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Gene: GDF6 (growth differentiation factor 6) Homo sapiens
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Symbol: GDF6
Name: growth differentiation factor 6
Description: Predicted to have cytokine activity and transforming growth factor beta receptor binding activity. Involved in positive regulation of chondrocyte differentiation; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to the extracellular space. Implicated in several diseases, including Klippel-Feil syndrome; Leber congenital amaurosis 17; cleft lip; isolated microphthalmia 4; and multiple synostoses syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP-13; BMP13; bone morphogenetic protein 13; CDMP2; GDF-6; growth/differentiation factor 16; growth/differentiation factor 6; KFM; KFS; KFS1; KFSL; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome; LCA17; MCOP4; MCOPCB6; MGC158100; MGC158101; SCDO4; segmentation syndrome 1; SGM1; SYNS4
Orthologs:
Mus musculus (house mouse) : Gdf6 (growth differentiation factor 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gdf6 (growth differentiation factor 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdf6 (growth differentiation factor 6)
Pan paniscus (bonobo/pygmy chimpanzee) : GDF6 (growth differentiation factor 6)
Canis lupus familiaris (dog) : GDF6 (growth differentiation factor 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdf6 (growth differentiation factor 6)
Sus scrofa (pig) : GDF6 (growth differentiation factor 6)
Chlorocebus sabaeus (green monkey) : GDF6 (growth differentiation factor 6)
Heterocephalus glaber (naked mole-rat) : Gdf6 (growth differentiation factor 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl896,142,333 - 96,160,806 (-)Ensembl
GRCh38896,142,333 - 96,160,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37897,154,558 - 97,173,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36897,223,734 - 97,242,196 (-)NCBINCBI36hg18NCBI36
Build 34897,223,737 - 97,242,196NCBI
Celera893,340,541 - 93,359,001 (-)NCBI
Cytogenetic Map8q22.1NCBI
HuRef892,360,118 - 92,378,582 (-)NCBIHuRef
CHM1_1897,194,809 - 97,213,265 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression

Sequence

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Nomenclature History
 
More on GDF6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347722
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.