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Gene: PTPRR (protein tyrosine phosphatase receptor type R) Homo sapiens
Symbol: PTPRR
Name: protein tyrosine phosphatase receptor type R
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Ch-1 PTPase; ch-1PTPase; DKFZp781C1038; EC-PTP; FLJ34328; MGC131968; MGC148170; NC-PTPCOM1; PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein-tyrosine phosphatase NC-PTPCOM1; protein-tyrosine phosphatase PCPTP1; PTP-SL; PTPBR7; PTPRQ; R-PTP-R; receptor-type tyrosine-protein phosphatase R
Mus musculus (house mouse) : Ptprr (protein tyrosine phosphatase, receptor type, R)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptprr (protein tyrosine phosphatase, receptor type, R)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprr (protein tyrosine phosphatase receptor type R)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRR (protein tyrosine phosphatase receptor type R)
Canis lupus familiaris (dog) : PTPRR (protein tyrosine phosphatase receptor type R)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101964395 (receptor-type tyrosine-protein phosphatase R)
Sus scrofa (pig) : PTPRR (protein tyrosine phosphatase receptor type R)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381270,638,073 - 70,920,804 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371271,031,853 - 71,314,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,318,129 - 69,600,853 (-)NCBINCBI36hg18NCBI36
Build 341269,318,128 - 69,434,632NCBI
Celera1270,695,535 - 70,977,822 (-)NCBI
Cytogenetic Map12q15NCBI
HuRef1268,081,248 - 68,364,028 (-)NCBIHuRef
CHM1_11271,001,121 - 71,283,977 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPRR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348456
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.