CD8B2 (CD8b2 molecule) - Rat Genome Database
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Gene: CD8B2 (CD8b2 molecule) Homo sapiens
Analyze
No known orthologs.
Symbol: CD8B2
Name: CD8b2 molecule
RGD ID: 1348494
HGNC Page HGNC
Description: Predicted to have MHC class I protein binding activity and coreceptor activity. Predicted to be involved in adaptive immune response and regulation of immune response. Predicted to localize to cell surface; INTERACTS WITH benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cd8 antigen, beta polypeptide 2, pseudogene (p37); CD8 antigen, beta polypeptide pseudogene; CD8b molecule pseudogene; CD8b pseudogene; CD8BP; putative T-cell surface glycoprotein CD8 beta-2 chain; T-cell surface glycoprotein CD8 beta-2 chain
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2106,487,364 - 106,544,297 (+)EnsemblGRCh38hg38GRCh38
GRCh382106,487,335 - 106,544,297 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372107,103,824 - 107,124,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362106,470,165 - 106,490,647 (+)NCBINCBI36hg18NCBI36
Cytogenetic Map2q12.2NCBI
HuRef2100,793,324 - 100,798,515 (+)NCBIHuRef
CHM1_12107,107,987 - 107,128,300 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
schizophrenia  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1541829   PMID:3860845   PMID:8346216   PMID:8436166   PMID:8575821   PMID:21873635   PMID:30228200  


Genomics

Position Markers
RH70958  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37287,068,841 - 87,069,059UniSTSGRCh37
GRCh372107,123,767 - 107,123,985UniSTSGRCh37
Build 362106,490,199 - 106,490,417RGDNCBI36
Cytogenetic Map2q12.1UniSTS
Cytogenetic Map2p12UniSTS
HuRef2100,798,165 - 100,798,383UniSTS
GeneMap99-GB4 RH Map2306.01UniSTS
NCBI RH Map2460.4UniSTS
D2S2568  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37287,069,182 - 87,069,359UniSTSGRCh37
GRCh372107,123,467 - 107,123,644UniSTSGRCh37
Build 362106,489,899 - 106,490,076RGDNCBI36
Cytogenetic Map2q12.1UniSTS
Cytogenetic Map2p12UniSTS
HuRef2100,797,865 - 100,798,042UniSTS
TNG Radiation Hybrid Map255678.0UniSTS
Stanford-G3 RH Map23821.0UniSTS
GeneMap99-G3 RH Map24233.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:649
Count of miRNA genes:507
Interacting mature miRNAs:552
Transcripts:ENST00000303432, ENST00000416057, ENST00000417670, ENST00000446559
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 4 3 15 1 9 1 3 18 6 9 9 3
Low 314 440 322 133 682 14 1105 24 2632 102 395 171 119 198 527
Below cutoff 961 923 462 163 458 127 1339 476 521 146 490 623 38 536 782 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000416057   ⟹   ENSP00000495575
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,487,364 - 106,544,297 (+)Ensembl
RefSeq Acc Id: ENST00000643224   ⟹   ENSP00000496416
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,487,364 - 106,511,095 (+)Ensembl
RefSeq Acc Id: NM_001349727   ⟹   NP_001336656
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,487,364 - 106,511,095 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001368307   ⟹   NP_001355236
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,487,364 - 106,544,297 (+)NCBI
RefSeq Acc Id: XM_024453217   ⟹   XP_024308985
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,487,335 - 106,511,083 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001336656 (Get FASTA)   NCBI Sequence Viewer  
  NP_001355236 (Get FASTA)   NCBI Sequence Viewer  
  XP_024308985 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6NJW9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_024308985   ⟸   XM_024453217
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001336656   ⟸   NM_001349727
- Peptide Label: isoform 1 precursor
- Sequence:
RefSeq Acc Id: NP_001355236   ⟸   NM_001368307
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: ENSP00000495575   ⟸   ENST00000416057
RefSeq Acc Id: ENSP00000496416   ⟸   ENST00000643224
Protein Domains
Ig-like   Ig-like V-type


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q11.2-12.3(chr2:100378510-108472871)x3 copy number gain See cases [RCV000050836] Chr2:100378510..108472871 [GRCh38]
Chr2:100994972..109089327 [GRCh37]
Chr2:100361404..108455759 [NCBI36]
Chr2:2q11.2-12.3
pathogenic
GRCh38/hg38 2q12.2-12.3(chr2:106260759-107904531)x1 copy number loss See cases [RCV000051289] Chr2:106260759..107904531 [GRCh38]
Chr2:106877215..108520987 [GRCh37]
Chr2:106243647..107887419 [NCBI36]
Chr2:2q12.2-12.3
uncertain significance
GRCh38/hg38 2q12.2-12.3(chr2:106261594-107786796)x1 copy number loss See cases [RCV000051290] Chr2:106261594..107786796 [GRCh38]
Chr2:106878050..108403252 [GRCh37]
Chr2:106244482..107769684 [NCBI36]
Chr2:2q12.2-12.3
uncertain significance
GRCh38/hg38 2q12.2-12.3(chr2:105828398-108080417)x3 copy number gain See cases [RCV000052691] Chr2:105828398..108080417 [GRCh38]
Chr2:106444854..108696873 [GRCh37]
Chr2:105811286..108063305 [NCBI36]
Chr2:2q12.2-12.3
uncertain significance
GRCh38/hg38 2q11.2-13(chr2:97672522-110211318)x3 copy number gain See cases [RCV000052947] Chr2:97672522..110211318 [GRCh38]
Chr2:98288985..110968895 [GRCh37]
Chr2:97655417..110326184 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q12.2(chr2:106312801-106536530)x3 copy number gain See cases [RCV000134224] Chr2:106312801..106536530 [GRCh38]
Chr2:106929257..107152986 [GRCh37]
Chr2:106295689..106519418 [NCBI36]
Chr2:2q12.2
benign
GRCh38/hg38 2q12.1-12.3(chr2:104381722-107312459)x1 copy number loss See cases [RCV000135282] Chr2:104381722..107312459 [GRCh38]
Chr2:104998180..107928915 [GRCh37]
Chr2:104364612..107295347 [NCBI36]
Chr2:2q12.1-12.3
likely pathogenic
GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3 copy number gain See cases [RCV000138645] Chr2:101710825..110791418 [GRCh38]
Chr2:102327287..111548995 [GRCh37]
Chr2:101693719..111265466 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q12.2-14.1(chr2:106428663-112379067)x3 copy number gain See cases [RCV000140834] Chr2:106428663..112379067 [GRCh38]
Chr2:107045119..113136644 [GRCh37]
Chr2:106411551..112853115 [NCBI36]
Chr2:2q12.2-14.1
uncertain significance
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3 copy number gain See cases [RCV000141075] Chr2:94678532..110602409 [GRCh38]
Chr2:95344257..111359986 [GRCh37]
Chr2:94707984..111076455 [NCBI36]
Chr2:2q11.1-13
pathogenic
GRCh38/hg38 2q12.2-12.3(chr2:106261594-107166471)x3 copy number gain See cases [RCV000141079] Chr2:106261594..107166471 [GRCh38]
Chr2:106878050..107782927 [GRCh37]
Chr2:106244482..107149359 [NCBI36]
Chr2:2q12.2-12.3
likely benign
GRCh38/hg38 2q11.2-12.2(chr2:100478285-106498909)x3 copy number gain See cases [RCV000141445] Chr2:100478285..106498909 [GRCh38]
Chr2:101094747..107115365 [GRCh37]
Chr2:100461179..106481797 [NCBI36]
Chr2:2q11.2-12.2
uncertain significance
GRCh38/hg38 2q12.2-12.3(chr2:106170872-106809420)x3 copy number gain See cases [RCV000142302] Chr2:106170872..106809420 [GRCh38]
Chr2:106787328..107425876 [GRCh37]
Chr2:106153760..106792308 [NCBI36]
Chr2:2q12.2-12.3
uncertain significance
NC_000002.12:g.(?_106480385)_(107825992_?)del deletion Schizophrenia [RCV000416711] Chr2:106480385..107825992 [GRCh38]
Chr2:107096841..108442448 [GRCh37]
Chr2:106463273..107808880 [NCBI36]
Chr2:2q12.2-12.3
likely pathogenic
NC_000002.12:g.(?_106287425)_(107812162_?)dup duplication Schizophrenia [RCV000416938] Chr2:106287425..107812162 [GRCh38]
Chr2:106903881..108428618 [GRCh37]
Chr2:106270313..107795050 [NCBI36]
Chr2:2q12.2-12.3
likely pathogenic
Single allele deletion not provided [RCV000677995] Chr2:106312802..107890728 [GRCh38]
Chr2:106929257..108507183 [GRCh37]
Chr2:2q12.2-12.3
uncertain significance
NC_000002.12:g.(?_106445028)_(107839483_?)del deletion Schizophrenia [RCV000754224] Chr2:106445028..107839483 [GRCh38]
Chr2:2q12.2-12.3
likely pathogenic
GRCh38/hg38 2q12.2-13(chr2:106516472-110576905)x3 copy number gain See cases [RCV000139569] Chr2:106516472..110576905 [GRCh38]
Chr2:107132928..111334482 [GRCh37]
Chr2:106499360..110857227 [NCBI36]
Chr2:2q12.2-13
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1708 AgrOrtholog
COSMIC CD8B2 COSMIC
Ensembl Genes ENSG00000254126 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000495575 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000496416 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000416057 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000643224 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000254126 GTEx
HGNC ID HGNC:1708 ENTREZGENE
Human Proteome Map CD8B2 Human Proteome Map
InterPro CD8B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 927 ENTREZGENE
PANTHER PTHR11292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26246 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.534308 ENTREZGENE
UniProt A0A2R8Y6U7_HUMAN UniProtKB/TrEMBL
  A6NJW9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A2R8Y7N9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-04 CD8B2  CD8b2 molecule  CD8BP  CD8b molecule pseudogene  Symbol and/or name change 5135510 APPROVED