DXO (decapping exoribonuclease) - Rat Genome Database
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Gene: DXO (decapping exoribonuclease) Homo sapiens
Analyze
Symbol: DXO
Name: decapping exoribonuclease
RGD ID: 1348619
HGNC Page HGNC
Description: Predicted to have several functions, including 5'-3' exonuclease activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; and magnesium ion binding activity. Involved in NAD-cap decapping and mRNA catabolic process. Localizes to cytosol; nucleoplasm; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5'-3' exoribonuclease DXO; decapping and exoribonuclease protein; deNADding enzyme DXO; DOM3L; DOM3Z; NAD-capped RNA hydrolase DXO; NG6; RAI1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,969,810 - 31,972,290 (-)EnsemblGRCh38hg38GRCh38
GRCh38631,969,811 - 31,972,290 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,937,588 - 31,940,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,045,567 - 32,048,011 (-)NCBINCBI36hg18NCBI36
Build 34632,045,566 - 32,048,011NCBI
Celera633,537,350 - 33,539,794 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,724,525 - 31,726,969 (-)NCBIHuRef
CHM1_1631,939,669 - 31,942,113 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)
plasma membrane  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9799600   PMID:10072631   PMID:10686478   PMID:12477932   PMID:14574404   PMID:14656967   PMID:14667819   PMID:15231747   PMID:15489334   PMID:19204726   PMID:19913121   PMID:20628086  
PMID:21323541   PMID:21873635   PMID:23263863   PMID:23455924   PMID:23523372   PMID:23535732   PMID:26186194   PMID:26344197   PMID:28283058   PMID:28514442   PMID:28986522   PMID:29601584  
PMID:29672716   PMID:30021884   PMID:31101919   PMID:31164795  


Genomics

Comparative Map Data
DXO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,969,810 - 31,972,290 (-)EnsemblGRCh38hg38GRCh38
GRCh38631,969,811 - 31,972,290 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,937,588 - 31,940,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,045,567 - 32,048,011 (-)NCBINCBI36hg18NCBI36
Build 34632,045,566 - 32,048,011NCBI
Celera633,537,350 - 33,539,794 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,724,525 - 31,726,969 (-)NCBIHuRef
CHM1_1631,939,669 - 31,942,113 (-)NCBICHM1_1
Dxo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,055,972 - 35,058,162 (+)NCBIGRCm39mm39
GRCm381734,836,996 - 34,839,187 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,837,019 - 34,839,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,973,964 - 34,976,131 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,445,139 - 34,447,289 (+)NCBImm8
Celera1737,932,348 - 37,934,515 (+)NCBICelera
Cytogenetic Map17B1NCBI
Dxo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0204,517,307 - 4,519,391 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,517,307 - 4,519,389 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,597,106 - 6,599,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,093,718 - 4,095,802 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,093,893 - 4,096,049 (-)NCBI
Celera204,035,291 - 4,037,375 (+)NCBICelera
Cytogenetic Map20p12NCBI
Dxo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437481,554 - 484,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437482,866 - 484,989 (-)NCBIChiLan1.0ChiLan1.0
DXO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,517,086 - 32,519,566 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,517,086 - 32,519,566 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,630,523 - 31,632,363 (-)NCBIMhudiblu_PPA_v0panPan3
DXO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl121,424,591 - 1,426,452 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1121,424,584 - 1,426,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dxo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367271,576,823 - 1,579,158 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DXO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,050,397 - 24,059,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,057,670 - 24,060,108 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,752,093 - 27,754,531 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DXO
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,049,679 - 40,052,114 (+)NCBI
ChlSab1.1 Ensembl1740,050,257 - 40,052,050 (+)Ensembl
Dxo
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,281,099 - 24,283,403 (+)NCBI

Position Markers
WI-16314  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,937,397 - 31,937,513UniSTSGRCh37
Build 36632,045,376 - 32,045,492RGDNCBI36
Celera633,537,159 - 33,537,275RGD
Cytogenetic Map6p21UniSTS
Cytogenetic Map6p21.3UniSTS
HuRef631,724,334 - 31,724,450UniSTS
GeneMap99-GB4 RH Map6120.15UniSTS
Whitehead-RH Map6177.9UniSTS
NCBI RH Map6509.1UniSTS
DOM3Z  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,938,427 - 31,938,623UniSTSGRCh37
Celera633,538,189 - 33,538,385UniSTS
HuRef631,725,364 - 31,725,560UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2920
Count of miRNA genes:767
Interacting mature miRNAs:928
Transcripts:ENST00000337523, ENST00000375349, ENST00000375356, ENST00000460058, ENST00000473976, ENST00000474587, ENST00000477826, ENST00000478221, ENST00000480240, ENST00000485557, ENST00000487914, ENST00000491327, ENST00000492946, ENST00000495340, ENST00000498357
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2407 2248 1685 587 1455 431 3730 1337 3299 353 1438 1582 169 1203 2171 3
Low 30 741 41 36 496 34 626 859 435 66 21 31 5 1 1 617 2 1
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001371205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_926082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF019413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR753822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR753845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000337523   ⟹   ENSP00000337759
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,815 - 31,972,138 (-)Ensembl
RefSeq Acc Id: ENST00000375349   ⟹   ENSP00000364498
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,813 - 31,972,290 (-)Ensembl
RefSeq Acc Id: ENST00000375356   ⟹   ENSP00000364505
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,844 - 31,971,984 (-)Ensembl
RefSeq Acc Id: ENST00000460058
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,970,898 - 31,972,009 (-)Ensembl
RefSeq Acc Id: ENST00000473976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,815 - 31,972,095 (-)Ensembl
RefSeq Acc Id: ENST00000474587
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,948 - 31,972,098 (-)Ensembl
RefSeq Acc Id: ENST00000477826
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,810 - 31,972,252 (-)Ensembl
RefSeq Acc Id: ENST00000478221
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,817 - 31,972,238 (-)Ensembl
RefSeq Acc Id: ENST00000480240   ⟹   ENSP00000418632
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,907 - 31,972,136 (-)Ensembl
RefSeq Acc Id: ENST00000485557
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,810 - 31,972,209 (-)Ensembl
RefSeq Acc Id: ENST00000487914
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,970,643 - 31,971,989 (-)Ensembl
RefSeq Acc Id: ENST00000491327
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,810 - 31,971,685 (-)Ensembl
RefSeq Acc Id: ENST00000492946
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,970,442 - 31,972,162 (-)Ensembl
RefSeq Acc Id: ENST00000495340   ⟹   ENSP00000419588
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,815 - 31,970,923 (-)Ensembl
RefSeq Acc Id: ENST00000498357
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,969,887 - 31,971,683 (-)Ensembl
RefSeq Acc Id: NM_001371205   ⟹   NP_001358134
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,815 - 31,972,138 (-)NCBI
RefSeq Acc Id: NM_001371206   ⟹   NP_001358135
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,815 - 31,972,138 (-)NCBI
RefSeq Acc Id: NM_005510   ⟹   NP_005501
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,815 - 31,972,138 (-)NCBI
GRCh37631,937,588 - 31,940,032 (-)RGD
Build 36632,045,567 - 32,048,011 (-)NCBI Archive
Celera633,537,350 - 33,539,794 (-)RGD
HuRef631,724,525 - 31,726,969 (-)RGD
CHM1_1631,939,669 - 31,942,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006715005   ⟹   XP_006715068
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,812 - 31,972,290 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002956262
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,811 - 31,972,254 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002956263
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,811 - 31,972,254 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002956264
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,811 - 31,972,254 (-)NCBI
Sequence:
RefSeq Acc Id: XR_926082
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,969,811 - 31,971,988 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005501   ⟸   NM_005510
- Peptide Label: isoform 2
- UniProtKB: O77932 (UniProtKB/Swiss-Prot),   A0A024RCW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006715068   ⟸   XM_006715005
- Peptide Label: isoform X1
- UniProtKB: O77932 (UniProtKB/Swiss-Prot),   A0A024RCW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001358135   ⟸   NM_001371206
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001358134   ⟸   NM_001371205
- Peptide Label: isoform 1
RefSeq Acc Id: ENSP00000364498   ⟸   ENST00000375349
RefSeq Acc Id: ENSP00000364505   ⟸   ENST00000375356
RefSeq Acc Id: ENSP00000337759   ⟸   ENST00000337523
RefSeq Acc Id: ENSP00000418632   ⟸   ENST00000480240
RefSeq Acc Id: ENSP00000419588   ⟸   ENST00000495340
Protein Domains
RAI1

Promoters
RGD ID:6872698
Promoter ID:EPDNEW_H9514
Type:initiation region
Name:DXO_2
Description:decapping exoribonuclease
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9515  EPDNEW_H9516  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,971,972 - 31,972,032EPDNEW
RGD ID:6872700
Promoter ID:EPDNEW_H9515
Type:initiation region
Name:DXO_1
Description:decapping exoribonuclease
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9514  EPDNEW_H9516  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,972,138 - 31,972,198EPDNEW
RGD ID:6872702
Promoter ID:EPDNEW_H9516
Type:initiation region
Name:DXO_3
Description:decapping exoribonuclease
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9514  EPDNEW_H9515  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,972,248 - 31,972,308EPDNEW
RGD ID:6803948
Promoter ID:HG_KWN:53034
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000375349,   OTTHUMT00000076590,   OTTHUMT00000076591,   OTTHUMT00000268627,   OTTHUMT00000268629,   OTTHUMT00000268631,   OTTHUMT00000268632,   OTTHUMT00000268633,   OTTHUMT00000268634,   OTTHUMT00000268635,   OTTHUMT00000268636,   OTTHUMT00000268637,   UC003NYO.1,   UC003NYQ.1,   UC003NYU.1,   UC010JTL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36632,046,761 - 32,049,007 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.33(chr6:31971993-32012974)x1 copy number loss See cases [RCV000141578] Chr6:31971993..32012974 [GRCh38]
Chr6:31939770..31980751 [GRCh37]
Chr6:32047749..32088729 [NCBI36]
Chr6:6p21.33
benign
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
NM_005510.4(DXO):c.783C>A (p.His261Gln) single nucleotide variant not specified [RCV000454484] Chr6:31970635 [GRCh38]
Chr6:31938412 [GRCh37]
Chr6:6p21.33
benign
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_005510.4(DXO):c.744A>G (p.Pro248=) single nucleotide variant not specified [RCV000455129] Chr6:31970674 [GRCh38]
Chr6:31938451 [GRCh37]
Chr6:6p21.33
benign
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32
uncertain significance
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
Chr6:6p21.33-21.31
likely pathogenic
GRCh37/hg19 6p21.33-21.32(chr6:31916915-32278000)x3 copy number gain not provided [RCV001005792] Chr6:31916915..32278000 [GRCh37]
Chr6:6p21.33-21.32
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2992 AgrOrtholog
COSMIC DXO COSMIC
Ensembl Genes ENSG00000204348 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000206346 UniProtKB/Swiss-Prot
  ENSG00000224313 UniProtKB/Swiss-Prot
  ENSG00000225682 UniProtKB/Swiss-Prot
  ENSG00000234798 UniProtKB/Swiss-Prot
  ENSG00000236765 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000337759 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000364498 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000364505 UniProtKB/Swiss-Prot
  ENSP00000372820 UniProtKB/Swiss-Prot
  ENSP00000382818 UniProtKB/Swiss-Prot
  ENSP00000382819 UniProtKB/Swiss-Prot
  ENSP00000391123 UniProtKB/Swiss-Prot
  ENSP00000391349 UniProtKB/Swiss-Prot
  ENSP00000391532 UniProtKB/Swiss-Prot
  ENSP00000394167 UniProtKB/Swiss-Prot
  ENSP00000395262 UniProtKB/Swiss-Prot
  ENSP00000400173 UniProtKB/Swiss-Prot
  ENSP00000401315 UniProtKB/Swiss-Prot
  ENSP00000406143 UniProtKB/Swiss-Prot
  ENSP00000410404 UniProtKB/Swiss-Prot
  ENSP00000411380 UniProtKB/Swiss-Prot
  ENSP00000413860 UniProtKB/Swiss-Prot
  ENSP00000415675 UniProtKB/Swiss-Prot
  ENSP00000418632 UniProtKB/TrEMBL
  ENSP00000419588 UniProtKB/TrEMBL
Ensembl Transcript ENST00000337523 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000375349 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000375356 UniProtKB/Swiss-Prot
  ENST00000383330 UniProtKB/Swiss-Prot
  ENST00000399936 UniProtKB/Swiss-Prot
  ENST00000399937 UniProtKB/Swiss-Prot
  ENST00000414092 UniProtKB/Swiss-Prot
  ENST00000419797 UniProtKB/Swiss-Prot
  ENST00000426498 UniProtKB/Swiss-Prot
  ENST00000427627 UniProtKB/Swiss-Prot
  ENST00000427690 UniProtKB/Swiss-Prot
  ENST00000432110 UniProtKB/Swiss-Prot
  ENST00000439989 UniProtKB/Swiss-Prot
  ENST00000443250 UniProtKB/Swiss-Prot
  ENST00000446967 UniProtKB/Swiss-Prot
  ENST00000453742 UniProtKB/Swiss-Prot
  ENST00000454430 UniProtKB/Swiss-Prot
  ENST00000458308 UniProtKB/Swiss-Prot
  ENST00000474587 ENTREZGENE
  ENST00000480240 UniProtKB/TrEMBL
  ENST00000495340 UniProtKB/TrEMBL
GTEx ENSG00000204348 GTEx
  ENSG00000206346 GTEx
  ENSG00000224313 GTEx
  ENSG00000225682 GTEx
  ENSG00000234798 GTEx
  ENSG00000236765 GTEx
HGNC ID HGNC:2992 ENTREZGENE
Human Proteome Map DXO Human Proteome Map
InterPro RAI1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAI1-like_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1797 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1797 ENTREZGENE
OMIM 605996 OMIM
PANTHER PTHR12395 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RAI1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27458 PharmGKB
UniGene Hs.153299 ENTREZGENE
UniProt A0A024RCW8 ENTREZGENE, UniProtKB/TrEMBL
  DXO_HUMAN UniProtKB/Swiss-Prot
  F8WC68_HUMAN UniProtKB/TrEMBL
  H7C5D2_HUMAN UniProtKB/TrEMBL
  O77932 ENTREZGENE
UniProt Secondary A2CER3 UniProtKB/Swiss-Prot
  B0UZ80 UniProtKB/Swiss-Prot
  O15004 UniProtKB/Swiss-Prot
  O78127 UniProtKB/Swiss-Prot
  O78128 UniProtKB/Swiss-Prot
  Q5ST60 UniProtKB/Swiss-Prot
  Q6IPZ2 UniProtKB/Swiss-Prot
  Q9NPK4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-17 DXO  decapping exoribonuclease  DOM3Z  dom-3 homolog Z (C. elegans)  Symbol and/or name change 5135510 APPROVED