PYY (peptide YY) - Rat Genome Database

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Gene: PYY (peptide YY) Homo sapiens
Analyze
Symbol: PYY
Name: peptide YY
RGD ID: 1348512
HGNC Page HGNC:9748
Description: Enables G protein-coupled receptor binding activity. Predicted to be involved in feeding behavior and neuropeptide signaling pathway. Predicted to act upstream of or within eating behavior. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: peptide tyrosine tyrosine; prepro-PYY; PYY-I; PYY1
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: PYY2   PYY3  
Allele / Splice: See ClinVar data
Candidate Gene For: BW109_H BW110_H BW444_H BW453_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,952,733 - 44,004,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,952,733 - 44,004,469 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,030,101 - 42,081,813 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,385,632 - 39,437,363 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,385,634 - 39,437,363NCBI
Celera1738,738,148 - 38,789,925 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,794,371 - 37,846,167 (-)NCBIHuRef
CHM1_11742,265,688 - 42,317,273 (-)NCBICHM1_1
T2T-CHM13v2.01744,805,282 - 44,856,956 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Obesity  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Low serum PYY is linked to insulin resistance in first-degree relatives of subjects with type 2 diabetes. Boey D, etal., Neuropeptides. 2006 Oct;40(5):317-24. Epub 2006 Oct 12.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2587421   PMID:2721879   PMID:2834384   PMID:3202875   PMID:3517149   PMID:3840109   PMID:7493937   PMID:7592911   PMID:7782089   PMID:8318545   PMID:10029457   PMID:10488139  
PMID:10698177   PMID:11278902   PMID:11408607   PMID:11825640   PMID:11825641   PMID:11825649   PMID:11825650   PMID:11825653   PMID:11825654   PMID:11825655   PMID:11825656   PMID:12477932  
PMID:12665544   PMID:14687084   PMID:15331560   PMID:15489334   PMID:15855352   PMID:15972581   PMID:15983231   PMID:15998659   PMID:16174724   PMID:16204364   PMID:16278259   PMID:16362815  
PMID:16368708   PMID:16420657   PMID:16563563   PMID:16720664   PMID:16819834   PMID:16828127   PMID:16907966   PMID:17087952   PMID:17119001   PMID:17138722   PMID:17235527   PMID:17325259  
PMID:17597642   PMID:17726080   PMID:17934448   PMID:17936861   PMID:18154642   PMID:18239577   PMID:18486583   PMID:18534636   PMID:18567824   PMID:18577758   PMID:18622237   PMID:18929607  
PMID:18987287   PMID:19011469   PMID:19058789   PMID:19086053   PMID:19247279   PMID:19344792   PMID:19737911   PMID:19820027   PMID:19875990   PMID:19913121   PMID:20375207   PMID:20468064  
PMID:20602615   PMID:20628086   PMID:20642810   PMID:21098684   PMID:21324568   PMID:21360523   PMID:21502892   PMID:21610227   PMID:21667426   PMID:21722955   PMID:21873635   PMID:22028819  
PMID:22183081   PMID:22303574   PMID:22563842   PMID:22954902   PMID:22979996   PMID:23006423   PMID:23064014   PMID:23155335   PMID:23239758   PMID:23292145   PMID:23371976   PMID:23509106  
PMID:23519462   PMID:23597562   PMID:23831742   PMID:24001751   PMID:24012997   PMID:24188711   PMID:24743402   PMID:24969624   PMID:25127083   PMID:25361054   PMID:25494974   PMID:25568079  
PMID:25661189   PMID:25823991   PMID:25990478   PMID:26002416   PMID:26506614   PMID:26718419   PMID:26762368   PMID:27022941   PMID:27117413   PMID:27264721   PMID:27405092   PMID:27447725  
PMID:27465830   PMID:27513679   PMID:27721013   PMID:27918953   PMID:29412828   PMID:29455414   PMID:30991633   PMID:32296183   PMID:33933736   PMID:33961781   PMID:35180645   PMID:36088864  
PMID:36525977   PMID:37380814   PMID:37995867  


Genomics

Comparative Map Data
PYY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,952,733 - 44,004,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,952,733 - 44,004,469 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,030,101 - 42,081,813 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,385,632 - 39,437,363 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,385,634 - 39,437,363NCBI
Celera1738,738,148 - 38,789,925 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,794,371 - 37,846,167 (-)NCBIHuRef
CHM1_11742,265,688 - 42,317,273 (-)NCBICHM1_1
T2T-CHM13v2.01744,805,282 - 44,856,956 (-)NCBIT2T-CHM13v2.0
Pyy
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,997,502 - 101,998,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,997,502 - 101,998,658 (-)EnsemblGRCm39 Ensembl
GRCm3811102,106,676 - 102,107,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,106,676 - 102,107,832 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,967,990 - 101,969,090 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,922,766 - 101,923,866 (-)NCBIMGSCv36mm8
Celera11113,812,585 - 113,813,685 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Pyy
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,561,347 - 87,562,470 (-)NCBIGRCr8
mRatBN7.21087,061,155 - 87,062,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,061,161 - 87,061,815 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,091,005 - 92,092,128 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,562,889 - 91,564,012 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,956,205 - 86,957,328 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,047,989 - 90,049,155 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,047,993 - 90,049,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,837,470 - 89,838,642 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,174,365 - 91,175,488 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1085,778,728 - 85,779,851 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
PYY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,939,310 - 20,953,204 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,903,599 - 22,917,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,390,801 - 13,442,536 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,595,066 - 13,608,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,608,080 - 13,608,827 (+)Ensemblpanpan1.1panPan2
PYY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,370,520 - 19,386,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,775,262 - 18,776,555 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,080,778 - 20,082,071 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,081,259 - 20,082,069 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,934,071 - 18,935,364 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,117,021 - 19,118,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,261,926 - 19,263,237 (+)NCBIUU_Cfam_GSD_1.0
Pyy
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,720,794 - 18,723,792 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541470,966 - 471,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541470,806 - 471,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11219,190,703 - 19,208,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,427,298 - 19,444,944 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PYY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,405,505 - 62,441,054 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,439,813 - 62,441,031 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,214,379 - 33,215,755 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pyy
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795902,260 - 903,409 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795887,963 - 903,315 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PYY
36 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
NM_004160.4(PYY):c.-463+3717C>T single nucleotide variant Lung cancer [RCV000100471] Chr17:44000674 [GRCh38]
Chr17:42078042 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.185A>C (p.Gln62Pro) single nucleotide variant Obesity [RCV000033193] Chr17:43953299 [GRCh38]
Chr17:42030667 [GRCh37]
Chr17:17q21.31		 risk factor|uncertain significance
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31		 pathogenic
GRCh38/hg38 17q21.31(chr17:43570878-44762377)x1 copy number loss See cases [RCV000053429] Chr17:43570878..44762377 [GRCh38]
Chr17:41648246..42839745 [GRCh37]
Chr17:39003772..40195271 [NCBI36]
Chr17:17q21.31		 pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q21.31(chr17:43934167-44854025)x1 copy number loss See cases [RCV000134949] Chr17:43934167..44854025 [GRCh38]
Chr17:42011535..42931393 [GRCh37]
Chr17:39367061..40286919 [NCBI36]
Chr17:17q21.31		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_001394028.1(PYY):c.247G>A (p.Glu83Lys) single nucleotide variant not specified [RCV004333607] Chr17:43953131 [GRCh38]
Chr17:42030499 [GRCh37]
Chr17:17q21.31		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q21.31(chr17:41540257-42044249)x1 copy number loss not provided [RCV000683936] Chr17:41540257..42044249 [GRCh37]
Chr17:17q21.31		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_001394028.1(PYY):c.215C>G (p.Thr72Arg) single nucleotide variant not provided [RCV001534436] Chr17:43953163 [GRCh38]
Chr17:42030531 [GRCh37]
Chr17:17q21.31		 benign
NM_001394028.1(PYY):c.150C>T (p.Ala50=) single nucleotide variant not provided [RCV000880700] Chr17:43953334 [GRCh38]
Chr17:42030702 [GRCh37]
Chr17:17q21.31		 benign
NM_001394028.1(PYY):c.109C>G (p.Arg37Gly) single nucleotide variant not provided [RCV000947829] Chr17:43953375 [GRCh38]
Chr17:42030743 [GRCh37]
Chr17:17q21.31		 benign
NM_001394028.1(PYY):c.218T>C (p.Leu73Pro) single nucleotide variant not provided [RCV000947828] Chr17:43953160 [GRCh38]
Chr17:42030528 [GRCh37]
Chr17:17q21.31		 benign
NM_001394028.1(PYY):c.*149C>A single nucleotide variant not provided [RCV001657099] Chr17:43952807 [GRCh38]
Chr17:42030175 [GRCh37]
Chr17:17q21.31		 benign
NM_004160.6(PYY):c.-463+2622_-463+2623insC insertion not provided [RCV001609804] Chr17:44001768..44001769 [GRCh38]
Chr17:42079136..42079137 [GRCh37]
Chr17:17q21.31		 benign
NM_001394028.1(PYY):c.270-61C>T single nucleotide variant not provided [RCV001644014] Chr17:43953041 [GRCh38]
Chr17:42030409 [GRCh37]
Chr17:17q21.31		 benign
NM_004160.6(PYY):c.-463+3069G>T single nucleotide variant not provided [RCV001670381] Chr17:44001322 [GRCh38]
Chr17:42078690 [GRCh37]
Chr17:17q21.31		 benign
NM_004160.6(PYY):c.-463+2881_-463+2883del microsatellite not provided [RCV001598714] Chr17:44001508..44001510 [GRCh38]
Chr17:42078876..42078878 [GRCh37]
Chr17:17q21.31		 benign
GRCh37/hg19 17q21.31(chr17:41399892-42125780)x3 copy number gain not provided [RCV001006903] Chr17:41399892..42125780 [GRCh37]
Chr17:17q21.31		 uncertain significance
NC_000017.11:g.44001599A>T single nucleotide variant Hyperammonemia, type III [RCV001533007] Chr17:44001599 [GRCh38]
Chr17:42078967 [GRCh37]
Chr17:17q21.31		 likely pathogenic
NC_000017.11:g.44001566C>T single nucleotide variant Hyperammonemia, type III [RCV001542099]|not specified [RCV004587175] Chr17:44001566 [GRCh38]
Chr17:42078934 [GRCh37]
Chr17:17q21.31		 likely pathogenic|uncertain significance
NM_004160.6(PYY):c.-114G>A single nucleotide variant not provided [RCV004710345]|not specified [RCV001733609] Chr17:43953963 [GRCh38]
Chr17:42031331 [GRCh37]
Chr17:17q21.31		 benign
NM_001394028.1(PYY):c.178A>G (p.Thr60Ala) single nucleotide variant not specified [RCV004321579] Chr17:43953306 [GRCh38]
Chr17:42030674 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.232T>G (p.Phe78Val) single nucleotide variant not specified [RCV004132206] Chr17:43953146 [GRCh38]
Chr17:42030514 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.149C>T (p.Ala50Val) single nucleotide variant not specified [RCV004123439] Chr17:43953335 [GRCh38]
Chr17:42030703 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.209C>T (p.Pro70Leu) single nucleotide variant not specified [RCV004154374] Chr17:43953169 [GRCh38]
Chr17:42030537 [GRCh37]
Chr17:17q21.31		 uncertain significance
NC_000017.11:g.44001638C>T single nucleotide variant Hyperammonemia, type III [RCV002620899] Chr17:44001638 [GRCh38]
Chr17:42079006 [GRCh37]
Chr17:17q21.31		 conflicting interpretations of pathogenicity|uncertain significance
NM_001394028.1(PYY):c.251A>G (p.Asp84Gly) single nucleotide variant not specified [RCV004173625] Chr17:43953127 [GRCh38]
Chr17:42030495 [GRCh37]
Chr17:17q21.31		 uncertain significance
GRCh38/hg38 17q21.31(chr17:43603558-44033313) copy number gain Anomalous pulmonary venous return [RCV003223581] Chr17:43603558..44033313 [GRCh38]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.241G>A (p.Asp81Asn) single nucleotide variant not specified [RCV004250253] Chr17:43953137 [GRCh38]
Chr17:42030505 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.190T>G (p.Tyr64Asp) single nucleotide variant not specified [RCV004338292] Chr17:43953188 [GRCh38]
Chr17:42030556 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.172C>A (p.Leu58Met) single nucleotide variant not specified [RCV004352563] Chr17:43953312 [GRCh38]
Chr17:42030680 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.226A>G (p.Lys76Glu) single nucleotide variant not specified [RCV004351341] Chr17:43953152 [GRCh38]
Chr17:42030520 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.272C>T (p.Ser91Leu) single nucleotide variant not specified [RCV004440684] Chr17:43952978 [GRCh38]
Chr17:42030346 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.40G>C (p.Val14Leu) single nucleotide variant not specified [RCV004440685] Chr17:43953444 [GRCh38]
Chr17:42030812 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.14G>A (p.Arg5His) single nucleotide variant not specified [RCV004440682] Chr17:43953470 [GRCh38]
Chr17:42030838 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.209C>G (p.Pro70Arg) single nucleotide variant not specified [RCV004440683] Chr17:43953169 [GRCh38]
Chr17:42030537 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.178A>C (p.Thr60Pro) single nucleotide variant not specified [RCV004662875] Chr17:43953306 [GRCh38]
Chr17:42030674 [GRCh37]
Chr17:17q21.31		 uncertain significance
Single allele deletion Breast-ovarian cancer, familial, susceptibility to, 1 [RCV004759420] Chr17:41231503..41277589 [GRCh37]
Chr17:17q21.31-22		 pathogenic
GRCh37/hg19 17q12-22(chr17:41196270-41277589) copy number loss Breast-ovarian cancer, familial, susceptibility to, 1 [RCV004759419] Chr17:41196270..41277589 [GRCh37]
Chr17:17q12-22		 pathogenic
NM_001394028.1(PYY):c.182G>T (p.Arg61Leu) single nucleotide variant not specified [RCV004851858] Chr17:43953302 [GRCh38]
Chr17:42030670 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.221T>C (p.Leu74Pro) single nucleotide variant not specified [RCV004851859] Chr17:43953157 [GRCh38]
Chr17:42030525 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.139C>A (p.Arg47Ser) single nucleotide variant not specified [RCV004851857] Chr17:43953345 [GRCh38]
Chr17:42030713 [GRCh37]
Chr17:17q21.31		 uncertain significance
NM_001394028.1(PYY):c.196A>C (p.Lys66Gln) single nucleotide variant not specified [RCV004851860] Chr17:43953182 [GRCh38]
Chr17:42030550 [GRCh37]
Chr17:17q21.31		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:715
Count of miRNA genes:386
Interacting mature miRNAs:423
Transcripts:ENST00000360085, ENST00000592796
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597376218GWAS1472292_Hgut microbiome measurement QTL GWAS1472292 (human)0.0000003gut microbiome measurement174398056943980570Human
597431165GWAS1527239_Hdiverticular disease QTL GWAS1527239 (human)0.000005diverticular disease174399416943994170Human
597474446GWAS1570520_HDNA methylation QTL GWAS1570520 (human)3e-08DNA methylation174398150543981506Human
597360025GWAS1456099_Htrait in response to paclitaxel QTL GWAS1456099 (human)0.000009trait in response to paclitaxel174398761943987620Human
597520920GWAS1616994_HTinnitus QTL GWAS1616994 (human)0.000003Tinnitus174398920843989209Human
597468795GWAS1564869_Hfish oil supplement exposure measurement, high density lipoprotein cholesterol measurement QTL GWAS1564869 (human)3e-16fish oil supplement exposure measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)174398390943983910Human
597479110GWAS1575184_Hblood protein measurement QTL GWAS1575184 (human)2e-14blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)174396343943963440Human
597359271GWAS1455345_Hpulse pressure measurement QTL GWAS1455345 (human)4e-08pulse pressure measurementpulse pressure (CMO:0000292)174398326343983264Human
597374950GWAS1471024_Hresponse to trauma exposure QTL GWAS1471024 (human)0.000007response to trauma exposure174399759243997593Human
597392020GWAS1488094_Htriglyceride measurement QTL GWAS1488094 (human)1e-15triglyceride measurementblood triglyceride level (CMO:0000118)174395440243954403Human

Markers in Region
RH80747  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371742,030,263 - 42,030,464UniSTSGRCh37
Build 361739,385,789 - 39,385,990RGDNCBI36
Celera1738,738,305 - 38,738,506RGD
Cytogenetic Map17q21.1UniSTS
HuRef1737,794,528 - 37,794,729UniSTS
D17S1206  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371742,044,822 - 42,044,992UniSTSGRCh37
Build 361739,400,348 - 39,400,518RGDNCBI36
Celera1738,752,878 - 38,753,048RGD
Cytogenetic Map17q21.1UniSTS
HuRef1737,809,107 - 37,809,277UniSTS
PYY_s24  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371726,554,410 - 26,555,067UniSTSGRCh37
GRCh371742,030,125 - 42,030,773UniSTSGRCh37
Celera1723,416,142 - 23,416,799UniSTS
Celera1738,738,167 - 38,738,815UniSTS
HuRef1737,794,390 - 37,795,038UniSTS
HuRef1722,762,439 - 22,763,096UniSTS
UniSTS:480767  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371742,030,237 - 42,031,287UniSTSGRCh37
Celera1738,738,279 - 38,739,329UniSTS
HuRef1737,794,502 - 37,795,552UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
681 1864 1810 1148 4278 1406 2000 4 464 1142 392 1732 4512 3567 50 3324 726 1488 1394 84

Sequence


Ensembl Acc Id: ENST00000360085   ⟹   ENSP00000353198
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1743,952,738 - 44,004,469 (-)Ensembl
Ensembl Acc Id: ENST00000592796   ⟹   ENSP00000467310
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1743,952,741 - 43,953,940 (-)Ensembl
Ensembl Acc Id: ENST00000692052   ⟹   ENSP00000509262
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1743,952,733 - 43,953,940 (-)Ensembl
RefSeq Acc Id: NM_001394028   ⟹   NP_001380957
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381743,952,733 - 43,953,940 (-)NCBI
T2T-CHM13v2.01744,805,282 - 44,806,489 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394029   ⟹   NP_001380958
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381743,952,733 - 43,953,940 (-)NCBI
T2T-CHM13v2.01744,805,282 - 44,806,489 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004160   ⟹   NP_004151
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381743,952,733 - 44,004,445 (-)NCBI
GRCh371742,030,101 - 42,081,837 (-)NCBI
Build 361739,385,632 - 39,437,363 (-)NCBI Archive
HuRef1737,794,371 - 37,846,167 (-)ENTREZGENE
CHM1_11742,265,683 - 42,317,273 (-)NCBI
T2T-CHM13v2.01744,805,282 - 44,856,956 (-)NCBI
Sequence:
RefSeq Acc Id: NP_004151   ⟸   NM_004160
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q5U5Q6 (UniProtKB/Swiss-Prot),   P10082 (UniProtKB/Swiss-Prot),   Q6FGH8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000353198   ⟸   ENST00000360085
Ensembl Acc Id: ENSP00000467310   ⟸   ENST00000592796
RefSeq Acc Id: NP_001380957   ⟸   NM_001394028
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q5U5Q6 (UniProtKB/Swiss-Prot),   P10082 (UniProtKB/Swiss-Prot),   Q6FGH8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001380958   ⟸   NM_001394029
- Peptide Label: isoform 2 precursor
Ensembl Acc Id: ENSP00000509262   ⟸   ENST00000692052

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10082-F1-model_v2 AlphaFold P10082 1-97 view protein structure

Promoters
RGD ID:7235215
Promoter ID:EPDNEW_H23353
Type:multiple initiation site
Name:PYY_1
Description:peptide YY
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23354  EPDNEW_H23355  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381743,953,940 - 43,954,000EPDNEW
RGD ID:7235217
Promoter ID:EPDNEW_H23354
Type:multiple initiation site
Name:PYY_3
Description:peptide YY
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23353  EPDNEW_H23355  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381743,982,577 - 43,982,637EPDNEW
RGD ID:7235219
Promoter ID:EPDNEW_H23355
Type:initiation region
Name:PYY_2
Description:peptide YY
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23353  EPDNEW_H23354  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381744,004,445 - 44,004,505EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9748 AgrOrtholog
COSMIC PYY COSMIC
Ensembl Genes ENSG00000131096 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000360085 ENTREZGENE
  ENST00000360085.6 UniProtKB/Swiss-Prot
  ENST00000592796 ENTREZGENE
  ENST00000592796.2 UniProtKB/Swiss-Prot
  ENST00000692052 ENTREZGENE
  ENST00000692052.1 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.900 UniProtKB/Swiss-Prot
GTEx ENSG00000131096 GTEx
HGNC ID HGNC:9748 ENTREZGENE
Human Proteome Map PYY Human Proteome Map
InterPro Pancreatic_hormone-like UniProtKB/Swiss-Prot
  Pancreatic_hormone-like_CS UniProtKB/Swiss-Prot
KEGG Report hsa:5697 UniProtKB/Swiss-Prot
NCBI Gene 5697 ENTREZGENE
OMIM 600781 OMIM
PANTHER PEPTIDE YY-RELATED UniProtKB/Swiss-Prot
  PTHR10533 UniProtKB/Swiss-Prot
Pfam Hormone_3 UniProtKB/Swiss-Prot
PharmGKB PA34090 PharmGKB
PRINTS PANCHORMONE UniProtKB/Swiss-Prot
PROSITE PANCREATIC_HORMONE_1 UniProtKB/Swiss-Prot
  PANCREATIC_HORMONE_2 UniProtKB/Swiss-Prot
SMART PAH UniProtKB/Swiss-Prot
UniProt P10082 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5U5Q6 ENTREZGENE
  Q6FGH8 ENTREZGENE
UniProt Secondary Q5U5Q6 UniProtKB/Swiss-Prot
  Q6FGH8 UniProtKB/Swiss-Prot