C6orf136 (chromosome 6 open reading frame 136) - Rat Genome Database

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Gene: C6orf136 (chromosome 6 open reading frame 136) Homo sapiens
Analyze
Symbol: C6orf136
Name: chromosome 6 open reading frame 136
RGD ID: 1348259
HGNC Page HGNC:21301
Description: Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC221545; MGC15854; uncharacterized protein C6orf136
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,647,133 - 30,653,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,647,039 - 30,653,210 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,614,910 - 30,620,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,722,780 - 30,728,963 (+)NCBINCBI36Build 36hg18NCBI36
Build 34630,723,186 - 30,728,857NCBI
Celera632,212,933 - 32,219,096 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,414,983 - 30,420,920 (+)NCBIHuRef
CHM1_1630,616,924 - 30,623,095 (+)NCBICHM1_1
T2T-CHM13v2.0630,511,313 - 30,517,381 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
megacolon  (IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:14574404   PMID:14702039   PMID:15342556   PMID:15489334   PMID:16344560   PMID:17207965   PMID:21900206   PMID:22461910   PMID:26354767   PMID:26496610  
PMID:32513696   PMID:33961781   PMID:35559673   PMID:36894917  


Genomics

Comparative Map Data
C6orf136
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,647,133 - 30,653,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,647,039 - 30,653,210 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,614,910 - 30,620,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,722,780 - 30,728,963 (+)NCBINCBI36Build 36hg18NCBI36
Build 34630,723,186 - 30,728,857NCBI
Celera632,212,933 - 32,219,096 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,414,983 - 30,420,920 (+)NCBIHuRef
CHM1_1630,616,924 - 30,623,095 (+)NCBICHM1_1
T2T-CHM13v2.0630,511,313 - 30,517,381 (+)NCBIT2T-CHM13v2.0
2310061I04Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,203,569 - 36,208,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,203,569 - 36,208,323 (-)EnsemblGRCm39 Ensembl
GRCm381735,892,677 - 35,897,378 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,892,677 - 35,897,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv371736,029,622 - 36,034,323 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,500,730 - 35,505,444 (-)NCBIMGSCv36mm8
Celera1739,401,928 - 39,406,638 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.75NCBI
C20h6orf136
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,862,567 - 2,866,756 (+)NCBIGRCr8
mRatBN7.2202,857,840 - 2,861,952 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx202,909,600 - 2,913,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,914,570 - 2,918,678 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,940,739 - 2,944,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,364,787 - 3,368,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,364,814 - 3,368,923 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,462,189 - 5,466,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,005,613 - 3,009,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,005,824 - 3,009,939 (+)NCBI
Celera20283,823 - 287,969 (+)NCBICelera
Cytogenetic Map20p12NCBI
CUNH6orf136
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955583653,994 - 657,385 (+)NCBIChiLan1.0ChiLan1.0
C5H6orf136
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,207,246 - 45,213,196 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,170,646 - 41,176,404 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,391,980 - 30,397,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,261,960 - 31,267,646 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,262,032 - 31,267,457 (+)Ensemblpanpan1.1panPan2
C12H6orf136
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112456,534 - 460,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12456,657 - 460,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12594,174 - 598,157 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012599,757 - 603,738 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12599,882 - 603,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112457,426 - 461,411 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012526,890 - 530,863 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012595,503 - 599,468 (+)NCBIUU_Cfam_GSD_1.0
CUNH6orf136
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494633,955,018 - 33,958,977 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837320,270 - 324,236 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837320,138 - 324,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C7H6orf136
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,185,599 - 23,190,299 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,185,588 - 23,190,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,907,653 - 26,912,226 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH6orf136
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,801,354 - 41,807,255 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604430,344,171 - 30,349,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH6orf136
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475425,050,910 - 25,057,947 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475425,054,765 - 25,058,103 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33		 pathogenic
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33		 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32		 uncertain significance
NC_000006.11:g.28005012_31683185del deletion Megacolon [RCV001290055] Chr6:28005012..31683185 [GRCh37]
Chr6:6p22.1-21.33		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2605
Count of miRNA genes:680
Interacting mature miRNAs:758
Transcripts:ENST00000293604, ENST00000376471, ENST00000376473, ENST00000446773, ENST00000460172, ENST00000463794, ENST00000465699, ENST00000467801, ENST00000468785, ENST00000484551, ENST00000487873, ENST00000488383, ENST00000493705, ENST00000528347
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH98618  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,614,357 - 30,614,478UniSTSGRCh37
Build 36630,722,336 - 30,722,457RGDNCBI36
Celera632,212,474 - 32,212,595RGD
Cytogenetic Map6p21.33UniSTS
HuRef630,414,524 - 30,414,645UniSTS
GeneMap99-GB4 RH Map6117.86UniSTS
D6S1533E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,620,983 - 30,621,047UniSTSGRCh37
Build 36630,728,962 - 30,729,026RGDNCBI36
Celera632,219,092 - 32,219,156RGD
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map6p21.3UniSTS
HuRef630,420,916 - 30,420,980UniSTS
STS-N98554  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,620,979 - 30,621,136UniSTSGRCh37
Build 36630,728,958 - 30,729,115RGDNCBI36
Celera632,219,088 - 32,219,245RGD
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map6p21.3UniSTS
HuRef630,420,912 - 30,421,069UniSTS
GeneMap99-GB4 RH Map6120.03UniSTS
NCBI RH Map6499.1UniSTS
C4_2_24  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,619,668 - 30,620,088UniSTSGRCh37
Build 36630,727,647 - 30,728,067RGDNCBI36
Celera632,217,785 - 32,218,197RGD
Cytogenetic Map6p21.33UniSTS
HuRef630,419,607 - 30,420,021UniSTS
HL002  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,619,917 - 30,620,116UniSTSGRCh37
Celera632,218,034 - 32,218,225UniSTS
HuRef630,419,856 - 30,420,049UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2386 2007 1622 531 1258 374 4197 2085 3495 393 1429 1577 173 995 2663 4
Low 53 984 104 93 693 91 159 112 239 26 31 36 2 1 209 125 2 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001161376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054330240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054330241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054330532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054330783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054330784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054331020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054331021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054331286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054331287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI536982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM695485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP255323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ022831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX119957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX908728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR753328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA200997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000293604   ⟹   ENSP00000293604
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,039 - 30,653,209 (+)Ensembl
RefSeq Acc Id: ENST00000376471   ⟹   ENSP00000365654
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,164 - 30,652,915 (+)Ensembl
RefSeq Acc Id: ENST00000376473   ⟹   ENSP00000365656
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,073 - 30,653,210 (+)Ensembl
RefSeq Acc Id: ENST00000446773   ⟹   ENSP00000415810
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,421 - 30,653,109 (+)Ensembl
RefSeq Acc Id: ENST00000460172
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,652,611 - 30,652,947 (+)Ensembl
RefSeq Acc Id: ENST00000463794   ⟹   ENSP00000418223
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,126 - 30,652,713 (+)Ensembl
RefSeq Acc Id: ENST00000465699   ⟹   ENSP00000418154
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,651,054 - 30,653,109 (+)Ensembl
RefSeq Acc Id: ENST00000467801   ⟹   ENSP00000419610
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,651,266 - 30,653,102 (+)Ensembl
RefSeq Acc Id: ENST00000468785   ⟹   ENSP00000419460
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,651,384 - 30,653,210 (+)Ensembl
RefSeq Acc Id: ENST00000484551   ⟹   ENSP00000418599
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,039 - 30,651,315 (+)Ensembl
RefSeq Acc Id: ENST00000487873   ⟹   ENSP00000418616
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,649,906 - 30,652,749 (+)Ensembl
RefSeq Acc Id: ENST00000488383   ⟹   ENSP00000419968
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,055 - 30,653,109 (+)Ensembl
RefSeq Acc Id: ENST00000493705
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,186 - 30,649,913 (+)Ensembl
RefSeq Acc Id: ENST00000651131   ⟹   ENSP00000499201
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,647,133 - 30,653,207 (+)Ensembl
RefSeq Acc Id: NM_001109938   ⟹   NP_001103408
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,133 - 30,653,207 (+)NCBI
GRCh37630,614,816 - 30,620,987 (+)RGD
Build 36630,722,780 - 30,728,963 (+)NCBI Archive
Celera632,212,933 - 32,219,096 (+)RGD
HuRef630,414,983 - 30,420,920 (+)RGD
CHM1_1630,616,924 - 30,623,095 (+)NCBI
T2T-CHM13v2.0630,511,313 - 30,517,381 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001161376   ⟹   NP_001154848
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,133 - 30,653,207 (+)NCBI
GRCh37630,614,816 - 30,620,987 (+)RGD
Celera632,212,933 - 32,219,096 (+)RGD
HuRef630,414,983 - 30,420,920 (+)RGD
CHM1_1630,616,924 - 30,623,095 (+)NCBI
T2T-CHM13v2.0630,511,313 - 30,517,381 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145029   ⟹   NP_659466
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,133 - 30,653,207 (+)NCBI
GRCh37630,614,816 - 30,620,987 (+)RGD
Build 36630,723,177 - 30,728,963 (+)NCBI Archive
Celera632,212,933 - 32,219,096 (+)RGD
HuRef630,414,983 - 30,420,920 (+)RGD
CHM1_1630,616,924 - 30,623,095 (+)NCBI
T2T-CHM13v2.0630,511,313 - 30,517,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011514384   ⟹   XP_011512686
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,133 - 30,653,207 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047418351   ⟹   XP_047274307
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,133 - 30,651,355 (+)NCBI
RefSeq Acc Id: XM_054354598   ⟹   XP_054210573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0630,511,313 - 30,515,535 (+)NCBI
RefSeq Acc Id: XM_054354599   ⟹   XP_054210574
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0630,511,313 - 30,517,381 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001103408 (Get FASTA)   NCBI Sequence Viewer  
  NP_001154848 (Get FASTA)   NCBI Sequence Viewer  
  NP_659466 (Get FASTA)   NCBI Sequence Viewer  
  XP_011512686 (Get FASTA)   NCBI Sequence Viewer  
  XP_047274307 (Get FASTA)   NCBI Sequence Viewer  
  XP_054185723 (Get FASTA)   NCBI Sequence Viewer  
  XP_054185724 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186215 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186216 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186507 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186758 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186759 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186995 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186996 (Get FASTA)   NCBI Sequence Viewer  
  XP_054187261 (Get FASTA)   NCBI Sequence Viewer  
  XP_054187262 (Get FASTA)   NCBI Sequence Viewer  
  XP_054210573 (Get FASTA)   NCBI Sequence Viewer  
  XP_054210574 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH16167 (Get FASTA)   NCBI Sequence Viewer  
  AAH64397 (Get FASTA)   NCBI Sequence Viewer  
  AQY76727 (Get FASTA)   NCBI Sequence Viewer  
  AQY76728 (Get FASTA)   NCBI Sequence Viewer  
  BAC87037 (Get FASTA)   NCBI Sequence Viewer  
  EAX03310 (Get FASTA)   NCBI Sequence Viewer  
  EAX03311 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000293604.6
  ENSP00000365654
  ENSP00000365654.4
  ENSP00000365656
  ENSP00000365656.5
  ENSP00000373074.4
  ENSP00000373075.4
  ENSP00000387592.2
  ENSP00000389259.2
  ENSP00000390275.2
  ENSP00000391657.2
  ENSP00000393004.2
  ENSP00000395979.2
  ENSP00000396916.2
  ENSP00000398769.2
  ENSP00000402805.2
  ENSP00000403409.2
  ENSP00000404560.2
  ENSP00000404588.2
  ENSP00000405594.2
  ENSP00000411113.2
  ENSP00000415028.2
  ENSP00000415810.2
  ENSP00000415915.2
  ENSP00000418154.1
  ENSP00000418223.1
  ENSP00000418599.1
  ENSP00000418616.1
  ENSP00000419460.1
  ENSP00000419610.2
  ENSP00000419968.1
  ENSP00000499201
  ENSP00000499201.1
GenBank Protein Q5SQH8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001103408   ⟸   NM_001109938
- Peptide Label: isoform 1
- UniProtKB: Q6ZSB7 (UniProtKB/Swiss-Prot),   Q5SU01 (UniProtKB/Swiss-Prot),   F8VX15 (UniProtKB/Swiss-Prot),   A9R9P9 (UniProtKB/Swiss-Prot),   Q8TB84 (UniProtKB/Swiss-Prot),   Q5SQH8 (UniProtKB/Swiss-Prot),   A0A1U9X7F4 (UniProtKB/TrEMBL),   A0A1U9X7G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_659466   ⟸   NM_145029
- Peptide Label: isoform 2
- UniProtKB: Q5SQH8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001154848   ⟸   NM_001161376
- Peptide Label: isoform 3
- UniProtKB: Q0P5T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011512686   ⟸   XM_011514384
- Peptide Label: isoform X2
- UniProtKB: Q5SQH8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000418223   ⟸   ENST00000463794
RefSeq Acc Id: ENSP00000293604   ⟸   ENST00000293604
RefSeq Acc Id: ENSP00000418154   ⟸   ENST00000465699
RefSeq Acc Id: ENSP00000419610   ⟸   ENST00000467801
RefSeq Acc Id: ENSP00000419460   ⟸   ENST00000468785
RefSeq Acc Id: ENSP00000365654   ⟸   ENST00000376471
RefSeq Acc Id: ENSP00000365656   ⟸   ENST00000376473
RefSeq Acc Id: ENSP00000499201   ⟸   ENST00000651131
RefSeq Acc Id: ENSP00000418599   ⟸   ENST00000484551
RefSeq Acc Id: ENSP00000415810   ⟸   ENST00000446773
RefSeq Acc Id: ENSP00000418616   ⟸   ENST00000487873
RefSeq Acc Id: ENSP00000419968   ⟸   ENST00000488383
RefSeq Acc Id: XP_047274307   ⟸   XM_047418351
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054210574   ⟸   XM_054354599
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054210573   ⟸   XM_054354598
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5SQH8-F1-model_v2 AlphaFold Q5SQH8 1-315 view protein structure

Promoters
RGD ID:6872400
Promoter ID:EPDNEW_H9365
Type:initiation region
Name:C6orf136_3
Description:chromosome 6 open reading frame 136
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9366  EPDNEW_H9367  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,024 - 30,647,084EPDNEW
RGD ID:6872402
Promoter ID:EPDNEW_H9366
Type:initiation region
Name:C6orf136_1
Description:chromosome 6 open reading frame 136
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9365  EPDNEW_H9367  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,133 - 30,647,193EPDNEW
RGD ID:6872404
Promoter ID:EPDNEW_H9367
Type:initiation region
Name:C6orf136_2
Description:chromosome 6 open reading frame 136
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9365  EPDNEW_H9366  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,647,417 - 30,647,477EPDNEW
RGD ID:6803829
Promoter ID:HG_KWN:52843
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001161376,   NM_145029,   OTTHUMT00000076458,   OTTHUMT00000256234,   OTTHUMT00000256235,   OTTHUMT00000256236,   UC003NQW.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,722,111 - 30,723,382 (+)MPROMDB
RGD ID:6803828
Promoter ID:HG_KWN:52844
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000256237
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,726,686 - 30,727,186 (+)MPROMDB
RGD ID:6812919
Promoter ID:HG_ACW:67929
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:C6ORF136.KAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,728,261 - 30,728,761 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21301 AgrOrtholog
COSMIC C6orf136 COSMIC
Ensembl Genes ENSG00000204564 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000206487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000224120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000233164 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000233641 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000237012 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000237100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000293604.10 UniProtKB/Swiss-Prot
  ENST00000376471 ENTREZGENE
  ENST00000376471.8 UniProtKB/Swiss-Prot
  ENST00000376473 ENTREZGENE
  ENST00000376473.9 UniProtKB/Swiss-Prot
  ENST00000383580.8 UniProtKB/Swiss-Prot
  ENST00000383581.8 UniProtKB/Swiss-Prot
  ENST00000411654.2 UniProtKB/TrEMBL
  ENST00000415931.6 UniProtKB/Swiss-Prot
  ENST00000417076.6 UniProtKB/Swiss-Prot
  ENST00000417649.6 UniProtKB/Swiss-Prot
  ENST00000419321.6 UniProtKB/Swiss-Prot
  ENST00000422530.6 UniProtKB/Swiss-Prot
  ENST00000424031.2 UniProtKB/TrEMBL
  ENST00000425581.6 UniProtKB/Swiss-Prot
  ENST00000430141.6 UniProtKB/Swiss-Prot
  ENST00000442792.6 UniProtKB/TrEMBL
  ENST00000446773.6 UniProtKB/TrEMBL
  ENST00000447330.2 UniProtKB/TrEMBL
  ENST00000447505.6 UniProtKB/Swiss-Prot
  ENST00000449122.2 UniProtKB/TrEMBL
  ENST00000453871.2 UniProtKB/TrEMBL
  ENST00000455682.2 UniProtKB/Swiss-Prot
  ENST00000456444.6 UniProtKB/Swiss-Prot
  ENST00000463794.1 UniProtKB/TrEMBL
  ENST00000465699.5 UniProtKB/TrEMBL
  ENST00000467801.2 UniProtKB/TrEMBL
  ENST00000468785.1 UniProtKB/TrEMBL
  ENST00000484551.1 UniProtKB/TrEMBL
  ENST00000487873.1 UniProtKB/TrEMBL
  ENST00000488383.5 UniProtKB/TrEMBL
  ENST00000651131 ENTREZGENE
  ENST00000651131.1 UniProtKB/Swiss-Prot
GTEx ENSG00000204564 GTEx
  ENSG00000206487 GTEx
  ENSG00000224120 GTEx
  ENSG00000233164 GTEx
  ENSG00000233641 GTEx
  ENSG00000237012 GTEx
  ENSG00000237100 GTEx
HGNC ID HGNC:21301 ENTREZGENE
Human Proteome Map C6orf136 Human Proteome Map
InterPro DUF2358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:221545 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 221545 ENTREZGENE
PANTHER PTHR31094 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIKEN CDNA 2310061I04 GENE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF2358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134962744 PharmGKB
UniProt A0A140T9G8_HUMAN UniProtKB/TrEMBL
  A0A1U9X7F4 ENTREZGENE, UniProtKB/TrEMBL
  A0A1U9X7G3 ENTREZGENE, UniProtKB/TrEMBL
  A9R9P9 ENTREZGENE
  CF136_HUMAN UniProtKB/Swiss-Prot
  F8VX15 ENTREZGENE
  F8WBB4_HUMAN UniProtKB/TrEMBL
  F8WC77_HUMAN UniProtKB/TrEMBL
  F8WEV2_HUMAN UniProtKB/TrEMBL
  H7C4U4_HUMAN UniProtKB/TrEMBL
  H7C4Z6_HUMAN UniProtKB/TrEMBL
  H7C5B5_HUMAN UniProtKB/TrEMBL
  H7C5D3_HUMAN UniProtKB/TrEMBL
  Q0P5T2 ENTREZGENE, UniProtKB/TrEMBL
  Q5SQH8 ENTREZGENE
  Q5SU01 ENTREZGENE
  Q6ZSB7 ENTREZGENE
  Q8TB84 ENTREZGENE
UniProt Secondary A9R9P9 UniProtKB/Swiss-Prot
  F8VX15 UniProtKB/Swiss-Prot
  Q5SU01 UniProtKB/Swiss-Prot
  Q6ZSB7 UniProtKB/Swiss-Prot
  Q8TB84 UniProtKB/Swiss-Prot