MIR198 (microRNA 198) - Rat Genome Database

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Gene: MIR198 (microRNA 198) Homo sapiens
Analyze
Symbol: MIR198
Name: microRNA 198
RGD ID: 1347765
HGNC Page HGNC:31570
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing. Located in extracellular vesicle.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: miR-198; MIRN198
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383120,395,668 - 120,395,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3120,395,668 - 120,395,729 (-)EnsemblGRCh38hg38GRCh38
GRCh373120,114,515 - 120,114,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,597,204 - 121,597,265 (-)NCBINCBI36Build 36hg18NCBI36
Celera3118,523,918 - 118,523,979 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3117,490,350 - 117,490,411 (-)NCBIHuRef
CHM1_13120,078,161 - 120,078,222 (-)NCBICHM1_1
T2T-CHM13v2.03123,115,214 - 123,115,275 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12554859   PMID:16381832   PMID:17604727   PMID:19671678   PMID:20167074   PMID:20347265   PMID:21658389   PMID:22295894   PMID:23069480   PMID:23354517   PMID:23391410   PMID:23395958  
PMID:23989979   PMID:24357456   PMID:25174450   PMID:25908274   PMID:26225959   PMID:26852230   PMID:26970302   PMID:27063186   PMID:28425046   PMID:28492138   PMID:28765921   PMID:28798470  
PMID:28944868   PMID:29065427   PMID:29394946   PMID:29762851   PMID:30219673   PMID:30840270   PMID:30927924   PMID:30975221   PMID:31138759   PMID:31201066   PMID:31322262   PMID:31381176  
PMID:32192774   PMID:32495982   PMID:32685526   PMID:33336742   PMID:33351694   PMID:33982769   PMID:34181826   PMID:34314379   PMID:34516314   PMID:34799875   PMID:34952425   PMID:36050615  
PMID:37158446  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q13.33(chr3:120286468-121375425)x3 copy number gain See cases [RCV000134744] Chr3:120286468..121375425 [GRCh38]
Chr3:120005315..121094272 [GRCh37]
Chr3:121488005..122576962 [NCBI36]
Chr3:3q13.33		 uncertain significance
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q13.32-13.33(chr3:117844958-120797026)x4 copy number gain See cases [RCV000135591] Chr3:117844958..120797026 [GRCh38]
Chr3:117563805..120515873 [GRCh37]
Chr3:119046495..121998563 [NCBI36]
Chr3:3q13.32-13.33		 uncertain significance
GRCh38/hg38 3q13.31-21.1(chr3:115019074-122513398)x1 copy number loss See cases [RCV000135961] Chr3:115019074..122513398 [GRCh38]
Chr3:114737921..122232245 [GRCh37]
Chr3:116220611..123714935 [NCBI36]
Chr3:3q13.31-21.1		 pathogenic
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3		 pathogenic
GRCh38/hg38 3q13.31-21.2(chr3:114122562-124532374)x1 copy number loss See cases [RCV000142009] Chr3:114122562..124532374 [GRCh38]
Chr3:113841409..124251221 [GRCh37]
Chr3:115324099..125733911 [NCBI36]
Chr3:3q13.31-21.2		 pathogenic
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
GRCh38/hg38 3q13.32-13.33(chr3:117844958-120826621)x4 copy number gain See cases [RCV000142877] Chr3:117844958..120826621 [GRCh38]
Chr3:117563805..120545468 [GRCh37]
Chr3:119046495..122028158 [NCBI36]
Chr3:3q13.32-13.33		 uncertain significance
GRCh38/hg38 3q13.32-21.3(chr3:118673898-126540730)x1 copy number loss See cases [RCV000143695] Chr3:118673898..126540730 [GRCh38]
Chr3:118392745..126259573 [GRCh37]
Chr3:119875435..127742263 [NCBI36]
Chr3:3q13.32-21.3		 pathogenic
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1		 pathogenic
GRCh38/hg38 3q13.32-21.2(chr3:119117166-125920734)x1 copy number loss See cases [RCV000051546] Chr3:119117166..125920734 [GRCh38]
Chr3:118836013..125639577 [GRCh37]
Chr3:120318703..127122267 [NCBI36]
Chr3:3q13.32-21.2		 pathogenic
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
CCNT1hsa-miR-198Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19148268
NTRK3hsa-miR-198Mirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI19370765
MYBhsa-miR-198Mirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)18667440
MYBhsa-miR-198Tarbaseexternal_infoqPCRPOSITIVE
METhsa-miR-198OncomiRDBexternal_infoNANA21658389

Predicted Targets
Summary Value
Count of predictions:21597
Count of gene targets:9731
Count of transcripts:18293
Interacting mature miRNAs:hsa-miR-198
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-77238  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373120,115,006 - 120,115,205UniSTSGRCh37
Build 363121,597,696 - 121,597,895RGDNCBI36
Celera3118,524,409 - 118,524,608RGD
Cytogenetic Map3q13.33UniSTS
HuRef3117,490,841 - 117,491,040UniSTS
TNG Radiation Hybrid Map367616.0UniSTS
GeneMap99-GB4 RH Map3418.82UniSTS
NCBI RH Map3929.8UniSTS
D3S2939E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373120,114,261 - 120,114,436UniSTSGRCh37
Build 363121,596,951 - 121,597,126RGDNCBI36
Celera3118,523,664 - 118,523,839RGD
Cytogenetic Map3q13.33UniSTS
HuRef3117,490,096 - 117,490,271UniSTS
SHGC-77232  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373120,114,564 - 120,114,740UniSTSGRCh37
Build 363121,597,254 - 121,597,430RGDNCBI36
Celera3118,523,967 - 118,524,143RGD
Cytogenetic Map3q13.33UniSTS
HuRef3117,490,399 - 117,490,575UniSTS
TNG Radiation Hybrid Map367616.0UniSTS
GeneMap99-GB4 RH Map3418.72UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000637333
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3120,395,668 - 120,395,729 (-)Ensembl
RefSeq Acc Id: NR_029584
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383120,395,668 - 120,395,729 (-)NCBI
GRCh373120,114,515 - 120,114,576 (-)RGD
Celera3118,523,918 - 118,523,979 (-)RGD
HuRef3117,490,350 - 117,490,411 (-)ENTREZGENE
CHM1_13120,078,161 - 120,078,222 (-)NCBI
T2T-CHM13v2.03123,115,214 - 123,115,275 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR198 COSMIC
Ensembl Genes ENSG00000284121 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000637333 ENTREZGENE
GTEx ENSG00000284121 GTEx
HGNC ID HGNC:31570 ENTREZGENE
Human Proteome Map MIR198 Human Proteome Map
miRBase MI0000240 ENTREZGENE
NCBI Gene 406975 ENTREZGENE
PharmGKB PA164722568 PharmGKB
RNAcentral URS0000471A62 RNACentral
  URS000075CAC3 RNACentral