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Gene: DXO (decapping exoribonuclease) Homo sapiens

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Symbol:

DXO

Name:

decapping exoribonuclease

RGD ID:

1348619

HGNC Page

HGNC:2992

Description:

Predicted to enable several functions, including 5'-3' exonuclease activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; and magnesium ion binding activity. Involved in NAD-cap decapping and mRNA catabolic process. Located in cytosol; nucleoplasm; and plasma membrane.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

5'-3' exoribonuclease DXO; decapping and exoribonuclease protein; deNADding enzyme DXO; DOM3L; DOM3Z; NAD-capped RNA hydrolase DXO; NG6; RAI1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Dxo (decapping exoribonuclease)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Dxo (decapping exoribonuclease)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Dxo (decapping exoribonuclease)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	DXO (decapping exoribonuclease)	NCBI	Ortholog
Canis lupus familiaris (dog):	DXO (decapping exoribonuclease)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dxo (decapping exoribonuclease)	NCBI	Ortholog
Sus scrofa (pig):	DXO (decapping exoribonuclease)	HGNC	Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	DXO (decapping exoribonuclease)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Dxo (decapping exoribonuclease)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Dxo (decapping exoribonuclease)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dxo (decapping exoribonuclease)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dxo (decapping exoribonuclease)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	CG9125	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	RAI1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	cuff	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	dom-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	dxo.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	dxo	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,969,815 - 31,972,138 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,969,810 - 31,972,290 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,937,592 - 31,939,915 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,045,567 - 32,048,011 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,045,566 - 32,048,011	NCBI
Celera	6	33,537,350 - 33,539,794 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,724,525 - 31,726,969 (-)	NCBI		HuRef
CHM1_1	6	31,939,669 - 31,942,113 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,823,020 - 31,825,343 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

proteasome-associated autoinflammatory syndrome 1 (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

Benoxacor (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

CGP 52608 (EXP)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

doxorubicin (EXP)

elemental selenium (EXP)

endosulfan (ISO)

folic acid (ISO)

fulvestrant (EXP)

glyphosate (EXP)

isoprenaline (ISO)

lead(0) (EXP)

methotrexate (EXP)

N-nitrosodiethylamine (ISO)

ozone (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (EXP)

selenium atom (EXP)

sunitinib (EXP)

thiram (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

tunicamycin (EXP)

vinclozolin (ISO)

vitamin E (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA catabolic process (IDA,ISS)

NAD-cap decapping (IBA,IDA)

nuclear mRNA surveillance (ISS)

nuclear-transcribed mRNA catabolic process (IBA)

RNA destabilization (ISS)

Cellular Component

cytosol (IBA,IDA)

nucleoplasm (IDA)

nucleus (IBA,IDA,IEA)

plasma membrane (IDA)

Molecular Function

5'-3' exonuclease activity (ISS)

exonuclease activity (IEA)

magnesium ion binding (ISS)

metal ion binding (IEA)

mRNA 5'-diphosphatase activity (IBA,ISS)

mRNA binding (ISS)

nuclease activity (IEA)

nucleotide binding (IEA)

protein binding (IPI)

RNA binding (IEA)

RNA NAD+-cap (NAD+-forming) hydrolase activity (IEA,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

3'-end pre-mRNA processing pathway (TAS)

RNA polymerase II transcription termination pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Pre-mRNA 3'-end processing complex assembly and function.	Chan S, etal., Wiley Interdiscip Rev RNA. 2011 May-Jun;2(3):321-35. doi: 10.1002/wrna.54. Epub 2010 Oct 18.
2.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9799600	PMID:10072631	PMID:10686478	PMID:12477932	PMID:14574404	PMID:14656967	PMID:14667819	PMID:15231747	PMID:15489334	PMID:19204726	PMID:19913121	PMID:20628086
PMID:21323541	PMID:21873635	PMID:23263863	PMID:23455924	PMID:23523372	PMID:23535732	PMID:26186194	PMID:26344197	PMID:28283058	PMID:28514442	PMID:28986522	PMID:29601584
PMID:29672716	PMID:30021884	PMID:31101919	PMID:31164795	PMID:32393512	PMID:32814053	PMID:33961781

Genomics

Comparative Map Data

DXO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,969,815 - 31,972,138 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,969,810 - 31,972,290 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,937,592 - 31,939,915 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,045,567 - 32,048,011 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,045,566 - 32,048,011	NCBI
Celera	6	33,537,350 - 33,539,794 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,724,525 - 31,726,969 (-)	NCBI		HuRef
CHM1_1	6	31,939,669 - 31,942,113 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,823,020 - 31,825,343 (-)	NCBI		T2T-CHM13v2.0

Dxo
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	35,055,998 - 35,058,162 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	35,055,995 - 35,058,209 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,836,996 - 34,839,187 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,837,019 - 34,839,233 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,973,964 - 34,976,131 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,445,139 - 34,447,289 (+)	NCBI		MGSCv36	mm8
Celera	17	37,932,348 - 37,934,515 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.39	NCBI

Dxo
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,997,953 - 4,000,115 (-)	NCBI		GRCr8
mRatBN7.2	20	3,993,322 - 3,995,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,993,327 - 3,995,494 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,693,280 - 4,695,364 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,055,028 - 4,057,112 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,592,209 - 4,594,293 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,517,307 - 4,519,391 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,517,307 - 4,519,389 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,597,106 - 6,599,190 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,093,718 - 4,095,802 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,093,893 - 4,096,049 (-)	NCBI
Celera	20	4,035,291 - 4,037,375 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Dxo
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	481,554 - 484,989 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	482,866 - 484,989 (-)	NCBI	ChiLan1.0	ChiLan1.0

DXO
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,446,379 - 46,448,629 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,407,867 - 42,410,121 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,630,523 - 31,632,363 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,517,086 - 32,519,566 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,517,086 - 32,519,566 (-)	Ensembl	panpan1.1		panPan2

DXO
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,424,584 - 1,426,275 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,424,591 - 1,426,452 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,559,785 - 1,562,016 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,566,885 - 1,568,996 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,566,892 - 1,568,726 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,424,344 - 1,426,575 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,492,527 - 1,494,758 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,559,127 - 1,561,358 (-)	NCBI		UU_Cfam_GSD_1.0

Dxo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,982,182 - 35,984,452 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,576,886 - 1,579,154 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,576,823 - 1,579,158 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DXO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	24,056,525 - 24,060,011 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	24,057,670 - 24,060,108 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	27,752,093 - 27,754,531 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DXO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,049,679 - 40,052,114 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,050,257 - 40,052,050 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	31,886,210 - 31,888,644 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dxo
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,281,101 - 24,287,647 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,281,099 - 24,283,403 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in DXO
27 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 6p21.33(chr6:31971993-32012974)x1	copy number loss	See cases [RCV000141578]	Chr6:31971993..32012974 [GRCh38] Chr6:31939770..31980751 [GRCh37] Chr6:32047749..32088729 [NCBI36] Chr6:6p21.33	benign
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3	copy number gain	See cases [RCV000143497]	Chr6:156974..46789291 [GRCh38] Chr6:156974..46757028 [GRCh37] Chr6:101974..46864987 [NCBI36] Chr6:6p25.3-12.3	pathogenic
NC_000006.12:g.31970635G>T	single nucleotide variant	not specified [RCV000454484]	Chr6:31970635 [GRCh38] Chr6:31938412 [GRCh37] Chr6:6p21.33	benign
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
NC_000006.12:g.31970674T>C	single nucleotide variant	not specified [RCV000455129]	Chr6:31970674 [GRCh38] Chr6:31938451 [GRCh37] Chr6:6p21.33	benign
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367)	copy number gain	not provided [RCV000767714]	Chr6:29455465..81447367 [GRCh37] Chr6:6p22.1-q14.1	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3	copy number gain	not provided [RCV000745592]	Chr6:28130359..32108367 [GRCh37] Chr6:6p22.1-21.32	uncertain significance
NM_005510.4(DXO):c.503C>T (p.Pro168Leu)	single nucleotide variant	not specified [RCV004320526]	Chr6:31971001 [GRCh38] Chr6:31938778 [GRCh37] Chr6:6p21.33	uncertain significance
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3	copy number gain	not provided [RCV001005791]	Chr6:31036397..34088832 [GRCh37] Chr6:6p21.33-21.31	likely pathogenic
GRCh37/hg19 6p21.33-21.32(chr6:31916915-32278000)x3	copy number gain	not provided [RCV001005792]	Chr6:31916915..32278000 [GRCh37] Chr6:6p21.33-21.32	uncertain significance
NM_005510.4(DXO):c.308T>C (p.Leu103Pro)	single nucleotide variant	not specified [RCV004265176]	Chr6:31971368 [GRCh38] Chr6:31939145 [GRCh37] Chr6:6p21.33	uncertain significance
NC_000006.11:g.(?_30695893)_(36953949_?)dup	duplication	Proteasome-associated autoinflammatory syndrome 1 [RCV003113679]	Chr6:30695893..36953949 [GRCh37] Chr6:6p21.33-21.2	uncertain significance
NM_005510.4(DXO):c.956G>A (p.Arg319His)	single nucleotide variant	not specified [RCV004287613]	Chr6:31970196 [GRCh38] Chr6:31937973 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.1045C>T (p.Leu349Phe)	single nucleotide variant	not specified [RCV004119322]	Chr6:31970023 [GRCh38] Chr6:31937800 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.661C>T (p.Arg221Cys)	single nucleotide variant	not specified [RCV004235386]	Chr6:31970757 [GRCh38] Chr6:31938534 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.191C>A (p.Ala64Asp)	single nucleotide variant	not specified [RCV004136723]	Chr6:31971485 [GRCh38] Chr6:31939262 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.1081G>C (p.Val361Leu)	single nucleotide variant	not specified [RCV004163612]	Chr6:31969987 [GRCh38] Chr6:31937764 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.767C>T (p.Thr256Ile)	single nucleotide variant	not specified [RCV004212353]	Chr6:31970651 [GRCh38] Chr6:31938428 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.529C>T (p.Arg177Trp)	single nucleotide variant	not specified [RCV004188060]	Chr6:31970975 [GRCh38] Chr6:31938752 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.59A>G (p.Asn20Ser)	single nucleotide variant	not specified [RCV004149050]	Chr6:31971617 [GRCh38] Chr6:31939394 [GRCh37] Chr6:6p21.33	uncertain significance
NM_032454.1(STK19):c.112G>A (p.Val38Met)	single nucleotide variant	not specified [RCV004082264]	Chr6:31972108 [GRCh38] Chr6:31939885 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.165T>G (p.Asp55Glu)	single nucleotide variant	not specified [RCV004083050]	Chr6:31971511 [GRCh38] Chr6:31939288 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.236G>A (p.Gly79Asp)	single nucleotide variant	not specified [RCV004271576]	Chr6:31971440 [GRCh38] Chr6:31939217 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.902C>T (p.Ser301Phe)	single nucleotide variant	not specified [RCV004258002]	Chr6:31970389 [GRCh38] Chr6:31938166 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.450G>C (p.Gln150His)	single nucleotide variant	not specified [RCV004260857]	Chr6:31971054 [GRCh38] Chr6:31938831 [GRCh37] Chr6:6p21.33	uncertain significance
NM_004197.1(STK19):c.125C>T (p.Ala42Val)	single nucleotide variant	not provided [RCV003428811]	Chr6:31972121 [GRCh38] Chr6:31939898 [GRCh37] Chr6:6p21.33	likely benign
NM_005510.4(DXO):c.434G>A (p.Arg145Gln)	single nucleotide variant	not specified [RCV004360515]	Chr6:31971070 [GRCh38] Chr6:31938847 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.554T>C (p.Met185Thr)	single nucleotide variant	not specified [RCV004379807]	Chr6:31970950 [GRCh38] Chr6:31938727 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.500C>T (p.Thr167Ile)	single nucleotide variant	not specified [RCV004379805]	Chr6:31971004 [GRCh38] Chr6:31938781 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.530G>A (p.Arg177Gln)	single nucleotide variant	not specified [RCV004379806]	Chr6:31970974 [GRCh38] Chr6:31938751 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.1139A>C (p.Glu380Ala)	single nucleotide variant	not specified [RCV004379803]	Chr6:31969929 [GRCh38] Chr6:31937706 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.402C>A (p.His134Gln)	single nucleotide variant	not specified [RCV004617250]	Chr6:31971102 [GRCh38] Chr6:31938879 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.1022C>T (p.Thr341Met)	single nucleotide variant	not specified [RCV004617249]	Chr6:31970130 [GRCh38] Chr6:31937907 [GRCh37] Chr6:6p21.33	uncertain significance
NM_005510.4(DXO):c.320T>G (p.Leu107Arg)	single nucleotide variant	not specified [RCV004617251]	Chr6:31971356 [GRCh38] Chr6:31939133 [GRCh37] Chr6:6p21.33	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2920
Count of miRNA genes:	767
Interacting mature miRNAs:	928
Transcripts:	ENST00000337523, ENST00000375349, ENST00000375356, ENST00000460058, ENST00000473976, ENST00000474587, ENST00000477826, ENST00000478221, ENST00000480240, ENST00000485557, ENST00000487914, ENST00000491327, ENST00000492946, ENST00000495340, ENST00000498357
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358839	MULTSCL5_H	Multiple sclerosis susceptibility QTL 5 (human)			Multiple sclerosis susceptibility		6	19584311	45584311	Human
407143296	GWAS792272_H	tenascin-X measurement QTL GWAS792272 (human)		3e-116	tenascin-X measurement		6	31970343	31970344	Human
407063751	GWAS712727_H	interleukin 18 receptor accessory protein measurement QTL GWAS712727 (human)		9e-09	interleukin 18 receptor accessory protein measurement		6	31971568	31971569	Human
1643377	BW325_H	Body weight QTL 325 (human)	2.32	0.0005	Body fat amount		6	6911960	32911960	Human
1643569	GLUCO21_H	Glucose level QTL 21 (human)		0.021	Glucose level	non-insulin-dependent	6	6911960	32911960	Human
1298458	BW9_H	Body weight QTL 9 (human)	2.7	0.0002	Body fat amount		6	6911960	32911960	Human
407133966	GWAS782942_H	complement C4 measurement QTL GWAS782942 (human)		4e-41	complement C4 measurement		6	31970089	31970090	Human
1298431	RA11_H	Rheumatoid arthritis QTL 11 (human)		0.0000024	Joint/bone inflammation	rheumatoid arthritis	6	19911883	40191709	Human
407064333	GWAS713309_H	blood protein measurement QTL GWAS713309 (human)		6e-25	blood protein measurement	blood protein measurement (CMO:0000028)	6	31971747	31971748	Human
1358854	MULTSCL4_H	Multiple sclerosis susceptibility QTL 4 (human)			Multiple sclerosis susceptibility		6	6911960	32911960	Human
407139633	GWAS788609_H	Varicose veins QTL GWAS788609 (human)		3e-09	Varicose veins		6	31970330	31970331	Human
407139384	GWAS788360_H	alpha-2-macroglobulin receptor-associated protein measurement QTL GWAS788360 (human)		2e-13	alpha-2-macroglobulin receptor-associated protein measurement		6	31970674	31970675	Human
1358857	MULTSCL19_H	Multiple sclerosis susceptibility QTL 19 (human)			Multiple sclerosis susceptibility		6	19584311	45584311	Human
1643399	BMD5_H	Bone mineral density QTL 5 (human)	2.32	0.0005	Bone mineral density		6	6911960	32911960	Human

Markers in Region

WI-16314

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,937,397 - 31,937,513	UniSTS	GRCh37
Build 36	6	32,045,376 - 32,045,492	RGD	NCBI36
Celera	6	33,537,159 - 33,537,275	RGD
Cytogenetic Map	6	p21	UniSTS
Cytogenetic Map	6	p21.3	UniSTS
HuRef	6	31,724,334 - 31,724,450	UniSTS
GeneMap99-GB4 RH Map	6	120.15	UniSTS
Whitehead-RH Map	6	177.9	UniSTS
NCBI RH Map	6	509.1	UniSTS

DOM3Z

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,938,427 - 31,938,623	UniSTS	GRCh37
Celera	6	33,538,189 - 33,538,385	UniSTS
HuRef	6	31,725,364 - 31,725,560	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2437	2788	2251	4973	1726	2351	5	623	1951	465	2269	7302	6469	53	3734	1	852	1744	1617	174	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001371205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001371206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_005510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006715005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047418262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047418263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047418264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054354416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054354417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054354418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054354419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002956262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002956263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002956264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_926082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF019413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF059252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF059253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF059254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK310107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL049547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL645922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL662849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL844853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC009344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC019083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC030235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC050618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC058885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC071651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR753822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR753845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR759782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000337523 ⟹ ENSP00000337759

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,815 - 31,972,138 (-)	Ensembl

Ensembl Acc Id:

ENST00000375349 ⟹ ENSP00000364498

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,813 - 31,972,290 (-)	Ensembl

Ensembl Acc Id:

ENST00000375356 ⟹ ENSP00000364505

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,844 - 31,971,984 (-)	Ensembl

Ensembl Acc Id:

ENST00000460058

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,970,898 - 31,972,009 (-)	Ensembl

Ensembl Acc Id:

ENST00000473976

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,815 - 31,972,095 (-)	Ensembl

Ensembl Acc Id:

ENST00000474587

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,948 - 31,972,098 (-)	Ensembl

Ensembl Acc Id:

ENST00000477826

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,810 - 31,972,252 (-)	Ensembl

Ensembl Acc Id:

ENST00000478221

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,817 - 31,972,238 (-)	Ensembl

Ensembl Acc Id:

ENST00000480240 ⟹ ENSP00000418632

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,907 - 31,972,136 (-)	Ensembl

Ensembl Acc Id:

ENST00000485557

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,810 - 31,972,209 (-)	Ensembl

Ensembl Acc Id:

ENST00000487914

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,970,643 - 31,971,989 (-)	Ensembl

Ensembl Acc Id:

ENST00000491327

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,810 - 31,971,685 (-)	Ensembl

Ensembl Acc Id:

ENST00000492946

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,970,442 - 31,972,162 (-)	Ensembl

Ensembl Acc Id:

ENST00000495340 ⟹ ENSP00000419588

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,815 - 31,970,923 (-)	Ensembl

Ensembl Acc Id:

ENST00000498357

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,969,887 - 31,971,683 (-)	Ensembl

RefSeq Acc Id:

NM_001371205 ⟹ NP_001358134

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,969,815 - 31,972,138 (-)	NCBI
T2T-CHM13v2.0	6	31,823,020 - 31,825,343 (-)	NCBI

Sequence:

show sequence

GTTGGCGGCGTGGAGGGGCGCCGGTGGCCACGTTGGTGTCAACCTCCTTCGTGAAGCTCACACC
TCCCCCGCCCCGGGAGGGGTTTGCCCGCCACTGTCGCTGAATGATTGCATCATCGAAAGCAGAA
AACCACTTTTGCATCCTTCGGCCTCTGGCGTGCCTGCCATGACGTCATAGCTCTGCGGAGGTGG
AAGTTGGGGAGCTTTGAGGCCTCCTCTGTAGAATGGAAACTCTGTACCCCTGCTTGTCTTAGGA
CCTCATGGATCCCAGGGGGACCAAGAGAGGAGCTGAGAAGACAGAGGTAGCTGAGCCTCGGAAC
AAACTACCTCGTCCAGCACCTTCTCTGCCCACAGACCCTGCCCTCTACTCTGGGCCCTTTCCTT
TCTACCGGCGCCCTTCGGAACTGGGCTGCTTCTCCCTGGATGCTCAACGCCAGTACCATGGAGA
TGCCCGAGCCCTGCGCTACTATAGCCCACCCCCCACTAACGGTCCAGGCCCCAACTTTGACCTC
AGAGACGGATACCCGGATCGATACCAGCCCCGGGACGAGGAGGTCCAGGAAAGGCTGGACCACC
TGCTGTGCTGGCTCCTGGAACACCGAGGCCGGTTGGAGGGGTGAGCAAAGCGTGGGGTCCAGGC
TGGCTGGCAGAGGCCATAGTGACGTGGCGGGGGCACCTGACAAAACTGCTGACGACACCGTATG
AGCGGCAGGAGGGCTGGCAGCTGGCAGCCTCCCGGTTCCAGGGAACACTATACCTGAGTGAAGT
GGAGACACCGAACGCTCGGGCCCAGAGGCTTGCTCGGCCACCGCTCCTCCGGGAGCTTATGTAC
ATGGGATACAAATTTGAGCAGTACATGTGTGCAGACAAACCTGGAAGCTCCCCAGACCCCTCTG
GGGAGGTTAACACCAACGTGGCCTTCTGCTCTGTGCTACGCAGCCGCCTGGGAAGCCACCCTCT
GCTCTTCTCAGGGGAGGTAGACTGCACAGACCCCCAAGCCCCATCCACACAGCCCCCAACCTGC
TATGTGGAGCTCAAGACCTCCAAGGAGATGCACAGCCCTGGCCAATGGAGGAGTTTCTACAGAC
ACAAGCTCCTGAAATGGTGGGCTCAGTCATTCCTCCCAGGGGTCCCGAATGTTGTTGCTGGCTT
CCGTAACCCAGACGGTTTTGTCTCTTCCCTCAAGACCTTTCCTACCATGAAGATGTTTGAATAT
GTCAGGAATGACCGTGACGGCTGGAATCCCTCTGTGTGCATGAACTTCTGTGCCGCCTTCCTTA
GCTTTGCCCAGAGCACGGTTGTCCAGGATGACCCCAGGCTCGTTCATCTCTTCTCTTGGGAGCC
TGGCGGCCCAGTCACCGTGTCTGTACACCAAGATGCACCTTACGCCTTCCTGCCCATATGGTAT
GTGGAAGCTATGACTCAGGACCTCCCATCACCCCCCAAGACTCCCTCTCCCAAATAGTAATGCT
TTAGAGGGAGGCAGTCATATCTCTGTGTGCAGATAATAAAAGCATATTTCTAAGA

hide sequence

RefSeq Acc Id:

NM_001371206 ⟹ NP_001358135

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,969,815 - 31,972,138 (-)	NCBI
T2T-CHM13v2.0	6	31,823,020 - 31,825,343 (-)	NCBI

Sequence:

show sequence

GTTGGCGGCGTGGAGGGGCGCCGGTGGCCACGTTGGTGTCAACCTCCTTCGTGAAGCTCACACC
TCCCCCGCCCCGGGAGGGGTTTGCCCGCCACTGTCGCTGAATGATTGCATCATCGAAAGCAGAA
AACCACTTTTGCATCCTTCGGCCTCTGGCGTGCCTGCCATGACGTCATAGCTCTGCGGAGGTGG
AAGTTGGGGAGCTTTGAGACCCTGCCCTCTACTCTGGGCCCTTTCCTTTCTACCGGCGCCCTTC
GGAACTGGGCTGCTTCTCCCTGGATGCTCAACGCCAGTACCATGGAGATGCCCGAGCCCTGCGC
TACTATAGCCCACCCCCCACTAACGGTCCAGGCCCCAACTTTGACCTCAGAGACGGATACCCGG
ATCGATACCAGCCCCGGGACGAGGAGGTCCAGGAAAGGCTGGACCACCTGCTGTGCTGGCTCCT
GGAACACCGAGGCCGGTTGGAGGGGGGTCCAGGCTGGCTGGCAGAGGCCATAGTGACGTGGCGG
GGGCACCTGACAAAACTGCTGACGACACCGTATGAGCGGCAGGAGGGCTGGCAGCTGGCAGCCT
CCCGGTTCCAGGGAACACTATACCTGAGTGAAGTGGAGACACCGAACGCTCGGGCCCAGAGGCT
TGCTCGGCCACCGCTCCTCCGGGAGCTTATGTACATGGGATACAAATTTGAGCAGTACATGTGT
GCAGACAAACCTGGAAGCTCCCCAGACCCCTCTGGGGAGGTTAACACCAACGTGGCCTTCTGCT
CTGTGCTACGCAGCCGCCTGGGAAGCCACCCTCTGCTCTTCTCAGGGGAGGTAGACTGCACAGA
CCCCCAAGCCCCATCCACACAGCCCCCAACCTGCTATGTGGAGCTCAAGACCTCCAAGGAGATG
CACAGCCCTGGCCAATGGAGGAGTTTCTACAGACACAAGCTCCTGAAATGGTGGGCTCAGTCAT
TCCTCCCAGGGGTCCCGAATGTTGTTGCTGGCTTCCGTAACCCAGACGGTTTTGTCTCTTCCCT
CAAGACCTTTCCTACCATGAAGATGTTTGAATATGTCAGGAATGACCGTGACGGCTGGAATCCC
TCTGTGTGCATGAACTTCTGTGCCGCCTTCCTTAGCTTTGCCCAGAGCACGGTTGTCCAGGATG
ACCCCAGGCTCGTTCATCTCTTCTCTTGGGAGCCTGGCGGCCCAGTCACCGTGTCTGTACACCA
AGATGCACCTTACGCCTTCCTGCCCATATGGTATGTGGAAGCTATGACTCAGGACCTCCCATCA
CCCCCCAAGACTCCCTCTCCCAAATAGTAATGCTTTAGAGGGAGGCAGTCATATCTCTGTGTGC
AGATAATAAAAGCATATTTCTAAGA

hide sequence

RefSeq Acc Id:

NM_005510 ⟹ NP_005501

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,969,815 - 31,972,138 (-)	NCBI
GRCh37	6	31,937,588 - 31,940,032 (-)	RGD
Build 36	6	32,045,567 - 32,048,011 (-)	NCBI Archive
Celera	6	33,537,350 - 33,539,794 (-)	RGD
HuRef	6	31,724,525 - 31,726,969 (-)	RGD
CHM1_1	6	31,939,669 - 31,942,113 (-)	NCBI
T2T-CHM13v2.0	6	31,823,020 - 31,825,343 (-)	NCBI

Sequence:

show sequence

GTTGGCGGCGTGGAGGGGCGCCGGTGGCCACGTTGGTGTCAACCTCCTTCGTGAAGCTCACACC
TCCCCCGCCCCGGGAGGGGTTTGCCCGCCACTGTCGCTGAATGATTGCATCATCGAAAGCAGAA
AACCACTTTTGCATCCTTCGGCCTCTGGCGTGCCTGCCATGACGTCATAGCTCTGCGGAGGTGG
AAGTTGGGGAGCTTTGAGGACCTCATGGATCCCAGGGGGACCAAGAGAGGAGCTGAGAAGACAG
AGGTAGCTGAGCCTCGGAACAAACTACCTCGTCCAGCACCTTCTCTGCCCACAGACCCTGCCCT
CTACTCTGGGCCCTTTCCTTTCTACCGGCGCCCTTCGGAACTGGGCTGCTTCTCCCTGGATGCT
CAACGCCAGTACCATGGAGATGCCCGAGCCCTGCGCTACTATAGCCCACCCCCCACTAACGGTC
CAGGCCCCAACTTTGACCTCAGAGACGGATACCCGGATCGATACCAGCCCCGGGACGAGGAGGT
CCAGGAAAGGCTGGACCACCTGCTGTGCTGGCTCCTGGAACACCGAGGCCGGTTGGAGGGGGGT
CCAGGCTGGCTGGCAGAGGCCATAGTGACGTGGCGGGGGCACCTGACAAAACTGCTGACGACAC
CGTATGAGCGGCAGGAGGGCTGGCAGCTGGCAGCCTCCCGGTTCCAGGGAACACTATACCTGAG
TGAAGTGGAGACACCGAACGCTCGGGCCCAGAGGCTTGCTCGGCCACCGCTCCTCCGGGAGCTT
ATGTACATGGGATACAAATTTGAGCAGTACATGTGTGCAGACAAACCTGGAAGCTCCCCAGACC
CCTCTGGGGAGGTTAACACCAACGTGGCCTTCTGCTCTGTGCTACGCAGCCGCCTGGGAAGCCA
CCCTCTGCTCTTCTCAGGGGAGGTAGACTGCACAGACCCCCAAGCCCCATCCACACAGCCCCCA
ACCTGCTATGTGGAGCTCAAGACCTCCAAGGAGATGCACAGCCCTGGCCAATGGAGGAGTTTCT
ACAGACACAAGCTCCTGAAATGGTGGGCTCAGTCATTCCTCCCAGGGGTCCCGAATGTTGTTGC
TGGCTTCCGTAACCCAGACGGTTTTGTCTCTTCCCTCAAGACCTTTCCTACCATGAAGATGTTT
GAATATGTCAGGAATGACCGTGACGGCTGGAATCCCTCTGTGTGCATGAACTTCTGTGCCGCCT
TCCTTAGCTTTGCCCAGAGCACGGTTGTCCAGGATGACCCCAGGCTCGTTCATCTCTTCTCTTG
GGAGCCTGGCGGCCCAGTCACCGTGTCTGTACACCAAGATGCACCTTACGCCTTCCTGCCCATA
TGGTATGTGGAAGCTATGACTCAGGACCTCCCATCACCCCCCAAGACTCCCTCTCCCAAATAGT
AATGCTTTAGAGGGAGGCAGTCATATCTCTGTGTGCAGATAATAAAAGCATATTTCTAAGA

hide sequence

RefSeq Acc Id:

XM_006715005 ⟹ XP_006715068

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,969,815 - 31,972,138 (-)	NCBI

Sequence:

show sequence

GATGACGAAAGGAGCGTCAACTTGTCGTCCCTCAGGCCCGTCAGTGCTGGGAGGGGCGGTGGCG
ACGCACATACCAGCATCACCTCCGCCAGGCCGGGCCCCACGCCGGCCGCGGATTGGCTCCCTCC
AAGGGCACGCACGCCCGGGGACTCGTTGGCGGCGTGGAGGGGCGCCGGTGGCCACGTTGGTGTC
AACCTCCTTCGTGAAGCTCACACCTCCCCCGCCCCGGGAGGGGTTTGCCCGCCACTGTCGCTGA
ATGATTGCATCATCGAAAGCAGAAAACCACTTTTGCATCCTTCGGCCTCTGGCGTGCCTGCCAT
GACGTCATAGCTCTGCGGAGGTGGAAGTTGGGGAGCTTTGAGGCCTCCTCTGTAGAATGGAAAC
TCTGTACCCCTGCTTGTCTTAGGACCTCATGGATCCCAGGGGGACCAAGAGAGGAGCTGAGAAG
ACAGAGGTAGCTGAGCCTCGGAACAAACTACCTCGTCCAGCACCTTCTCTGCCCACAGACCCTG
CCCTCTACTCTGGGCCCTTTCCTTTCTACCGGCGCCCTTCGGAACTGGGCTGCTTCTCCCTGGA
TGCTCAACGCCAGTACCATGGAGATGCCCGAGCCCTGCGCTACTATAGCCCACCCCCCACTAAC
GGTCCAGGCCCCAACTTTGACCTCAGAGACGGATACCCGGATCGATACCAGCCCCGGGACGAGG
AGGTCCAGGAAAGGCTGGACCACCTGCTGTGCTGGCTCCTGGAACACCGAGGCCGGTTGGAGGG
GGGTCCAGGCTGGCTGGCAGAGGCCATAGTGACGTGGCGGGGGCACCTGACAAAACTGCTGACG
ACACCGTATGAGCGGCAGGAGGGCTGGCAGCTGGCAGCCTCCCGGTTCCAGGGAACACTATACC
TGAGTGAAGTGGAGACACCGAACGCTCGGGCCCAGAGGCTTGCTCGGCCACCGCTCCTCCGGGA
GCTTATGTACATGGGATACAAATTTGAGCAGTACATGTGTGCAGACAAACCTGGAAGCTCCCCA
GACCCCTCTGGGGAGGTTAACACCAACGTGGCCTTCTGCTCTGTGCTACGCAGCCGCCTGGGAA
GCCACCCTCTGCTCTTCTCAGGGGAGGTAGACTGCACAGACCCCCAAGCCCCATCCACACAGCC
CCCAACCTGCTATGTGGAGCTCAAGACCTCCAAGGAGATGCACAGCCCTGGCCAATGGAGGAGT
TTCTACAGACACAAGCTCCTGAAATGGTGGGCTCAGTCATTCCTCCCAGGGGTCCCGAATGTTG
TTGCTGGCTTCCGTAACCCAGACGGTTTTGTCTCTTCCCTCAAGACCTTTCCTACCATGAAGAT
GTTTGAATATGTCAGGAATGACCGTGACGGCTGGAATCCCTCTGTGTGCATGAACTTCTGTGCC
GCCTTCCTTAGCTTTGCCCAGAGCACGGTTGTCCAGGATGACCCCAGGCTCGTTCATCTCTTCT
CTTGGGAGCCTGGCGGCCCAGTCACCGTGTCTGTACACCAAGATGCACCTTACGCCTTCCTGCC
CATATGGTATGTGGAAGCTATGACTCAGGACCTCCCATCACCCCCCAAGACTCCCTCTCCCAAA
TAGTAATGCTTTAGAGGGAGGCAGTCATATCTCTGTGTGCAGATAATAAAAGCATATTTCTAAG
AGGT

hide sequence

RefSeq Acc Id:

XM_047418262 ⟹ XP_047274218

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,969,815 - 31,972,138 (-)	NCBI

RefSeq Acc Id:

XM_047418263 ⟹ XP_047274219

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,970,109 - 31,972,138 (-)	NCBI

RefSeq Acc Id:

XM_047418264 ⟹ XP_047274220

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,970,612 - 31,972,138 (-)	NCBI

RefSeq Acc Id:

XM_054354416 ⟹ XP_054210391

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	6	31,823,020 - 31,825,343 (-)	NCBI

RefSeq Acc Id:

XM_054354417 ⟹ XP_054210392

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	6	31,823,314 - 31,824,880 (-)	NCBI

RefSeq Acc Id:

XM_054354418 ⟹ XP_054210393

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	6	31,823,320 - 31,824,880 (-)	NCBI

RefSeq Acc Id:

XM_054354419 ⟹ XP_054210394

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	6	31,823,817 - 31,824,880 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001358134	(Get FASTA)	NCBI Sequence Viewer
	NP_001358135	(Get FASTA)	NCBI Sequence Viewer
	NP_005501	(Get FASTA)	NCBI Sequence Viewer
	XP_006715068	(Get FASTA)	NCBI Sequence Viewer
	XP_047274218	(Get FASTA)	NCBI Sequence Viewer
	XP_047274219	(Get FASTA)	NCBI Sequence Viewer
	XP_047274220	(Get FASTA)	NCBI Sequence Viewer
	XP_054185719	(Get FASTA)	NCBI Sequence Viewer
	XP_054185720	(Get FASTA)	NCBI Sequence Viewer
	XP_054185721	(Get FASTA)	NCBI Sequence Viewer
	XP_054186212	(Get FASTA)	NCBI Sequence Viewer
	XP_054186213	(Get FASTA)	NCBI Sequence Viewer
	XP_054186754	(Get FASTA)	NCBI Sequence Viewer
	XP_054186755	(Get FASTA)	NCBI Sequence Viewer
	XP_054186756	(Get FASTA)	NCBI Sequence Viewer
	XP_054186990	(Get FASTA)	NCBI Sequence Viewer
	XP_054186991	(Get FASTA)	NCBI Sequence Viewer
	XP_054186992	(Get FASTA)	NCBI Sequence Viewer
	XP_054187256	(Get FASTA)	NCBI Sequence Viewer
	XP_054187257	(Get FASTA)	NCBI Sequence Viewer
	XP_054187258	(Get FASTA)	NCBI Sequence Viewer
	XP_054210391	(Get FASTA)	NCBI Sequence Viewer
	XP_054210392	(Get FASTA)	NCBI Sequence Viewer
	XP_054210393	(Get FASTA)	NCBI Sequence Viewer
	XP_054210394	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB67983	(Get FASTA)	NCBI Sequence Viewer
	AAC78603	(Get FASTA)	NCBI Sequence Viewer
	AAC78604	(Get FASTA)	NCBI Sequence Viewer
	AAC78605	(Get FASTA)	NCBI Sequence Viewer
	AAH09344	(Get FASTA)	NCBI Sequence Viewer
	AAH19083	(Get FASTA)	NCBI Sequence Viewer
	AQY76798	(Get FASTA)	NCBI Sequence Viewer
	AQY76799	(Get FASTA)	NCBI Sequence Viewer
	AQY76800	(Get FASTA)	NCBI Sequence Viewer
	AQY76801	(Get FASTA)	NCBI Sequence Viewer
	AQY76802	(Get FASTA)	NCBI Sequence Viewer
	AQY76803	(Get FASTA)	NCBI Sequence Viewer
	CAB89305	(Get FASTA)	NCBI Sequence Viewer
	CAB89306	(Get FASTA)	NCBI Sequence Viewer
	EAX03558	(Get FASTA)	NCBI Sequence Viewer
	EAX03559	(Get FASTA)	NCBI Sequence Viewer
	EAX03560	(Get FASTA)	NCBI Sequence Viewer
	EAX03561	(Get FASTA)	NCBI Sequence Viewer
	EAX03562	(Get FASTA)	NCBI Sequence Viewer
	EAX03563	(Get FASTA)	NCBI Sequence Viewer
	EAX03564	(Get FASTA)	NCBI Sequence Viewer
	EAX03565	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000337759
	ENSP00000337759.5
	ENSP00000364498
	ENSP00000364498.3
	ENSP00000364505
	ENSP00000364505.3
	ENSP00000372820.4
	ENSP00000382818.1
	ENSP00000382819.1
	ENSP00000391123.2
	ENSP00000391349.1
	ENSP00000391532.2
	ENSP00000394167.1
	ENSP00000395262.1
	ENSP00000400173.1
	ENSP00000401315.1
	ENSP00000406143.1
	ENSP00000410404.2
	ENSP00000411380.2
	ENSP00000413860.1
	ENSP00000415675.1
	ENSP00000418632
	ENSP00000418632.1
	ENSP00000419588.1
GenBank Protein	O77932	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_005501 ⟸ NM_005510
- Peptide Label:	isoform 2
- UniProtKB:	Q6IPZ2 (UniProtKB/Swiss-Prot), Q5ST60 (UniProtKB/Swiss-Prot), O78128 (UniProtKB/Swiss-Prot), O78127 (UniProtKB/Swiss-Prot), O15004 (UniProtKB/Swiss-Prot), B0UZ80 (UniProtKB/Swiss-Prot), A2CER3 (UniProtKB/Swiss-Prot), Q9NPK4 (UniProtKB/Swiss-Prot), O77932 (UniProtKB/Swiss-Prot), A0A024RCW8 (UniProtKB/TrEMBL), A0A1U9X7P1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDPRGTKRGAEKTEVAEPRNKLPRPAPSLPTDPALYSGPFPFYRRPSELGCFSLDAQRQYHGDA RALRYYSPPPTNGPGPNFDLRDGYPDRYQPRDEEVQERLDHLLCWLLEHRGRLEGGPGWLAEAI VTWRGHLTKLLTTPYERQEGWQLAASRFQGTLYLSEVETPNARAQRLARPPLLRELMYMGYKFE QYMCADKPGSSPDPSGEVNTNVAFCSVLRSRLGSHPLLFSGEVDCTDPQAPSTQPPTCYVELKT SKEMHSPGQWRSFYRHKLLKWWAQSFLPGVPNVVAGFRNPDGFVSSLKTFPTMKMFEYVRNDRD GWNPSVCMNFCAAFLSFAQSTVVQDDPRLVHLFSWEPGGPVTVSVHQDAPYAFLPIWYVEAMTQ DLPSPPKTPSPK hide sequence

RefSeq Acc Id:	XP_006715068 ⟸ XM_006715005
- Peptide Label:	isoform X1
- UniProtKB:	Q6IPZ2 (UniProtKB/Swiss-Prot), Q5ST60 (UniProtKB/Swiss-Prot), O78128 (UniProtKB/Swiss-Prot), O78127 (UniProtKB/Swiss-Prot), O15004 (UniProtKB/Swiss-Prot), B0UZ80 (UniProtKB/Swiss-Prot), A2CER3 (UniProtKB/Swiss-Prot), Q9NPK4 (UniProtKB/Swiss-Prot), O77932 (UniProtKB/Swiss-Prot), A0A024RCW8 (UniProtKB/TrEMBL), A0A1U9X7P1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDPRGTKRGAEKTEVAEPRNKLPRPAPSLPTDPALYSGPFPFYRRPSELGCFSLDAQRQYHGDA RALRYYSPPPTNGPGPNFDLRDGYPDRYQPRDEEVQERLDHLLCWLLEHRGRLEGGPGWLAEAI VTWRGHLTKLLTTPYERQEGWQLAASRFQGTLYLSEVETPNARAQRLARPPLLRELMYMGYKFE QYMCADKPGSSPDPSGEVNTNVAFCSVLRSRLGSHPLLFSGEVDCTDPQAPSTQPPTCYVELKT SKEMHSPGQWRSFYRHKLLKWWAQSFLPGVPNVVAGFRNPDGFVSSLKTFPTMKMFEYVRNDRD GWNPSVCMNFCAAFLSFAQSTVVQDDPRLVHLFSWEPGGPVTVSVHQDAPYAFLPIWYVEAMTQ DLPSPPKTPSPK hide sequence

RefSeq Acc Id:	NP_001358135 ⟸ NM_001371206
- Peptide Label:	isoform 1
- UniProtKB:	H7C5D2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001358134 ⟸ NM_001371205
- Peptide Label:	isoform 1
- UniProtKB:	H7C5D2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSP00000364498 ⟸ ENST00000375349

Ensembl Acc Id:

ENSP00000364505 ⟸ ENST00000375356

Ensembl Acc Id:

ENSP00000337759 ⟸ ENST00000337523

Ensembl Acc Id:

ENSP00000418632 ⟸ ENST00000480240

Ensembl Acc Id:

ENSP00000419588 ⟸ ENST00000495340

RefSeq Acc Id:	XP_047274218 ⟸ XM_047418262
- Peptide Label:	isoform X1
- UniProtKB:	Q6IPZ2 (UniProtKB/Swiss-Prot), Q5ST60 (UniProtKB/Swiss-Prot), O78128 (UniProtKB/Swiss-Prot), O78127 (UniProtKB/Swiss-Prot), O77932 (UniProtKB/Swiss-Prot), O15004 (UniProtKB/Swiss-Prot), B0UZ80 (UniProtKB/Swiss-Prot), A2CER3 (UniProtKB/Swiss-Prot), Q9NPK4 (UniProtKB/Swiss-Prot), A0A024RCW8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_047274219 ⟸ XM_047418263
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_047274220 ⟸ XM_047418264
- Peptide Label:	isoform X3
- UniProtKB:	F8WC68 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054210391 ⟸ XM_054354416
- Peptide Label:	isoform X1
- UniProtKB:	Q5ST60 (UniProtKB/Swiss-Prot), O78128 (UniProtKB/Swiss-Prot), O78127 (UniProtKB/Swiss-Prot), O77932 (UniProtKB/Swiss-Prot), O15004 (UniProtKB/Swiss-Prot), B0UZ80 (UniProtKB/Swiss-Prot), A2CER3 (UniProtKB/Swiss-Prot), Q6IPZ2 (UniProtKB/Swiss-Prot), Q9NPK4 (UniProtKB/Swiss-Prot), A0A024RCW8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054210392 ⟸ XM_054354417
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_054210393 ⟸ XM_054354418
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_054210394 ⟸ XM_054354419
- Peptide Label:	isoform X3
- UniProtKB:	F8WC68 (UniProtKB/TrEMBL)

Protein Domains

RAI1-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O77932-F1-model_v2	AlphaFold	O77932	1-396	view protein structure

Promoters

RGD ID:

6872698

Promoter ID:

EPDNEW_H9514

Type:

initiation region

Name:

DXO_2

Description:

decapping exoribonuclease

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H9515 EPDNEW_H9516

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,971,972 - 31,972,032	EPDNEW

RGD ID:

6872700

Promoter ID:

EPDNEW_H9515

Type:

initiation region

Name:

DXO_1

Description:

decapping exoribonuclease

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H9514 EPDNEW_H9516

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,972,138 - 31,972,198	EPDNEW

RGD ID:

6872702

Promoter ID:

EPDNEW_H9516

Type:

initiation region

Name:

DXO_3

Description:

decapping exoribonuclease

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H9514 EPDNEW_H9515

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,972,248 - 31,972,308	EPDNEW

RGD ID:

6803948

Promoter ID:

HG_KWN:53034

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000375349, OTTHUMT00000076590, OTTHUMT00000076591, OTTHUMT00000268627, OTTHUMT00000268629, OTTHUMT00000268631, OTTHUMT00000268632, OTTHUMT00000268633, OTTHUMT00000268634, OTTHUMT00000268635, OTTHUMT00000268636, OTTHUMT00000268637, UC003NYO.1, UC003NYQ.1, UC003NYU.1, UC010JTL.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	6	32,046,761 - 32,049,007 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:2992	AgrOrtholog
COSMIC	DXO	COSMIC
Ensembl Genes	ENSG00000204348	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000206346	UniProtKB/Swiss-Prot
	ENSG00000224313	UniProtKB/Swiss-Prot
	ENSG00000225682	UniProtKB/Swiss-Prot
	ENSG00000234798	UniProtKB/Swiss-Prot
	ENSG00000236765	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000337523	ENTREZGENE
	ENST00000337523.10	UniProtKB/Swiss-Prot
	ENST00000375349	ENTREZGENE
	ENST00000375349.7	UniProtKB/Swiss-Prot
	ENST00000375356	ENTREZGENE
	ENST00000375356.7	UniProtKB/Swiss-Prot
	ENST00000383330.4	UniProtKB/Swiss-Prot
	ENST00000399936.5	UniProtKB/Swiss-Prot
	ENST00000399937.5	UniProtKB/Swiss-Prot
	ENST00000414092.2	UniProtKB/Swiss-Prot
	ENST00000419797.6	UniProtKB/Swiss-Prot
	ENST00000426498.5	UniProtKB/Swiss-Prot
	ENST00000427627.1	UniProtKB/Swiss-Prot
	ENST00000427690.5	UniProtKB/Swiss-Prot
	ENST00000432110.5	UniProtKB/Swiss-Prot
	ENST00000439989.5	UniProtKB/Swiss-Prot
	ENST00000443250.5	UniProtKB/Swiss-Prot
	ENST00000446967.5	UniProtKB/Swiss-Prot
	ENST00000453742.2	UniProtKB/Swiss-Prot
	ENST00000454430.2	UniProtKB/Swiss-Prot
	ENST00000458308.5	UniProtKB/Swiss-Prot
	ENST00000474587	ENTREZGENE
	ENST00000480240	ENTREZGENE
	ENST00000480240.5	UniProtKB/TrEMBL
	ENST00000495340.5	UniProtKB/TrEMBL
GTEx	ENSG00000204348	GTEx
	ENSG00000206346	GTEx
	ENSG00000224313	GTEx
	ENSG00000225682	GTEx
	ENSG00000234798	GTEx
	ENSG00000236765	GTEx
HGNC ID	HGNC:2992	ENTREZGENE
Human Proteome Map	DXO	Human Proteome Map
InterPro	RAI1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RAI1-like_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:1797	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	1797	ENTREZGENE
OMIM	605996	OMIM
PANTHER	DECAPPING AND EXORIBONUCLEASE PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12395	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RAI1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA27458	PharmGKB
UniProt	A0A024RCW8	ENTREZGENE, UniProtKB/TrEMBL
	A0A1U9X7N5	ENTREZGENE, UniProtKB/TrEMBL
	A0A1U9X7P1	ENTREZGENE, UniProtKB/TrEMBL
	A2CER3	ENTREZGENE
	B0UZ80	ENTREZGENE
	DXO_HUMAN	UniProtKB/Swiss-Prot
	F8WC68	ENTREZGENE, UniProtKB/TrEMBL
	H7C5D2	ENTREZGENE, UniProtKB/TrEMBL
	O15004	ENTREZGENE
	O77932	ENTREZGENE
	O78127	ENTREZGENE
	O78128	ENTREZGENE
	Q5ST60	ENTREZGENE
	Q6IPZ2	ENTREZGENE
	Q9NPK4	ENTREZGENE
UniProt Secondary	A2CER3	UniProtKB/Swiss-Prot
	B0UZ80	UniProtKB/Swiss-Prot
	O15004	UniProtKB/Swiss-Prot
	O78127	UniProtKB/Swiss-Prot
	O78128	UniProtKB/Swiss-Prot
	Q5ST60	UniProtKB/Swiss-Prot
	Q6IPZ2	UniProtKB/Swiss-Prot
	Q9NPK4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-17	DXO	decapping exoribonuclease	DOM3Z	dom-3 homolog Z (C. elegans)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations