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Gene: DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3) Homo sapiens
Symbol: DNAJC3
Name: DnaJ heat shock protein family (Hsp40) member C3
Description: Predicted to have several functions, including chaperone binding activity; misfolded protein binding activity; and protein kinase inhibitor activity. Involved in negative regulation of apoptotic process and negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation. Localizes to the extracellular exosome and membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACPHD; DnaJ (Hsp40) homolog, subfamily C, member 3; dnaJ homolog subfamily C member 3; endoplasmic reticulum DNA J domain-containing protein 6; endoplasmic reticulum DnaJ protein 6; ER-resident protein ERdj6; ERdj6; FLJ21288; HP58; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; P58; p58(IPK); P58IPK; PRKRI; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381395,677,139 - 95,794,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371396,329,393 - 96,447,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361395,127,484 - 95,241,285 (+)NCBINCBI36hg18NCBI36
Build 341395,127,483 - 95,241,285NCBI
Celera1377,177,188 - 77,295,039 (+)NCBI
Cytogenetic Map13q32.1NCBI
HuRef1376,927,193 - 77,044,763 (+)NCBIHuRef
CHM1_11396,299,542 - 96,417,377 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNAJC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347817
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.