OSBPL8 (oxysterol binding protein like 8) - Rat Genome Database
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Gene: OSBPL8 (oxysterol binding protein like 8) Homo sapiens
Analyze
Symbol: OSBPL8
Name: oxysterol binding protein like 8
RGD ID: 1348483
HGNC Page HGNC
Description: Exhibits cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Involved in fat cell differentiation; negative regulation of sequestering of triglyceride; and phospholipid transport. Localizes to cortical endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686A11164; MGC126578; MGC133203; MST120; MSTP120; ORP-8; ORP8; OSBP-related protein 8; OSBP10; oxysterol binding protein-like 8; oxysterol-binding protein-related protein 8
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1276,351,797 - 76,559,809 (-)EnsemblGRCh38hg38GRCh38
GRCh381276,351,797 - 76,559,805 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371276,745,577 - 76,953,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361275,269,708 - 75,477,720 (-)NCBINCBI36hg18NCBI36
Build 341275,248,047 - 75,456,057NCBI
Celera1276,411,526 - 76,618,915 (-)NCBI
Cytogenetic Map12q21.2NCBI
HuRef1273,797,739 - 74,006,667 (-)NCBIHuRef
CHM1_11276,711,170 - 76,919,193 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Weight Gain  (EXP)

References

Additional References at PubMed
PMID:10819331   PMID:11483621   PMID:11735225   PMID:12168954   PMID:12477932   PMID:14702039   PMID:15489334   PMID:16806233   PMID:17081983   PMID:17428193   PMID:17672918   PMID:17991739  
PMID:18029348   PMID:19946888   PMID:20379614   PMID:20562859   PMID:21698267   PMID:21873635   PMID:22119785   PMID:22586326   PMID:22683860   PMID:22990118   PMID:23028956   PMID:24163370  
PMID:24333576   PMID:24424245   PMID:24623722   PMID:25315684   PMID:25544563   PMID:25596532   PMID:25693804   PMID:25921289   PMID:26186194   PMID:26206935   PMID:26344197   PMID:26496610  
PMID:26638075   PMID:26972000   PMID:27113756   PMID:27375898   PMID:27530118   PMID:27983927   PMID:28190767   PMID:28225217   PMID:28514442   PMID:28515276   PMID:28675297   PMID:28970484  
PMID:29180619   PMID:29395067   PMID:29409900   PMID:29472386   PMID:29507755   PMID:29509190   PMID:29568061   PMID:29748134   PMID:29961565   PMID:30021884   PMID:30194290   PMID:30196744  
PMID:30463901   PMID:30581152   PMID:30833792   PMID:31010829   PMID:31056421   PMID:31073040   PMID:31091453   PMID:31177093   PMID:31410188   PMID:31504727   PMID:31527615   PMID:31586073  
PMID:31980649   PMID:32323800   PMID:32788342   PMID:32877691  


Genomics

Comparative Map Data
OSBPL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1276,351,797 - 76,559,809 (-)EnsemblGRCh38hg38GRCh38
GRCh381276,351,797 - 76,559,805 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371276,745,577 - 76,953,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361275,269,708 - 75,477,720 (-)NCBINCBI36hg18NCBI36
Build 341275,248,047 - 75,456,057NCBI
Celera1276,411,526 - 76,618,915 (-)NCBI
Cytogenetic Map12q21.2NCBI
HuRef1273,797,739 - 74,006,667 (-)NCBIHuRef
CHM1_11276,711,170 - 76,919,193 (-)NCBICHM1_1
Osbpl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910111,000,663 - 111,133,110 (+)NCBIGRCm39mm39
GRCm39 Ensembl10111,000,613 - 111,133,110 (+)Ensembl
GRCm3810111,164,742 - 111,297,249 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10111,164,752 - 111,297,249 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710110,601,858 - 110,734,303 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610110,568,912 - 110,701,357 (+)NCBImm8
Celera10113,097,050 - 113,230,968 (+)NCBICelera
Cytogenetic Map10D1NCBI
Osbpl8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2746,596,944 - 46,749,888 (+)NCBI
Rnor_6.0 Ensembl753,878,610 - 54,027,892 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0753,878,906 - 54,030,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0753,888,262 - 54,039,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4750,308,713 - 50,313,369 (+)NCBIRGSC3.4rn4RGSC3.4
Celera743,400,573 - 43,550,915 (+)NCBICelera
Cytogenetic Map7q22NCBI
Osbpl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540515,577,003 - 15,728,983 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540515,577,003 - 15,728,983 (-)NCBIChiLan1.0ChiLan1.0
OSBPL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11276,720,276 - 76,927,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1276,720,276 - 76,820,830 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01273,870,094 - 74,078,073 (-)NCBIMhudiblu_PPA_v0panPan3
OSBPL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1519,142,987 - 19,637,708 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11519,339,385 - 19,441,583 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Osbpl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365684,646,409 - 4,806,283 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSBPL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl539,568,141 - 39,744,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1539,568,136 - 39,744,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2543,258,249 - 43,435,452 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OSBPL8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11171,927,862 - 72,142,631 (-)NCBI
ChlSab1.1 Ensembl1171,927,688 - 72,141,587 (-)Ensembl
Osbpl8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475021,569,352 - 21,757,660 (+)NCBI

Position Markers
A008I27  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371276,747,240 - 76,747,383UniSTSGRCh37
Build 361275,271,371 - 75,271,514RGDNCBI36
Celera1276,413,189 - 76,413,332RGD
Cytogenetic Map12q14UniSTS
GeneMap99-GB4 RH Map12315.64UniSTS
NCBI RH Map12554.1UniSTS
D12S1458  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371276,819,544 - 76,819,644UniSTSGRCh37
Build 361275,343,675 - 75,343,775RGDNCBI36
Celera1276,485,508 - 76,485,608RGD
Cytogenetic Map12q14UniSTS
HuRef1273,871,827 - 73,871,927UniSTS
Whitehead-RH Map12413.6UniSTS
Whitehead-YAC Contig Map12 UniSTS
RH93610  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371276,767,193 - 76,767,344UniSTSGRCh37
Build 361275,291,324 - 75,291,475RGDNCBI36
Celera1276,433,152 - 76,433,303RGD
Cytogenetic Map12q14UniSTS
HuRef1273,819,364 - 73,819,515UniSTS
GeneMap99-GB4 RH Map12315.73UniSTS
WI-17709  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371276,747,098 - 76,747,247UniSTSGRCh37
Build 361275,271,229 - 75,271,378RGDNCBI36
Celera1276,413,047 - 76,413,196RGD
Cytogenetic Map12q14UniSTS
HuRef1273,799,259 - 73,799,408UniSTS
GeneMap99-GB4 RH Map12315.73UniSTS
Whitehead-RH Map12417.8UniSTS
NCBI RH Map12548.5UniSTS
D12S1061  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371276,892,972 - 76,893,215UniSTSGRCh37
Build 361275,417,103 - 75,417,346RGDNCBI36
Celera1276,558,324 - 76,558,575RGD
Cytogenetic Map12q14UniSTS
HuRef1273,946,082 - 73,946,333UniSTS
RH68111  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371276,767,160 - 76,767,338UniSTSGRCh37
Build 361275,291,291 - 75,291,469RGDNCBI36
Celera1276,433,119 - 76,433,297RGD
Cytogenetic Map12q14UniSTS
HuRef1273,819,331 - 73,819,509UniSTS
GeneMap99-GB4 RH Map12316.97UniSTS
NCBI RH Map12548.5UniSTS
OSBPL8__5792  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371276,747,040 - 76,747,803UniSTSGRCh37
Build 361275,271,171 - 75,271,934RGDNCBI36
Celera1276,412,989 - 76,413,752RGD
HuRef1273,799,202 - 73,799,964UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4318
Count of miRNA genes:1100
Interacting mature miRNAs:1354
Transcripts:ENST00000261183, ENST00000393249, ENST00000393250, ENST00000546946, ENST00000547540, ENST00000547544, ENST00000548341, ENST00000548485, ENST00000548535, ENST00000549570, ENST00000549646, ENST00000550628, ENST00000550865, ENST00000551927, ENST00000552178, ENST00000552586, ENST00000553139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1295 1780 901 231 1485 110 3672 809 1996 302 1038 1503 133 1125 2133 3
Low 1144 1206 825 393 462 355 684 1386 1738 117 422 110 41 1 79 655 3 2
Below cutoff 5 4 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB040884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF173895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF323730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF392452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF584155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261183   ⟹   ENSP00000261183
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,351,797 - 76,559,771 (-)Ensembl
RefSeq Acc Id: ENST00000393249   ⟹   ENSP00000376939
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,351,797 - 76,559,535 (-)Ensembl
RefSeq Acc Id: ENST00000393250   ⟹   ENSP00000376940
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,355,836 - 76,559,809 (-)Ensembl
RefSeq Acc Id: ENST00000546946   ⟹   ENSP00000447893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,369,718 - 76,423,266 (-)Ensembl
RefSeq Acc Id: ENST00000547540   ⟹   ENSP00000450238
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,369,713 - 76,559,748 (-)Ensembl
RefSeq Acc Id: ENST00000547544   ⟹   ENSP00000447235
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,450,901 - 76,559,504 (-)Ensembl
RefSeq Acc Id: ENST00000548341   ⟹   ENSP00000446886
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,397,856 - 76,486,108 (-)Ensembl
RefSeq Acc Id: ENST00000548485
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,369,219 - 76,371,862 (-)Ensembl
RefSeq Acc Id: ENST00000548535
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,386,030 - 76,389,984 (-)Ensembl
RefSeq Acc Id: ENST00000549570   ⟹   ENSP00000449919
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,402,699 - 76,559,712 (-)Ensembl
RefSeq Acc Id: ENST00000549646   ⟹   ENSP00000448394
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,402,756 - 76,559,793 (-)Ensembl
RefSeq Acc Id: ENST00000550628   ⟹   ENSP00000447483
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,402,724 - 76,559,805 (-)Ensembl
RefSeq Acc Id: ENST00000550865
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,390,281 - 76,394,737 (-)Ensembl
RefSeq Acc Id: ENST00000551927   ⟹   ENSP00000447744
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,450,893 - 76,559,569 (-)Ensembl
RefSeq Acc Id: ENST00000552178
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,487,550 - 76,559,528 (-)Ensembl
RefSeq Acc Id: ENST00000552586
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,371,212 - 76,373,489 (-)Ensembl
RefSeq Acc Id: ENST00000553139   ⟹   ENSP00000449618
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,399,881 - 76,559,808 (-)Ensembl
RefSeq Acc Id: ENST00000611266   ⟹   ENSP00000478240
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1276,351,800 - 76,559,809 (-)Ensembl
RefSeq Acc Id: NM_001003712   ⟹   NP_001003712
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,797 - 76,559,771 (-)NCBI
GRCh371276,745,577 - 76,953,589 (-)RGD
Build 361275,269,708 - 75,477,720 (-)NCBI Archive
Celera1276,411,526 - 76,618,915 (-)RGD
HuRef1273,797,739 - 74,006,667 (-)ENTREZGENE
CHM1_11276,711,170 - 76,919,193 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001319652   ⟹   NP_001306581
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,797 - 76,559,771 (-)NCBI
CHM1_11276,711,170 - 76,919,193 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001319653   ⟹   NP_001306582
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,797 - 76,559,771 (-)NCBI
CHM1_11276,711,170 - 76,919,193 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001319655   ⟹   NP_001306584
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,797 - 76,423,285 (-)NCBI
CHM1_11276,711,170 - 76,782,478 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020841   ⟹   NP_065892
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,797 - 76,559,771 (-)NCBI
GRCh371276,745,577 - 76,953,589 (-)RGD
Build 361275,269,708 - 75,477,720 (-)NCBI Archive
Celera1276,411,526 - 76,618,915 (-)RGD
HuRef1273,797,739 - 74,006,667 (-)ENTREZGENE
CHM1_11276,711,170 - 76,919,193 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005268621   ⟹   XP_005268678
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,559,791 (-)NCBI
GRCh371276,745,577 - 76,953,589 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006719224   ⟹   XP_006719287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,559,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537855   ⟹   XP_011536157
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,487,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537856   ⟹   XP_011536158
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,559,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537857   ⟹   XP_011536159
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,559,791 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018768   ⟹   XP_016874257
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,558,614 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018769   ⟹   XP_016874258
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,559,791 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024448829   ⟹   XP_024304597
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,351,802 - 76,559,087 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003712 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306581 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306582 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306584 (Get FASTA)   NCBI Sequence Viewer  
  NP_065892 (Get FASTA)   NCBI Sequence Viewer  
  XP_005268678 (Get FASTA)   NCBI Sequence Viewer  
  XP_006719287 (Get FASTA)   NCBI Sequence Viewer  
  XP_011536157 (Get FASTA)   NCBI Sequence Viewer  
  XP_011536158 (Get FASTA)   NCBI Sequence Viewer  
  XP_011536159 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874257 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874258 (Get FASTA)   NCBI Sequence Viewer  
  XP_024304597 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG53411 (Get FASTA)   NCBI Sequence Viewer  
  AAH12935 (Get FASTA)   NCBI Sequence Viewer  
  AAH82235 (Get FASTA)   NCBI Sequence Viewer  
  AAH93834 (Get FASTA)   NCBI Sequence Viewer  
  AAI01530 (Get FASTA)   NCBI Sequence Viewer  
  AAI11729 (Get FASTA)   NCBI Sequence Viewer  
  AAL40665 (Get FASTA)   NCBI Sequence Viewer  
  AAQ13642 (Get FASTA)   NCBI Sequence Viewer  
  BAA95975 (Get FASTA)   NCBI Sequence Viewer  
  BAB71026 (Get FASTA)   NCBI Sequence Viewer  
  BAD18783 (Get FASTA)   NCBI Sequence Viewer  
  BAF82686 (Get FASTA)   NCBI Sequence Viewer  
  CAH18345 (Get FASTA)   NCBI Sequence Viewer  
  CAI46050 (Get FASTA)   NCBI Sequence Viewer  
  CCQ43652 (Get FASTA)   NCBI Sequence Viewer  
  EAW97324 (Get FASTA)   NCBI Sequence Viewer  
  EAW97325 (Get FASTA)   NCBI Sequence Viewer  
  EAW97326 (Get FASTA)   NCBI Sequence Viewer  
  EAW97327 (Get FASTA)   NCBI Sequence Viewer  
  Q9BZF1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_065892   ⟸   NM_020841
- Peptide Label: isoform a
- UniProtKB: Q9BZF1 (UniProtKB/Swiss-Prot),   A0A024RBB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001003712   ⟸   NM_001003712
- Peptide Label: isoform b
- UniProtKB: Q9BZF1 (UniProtKB/Swiss-Prot),   Q5HYM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005268678   ⟸   XM_005268621
- Peptide Label: isoform X3
- UniProtKB: Q9BZF1 (UniProtKB/Swiss-Prot),   A0A024RBB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006719287   ⟸   XM_006719224
- Peptide Label: isoform X6
- UniProtKB: Q9BZF1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011536158   ⟸   XM_011537856
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011536159   ⟸   XM_011537857
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011536157   ⟸   XM_011537855
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001306582   ⟸   NM_001319653
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001306581   ⟸   NM_001319652
- Peptide Label: isoform b
- UniProtKB: Q9BZF1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001306584   ⟸   NM_001319655
- Peptide Label: isoform d
- UniProtKB: Q9BZF1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016874258   ⟸   XM_017018769
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016874257   ⟸   XM_017018768
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024304597   ⟸   XM_024448829
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSP00000478240   ⟸   ENST00000611266
RefSeq Acc Id: ENSP00000447893   ⟸   ENST00000546946
RefSeq Acc Id: ENSP00000450238   ⟸   ENST00000547540
RefSeq Acc Id: ENSP00000447235   ⟸   ENST00000547544
RefSeq Acc Id: ENSP00000446886   ⟸   ENST00000548341
RefSeq Acc Id: ENSP00000448394   ⟸   ENST00000549646
RefSeq Acc Id: ENSP00000449919   ⟸   ENST00000549570
RefSeq Acc Id: ENSP00000261183   ⟸   ENST00000261183
RefSeq Acc Id: ENSP00000447483   ⟸   ENST00000550628
RefSeq Acc Id: ENSP00000376939   ⟸   ENST00000393249
RefSeq Acc Id: ENSP00000376940   ⟸   ENST00000393250
RefSeq Acc Id: ENSP00000447744   ⟸   ENST00000551927
RefSeq Acc Id: ENSP00000449618   ⟸   ENST00000553139
Protein Domains
PH

Promoters
RGD ID:6790339
Promoter ID:HG_KWN:16198
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001003712,   NM_020841,   UC001SYG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361275,477,376 - 75,477,917 (-)MPROMDB
RGD ID:7224873
Promoter ID:EPDNEW_H18182
Type:initiation region
Name:OSBPL8_2
Description:oxysterol binding protein like 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18183  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,559,536 - 76,559,596EPDNEW
RGD ID:7224875
Promoter ID:EPDNEW_H18183
Type:initiation region
Name:OSBPL8_1
Description:oxysterol binding protein like 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18182  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381276,559,771 - 76,559,831EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q21.2-21.31(chr12:75683698-80195649)x1 copy number loss See cases [RCV000050867] Chr12:75683698..80195649 [GRCh38]
Chr12:76077478..80589429 [GRCh37]
Chr12:74363745..79113560 [NCBI36]
Chr12:12q21.2-21.31
pathogenic
GRCh38/hg38 12q15-21.31(chr12:70337484-81761145)x1 copy number loss See cases [RCV000051313] Chr12:70337484..81761145 [GRCh38]
Chr12:70731264..82154924 [GRCh37]
Chr12:69017531..80679055 [NCBI36]
Chr12:12q15-21.31
pathogenic
GRCh38/hg38 12q15-21.2(chr12:70390897-79214318)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051314]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051314]|See cases [RCV000051314] Chr12:70390897..79214318 [GRCh38]
Chr12:70784677..79608098 [GRCh37]
Chr12:69070944..78132229 [NCBI36]
Chr12:12q15-21.2
pathogenic
NM_024685.3(BBS10):c.385A>T (p.Ile129Phe) single nucleotide variant Malignant melanoma [RCV000062606] Chr12:76347600 [GRCh38]
Chr12:76741380 [GRCh37]
Chr12:75265511 [NCBI36]
Chr12:12q21.2
not provided
NM_001003712.1(OSBPL8):c.-38-8160G>T single nucleotide variant Lung cancer [RCV000111299] Chr12:76459139 [GRCh38]
Chr12:76852919 [GRCh37]
Chr12:12q21.2
uncertain significance
GRCh38/hg38 12q15-21.2(chr12:69769737-76964217)x1 copy number loss See cases [RCV000136267] Chr12:69769737..76964217 [GRCh38]
Chr12:70163517..77357997 [GRCh37]
Chr12:68449784..75882128 [NCBI36]
Chr12:12q15-21.2
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q21.1-22(chr12:73485697-92795805)x1 copy number loss See cases [RCV000143099] Chr12:73485697..92795805 [GRCh38]
Chr12:73879477..93189581 [GRCh37]
Chr12:72165744..91713712 [NCBI36]
Chr12:12q21.1-22
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q21.2(chr12:76763038-76780400)x4 copy number gain Ductal breast carcinoma [RCV000207194] Chr12:76763038..76780400 [GRCh37]
Chr12:12q21.2
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q15-21.33(chr12:69608090-89629345)x1 copy number loss not provided [RCV000737927] Chr12:69608090..89629345 [GRCh37]
Chr12:12q15-21.33
pathogenic
GRCh37/hg19 12q21.2(chr12:76708985-76800739)x1 copy number loss not provided [RCV001006514] Chr12:76708985..76800739 [GRCh37]
Chr12:12q21.2
uncertain significance
GRCh37/hg19 12q21.2(chr12:76557730-76885572)x3 copy number gain not provided [RCV001259620] Chr12:76557730..76885572 [GRCh37]
Chr12:12q21.2
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16396 AgrOrtholog
COSMIC OSBPL8 COSMIC
Ensembl Genes ENSG00000091039 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000261183 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376939 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376940 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000446886 UniProtKB/TrEMBL
  ENSP00000447235 UniProtKB/TrEMBL
  ENSP00000447483 UniProtKB/TrEMBL
  ENSP00000447744 UniProtKB/TrEMBL
  ENSP00000447893 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000448394 UniProtKB/TrEMBL
  ENSP00000449618 UniProtKB/TrEMBL
  ENSP00000449919 UniProtKB/TrEMBL
  ENSP00000450238 UniProtKB/TrEMBL
  ENSP00000478240 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000261183 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393249 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393250 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000546946 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000547540 UniProtKB/TrEMBL
  ENST00000547544 UniProtKB/TrEMBL
  ENST00000548341 UniProtKB/TrEMBL
  ENST00000549570 UniProtKB/TrEMBL
  ENST00000549646 UniProtKB/TrEMBL
  ENST00000550628 UniProtKB/TrEMBL
  ENST00000551927 UniProtKB/TrEMBL
  ENST00000553139 UniProtKB/TrEMBL
  ENST00000611266 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000091039 GTEx
HGNC ID HGNC:16396 ENTREZGENE
Human Proteome Map OSBPL8 Human Proteome Map
InterPro OSBP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxysterol-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxysterol-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:114882 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114882 ENTREZGENE
OMIM 606736 OMIM
PANTHER PTHR10972 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Oxysterol_BP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32832 PharmGKB
PROSITE OSBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF144000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RBB8 ENTREZGENE, UniProtKB/TrEMBL
  F8VQX7_HUMAN UniProtKB/TrEMBL
  F8VS33_HUMAN UniProtKB/TrEMBL
  F8VUA7_HUMAN UniProtKB/TrEMBL
  F8VVD3_HUMAN UniProtKB/TrEMBL
  F8VVE7_HUMAN UniProtKB/TrEMBL
  F8VZ43_HUMAN UniProtKB/TrEMBL
  F8VZB8_HUMAN UniProtKB/TrEMBL
  F8W060_HUMAN UniProtKB/TrEMBL
  F8W1F1_HUMAN UniProtKB/TrEMBL
  L8ECJ0_HUMAN UniProtKB/TrEMBL
  OSBL8_HUMAN UniProtKB/Swiss-Prot
  Q5HYM3 ENTREZGENE, UniProtKB/TrEMBL
  Q641R2_HUMAN UniProtKB/TrEMBL
  Q96E43_HUMAN UniProtKB/TrEMBL
  Q9BZF1 ENTREZGENE
UniProt Secondary A8K1T2 UniProtKB/Swiss-Prot
  E9PE66 UniProtKB/Swiss-Prot
  E9PE68 UniProtKB/Swiss-Prot
  Q52LQ3 UniProtKB/Swiss-Prot
  Q68D75 UniProtKB/Swiss-Prot
  Q8WXP8 UniProtKB/Swiss-Prot
  Q9P277 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 OSBPL8  oxysterol binding protein like 8    oxysterol binding protein-like 8  Symbol and/or name change 5135510 APPROVED
2011-09-01 OSBPL8  oxysterol binding protein-like 8  OSBPL8  oxysterol binding protein-like 8  Symbol and/or name change 5135510 APPROVED