CA11 (carbonic anhydrase 11) - Rat Genome Database

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Gene: CA11 (carbonic anhydrase 11) Homo sapiens
Analyze
Symbol: CA11
Name: carbonic anhydrase 11
RGD ID: 1348503
HGNC Page HGNC
Description: Predicted to have hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Predicted to localize to basolateral plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CA-RP; CA-RP II; CA-XI; carbonic anhydrase XI; carbonic anhydrase-related protein 11; carbonic anhydrase-related protein 2; carbonic anhydrase-related protein XI; CARP XI; CARP-2; CARP2; CARPX1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,637,946 - 48,646,187 (-)EnsemblGRCh38hg38GRCh38
GRCh381948,637,946 - 48,646,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,141,203 - 49,149,444 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,833,084 - 53,841,263 (-)NCBINCBI36hg18NCBI36
Build 341953,833,083 - 53,841,065NCBI
Celera1946,006,137 - 46,014,315 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,520,726 - 45,528,907 (-)NCBIHuRef
CHM1_11949,143,073 - 49,151,416 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (HEP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9878252   PMID:9878543   PMID:10350627   PMID:11311946   PMID:12044474   PMID:12477932   PMID:12975309   PMID:15489334   PMID:16335952   PMID:17113583   PMID:21060863   PMID:21873635  
PMID:21926972   PMID:23300138   PMID:24941225   PMID:26186194   PMID:28514442   PMID:29792187   PMID:29987050   PMID:30636076  


Genomics

Comparative Map Data
CA11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,637,946 - 48,646,187 (-)EnsemblGRCh38hg38GRCh38
GRCh381948,637,946 - 48,646,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,141,203 - 49,149,444 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,833,084 - 53,841,263 (-)NCBINCBI36hg18NCBI36
Build 341953,833,083 - 53,841,065NCBI
Celera1946,006,137 - 46,014,315 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,520,726 - 45,528,907 (-)NCBIHuRef
CHM1_11949,143,073 - 49,151,416 (-)NCBICHM1_1
Car11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,348,537 - 45,354,111 (+)NCBIGRCm39mm39
GRCm39 Ensembl745,349,267 - 45,354,106 (+)Ensembl
GRCm38745,699,171 - 45,704,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,699,843 - 45,704,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,955,337 - 52,960,041 (+)NCBIGRCm37mm9NCBIm37
MGSCv36745,568,009 - 45,572,713 (+)NCBImm8
Celera741,162,525 - 41,167,228 (+)NCBICelera
Cytogenetic Map7B3NCBI
Ca11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,169,900 - 96,175,191 (+)NCBI
Rnor_6.0 Ensembl1101,682,172 - 101,687,293 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,682,009 - 101,687,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,760,809 - 102,766,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,167,823 - 96,172,934 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,245,933 - 96,251,046 (+)NCBI
Celera190,423,279 - 90,428,390 (+)NCBICelera
Cytogenetic Map1q22NCBI
Ca11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,910,421 - 1,916,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,910,421 - 1,914,988 (+)NCBIChiLan1.0ChiLan1.0
CA11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,231,798 - 54,240,248 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,231,798 - 54,240,247 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,639,401 - 45,647,555 (-)NCBIMhudiblu_PPA_v0panPan3
CA11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,669,184 - 107,674,825 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,669,419 - 107,674,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,190,692 - 107,196,318 (+)NCBI
ROS_Cfam_1.01108,193,244 - 108,198,874 (+)NCBI
UMICH_Zoey_3.11107,859,799 - 107,865,425 (+)NCBI
UNSW_CanFamBas_1.01107,507,095 - 107,512,719 (+)NCBI
UU_Cfam_GSD_1.01108,342,794 - 108,348,418 (+)NCBI
Ca11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,064,700 - 21,070,330 (-)NCBI
SpeTri2.0NW_0049366642,682,814 - 2,688,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,993,393 - 53,999,174 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,993,183 - 53,999,357 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,740,565 - 49,746,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,889,786 - 41,905,358 (-)NCBI
ChlSab1.1 Ensembl641,889,504 - 41,905,561 (-)Ensembl
Ca11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,234,331 - 5,240,038 (+)NCBI

Position Markers
RH103095  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,141,365 - 49,142,288UniSTSGRCh37
Celera1946,006,230 - 46,007,152UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map19q13.33UniSTS
HuRef1945,520,819 - 45,521,741UniSTS
GeneMap99-GB4 RH Map19266.84UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:779
Count of miRNA genes:343
Interacting mature miRNAs:371
Transcripts:ENST00000084798, ENST00000594088, ENST00000596080, ENST00000599267
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 11
Medium 1898 1288 1242 146 460 26 2973 982 3659 265 1261 1211 123 600 1882
Low 534 1674 464 458 1451 420 1381 1207 59 148 184 392 49 1 604 906 3
Below cutoff 1 25 19 18 35 19 2 5 4 6 11 5 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000084798   ⟹   ENSP00000084798
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,637,946 - 48,646,187 (-)Ensembl
RefSeq Acc Id: ENST00000594088
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,638,016 - 48,638,385 (-)Ensembl
RefSeq Acc Id: ENST00000596080   ⟹   ENSP00000469234
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,638,022 - 48,639,459 (-)Ensembl
RefSeq Acc Id: ENST00000599267
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,638,015 - 48,639,138 (-)Ensembl
RefSeq Acc Id: NM_001217   ⟹   NP_001208
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,637,946 - 48,646,187 (-)NCBI
GRCh371949,141,272 - 49,149,451 (-)RGD
Build 361953,833,084 - 53,841,263 (-)NCBI Archive
Celera1946,006,137 - 46,014,315 (-)RGD
HuRef1945,520,726 - 45,528,907 (-)ENTREZGENE
CHM1_11949,143,073 - 49,151,416 (-)NCBI
Sequence:
RefSeq Acc Id: NR_136241
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,637,946 - 48,646,187 (-)NCBI
CHM1_11949,143,073 - 49,151,416 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002958355
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,638,888 - 48,646,050 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001208   ⟸   NM_001217
- Peptide Label: precursor
- UniProtKB: O75493 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000469234   ⟸   ENST00000596080
RefSeq Acc Id: ENSP00000084798   ⟸   ENST00000084798
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:13204993
Promoter ID:EPDNEW_H26077
Type:initiation region
Name:CA11_1
Description:carbonic anhydrase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26078  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,646,070 - 48,646,130EPDNEW
RGD ID:13204995
Promoter ID:EPDNEW_H26078
Type:initiation region
Name:CA11_2
Description:carbonic anhydrase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26077  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,646,396 - 48,646,456EPDNEW
RGD ID:6811516
Promoter ID:HG_ACW:42181
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:CA11.DAPR07,   CA11.FAPR07-UNSPLICED,   CA11.GAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361953,835,011 - 53,835,511 (-)MPROMDB
RGD ID:6811517
Promoter ID:HG_ACW:42182
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid,   NB4
Transcripts:CA11.BAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361953,839,836 - 53,840,336 (-)MPROMDB
RGD ID:6795232
Promoter ID:HG_KWN:30463
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001217
Position:
Human AssemblyChrPosition (strand)Source
Build 361953,841,286 - 53,841,912 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
NM_001217.3(CA11):c.308C>T (p.Thr103Ile) single nucleotide variant Malignant melanoma [RCV000072238] Chr19:48640258 [GRCh38]
Chr19:49143515 [GRCh37]
Chr19:53835327 [NCBI36]
Chr19:19q13.33
not provided
GRCh38/hg38 19q13.33(chr19:48577651-48839042)x3 copy number gain See cases [RCV000135686] Chr19:48577651..48839042 [GRCh38]
Chr19:49080908..49342299 [GRCh37]
Chr19:53772720..54034111 [NCBI36]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q13.33(chr19:48119589-49595956)x3 copy number gain not provided [RCV000848800] Chr19:48119589..49595956 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42
not provided
GRCh37/hg19 19q13.33(chr19:48854319-49430535)x3 copy number gain not provided [RCV001259943] Chr19:48854319..49430535 [GRCh37]
Chr19:19q13.33
likely pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1370 AgrOrtholog
COSMIC CA11 COSMIC
Ensembl Genes ENSG00000063180 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000084798 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000469234 UniProtKB/TrEMBL
Ensembl Transcript ENST00000084798 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000596080 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000063180 GTEx
HGNC ID HGNC:1370 ENTREZGENE
Human Proteome Map CA11 Human Proteome Map
InterPro alpha_CARP_X/XI UniProtKB/Swiss-Prot
  CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:770 UniProtKB/Swiss-Prot
NCBI Gene 770 ENTREZGENE
OMIM 604644 OMIM
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25986 PharmGKB
PROSITE ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CAH11_HUMAN UniProtKB/Swiss-Prot
  M0QXK8_HUMAN UniProtKB/TrEMBL
  O75493 ENTREZGENE
UniProt Secondary O60596 UniProtKB/Swiss-Prot
  Q6FHI1 UniProtKB/Swiss-Prot
  Q9UEC4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 CA11  carbonic anhydrase 11    carbonic anhydrase XI  Symbol and/or name change 5135510 APPROVED