MIR33A (microRNA 33a) - Rat Genome Database

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Gene: MIR33A (microRNA 33a) Homo sapiens
Analyze
Symbol: MIR33A
Name: microRNA 33a
RGD ID: 1348329
HGNC Page HGNC:31634
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in apolipoprotein A-I-mediated signaling pathway; negative regulation of biosynthetic process; and negative regulation of transport. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-33; hsa-mir-33a; miR-33; mir-33a; MIR33; MIRN33; MIRN33A; miRNA33A
RGD Orthologs
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,900,944 - 41,901,012 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,900,944 - 41,901,012 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,296,948 - 42,297,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,626,893 - 40,626,961 (+)NCBINCBI36Build 36hg18NCBI36
Celera2226,103,182 - 26,103,250 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,262,647 - 25,262,715 (+)NCBIHuRef
CHM1_12242,257,156 - 42,257,224 (+)NCBICHM1_1
T2T-CHM13v2.02242,379,729 - 42,379,797 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11679670   PMID:16381832   PMID:17604727   PMID:20466882   PMID:20466885   PMID:20566875   PMID:20732877   PMID:20855588   PMID:21037258   PMID:21576456   PMID:21743487   PMID:22315319  
PMID:22325218   PMID:22333591   PMID:22767443   PMID:23261171   PMID:23458685   PMID:23536474   PMID:23547260   PMID:23625920   PMID:24015284   PMID:24100264   PMID:24300912   PMID:24468065  
PMID:24591767   PMID:24656994   PMID:25081906   PMID:25155445   PMID:25202981   PMID:25336585   PMID:25386083   PMID:25544258   PMID:25733328   PMID:25744742   PMID:25880168   PMID:25891797  
PMID:26002865   PMID:26051418   PMID:26084456   PMID:26113407   PMID:26229086   PMID:26329295   PMID:26352175   PMID:26498766   PMID:26507842   PMID:26538644   PMID:26641802   PMID:26785690  
PMID:26819305   PMID:26945479   PMID:27055396   PMID:27129293   PMID:27285759   PMID:27593936   PMID:27629254   PMID:27664032   PMID:27769047   PMID:27856248   PMID:27881008   PMID:27921232  
PMID:28141816   PMID:28291769   PMID:28428217   PMID:28677777   PMID:28751193   PMID:28790455   PMID:28871425   PMID:29207162   PMID:29237428   PMID:29441904   PMID:29484434   PMID:29601916  
PMID:29653102   PMID:29804249   PMID:29940760   PMID:30022694   PMID:30232400   PMID:30243081   PMID:30336533   PMID:30466075   PMID:30537863   PMID:31170866   PMID:31209892   PMID:31250570  
PMID:31257519   PMID:31294459   PMID:31318088   PMID:31401158   PMID:31401160   PMID:31515968   PMID:31534537   PMID:31767975   PMID:31771093   PMID:31853766   PMID:31941509   PMID:32151944  
PMID:32296037   PMID:32305057   PMID:32505219   PMID:32592422   PMID:32945470   PMID:32996692   PMID:33098283   PMID:33140190   PMID:33340492   PMID:33657886   PMID:33671114   PMID:33938628  
PMID:34090323   PMID:34146198   PMID:34426559   PMID:34888137   PMID:35090377   PMID:35579082   PMID:36626225   PMID:36631465   PMID:37047348   PMID:37432067   PMID:37604948   PMID:38904337  
PMID:39201292  


Genomics

Comparative Map Data
MIR33A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,900,944 - 41,901,012 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,900,944 - 41,901,012 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,296,948 - 42,297,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,626,893 - 40,626,961 (+)NCBINCBI36Build 36hg18NCBI36
Celera2226,103,182 - 26,103,250 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,262,647 - 25,262,715 (+)NCBIHuRef
CHM1_12242,257,156 - 42,257,224 (+)NCBICHM1_1
T2T-CHM13v2.02242,379,729 - 42,379,797 (+)NCBIT2T-CHM13v2.0
Mir33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,082,323 - 82,082,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,082,323 - 82,082,391 (+)EnsemblGRCm39 Ensembl
GRCm381582,198,122 - 82,198,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,198,122 - 82,198,190 (+)EnsemblGRCm38mm10GRCm38
MGSCv371582,028,552 - 82,028,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1584,321,842 - 84,321,910 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.54NCBI
Mir33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,593,952 - 115,594,020 (+)NCBIGRCr8
mRatBN7.27113,713,855 - 113,713,923 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,713,855 - 113,713,923 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,469,859 - 115,469,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,693,366 - 117,693,434 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,662,807 - 117,662,875 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,431,612 - 123,431,680 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,431,612 - 123,431,680 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,415,303 - 123,415,371 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7110,029,025 - 110,029,093 (+)NCBICelera
Cytogenetic Map7q34NCBI
MIR33A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,456,613 - 23,456,673 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,456,613 - 23,456,673 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,390,695 - 23,390,755 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,201,614 - 24,201,674 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,201,614 - 24,201,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,918,597 - 23,918,657 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,239,834 - 24,239,894 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,413,986 - 24,414,046 (-)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q12.3-13.33(chr22:33768441-50739977)x3 copy number gain See cases [RCV000051682] Chr22:33768441..50739977 [GRCh38]
Chr22:34164428..51178405 [GRCh37]
Chr22:32494428..49525271 [NCBI36]
Chr22:22q12.3-13.33		 pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:37061769-50738932)x3 copy number gain See cases [RCV000051684] Chr22:37061769..50738932 [GRCh38]
Chr22:37457809..51177360 [GRCh37]
Chr22:35787755..49524226 [NCBI36]
Chr22:22q12.3-13.33		 pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q13.1-13.33(chr22:40202014-50735806)x3 copy number gain See cases [RCV000134513] Chr22:40202014..50735806 [GRCh38]
Chr22:40598018..51174234 [GRCh37]
Chr22:38927964..49521100 [NCBI36]
Chr22:22q13.1-13.33		 pathogenic
GRCh38/hg38 22q13.2(chr22:41645339-42565798)x1 copy number loss See cases [RCV000136528] Chr22:41645339..42565798 [GRCh38]
Chr22:42041343..42961804 [GRCh37]
Chr22:40371289..41291748 [NCBI36]
Chr22:22q13.2		 uncertain significance
GRCh38/hg38 22q13.2-13.33(chr22:41871143-50739836)x1 copy number loss See cases [RCV000136921] Chr22:41871143..50739836 [GRCh38]
Chr22:42267147..51178264 [GRCh37]
Chr22:40597093..49525130 [NCBI36]
Chr22:22q13.2-13.33		 pathogenic
GRCh38/hg38 22q13.2(chr22:41277822-42414957)x3 copy number gain See cases [RCV000136785] Chr22:41277822..42414957 [GRCh38]
Chr22:41673826..42810963 [GRCh37]
Chr22:40003772..41140907 [NCBI36]
Chr22:22q13.2		 pathogenic
GRCh38/hg38 22q13.2(chr22:41764466-41998153)x3 copy number gain See cases [RCV000142720] Chr22:41764466..41998153 [GRCh38]
Chr22:42160470..42394157 [GRCh37]
Chr22:40490416..40724103 [NCBI36]
Chr22:22q13.2		 uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q13.2(chr22:42207144-42776457)x1 copy number loss See cases [RCV000240146] Chr22:42207144..42776457 [GRCh37]
Chr22:22q13.2		 uncertain significance
GRCh37/hg19 22q12.3-13.33(chr22:35728929-51220961)x3 copy number gain See cases [RCV000240469] Chr22:35728929..51220961 [GRCh37]
Chr22:22q12.3-13.33		 pathogenic
GRCh37/hg19 22q13.1-13.33(chr22:40425714-51220961)x3 copy number gain See cases [RCV000240459] Chr22:40425714..51220961 [GRCh37]
Chr22:22q13.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q13.2(chr22:41835094-42756616)x3 copy number gain See cases [RCV000511241] Chr22:41835094..42756616 [GRCh37]
Chr22:22q13.2		 uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
NC_000022.11:g.(?_41301335)_(42070317_?)del deletion Immunodeficiency, common variable, 4 [RCV000648330] Chr22:41301335..42070317 [GRCh38]
Chr22:41697339..42466321 [GRCh37]
Chr22:22q13.2		 uncertain significance
GRCh37/hg19 22q13.2(chr22:41849322-42756616)x3 copy number gain not provided [RCV000684486] Chr22:41849322..42756616 [GRCh37]
Chr22:22q13.2		 likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q13.2-13.33(chr22:42151555-51195728)x1 copy number loss not provided [RCV000741989] Chr22:42151555..51195728 [GRCh37]
Chr22:22q13.2-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3 copy number gain not provided [RCV001007181] Chr22:30654764..51197838 [GRCh37]
Chr22:22q12.2-13.33		 pathogenic
GRCh37/hg19 22q13.1-13.33(chr22:40502364-51197838)x3 copy number gain not provided [RCV001007502] Chr22:40502364..51197838 [GRCh37]
Chr22:22q13.1-13.33		 pathogenic
GRCh37/hg19 22q13.2(chr22:41853620-42385978)x1 copy number loss not provided [RCV001258783] Chr22:41853620..42385978 [GRCh37]
Chr22:22q13.2		 uncertain significance
GRCh37/hg19 22q13.2(chr22:42158393-42409550)x3 copy number gain not provided [RCV001258784] Chr22:42158393..42409550 [GRCh37]
Chr22:22q13.2		 uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
NC_000022.10:g.(?_41697339)_(42466321_?)del deletion Common variable immunodeficiency 4 [RCV001305750] Chr22:41697339..42466321 [GRCh37]
Chr22:22q13.2		 uncertain significance
NC_000022.10:g.(?_41277754)_(43089957_?)dup duplication Immunodeficiency, common variable, 4 [RCV001979926] Chr22:41277754..43089957 [GRCh37]
Chr22:22q13.2		 uncertain significance
NC_000022.10:g.(?_35776672)_(42486826_?)dup duplication Adenylosuccinate lyase deficiency [RCV003119093] Chr22:35776672..42486826 [GRCh37]
Chr22:22q12.3-13.2		 uncertain significance
GRCh37/hg19 22q13.1-13.31(chr22:39044105-45794212)x3 copy number gain not specified [RCV003986179] Chr22:39044105..45794212 [GRCh37]
Chr22:22q13.1-13.31		 pathogenic
GRCh37/hg19 22q13.2(chr22:41591000-42869987)x1 copy number loss not provided [RCV004442758] Chr22:41591000..42869987 [GRCh37]
Chr22:22q13.2		 uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ABCA1hsa-miR-33a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20466885
ABCA1hsa-miR-33a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20466882
ABCA1hsa-miR-33a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20566875
NPC1hsa-miR-33a-5pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assay//WesFunctional MTI23547260
ABCB11hsa-miR-33a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22767443
BMI1hsa-miR-33a-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
PIM1hsa-miR-33a-5pMirtarbaseexternal_infoReporter assayFunctional MTI21743487
PTHLHhsa-miR-33a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23453925
RUNDC3Bhsa-miR-33a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
PCGF2hsa-miR-33a-5pTarbaseexternal_infoSequencingPOSITIVE
PTHLHhsa-miR-33a-5pOncomiRDBexternal_infoNANA23458685
PIM1hsa-miR-33a-5pOncomiRDBexternal_infoNANA21743487
PIM1hsa-miR-33a-5pOncomiRDBexternal_infoNANA21690566
CNIH1hsa-miR-33a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:38096
Count of gene targets:11442
Count of transcripts:23533
Interacting mature miRNAs:hsa-miR-33a-3p, hsa-miR-33a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
3 58 14 11 96 25 86 2 11 223 13 29 321 253 21 82 38 54 70 1

Sequence


Ensembl Acc Id: ENST00000385197
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2241,900,944 - 41,901,012 (+)Ensembl
RefSeq Acc Id: NR_029507
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382241,900,944 - 41,901,012 (+)NCBI
GRCh372242,296,948 - 42,297,016 (+)RGD
Celera2226,103,182 - 26,103,250 (+)RGD
HuRef2225,262,647 - 25,262,715 (+)RGD
CHM1_12242,257,156 - 42,257,224 (+)NCBI
T2T-CHM13v2.02242,379,729 - 42,379,797 (+)NCBI
Sequence:
Promoters
RGD ID:6814701
Promoter ID:HG_XEF:5290
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NR_029804,   NR_031206,   NR_031395,   NR_031847,   NR_032007,   NR_033063
Position:
Human AssemblyChrPosition (strand)Source
Build 362240,626,521 - 40,627,021 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31634 AgrOrtholog
COSMIC MIR33A COSMIC
Ensembl Genes ENSG00000207932 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385197 ENTREZGENE
GTEx ENSG00000207932 GTEx
HGNC ID HGNC:31634 ENTREZGENE
Human Proteome Map MIR33A Human Proteome Map
miRBase MI0000091 ENTREZGENE
NCBI Gene 407039 ENTREZGENE
OMIM 612156 OMIM
PharmGKB PA164722669 PharmGKB
RNAcentral URS00000CBE63 RNACentral
  URS00003E3B82 RNACentral
  URS0000483184 RNACentral