MIR194-1 (microRNA 194-1) - Rat Genome Database

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Gene: MIR194-1 (microRNA 194-1) Homo sapiens
Analyze
Symbol: MIR194-1
Name: microRNA 194-1
RGD ID: 1348209
HGNC Page HGNC:31564
Description: Enables mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing. Located in extracellular space.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-194-1; MIRN194-1
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,118,157 - 220,118,241 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,118,157 - 220,118,241 (-)EnsemblGRCh38hg38GRCh38
GRCh371220,291,499 - 220,291,583 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,358,121 - 218,358,205 (-)NCBINCBI36Build 36hg18NCBI36
Celera1193,510,708 - 193,510,792 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1190,965,852 - 190,965,936 (-)NCBIHuRef
CHM1_11221,563,984 - 221,564,068 (-)NCBICHM1_1
T2T-CHM13v2.01219,357,431 - 219,357,515 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12554859   PMID:14573789   PMID:16381832   PMID:17604727   PMID:21037258   PMID:21845495   PMID:21851624   PMID:22028325   PMID:22396742   PMID:23639576   PMID:23715501   PMID:23743335  
PMID:24002436   PMID:24398877   PMID:24691499   PMID:24748184   PMID:25096247   PMID:25203061   PMID:25285168   PMID:25405200   PMID:25412959   PMID:25602366   PMID:25960215   PMID:25984739  
PMID:26147452   PMID:26646931   PMID:26722431   PMID:26731713   PMID:26803515   PMID:26820911   PMID:26864161   PMID:26909612   PMID:26942205   PMID:27035759   PMID:27133066   PMID:27163678  
PMID:27305450   PMID:27480251   PMID:27573550   PMID:27959429   PMID:28011622   PMID:28040329   PMID:28098896   PMID:28122647   PMID:28164432   PMID:28358423   PMID:28618953   PMID:28798470  
PMID:28870889   PMID:29047232   PMID:29109785   PMID:29131027   PMID:29152664   PMID:29518783   PMID:29782828   PMID:30044042   PMID:30059664   PMID:30201567   PMID:30232383   PMID:30278464  
PMID:30332302   PMID:30334578   PMID:30474270   PMID:30542715   PMID:30720112   PMID:30782188   PMID:30844391   PMID:30945295   PMID:30948333   PMID:30959135   PMID:31127902   PMID:31132669  
PMID:31190349   PMID:31301177   PMID:31496625   PMID:31654502   PMID:31677346   PMID:31789416   PMID:31903950   PMID:31930555   PMID:31960990   PMID:32172218   PMID:32196598   PMID:32228703  
PMID:32335998   PMID:32533463   PMID:32534701   PMID:32919420   PMID:33200800   PMID:34098485   PMID:34310900   PMID:34600339   PMID:34681562   PMID:34718169   PMID:34814928   PMID:35008751  
PMID:35708677   PMID:36227673   PMID:36529725   PMID:36809521   PMID:37762600  


Genomics

Comparative Map Data
MIR194-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,118,157 - 220,118,241 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,118,157 - 220,118,241 (-)EnsemblGRCh38hg38GRCh38
GRCh371220,291,499 - 220,291,583 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,358,121 - 218,358,205 (-)NCBINCBI36Build 36hg18NCBI36
Celera1193,510,708 - 193,510,792 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1190,965,852 - 190,965,936 (-)NCBIHuRef
CHM1_11221,563,984 - 221,564,068 (-)NCBICHM1_1
T2T-CHM13v2.01219,357,431 - 219,357,515 (-)NCBIT2T-CHM13v2.0
Mir194-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,045,516 - 185,045,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,045,516 - 185,045,582 (+)EnsemblGRCm39 Ensembl
GRCm381185,313,319 - 185,313,385 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1185,313,319 - 185,313,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,137,198 - 187,137,264 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Cytogenetic Map1H5NCBI
cM Map189.49NCBI
Mir194-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81399,382,716 - 99,382,798 (+)NCBIGRCr8
mRatBN7.21396,851,166 - 96,851,248 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,851,166 - 96,851,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1399,350,308 - 99,350,390 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,756,265 - 100,756,347 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01397,932,562 - 97,932,644 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013103,250,576 - 103,250,658 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13103,250,576 - 103,250,658 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013107,924,394 - 107,924,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1396,366,365 - 96,366,447 (+)NCBICelera
Cytogenetic Map13q26NCBI
MIR194
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13814,895,401 - 14,895,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3814,895,401 - 14,895,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3814,938,022 - 14,938,079 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03814,930,881 - 14,930,938 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3814,930,881 - 14,930,938 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.03815,286,924 - 15,286,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03815,575,390 - 15,575,447 (-)NCBIUU_Cfam_GSD_1.0
MIR194B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl109,704,910 - 9,704,987 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1109,704,910 - 9,704,987 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21011,786,871 - 11,786,948 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q41(chr1:215206760-222004068)x1 copy number loss See cases [RCV000050298] Chr1:215206760..222004068 [GRCh38]
Chr1:215380103..222177410 [GRCh37]
Chr1:213446726..220244033 [NCBI36]
Chr1:1q41
pathogenic
GRCh38/hg38 1q32.3-44(chr1:214023812-248918469)x3 copy number gain See cases [RCV000050981] Chr1:214023812..248918469 [GRCh38]
Chr1:214197155..249212668 [GRCh37]
Chr1:212263778..247179291 [NCBI36]
Chr1:1q32.3-44
pathogenic
GRCh38/hg38 1q41(chr1:215447347-221971832)x3 copy number gain See cases [RCV000051874] Chr1:215447347..221971832 [GRCh38]
Chr1:215620690..222145174 [GRCh37]
Chr1:213687313..220211797 [NCBI36]
Chr1:1q41
pathogenic
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q32.2-44(chr1:209646207-248931113)x3 copy number gain See cases [RCV000051861] Chr1:209646207..248931113 [GRCh38]
Chr1:209819552..249225312 [GRCh37]
Chr1:207886175..247191935 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q32.2-44(chr1:209963625-248918469)x3 copy number gain See cases [RCV000134979] Chr1:209963625..248918469 [GRCh38]
Chr1:210136970..249212668 [GRCh37]
Chr1:208203593..247179291 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12
pathogenic
GRCh38/hg38 1q32.2-44(chr1:207346642-248930485)x3 copy number gain See cases [RCV000143727] Chr1:207346642..248930485 [GRCh38]
Chr1:207519987..249224684 [GRCh37]
Chr1:205586610..247191307 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q41(chr1:215206760-222004068)x1 copy number loss See cases [RCV000148255] Chr1:215206760..222004068 [GRCh38]
Chr1:215380103..222177410 [GRCh37]
Chr1:213446726..220244033 [NCBI36]
Chr1:1q41
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
Single allele deletion Loeys-Dietz syndrome 4 [RCV000210452] Chr1:215588712..222145072 [GRCh37]
Chr1:1q41
pathogenic
Single allele deletion Usher syndrome [RCV000505151] Chr1:216066818..222607612 [GRCh38]
Chr1:216240159..222780953 [GRCh37]
Chr1:1q41
likely pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1q41-44(chr1:214697099-249224684)x3 copy number gain See cases [RCV000449210] Chr1:214697099..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q41-44(chr1:218252551-249224684)x3 copy number gain not provided [RCV000684700] Chr1:218252551..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1q41(chr1:220262511-220346373)x1 copy number loss not provided [RCV000684703] Chr1:220262511..220346373 [GRCh37]
Chr1:1q41
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q41(chr1:219379258-222049547)x3 copy number gain not provided [RCV000848714] Chr1:219379258..222049547 [GRCh37]
Chr1:1q41
uncertain significance
GRCh37/hg19 1q41-43(chr1:219916966-239004378)x3 copy number gain not provided [RCV001005175] Chr1:219916966..239004378 [GRCh37]
Chr1:1q41-43
pathogenic
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q41(chr1:219959610-220609144)x3 copy number gain not provided [RCV001005177] Chr1:219959610..220609144 [GRCh37]
Chr1:1q41
uncertain significance
GRCh37/hg19 1q41-42.11(chr1:219734913-224104993)x1 copy number loss not provided [RCV001005174] Chr1:219734913..224104993 [GRCh37]
Chr1:1q41-42.11
pathogenic
GRCh37/hg19 1q32.2-44(chr1:210152794-249218992)x3 copy number gain See cases [RCV001194578] Chr1:210152794..249218992 [GRCh37]
Chr1:1q32.2-44
pathogenic
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44
pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
GRCh37/hg19 1q41(chr1:220070126-220600061)x3 copy number gain not provided [RCV001829108] Chr1:220070126..220600061 [GRCh37]
Chr1:1q41
uncertain significance
Single allele deletion Loeys-Dietz syndrome 4 [RCV001837015] Chr1:215199578..223035427 [GRCh37]
Chr1:1q41
pathogenic
NC_000001.10:g.(?_220088791)_(220406225_?)dup duplication Martsolf syndrome [RCV003116595] Chr1:220088791..220406225 [GRCh37]
Chr1:1q41
uncertain significance
NC_000001.10:g.(?_218520044)_(220986760_?)del deletion Martsolf syndrome [RCV003116596] Chr1:218520044..220986760 [GRCh37]
Chr1:1q41
pathogenic
NC_000001.10:g.(?_220088791)_(220445679_?)del deletion not provided [RCV003119869] Chr1:220088791..220445679 [GRCh37]
Chr1:1q41
pathogenic
NC_000001.10:g.(?_220088791)_(220986760_?)dup duplication not provided [RCV003119870] Chr1:220088791..220986760 [GRCh37]
Chr1:1q41
uncertain significance
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh38/hg38 1q32.2-42.13(chr1:228006998-228061271)x2 copy number loss Orofacial cleft 2 [RCV002481175] Chr1:228006998..228061271 [GRCh38]
Chr1:1q32.2-42.13
association
GRCh37/hg19 1q41(chr1:214853277-222111742)x1 copy number loss not provided [RCV003484033] Chr1:214853277..222111742 [GRCh37]
Chr1:1q41
pathogenic

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 3 1
Low 108 46 60 37 197 35 243 31 78 50 96 111 7 43 83 1
Below cutoff 73 35 22 9 19 5 130 37 39 10 24 19 4 47 68

Sequence


RefSeq Acc Id: ENST00000384892
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1220,118,157 - 220,118,241 (-)Ensembl
RefSeq Acc Id: NR_029711
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,118,157 - 220,118,241 (-)NCBI
GRCh371220,291,499 - 220,291,583 (-)RGD
Celera1193,510,708 - 193,510,792 (-)RGD
HuRef1190,965,852 - 190,965,936 (-)ENTREZGENE
CHM1_11221,563,984 - 221,564,068 (-)NCBI
T2T-CHM13v2.01219,357,431 - 219,357,515 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31564 AgrOrtholog
COSMIC MIR194-1 COSMIC
Ensembl Genes ENSG00000207624 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384892 ENTREZGENE
GTEx ENSG00000207624 GTEx
HGNC ID HGNC:31564 ENTREZGENE
Human Proteome Map MIR194-1 Human Proteome Map
miRBase MI0000488 ENTREZGENE
NCBI Gene 406969 ENTREZGENE
OMIM 610940 OMIM
PharmGKB PA164722553 PharmGKB
RNAcentral URS000029C2DC RNACentral
  URS00002D5B50 RNACentral