NOXRED1 (NADP dependent oxidoreductase domain containing 1) - Rat Genome Database

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Gene: NOXRED1 (NADP dependent oxidoreductase domain containing 1) Homo sapiens
Analyze
Symbol: NOXRED1
Name: NADP dependent oxidoreductase domain containing 1
RGD ID: 1348173
HGNC Page HGNC:20487
Description: Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C14orf148; FLJ32809; NADP-dependent oxidoreductase domain containing 1; NADP-dependent oxidoreductase domain-containing protein 1; pyrroline-5-carboxylate reductase-like protein C14orf148
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,394,021 - 77,426,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,394,021 - 77,423,523 (-)EnsemblGRCh38hg38GRCh38
GRCh371477,860,364 - 77,889,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361476,942,749 - 76,958,985 (-)NCBINCBI36Build 36hg18NCBI36
Build 341476,942,748 - 76,958,985NCBI
Celera1457,899,001 - 57,927,942 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1458,026,603 - 58,055,321 (-)NCBIHuRef
CHM1_11477,799,799 - 77,828,847 (-)NCBICHM1_1
T2T-CHM13v2.01471,603,400 - 71,635,393 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12508121   PMID:14702039   PMID:15489334   PMID:16344560   PMID:17207965   PMID:21873635   PMID:26186194   PMID:28514442   PMID:31435991   PMID:33961781  


Genomics

Comparative Map Data
NOXRED1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,394,021 - 77,426,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,394,021 - 77,423,523 (-)EnsemblGRCh38hg38GRCh38
GRCh371477,860,364 - 77,889,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361476,942,749 - 76,958,985 (-)NCBINCBI36Build 36hg18NCBI36
Build 341476,942,748 - 76,958,985NCBI
Celera1457,899,001 - 57,927,942 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1458,026,603 - 58,055,321 (-)NCBIHuRef
CHM1_11477,799,799 - 77,828,847 (-)NCBICHM1_1
T2T-CHM13v2.01471,603,400 - 71,635,393 (-)NCBIT2T-CHM13v2.0
Noxred1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,267,897 - 87,285,375 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,267,814 - 87,285,506 (-)EnsemblGRCm39 Ensembl
GRCm381287,221,123 - 87,238,601 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,221,040 - 87,238,732 (-)EnsemblGRCm38mm10GRCm38
MGSCv371288,562,073 - 88,579,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361288,110,129 - 88,127,835 (-)NCBIMGSCv36mm8
Celera1288,685,703 - 88,703,320 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.42NCBI
Noxred1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,593,296 - 112,619,113 (-)NCBIGRCr8
mRatBN7.26106,862,350 - 106,888,113 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,862,343 - 106,884,712 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06111,243,232 - 111,271,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,243,228 - 111,267,734 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,528,486 - 120,553,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6104,683,682 - 104,708,385 (-)NCBICelera
Cytogenetic Map6q31NCBI
Noxred1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554381,286,459 - 1,317,649 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554381,286,157 - 1,320,772 (-)NCBIChiLan1.0ChiLan1.0
NOXRED1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21578,477,924 - 78,512,627 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,691,853 - 77,729,131 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01457,946,614 - 57,979,637 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11477,148,487 - 77,180,676 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,148,487 - 77,179,648 (-)Ensemblpanpan1.1panPan2
NOXRED1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,203,260 - 50,228,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,203,261 - 50,233,922 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,890,911 - 49,921,841 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0850,437,046 - 50,467,998 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl850,437,166 - 50,467,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1850,099,658 - 50,130,631 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0850,122,811 - 50,153,706 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0850,520,680 - 50,551,630 (-)NCBIUU_Cfam_GSD_1.0
Noxred1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,821,776 - 25,849,383 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,219,753 - 6,244,440 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,219,528 - 6,245,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOXRED1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,464,454 - 100,478,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,458,164 - 100,482,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27106,475,759 - 106,492,719 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOXRED1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,653,026 - 54,684,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2454,653,629 - 54,684,070 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605342,845,105 - 42,876,717 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Noxred1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473424,468,506 - 24,514,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473424,465,061 - 24,514,874 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NOXRED1
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.3(chr14:73877072-78042422)x1 copy number loss See cases [RCV000051548] Chr14:73877072..78042422 [GRCh38]
Chr14:74343775..78508765 [GRCh37]
Chr14:73413528..77578518 [NCBI36]
Chr14:14q24.3		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:75489052-79610332)x1 copy number loss See cases [RCV000051549] Chr14:75489052..79610332 [GRCh38]
Chr14:75955395..80076675 [GRCh37]
Chr14:75025148..79146428 [NCBI36]
Chr14:14q24.3-31.1		 pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2		 pathogenic
NM_001010860.1(SAMD15):c.1839C>T (p.Phe613=) single nucleotide variant Malignant melanoma [RCV000070620] Chr14:77391058 [GRCh38]
Chr14:77857401 [GRCh37]
Chr14:76927154 [NCBI36]
Chr14:14q24.3		 not provided
NM_001010860.1(SAMD15):c.1876G>A (p.Gly626Ser) single nucleotide variant Malignant melanoma [RCV000070621] Chr14:77391095 [GRCh38]
Chr14:77857438 [GRCh37]
Chr14:76927191 [NCBI36]
Chr14:14q24.3		 not provided
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1 copy number loss See cases [RCV000134154] Chr14:69562099..81975384 [GRCh38]
Chr14:70028816..82441728 [GRCh37]
Chr14:69098569..81511481 [NCBI36]
Chr14:14q24.1-31.1		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:77193005-80476132)x1 copy number loss See cases [RCV000137421] Chr14:77193005..80476132 [GRCh38]
Chr14:77659348..80942475 [GRCh37]
Chr14:76729101..80012228 [NCBI36]
Chr14:14q24.3-31.1		 likely pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:73343213-78835059)x1 copy number loss See cases [RCV000143265] Chr14:73343213..78835059 [GRCh38]
Chr14:73809921..79301402 [GRCh37]
Chr14:72879674..78371155 [NCBI36]
Chr14:14q24.3-31.1		 pathogenic|likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q24.3(chr14:76082940-78372356)x1 copy number loss See cases [RCV000511668] Chr14:76082940..78372356 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.632C>A (p.Ala211Asp) single nucleotide variant Inborn genetic diseases [RCV003307110] Chr14:77406774 [GRCh38]
Chr14:77873117 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.541C>G (p.Leu181Val) single nucleotide variant Inborn genetic diseases [RCV003239408] Chr14:77406865 [GRCh38]
Chr14:77873208 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
NC_000014.8:g.(?_77743699)_(78082942_?)dup duplication Neuropathy, hereditary sensory and autonomic, type 1C [RCV000820601] Chr14:77277356..77616599 [GRCh38]
Chr14:77743699..78082942 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.3-32.11(chr14:77274990-89803137)x1 copy number loss not provided [RCV000847566] Chr14:77274990..89803137 [GRCh37]
Chr14:14q24.3-32.11		 pathogenic
NM_001113475.3(NOXRED1):c.290A>G (p.Gln97Arg) single nucleotide variant Inborn genetic diseases [RCV003292671] Chr14:77413993 [GRCh38]
Chr14:77880336 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.3(chr14:77862909-78274607) copy number gain not specified [RCV002053114] Chr14:77862909..78274607 [GRCh37]
Chr14:14q24.3		 uncertain significance
NC_000014.8:g.(?_77743719)_(78082922_?)del deletion Neuropathy, hereditary sensory and autonomic, type 1C [RCV001996609] Chr14:77743719..78082922 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33		 pathogenic
NM_001113475.3(NOXRED1):c.542T>C (p.Leu181Pro) single nucleotide variant Inborn genetic diseases [RCV002728803] Chr14:77406864 [GRCh38]
Chr14:77873207 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.508G>A (p.Val170Ile) single nucleotide variant Inborn genetic diseases [RCV002865221] Chr14:77407487 [GRCh38]
Chr14:77873830 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.647C>T (p.Thr216Met) single nucleotide variant Inborn genetic diseases [RCV002738934] Chr14:77406759 [GRCh38]
Chr14:77873102 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.62G>A (p.Arg21His) single nucleotide variant Inborn genetic diseases [RCV002875055] Chr14:77422828 [GRCh38]
Chr14:77889171 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.92G>A (p.Arg31Gln) single nucleotide variant Inborn genetic diseases [RCV002826250] Chr14:77422798 [GRCh38]
Chr14:77889141 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.979C>T (p.Pro327Ser) single nucleotide variant Inborn genetic diseases [RCV002789047] Chr14:77394732 [GRCh38]
Chr14:77861075 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.622G>A (p.Val208Ile) single nucleotide variant Inborn genetic diseases [RCV002920208] Chr14:77406784 [GRCh38]
Chr14:77873127 [GRCh37]
Chr14:14q24.3		 likely benign
NM_001113475.3(NOXRED1):c.722T>C (p.Phe241Ser) single nucleotide variant Inborn genetic diseases [RCV002713896] Chr14:77406096 [GRCh38]
Chr14:77872439 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.881A>G (p.Tyr294Cys) single nucleotide variant Inborn genetic diseases [RCV002900900] Chr14:77405937 [GRCh38]
Chr14:77872280 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.329C>G (p.Thr110Ser) single nucleotide variant Inborn genetic diseases [RCV003010811] Chr14:77413954 [GRCh38]
Chr14:77880297 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.418A>C (p.Ile140Leu) single nucleotide variant Inborn genetic diseases [RCV003184252] Chr14:77407577 [GRCh38]
Chr14:77873920 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.884G>A (p.Gly295Asp) single nucleotide variant Inborn genetic diseases [RCV003204098] Chr14:77405934 [GRCh38]
Chr14:77872277 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.14A>G (p.Gln5Arg) single nucleotide variant Inborn genetic diseases [RCV003218846] Chr14:77422876 [GRCh38]
Chr14:77889219 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.197T>C (p.Ile66Thr) single nucleotide variant Inborn genetic diseases [RCV003207823] Chr14:77414086 [GRCh38]
Chr14:77880429 [GRCh37]
Chr14:14q24.3		 likely benign
NM_001113475.3(NOXRED1):c.728C>T (p.Ala243Val) single nucleotide variant Inborn genetic diseases [RCV003340996] Chr14:77406090 [GRCh38]
Chr14:77872433 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_001113475.3(NOXRED1):c.314G>A (p.Ser105Asn) single nucleotide variant Inborn genetic diseases [RCV003371337] Chr14:77413969 [GRCh38]
Chr14:77880312 [GRCh37]
Chr14:14q24.3		 likely benign
GRCh37/hg19 14q24.3(chr14:77885734-78292290)x3 copy number gain not provided [RCV003485045] Chr14:77885734..78292290 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:514
Count of miRNA genes:383
Interacting mature miRNAs:406
Transcripts:ENST00000298358, ENST00000380835, ENST00000555603, ENST00000555901
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH98371  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371477,873,002 - 77,873,163UniSTSGRCh37
Build 361476,942,755 - 76,942,916RGDNCBI36
Celera1457,911,569 - 57,911,730RGD
Cytogenetic Map14q24.3UniSTS
HuRef1458,039,192 - 58,039,353UniSTS
GeneMap99-GB4 RH Map14208.42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 4 311
Low 1024 1096 1403 342 1503 236 2764 283 2159 268 981 1412 117 691 1602 3
Below cutoff 1401 1854 315 276 423 224 1568 1863 1543 148 155 193 53 513 1166 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005267330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI829015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB021944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC006808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC044735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000380835   ⟹   ENSP00000370215
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,394,021 - 77,423,523 (-)Ensembl
RefSeq Acc Id: ENST00000555603   ⟹   ENSP00000450597
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,406,736 - 77,423,517 (-)Ensembl
RefSeq Acc Id: ENST00000555901
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1477,394,443 - 77,423,056 (-)Ensembl
RefSeq Acc Id: NM_001113475   ⟹   NP_001106946
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,394,021 - 77,423,523 (-)NCBI
GRCh371477,859,827 - 77,890,225 (-)NCBI
Celera1457,899,001 - 57,927,942 (-)RGD
HuRef1458,026,603 - 58,055,321 (-)ENTREZGENE
CHM1_11477,799,799 - 77,828,847 (-)NCBI
T2T-CHM13v2.01471,603,400 - 71,632,902 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394980   ⟹   NP_001381909
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,394,021 - 77,423,523 (-)NCBI
T2T-CHM13v2.01471,603,400 - 71,632,902 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005267330   ⟹   XP_005267387
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,394,021 - 77,423,523 (-)NCBI
GRCh371477,859,827 - 77,890,225 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011536428   ⟹   XP_011534730
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,394,021 - 77,424,205 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011536429   ⟹   XP_011534731
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,394,021 - 77,426,013 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017020969   ⟹   XP_016876458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381477,394,021 - 77,423,523 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054375394   ⟹   XP_054231369
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01471,603,400 - 71,633,623 (-)NCBI
RefSeq Acc Id: XM_054375395   ⟹   XP_054231370
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01471,603,400 - 71,633,585 (-)NCBI
RefSeq Acc Id: XM_054375396   ⟹   XP_054231371
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01471,603,400 - 71,635,393 (-)NCBI
RefSeq Acc Id: XM_054375397   ⟹   XP_054231372
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01471,603,400 - 71,632,902 (-)NCBI
RefSeq Acc Id: XM_054375398   ⟹   XP_054231373
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01471,615,433 - 71,632,902 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001106946   ⟸   NM_001113475
- UniProtKB: B3KQ47 (UniProtKB/Swiss-Prot),   O95435 (UniProtKB/Swiss-Prot),   Q6NXP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005267387   ⟸   XM_005267330
- Peptide Label: isoform X1
- UniProtKB: B3KQ47 (UniProtKB/Swiss-Prot),   O95435 (UniProtKB/Swiss-Prot),   Q6NXP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534731   ⟸   XM_011536429
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011534730   ⟸   XM_011536428
- Peptide Label: isoform X1
- UniProtKB: B3KQ47 (UniProtKB/Swiss-Prot),   O95435 (UniProtKB/Swiss-Prot),   Q6NXP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016876458   ⟸   XM_017020969
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000450597   ⟸   ENST00000555603
RefSeq Acc Id: ENSP00000370215   ⟸   ENST00000380835
RefSeq Acc Id: NP_001381909   ⟸   NM_001394980
- UniProtKB: Q6NXP6 (UniProtKB/Swiss-Prot),   B3KQ47 (UniProtKB/Swiss-Prot),   O95435 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054231371   ⟸   XM_054375396
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054231369   ⟸   XM_054375394
- Peptide Label: isoform X1
- UniProtKB: O95435 (UniProtKB/Swiss-Prot),   Q6NXP6 (UniProtKB/Swiss-Prot),   B3KQ47 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054231370   ⟸   XM_054375395
- Peptide Label: isoform X1
- UniProtKB: O95435 (UniProtKB/Swiss-Prot),   Q6NXP6 (UniProtKB/Swiss-Prot),   B3KQ47 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054231372   ⟸   XM_054375397
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054231373   ⟸   XM_054375398
- Peptide Label: isoform X4
Protein Domains
Pyrroline-5-carboxylate reductase catalytic N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6NXP6-F1-model_v2 AlphaFold Q6NXP6 1-359 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:20487 AgrOrtholog
COSMIC NOXRED1 COSMIC
Ensembl Genes ENSG00000165555 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000380835 ENTREZGENE
  ENST00000380835.7 UniProtKB/Swiss-Prot
  ENST00000555603.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000165555 GTEx
HGNC ID HGNC:20487 ENTREZGENE
Human Proteome Map NOXRED1 Human Proteome Map
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P5C_Rdtase_cat_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:122945 UniProtKB/Swiss-Prot
NCBI Gene 122945 ENTREZGENE
PANTHER NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam F420_oxidored UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134935429 PharmGKB
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3KQ47 ENTREZGENE
  G3V2D4_HUMAN UniProtKB/TrEMBL
  NXRD1_HUMAN UniProtKB/Swiss-Prot
  O95435 ENTREZGENE
  Q6NXP6 ENTREZGENE
UniProt Secondary B3KQ47 UniProtKB/Swiss-Prot
  O95435 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-21 NOXRED1  NADP dependent oxidoreductase domain containing 1    NADP-dependent oxidoreductase domain containing 1  Symbol and/or name change 5135510 APPROVED
2011-10-04 NOXRED1  NADP-dependent oxidoreductase domain containing 1  C14orf148  chromosome 14 open reading frame 148  Symbol and/or name change 5135510 APPROVED