PTPRR (protein tyrosine phosphatase receptor type R) - Rat Genome Database

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Gene: PTPRR (protein tyrosine phosphatase receptor type R) Homo sapiens
Analyze
Symbol: PTPRR
Name: protein tyrosine phosphatase receptor type R
RGD ID: 1348456
HGNC Page HGNC
Description: Predicted to enable protein kinase binding activity. Involved in several processes, including ERBB2 signaling pathway; negative regulation of ERK1 and ERK2 cascade; and negative regulation of epithelial cell migration. Located in cell junction; cytosol; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Ch-1 PTPase; ch-1PTPase; DKFZp781C1038; EC-PTP; FLJ34328; MGC131968; MGC148170; NC-PTPCOM1; PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein-tyrosine phosphatase NC-PTPCOM1; protein-tyrosine phosphatase PCPTP1; PTP-SL; PTPBR7; PTPRQ; R-PTP-R; receptor-type tyrosine-protein phosphatase R
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1270,638,073 - 70,920,738 (-)EnsemblGRCh38hg38GRCh38
GRCh381270,638,073 - 70,920,738 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371271,031,853 - 71,314,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,318,129 - 69,600,853 (-)NCBINCBI36hg18NCBI36
Build 341269,318,128 - 69,434,632NCBI
Celera1270,695,535 - 70,977,822 (-)NCBI
Cytogenetic Map12q15NCBI
HuRef1268,081,248 - 68,364,028 (-)NCBIHuRef
CHM1_11271,001,121 - 71,283,977 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7814416   PMID:7836467   PMID:9857190   PMID:10066421   PMID:10393441   PMID:10419510   PMID:10601328   PMID:10705342   PMID:11147789   PMID:11493009   PMID:12042304   PMID:12477932  
PMID:12493773   PMID:14702039   PMID:16148006   PMID:16344560   PMID:16441242   PMID:16541075   PMID:18029348   PMID:19167335   PMID:20015382   PMID:20201926   PMID:20379614   PMID:21724833  
PMID:22100128   PMID:22330137   PMID:22664934   PMID:23382691   PMID:23396134   PMID:23422819   PMID:24242166   PMID:24407576   PMID:25241761   PMID:25592066   PMID:25921289   PMID:26186194  
PMID:26638075   PMID:27432908   PMID:27880917   PMID:28065597   PMID:28327445   PMID:28467119   PMID:28514442   PMID:28611215   PMID:28675297   PMID:31653698   PMID:31980649   PMID:32133801  
PMID:32296183   PMID:33961781  


Genomics

Comparative Map Data
PTPRR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1270,638,073 - 70,920,738 (-)EnsemblGRCh38hg38GRCh38
GRCh381270,638,073 - 70,920,738 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371271,031,853 - 71,314,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,318,129 - 69,600,853 (-)NCBINCBI36hg18NCBI36
Build 341269,318,128 - 69,434,632NCBI
Celera1270,695,535 - 70,977,822 (-)NCBI
Cytogenetic Map12q15NCBI
HuRef1268,081,248 - 68,364,028 (-)NCBIHuRef
CHM1_11271,001,121 - 71,283,977 (-)NCBICHM1_1
Ptprr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,854,093 - 116,110,837 (+)NCBIGRCm39mm39
GRCm39 Ensembl10115,854,118 - 116,110,837 (+)Ensembl
GRCm3810116,018,188 - 116,274,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10116,018,213 - 116,274,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710115,455,419 - 115,711,985 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610115,422,509 - 115,679,039 (+)NCBImm8
Celera10117,959,423 - 118,215,461 (+)NCBICelera
Cytogenetic Map10D2NCBI
Ptprr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2751,662,595 - 51,929,605 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl751,662,595 - 51,929,603 (+)Ensembl
Rnor_6.0759,039,717 - 59,325,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,039,720 - 59,325,947 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0759,041,711 - 59,084,462 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0759,207,155 - 59,335,376 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,324,246 - 55,612,945 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1755,344,975 - 55,633,672 (+)NCBI
Celera748,446,749 - 48,710,763 (+)NCBICelera
Cytogenetic Map7q22NCBI
Ptprr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540510,767,507 - 11,026,914 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540510,767,548 - 11,133,695 (-)NCBIChiLan1.0ChiLan1.0
PTPRR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11270,915,951 - 71,197,146 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1270,915,951 - 71,196,732 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01268,148,200 - 68,430,618 (-)NCBIMhudiblu_PPA_v0panPan3
PTPRR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,385,121 - 12,618,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,385,107 - 12,594,004 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1012,324,091 - 12,557,686 (-)NCBI
ROS_Cfam_1.01012,517,368 - 12,751,240 (-)NCBI
ROS_Cfam_1.0 Ensembl1012,517,368 - 12,751,216 (-)Ensembl
UMICH_Zoey_3.11012,382,959 - 12,616,783 (-)NCBI
UNSW_CanFamBas_1.01012,630,054 - 12,863,956 (-)NCBI
UU_Cfam_GSD_1.01012,754,267 - 12,988,172 (-)NCBI
Ptprr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494545,732,053 - 45,841,891 (+)NCBI
SpeTri2.0NW_0049365458,268,227 - 8,377,427 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1534,794,970 - 35,048,550 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2537,346,846 - 37,511,950 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11166,222,495 - 66,496,247 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1166,223,605 - 66,353,700 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037179,171,480 - 179,454,986 (+)NCBIVero_WHO_p1.0
Ptprr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475026,907,292 - 27,188,129 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D12S1496  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,226,626 - 71,227,129UniSTSGRCh37
Build 361269,512,893 - 69,513,396RGDNCBI36
Celera1270,889,867 - 70,890,370RGD
Cytogenetic Map12q15UniSTS
HuRef1268,276,061 - 68,276,564UniSTS
G64374  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,040,263 - 71,040,458UniSTSGRCh37
Build 361269,326,530 - 69,326,725RGDNCBI36
Celera1270,703,936 - 70,704,131RGD
Cytogenetic Map12q15UniSTS
HuRef1268,089,660 - 68,089,855UniSTS
SHGC-143350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,277,013 - 71,277,297UniSTSGRCh37
Build 361269,563,280 - 69,563,564RGDNCBI36
Celera1270,940,257 - 70,940,541RGD
Cytogenetic Map12q15UniSTS
HuRef1268,326,447 - 68,326,731UniSTS
TNG Radiation Hybrid Map1221204.0UniSTS
SHGC-145257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,081,846 - 71,081,986UniSTSGRCh37
Build 361269,368,113 - 69,368,253RGDNCBI36
Celera1270,745,508 - 70,745,648RGD
Cytogenetic Map12q15UniSTS
HuRef1268,131,307 - 68,131,447UniSTS
TNG Radiation Hybrid Map1233745.0UniSTS
SHGC-147260  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,209,731 - 71,210,044UniSTSGRCh37
Build 361269,495,998 - 69,496,311RGDNCBI36
Celera1270,872,971 - 70,873,284RGD
Cytogenetic Map12q15UniSTS
HuRef1268,259,174 - 68,259,487UniSTS
TNG Radiation Hybrid Map1221187.0UniSTS
RH44886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,076,200 - 71,076,313UniSTSGRCh37
Build 361269,362,467 - 69,362,580RGDNCBI36
Celera1270,739,862 - 70,739,975RGD
Cytogenetic Map12q15UniSTS
HuRef1268,125,578 - 68,125,691UniSTS
GeneMap99-GB4 RH Map12299.65UniSTS
D12S1025  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,122,985 - 71,123,167UniSTSGRCh37
Build 361269,409,252 - 69,409,434RGDNCBI36
Celera1270,786,285 - 70,786,455RGD
Cytogenetic Map12q15UniSTS
HuRef1268,172,321 - 68,172,491UniSTS
Whitehead-YAC Contig Map12 UniSTS
SHGC-31640  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,032,703 - 71,032,922UniSTSGRCh37
Build 361269,318,970 - 69,319,189RGDNCBI36
Celera1270,696,376 - 70,696,595RGD
Cytogenetic Map12q15-q21UniSTS
Cytogenetic Map12q15UniSTS
HuRef1268,082,098 - 68,082,317UniSTS
GeneMap99-GB4 RH Map12299.65UniSTS
Whitehead-RH Map12396.4UniSTS
GeneMap99-G3 RH Map122839.0UniSTS
D12S2195  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,123,027 - 71,123,186UniSTSGRCh37
Build 361269,409,294 - 69,409,453RGDNCBI36
Celera1270,786,327 - 70,786,474RGD
Cytogenetic Map12q15UniSTS
HuRef1268,172,363 - 68,172,510UniSTS
Marshfield Genetic Map1282.12UniSTS
deCODE Assembly Map1285.38UniSTS
RH26818  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map12q15UniSTS
T03332  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371271,077,934 - 71,078,524UniSTSGRCh37
Celera1270,741,596 - 70,742,186UniSTS
Cytogenetic Map12q15UniSTS
HuRef1268,127,312 - 68,127,902UniSTS
Whitehead-YAC Contig Map12 UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR150hsa-miR-150-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20218812

Predicted Target Of
Summary Value
Count of predictions:2833
Count of miRNA genes:853
Interacting mature miRNAs:1009
Transcripts:ENST00000283228, ENST00000342084, ENST00000378778, ENST00000440835, ENST00000537619, ENST00000547752, ENST00000548220, ENST00000549107, ENST00000549308, ENST00000550661, ENST00000551219
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 37 2 2 8 3 2 512 13 40 9 1
Low 1346 395 599 27 340 30 403 268 2040 146 320 701 7 55 281 2
Below cutoff 1028 2253 890 380 796 229 3857 1871 1158 238 1013 855 153 1135 2465 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001207015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001207016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_130846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC083809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC084877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC122866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX571751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA435261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D64053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA329806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC304601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC421975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U42361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z79693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000283228   ⟹   ENSP00000283228
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,638,079 - 70,920,738 (-)Ensembl
RefSeq Acc Id: ENST00000342084   ⟹   ENSP00000339605
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,638,931 - 70,788,982 (-)Ensembl
RefSeq Acc Id: ENST00000378778   ⟹   ENSP00000368054
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,638,074 - 70,754,759 (-)Ensembl
RefSeq Acc Id: ENST00000440835   ⟹   ENSP00000391750
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,638,073 - 70,754,661 (-)Ensembl
RefSeq Acc Id: ENST00000537619
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,638,079 - 70,664,677 (-)Ensembl
RefSeq Acc Id: ENST00000547752
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,638,082 - 70,664,372 (-)Ensembl
RefSeq Acc Id: ENST00000548220
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,660,990 - 70,754,759 (-)Ensembl
RefSeq Acc Id: ENST00000549107
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,639,130 - 70,684,896 (-)Ensembl
RefSeq Acc Id: ENST00000549308   ⟹   ENSP00000446943
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,639,060 - 70,754,716 (-)Ensembl
RefSeq Acc Id: ENST00000550661   ⟹   ENSP00000449616
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,684,732 - 70,754,735 (-)Ensembl
RefSeq Acc Id: ENST00000551219   ⟹   ENSP00000448049
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1270,638,079 - 70,754,591 (-)Ensembl
RefSeq Acc Id: NM_001207015   ⟹   NP_001193944
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,079 - 70,788,920 (-)NCBI
GRCh371271,031,853 - 71,314,584 (-)ENTREZGENE
HuRef1268,081,248 - 68,364,028 (-)ENTREZGENE
CHM1_11271,001,121 - 71,152,106 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001207016   ⟹   NP_001193945
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,073 - 70,754,759 (-)NCBI
GRCh371271,031,853 - 71,314,584 (-)ENTREZGENE
HuRef1268,081,248 - 68,364,028 (-)ENTREZGENE
CHM1_11271,001,121 - 71,117,947 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002849   ⟹   NP_002840
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,079 - 70,920,738 (-)NCBI
GRCh371271,031,853 - 71,314,584 (-)ENTREZGENE
Build 361269,318,129 - 69,600,853 (-)NCBI Archive
HuRef1268,081,248 - 68,364,028 (-)ENTREZGENE
CHM1_11271,001,121 - 71,283,977 (-)NCBI
Sequence:
RefSeq Acc Id: NM_130846   ⟹   NP_570897
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,079 - 70,754,608 (-)NCBI
GRCh371271,031,853 - 71,314,584 (-)ENTREZGENE
Build 361269,318,129 - 69,434,632 (-)NCBI Archive
HuRef1268,081,248 - 68,364,028 (-)ENTREZGENE
CHM1_11271,001,121 - 71,117,796 (-)NCBI
Sequence:
RefSeq Acc Id: NR_073474
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,079 - 70,754,608 (-)NCBI
GRCh371271,031,853 - 71,314,584 (-)NCBI
HuRef1268,081,248 - 68,364,028 (-)NCBI
CHM1_11271,001,121 - 71,117,796 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011538615   ⟹   XP_011536917
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,073 - 70,903,731 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001748830
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,093 - 70,920,732 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001748831
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,638,073 - 70,754,994 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002840   ⟸   NM_002849
- Peptide Label: isoform 1 precursor
- UniProtKB: Q15256 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001193944   ⟸   NM_001207015
- Peptide Label: isoform 3
- UniProtKB: Q15256 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001193945   ⟸   NM_001207016
- Peptide Label: isoform 4
- UniProtKB: Q15256 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_570897   ⟸   NM_130846
- Peptide Label: isoform 2
- UniProtKB: Q15256 (UniProtKB/Swiss-Prot),   Q7Z2V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011536917   ⟸   XM_011538615
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000283228   ⟸   ENST00000283228
RefSeq Acc Id: ENSP00000391750   ⟸   ENST00000440835
RefSeq Acc Id: ENSP00000368054   ⟸   ENST00000378778
RefSeq Acc Id: ENSP00000446943   ⟸   ENST00000549308
RefSeq Acc Id: ENSP00000449616   ⟸   ENST00000550661
RefSeq Acc Id: ENSP00000448049   ⟸   ENST00000551219
RefSeq Acc Id: ENSP00000339605   ⟸   ENST00000342084
Promoters
RGD ID:6790405
Promoter ID:HG_KWN:16148
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:UC001SWF.1,   UC001SWG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361269,344,361 - 69,344,861 (-)MPROMDB
RGD ID:6790402
Promoter ID:HG_KWN:16150
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:NM_130846,   UC009ZRS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361269,434,226 - 69,434,726 (-)MPROMDB
RGD ID:7224811
Promoter ID:EPDNEW_H18151
Type:initiation region
Name:PTPRR_2
Description:protein tyrosine phosphatase, receptor type R
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18152  EPDNEW_H18153  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,664,643 - 70,664,703EPDNEW
RGD ID:7224813
Promoter ID:EPDNEW_H18152
Type:initiation region
Name:PTPRR_1
Description:protein tyrosine phosphatase, receptor type R
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18151  EPDNEW_H18153  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,754,608 - 70,754,668EPDNEW
RGD ID:7224815
Promoter ID:EPDNEW_H18153
Type:initiation region
Name:PTPRR_3
Description:protein tyrosine phosphatase, receptor type R
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18151  EPDNEW_H18152  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381270,920,732 - 70,920,792EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q15-21.1(chr12:70051305-71116195)x1 copy number loss See cases [RCV000051312] Chr12:70051305..71116195 [GRCh38]
Chr12:70445085..71509975 [GRCh37]
Chr12:68731352..69796242 [NCBI36]
Chr12:12q15-21.1
pathogenic
GRCh38/hg38 12q15-21.31(chr12:70337484-81761145)x1 copy number loss See cases [RCV000051313] Chr12:70337484..81761145 [GRCh38]
Chr12:70731264..82154924 [GRCh37]
Chr12:69017531..80679055 [NCBI36]
Chr12:12q15-21.31
pathogenic
GRCh38/hg38 12q15-21.2(chr12:70390897-79214318)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051314]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051314]|See cases [RCV000051314] Chr12:70390897..79214318 [GRCh38]
Chr12:70784677..79608098 [GRCh37]
Chr12:69070944..78132229 [NCBI36]
Chr12:12q15-21.2
pathogenic
NM_002849.3(PTPRR):c.1225G>A (p.Glu409Lys) single nucleotide variant Malignant melanoma [RCV000062592] Chr12:70698319 [GRCh38]
Chr12:71092099 [GRCh37]
Chr12:69378366 [NCBI36]
Chr12:12q15
not provided
NM_001109754.2(PTPRB):c.323C>T (p.Ser108Phe) single nucleotide variant Malignant melanoma [RCV000070188] Chr12:70635799 [GRCh38]
Chr12:71029579 [GRCh37]
Chr12:69315846 [NCBI36]
Chr12:12q15
not provided
NM_001207015.1(PTPRR):c.1545-427C>T single nucleotide variant Lung cancer [RCV000111230] Chr12:70639704 [GRCh38]
Chr12:71033484 [GRCh37]
Chr12:12q15
uncertain significance
NM_002849.3(PTPRR):c.358-37925C>G single nucleotide variant Lung cancer [RCV000111231] Chr12:70802703 [GRCh38]
Chr12:71196483 [GRCh37]
Chr12:12q15
uncertain significance
GRCh38/hg38 12q15-21.2(chr12:68011417-75383054)x1 copy number loss See cases [RCV000135587] Chr12:68011417..75383054 [GRCh38]
Chr12:68405197..75776834 [GRCh37]
Chr12:66691464..74063101 [NCBI36]
Chr12:12q15-21.2
likely pathogenic|uncertain significance
GRCh38/hg38 12q15-21.2(chr12:69769737-76964217)x1 copy number loss See cases [RCV000136267] Chr12:69769737..76964217 [GRCh38]
Chr12:70163517..77357997 [GRCh37]
Chr12:68449784..75882128 [NCBI36]
Chr12:12q15-21.2
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q14.3-15(chr12:65445176-71026337)x1 copy number loss See cases [RCV000142445] Chr12:65445176..71026337 [GRCh38]
Chr12:65838956..71420117 [GRCh37]
Chr12:64125223..69706384 [NCBI36]
Chr12:12q14.3-15
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q15(chr12:70588735-71366869)x1 copy number loss See cases [RCV000445734] Chr12:70588735..71366869 [GRCh37]
Chr12:12q15
likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q15-21.1(chr12:70575476-73344659)x1 copy number loss See cases [RCV000511179] Chr12:70575476..73344659 [GRCh37]
Chr12:12q15-21.1
likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q15-21.33(chr12:69608090-89629345)x1 copy number loss not provided [RCV000737927] Chr12:69608090..89629345 [GRCh37]
Chr12:12q15-21.33
pathogenic
GRCh37/hg19 12q15-21.1(chr12:71081550-73526446)x1 copy number loss not provided [RCV000848737] Chr12:71081550..73526446 [GRCh37]
Chr12:12q15-21.1
uncertain significance
NM_002849.4(PTPRR):c.463C>T (p.Arg155Cys) single nucleotide variant not provided [RCV000891407] Chr12:70764673 [GRCh38]
Chr12:71158453 [GRCh37]
Chr12:12q15
benign
GRCh37/hg19 12q15-21.1(chr12:70403305-71510598)x1 copy number loss not provided [RCV001006510] Chr12:70403305..71510598 [GRCh37]
Chr12:12q15-21.1
uncertain significance
GRCh37/hg19 12q15(chr12:71270444-71373631)x1 copy number loss not provided [RCV001006511] Chr12:71270444..71373631 [GRCh37]
Chr12:12q15
uncertain significance
GRCh37/hg19 12q15(chr12:70973925-71245800)x3 copy number gain not provided [RCV001259619] Chr12:70973925..71245800 [GRCh37]
Chr12:12q15
uncertain significance
GRCh37/hg19 12q14.3-21.1(chr12:65251705-75263379)x1 copy number loss not provided [RCV001537907] Chr12:65251705..75263379 [GRCh37]
Chr12:12q14.3-21.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9680 AgrOrtholog
COSMIC PTPRR COSMIC
Ensembl Genes ENSG00000153233 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000283228 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000339605 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000368054 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000391750 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000446943 UniProtKB/Swiss-Prot
  ENSP00000448049 UniProtKB/TrEMBL
  ENSP00000449616 UniProtKB/TrEMBL
Ensembl Transcript ENST00000283228 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000342084 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000378778 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000440835 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000549308 UniProtKB/Swiss-Prot
  ENST00000550661 UniProtKB/TrEMBL
  ENST00000551219 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000153233 GTEx
HGNC ID HGNC:9680 ENTREZGENE
Human Proteome Map PTPRR Human Proteome Map
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_KIM-con UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_rcpt_R/non-rcpt_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5801 UniProtKB/Swiss-Prot
NCBI Gene 5801 ENTREZGENE
OMIM 602853 OMIM
PANTHER PTHR46198 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34025 PharmGKB
PIRSF PTPRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KIMPTPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F8VU63_HUMAN UniProtKB/TrEMBL
  F8VVE9_HUMAN UniProtKB/TrEMBL
  PTPRR_HUMAN UniProtKB/Swiss-Prot
  Q05B41_HUMAN UniProtKB/TrEMBL
  Q0VD90_HUMAN UniProtKB/TrEMBL
  Q15256 ENTREZGENE
  Q2TAJ3_HUMAN UniProtKB/TrEMBL
  Q569H9_HUMAN UniProtKB/TrEMBL
  Q7Z2V8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2R5Z7 UniProtKB/Swiss-Prot
  B7Z3J1 UniProtKB/Swiss-Prot
  F5GXR7 UniProtKB/Swiss-Prot
  O00342 UniProtKB/Swiss-Prot
  Q92682 UniProtKB/Swiss-Prot
  Q9UE65 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPRR  protein tyrosine phosphatase receptor type R    protein tyrosine phosphatase, receptor type R  Symbol and/or name change 5135510 APPROVED
2016-01-12 PTPRR  protein tyrosine phosphatase, receptor type R    protein tyrosine phosphatase, receptor type, R  Symbol and/or name change 5135510 APPROVED