Chr12:108686145 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.223A>G (p.Met75Val) single nucleotide variant Inborn genetic diseases [RCV002690017] Chr12:108292740 [GRCh38]
Chr12:108686517 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.130G>A (p.Val44Met) single nucleotide variant Inborn genetic diseases [RCV002661222] Chr12:108292833 [GRCh38]
Chr12:108686610 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.1061C>T (p.Thr354Ile) single nucleotide variant Inborn genetic diseases [RCV002955412] Chr12:108291902 [GRCh38]
Chr12:108685679 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.829C>G (p.His277Asp) single nucleotide variant Inborn genetic diseases [RCV002916885] Chr12:108292134 [GRCh38]
Chr12:108685911 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.109A>G (p.Arg37Gly) single nucleotide variant Inborn genetic diseases [RCV002964838] Chr12:108292854 [GRCh38]
Chr12:108686631 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.325A>T (p.Thr109Ser) single nucleotide variant Inborn genetic diseases [RCV003188459] Chr12:108292638 [GRCh38]
Chr12:108686415 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.1028G>T (p.Gly343Val) single nucleotide variant Inborn genetic diseases [RCV003204071] Chr12:108291935 [GRCh38]
Chr12:108685712 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.487A>G (p.Ile163Val) single nucleotide variant Inborn genetic diseases [RCV003185811] Chr12:108292476 [GRCh38]
Chr12:108686253 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.824C>T (p.Pro275Leu) single nucleotide variant Inborn genetic diseases [RCV003374030] Chr12:108292139 [GRCh38]
Chr12:108685916 [GRCh37]
Chr12:12q23.3		 uncertain significance
NM_001142343.2(CMKLR1):c.478T>C (p.Cys160Arg) single nucleotide variant Inborn genetic diseases [RCV003351235] Chr12:108292485 [GRCh38]
Chr12:108686262 [GRCh37]
Chr12:12q23.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6063
Count of miRNA genes:1064
Interacting mature miRNAs:1290
Transcripts:ENST00000312143, ENST00000397688, ENST00000412676, ENST00000549466, ENST00000550402, ENST00000550573, ENST00000552995
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D12S1605  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712108,703,842 - 108,704,042UniSTSGRCh37
Build 3612107,227,972 - 107,228,172RGDNCBI36
Celera12108,373,268 - 108,373,468RGD
Cytogenetic Map12q24.1UniSTS
HuRef12105,768,746 - 105,768,944UniSTS
Marshfield Genetic Map12116.66RGD
Marshfield Genetic Map12116.66UniSTS
Genethon Genetic Map12117.7UniSTS
deCODE Assembly Map12122.79UniSTS
Stanford-G3 RH Map124639.0UniSTS
GeneMap99-GB4 RH Map12428.95UniSTS
NCBI RH Map12706.3UniSTS
GeneMap99-G3 RH Map124585.0UniSTS
G54197  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712108,685,041 - 108,685,253UniSTSGRCh37
Build 3612107,209,171 - 107,209,383RGDNCBI36
Celera12108,354,470 - 108,354,682RGD
Cytogenetic Map12q24.1UniSTS
HuRef12105,749,720 - 105,749,932UniSTS
G54199  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712108,706,855 - 108,707,026UniSTSGRCh37
Build 3612107,230,985 - 107,231,156RGDNCBI36
Celera12108,376,281 - 108,376,452RGD
Cytogenetic Map12q24.1UniSTS
HuRef12105,771,757 - 105,771,928UniSTS
G59772  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712108,683,341 - 108,683,441UniSTSGRCh37
Build 3612107,207,471 - 107,207,571RGDNCBI36
Celera12108,352,770 - 108,352,870RGD
Cytogenetic Map12q24.1UniSTS
HuRef12105,748,020 - 105,748,120UniSTS
RH47923  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712108,683,295 - 108,683,449UniSTSGRCh37
Build 3612107,207,425 - 107,207,579RGDNCBI36
Celera12108,352,724 - 108,352,878RGD
Cytogenetic Map12q24.1UniSTS
HuRef12105,747,974 - 105,748,128UniSTS
GeneMap99-GB4 RH Map12424.23UniSTS
NCBI RH Map12704.8UniSTS
SHGC-152880  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712108,703,848 - 108,704,039UniSTSGRCh37
Build 3612107,227,978 - 107,228,169RGDNCBI36
Celera12108,373,274 - 108,373,465RGD
Cytogenetic Map12q24.1UniSTS
HuRef12105,768,752 - 105,768,941UniSTS
TNG Radiation Hybrid Map1031446.0UniSTS
STS-U79526  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712108,685,364 - 108,685,620UniSTSGRCh37
Build 3612107,209,494 - 107,209,750RGDNCBI36
Celera12108,354,793 - 108,355,049RGD
Cytogenetic Map12q24.1UniSTS
HuRef12105,750,043 - 105,750,299UniSTS
GeneMap99-GB4 RH Map12429.27UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 205 1352 566 35 540 12 1437 99 365 58 215 978 24 713 982 1
Low 2098 1601 1059 507 1159 366 2754 1973 2555 304 1109 413 139 491 1735 1 2
Below cutoff 23 28 78 69 99 69 107 88 763 19 51 40 1 71 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001142344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001142345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB112777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC009729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC063957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK126405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX646471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY497547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP328503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA466082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA939526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y14838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000312143   ⟹   ENSP00000311733
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12108,288,044 - 108,339,317 (-)Ensembl
RefSeq Acc Id: ENST00000412676   ⟹   ENSP00000401293
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12108,288,044 - 108,320,662 (-)Ensembl
RefSeq Acc Id: ENST00000549466   ⟹   ENSP00000448362
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12108,292,533 - 108,317,917 (-)Ensembl
RefSeq Acc Id: ENST00000550402   ⟹   ENSP00000449716
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12108,288,046 - 108,339,311 (-)Ensembl
RefSeq Acc Id: ENST00000550573   ⟹   ENSP00000448925
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12108,292,522 - 108,320,662 (-)Ensembl
RefSeq Acc Id: ENST00000552995   ⟹   ENSP00000447579
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12108,291,570 - 108,339,313 (-)Ensembl
RefSeq Acc Id: NM_001142343   ⟹   NP_001135815
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,288,046 - 108,339,311 (-)NCBI
GRCh3712108,681,821 - 108,733,094 (-)ENTREZGENE
HuRef12105,746,498 - 105,797,979 (-)ENTREZGENE
CHM1_112108,647,879 - 108,699,141 (-)NCBI
T2T-CHM13v2.012108,256,268 - 108,307,509 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001142344   ⟹   NP_001135816
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,288,046 - 108,339,311 (-)NCBI
GRCh3712108,681,821 - 108,733,094 (-)ENTREZGENE
HuRef12105,746,498 - 105,797,979 (-)ENTREZGENE
CHM1_112108,647,879 - 108,699,141 (-)NCBI
T2T-CHM13v2.012108,256,268 - 108,307,509 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001142345   ⟹   NP_001135817
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,288,046 - 108,320,642 (-)NCBI
GRCh3712108,681,821 - 108,733,094 (-)ENTREZGENE
HuRef12105,746,498 - 105,797,979 (-)ENTREZGENE
CHM1_112108,647,879 - 108,680,486 (-)NCBI
T2T-CHM13v2.012108,256,268 - 108,288,859 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004072   ⟹   NP_004063
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,288,046 - 108,339,311 (-)NCBI
GRCh3712108,681,821 - 108,733,094 (-)ENTREZGENE
Build 3612107,209,477 - 107,257,212 (-)NCBI Archive
HuRef12105,746,498 - 105,797,979 (-)ENTREZGENE
CHM1_112108,647,879 - 108,699,141 (-)NCBI
T2T-CHM13v2.012108,256,268 - 108,307,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047428313   ⟹   XP_047284269
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,288,046 - 108,304,871 (-)NCBI
RefSeq Acc Id: XM_054371128   ⟹   XP_054227103
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012108,256,268 - 108,273,156 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001135816   ⟸   NM_001142344
- Peptide Label: isoform a
- UniProtKB: Q5U0H0 (UniProtKB/Swiss-Prot),   Q3KP37 (UniProtKB/Swiss-Prot),   O75748 (UniProtKB/Swiss-Prot),   A8K6Y5 (UniProtKB/Swiss-Prot),   Q99789 (UniProtKB/Swiss-Prot),   Q99788 (UniProtKB/Swiss-Prot),   Q05KQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_004063   ⟸   NM_004072
- Peptide Label: isoform b
- UniProtKB: Q05KQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001135815   ⟸   NM_001142343
- Peptide Label: isoform a
- UniProtKB: Q5U0H0 (UniProtKB/Swiss-Prot),   Q3KP37 (UniProtKB/Swiss-Prot),   O75748 (UniProtKB/Swiss-Prot),   A8K6Y5 (UniProtKB/Swiss-Prot),   Q99789 (UniProtKB/Swiss-Prot),   Q99788 (UniProtKB/Swiss-Prot),   Q05KQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001135817   ⟸   NM_001142345
- Peptide Label: isoform a
- UniProtKB: Q5U0H0 (UniProtKB/Swiss-Prot),   Q3KP37 (UniProtKB/Swiss-Prot),   O75748 (UniProtKB/Swiss-Prot),   A8K6Y5 (UniProtKB/Swiss-Prot),   Q99789 (UniProtKB/Swiss-Prot),   Q99788 (UniProtKB/Swiss-Prot),   Q05KQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000401293   ⟸   ENST00000412676
RefSeq Acc Id: ENSP00000448362   ⟸   ENST00000549466
RefSeq Acc Id: ENSP00000311733   ⟸   ENST00000312143
RefSeq Acc Id: ENSP00000448925   ⟸   ENST00000550573
RefSeq Acc Id: ENSP00000449716   ⟸   ENST00000550402
RefSeq Acc Id: ENSP00000447579   ⟸   ENST00000552995
RefSeq Acc Id: XP_047284269   ⟸   XM_047428313
- Peptide Label: isoform X1
- UniProtKB: Q99788 (UniProtKB/Swiss-Prot),   Q5U0H0 (UniProtKB/Swiss-Prot),   Q3KP37 (UniProtKB/Swiss-Prot),   O75748 (UniProtKB/Swiss-Prot),   A8K6Y5 (UniProtKB/Swiss-Prot),   Q99789 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054227103   ⟸   XM_054371128
- Peptide Label: isoform X1
- UniProtKB: Q99788 (UniProtKB/Swiss-Prot),   Q5U0H0 (UniProtKB/Swiss-Prot),   Q3KP37 (UniProtKB/Swiss-Prot),   O75748 (UniProtKB/Swiss-Prot),   A8K6Y5 (UniProtKB/Swiss-Prot),   Q99789 (UniProtKB/Swiss-Prot)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99788-F1-model_v2 AlphaFold Q99788 1-373 view protein structure

Promoters
RGD ID:6789813
Promoter ID:HG_KWN:16565
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_001142345
Position:
Human AssemblyChrPosition (strand)Source
Build 3612107,238,319 - 107,238,819 (-)MPROMDB
RGD ID:7225297
Promoter ID:EPDNEW_H18395
Type:initiation region
Name:CMKLR1_1
Description:chemerin chemokine-like receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18396  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,339,311 - 108,339,371EPDNEW
RGD ID:7225301
Promoter ID:EPDNEW_H18396
Type:multiple initiation site
Name:CMKLR1_2
Description:chemerin chemokine-like receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18395  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,339,431 - 108,339,491EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2121 AgrOrtholog
COSMIC CMKLR1 COSMIC
Ensembl Genes ENSG00000174600 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000312143 ENTREZGENE
  ENST00000312143.11 UniProtKB/Swiss-Prot
  ENST00000412676 ENTREZGENE
  ENST00000412676.5 UniProtKB/Swiss-Prot
  ENST00000549466.1 UniProtKB/TrEMBL
  ENST00000550402 ENTREZGENE
  ENST00000550402.6 UniProtKB/Swiss-Prot
  ENST00000550573.5 UniProtKB/TrEMBL
  ENST00000552995 ENTREZGENE
  ENST00000552995.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000174600 GTEx
HGNC ID HGNC:2121 ENTREZGENE
Human Proteome Map CMKLR1 Human Proteome Map
InterPro Chemokine-like_recpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_rcpt-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1240 UniProtKB/Swiss-Prot
NCBI Gene 1240 ENTREZGENE
OMIM 602351 OMIM
PANTHER PTHR24225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24225:SF49 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26640 PharmGKB
PRINTS DEZORPHANR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K6Y5 ENTREZGENE
  CML1_HUMAN UniProtKB/Swiss-Prot
  F8VSC8_HUMAN UniProtKB/TrEMBL
  F8VYN7_HUMAN UniProtKB/TrEMBL
  O75748 ENTREZGENE
  Q05KQ8 ENTREZGENE, UniProtKB/TrEMBL
  Q3KP37 ENTREZGENE
  Q5U0H0 ENTREZGENE
  Q6LEE7_HUMAN UniProtKB/TrEMBL
  Q99788 ENTREZGENE
  Q99789 ENTREZGENE
UniProt Secondary A8K6Y5 UniProtKB/Swiss-Prot
  O75748 UniProtKB/Swiss-Prot
  Q3KP37 UniProtKB/Swiss-Prot
  Q5U0H0 UniProtKB/Swiss-Prot
  Q99789 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-14 CMKLR1  chemerin chemokine-like receptor 1    chemokine-like receptor 1  Symbol and/or name change 5135510 APPROVED