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Gene: XAGE3 (X antigen family member 3) Homo sapiens
Symbol: XAGE3
Name: X antigen family member 3
Description: This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cancer/testis antigen 12.3; cancer/testis antigen family 12, member 3a; cancer/testis antigen family 12, member 3b; CT12.3; CT12.3a; CT12.3b; G antigen family D member 4; G antigen, family D, 4; GAGED4; MGC71925; PLAC6; placenta-specific 6; placenta-specific gene 6 protein; pp9012; X antigen family, member 3; XAGE-3
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC106145437 (uncharacterized LOC106145437)
Chlorocebus sabaeus (African green monkey) : XAGE3 (X antigen family member 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX52,862,525 - 52,868,083 (-)Ensembl
GRCh38X52,862,528 - 52,868,140 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X52,891,557 - 52,897,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X52,908,282 - 52,913,824 (-)NCBINCBI36hg18NCBI36
Build 34X52,774,578 - 52,780,120NCBI
CeleraX56,714,096 - 56,719,656 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX49,956,402 - 49,962,124 (-)NCBIHuRef
CHM1_1X52,881,677 - 52,887,239 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on XAGE3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348257
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.