TPTE (transmembrane phosphatase with tensin homology) - Rat Genome Database

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Gene: TPTE (transmembrane phosphatase with tensin homology) Homo sapiens
Analyze
Symbol: TPTE
Name: transmembrane phosphatase with tensin homology
RGD ID: 1347469
HGNC Page HGNC:12023
Description: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cancer/testis antigen 44; CT44; PTEN-related tyrosine phosphatase; PTEN2; putative tyrosine-protein phosphatase TPTE; tensin, putative protein-tyrosine phosphatase; TPTE1; tumor antigen BJ-HCC-5
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Related Pseudogenes: TPTEP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382110,521,583 - 10,605,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2110,521,553 - 10,606,140 (+)EnsemblGRCh38hg38GRCh38
GRCh372110,906,741 - 10,990,874 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36219,928,612 - 10,012,791 (-)NCBINCBI36Build 36hg18NCBI36
Build 34219,928,074 - 10,012,791NCBI
Cytogenetic Map21p11.2NCBI
HuRef21136,639 - 139,791 (-)NCBIHuRef
HuRef2189,324 - 92,208 (-)NCBIHuRef
CHM1_12110,640,418 - 10,724,287 (-)NCBICHM1_1
T2T-CHM13v2.02110,521,020 - 10,605,159 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
membrane  (IEA,TAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9693027   PMID:10598804   PMID:10830953   PMID:11030409   PMID:11279206   PMID:11810268   PMID:12477932   PMID:14659893   PMID:15489334   PMID:18074101   PMID:18854154   PMID:21873635  
PMID:21988832   PMID:23936387   PMID:24639526   PMID:26350112   PMID:27432908   PMID:27880917   PMID:28065597   PMID:28298427   PMID:28330616   PMID:28675297   PMID:32296183   PMID:34857952  
PMID:35044719   PMID:38546751  


Genomics

Comparative Map Data
TPTE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382110,521,583 - 10,605,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2110,521,553 - 10,606,140 (+)EnsemblGRCh38hg38GRCh38
GRCh372110,906,741 - 10,990,874 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36219,928,612 - 10,012,791 (-)NCBINCBI36Build 36hg18NCBI36
Build 34219,928,074 - 10,012,791NCBI
Cytogenetic Map21p11.2NCBI
HuRef21136,639 - 139,791 (-)NCBIHuRef
HuRef2189,324 - 92,208 (-)NCBIHuRef
CHM1_12110,640,418 - 10,724,287 (-)NCBICHM1_1
T2T-CHM13v2.02110,521,020 - 10,605,159 (-)NCBIT2T-CHM13v2.0
Tpte
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,773,457 - 22,861,432 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,773,457 - 22,861,434 (+)EnsemblGRCm39 Ensembl
GRCm38822,283,315 - 22,371,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,283,441 - 22,371,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,393,913 - 23,481,890 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,748,986 - 23,836,963 (+)NCBIMGSCv36mm8
Celera823,776,216 - 23,864,320 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.2NCBI

Variants

.
Variants in TPTE
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 21p11.1-q11.2(chr21:10953431-15707444)x1 copy number loss See cases [RCV000052775] Chr21:10953431..15707444 [GRCh37]
Chr21:9975302..14629315 [NCBI36]
Chr21:21p11.1-q11.2		 pathogenic
NM_199261.3(TPTE):c.1633G>A (p.Asp545Asn) single nucleotide variant Malignant melanoma [RCV000072880] Chr21:10605529 [GRCh38]
Chr21:10906928 [GRCh37]
Chr21:9928799 [NCBI36]
Chr21:21p11.2		 not provided
NM_199261.3(TPTE):c.1222C>T (p.Leu408Phe) single nucleotide variant Malignant melanoma [RCV000072881] Chr21:10596033 [GRCh38]
Chr21:10916424 [GRCh37]
Chr21:9938295 [NCBI36]
Chr21:21p11.2		 not provided
NM_199261.3(TPTE):c.1357-1241C>G single nucleotide variant Lung cancer [RCV000101790] Chr21:10600817 [GRCh38]
Chr21:10911640 [GRCh37]
Chr21:21p11.2		 uncertain significance
NM_199261.3(TPTE):c.1356+842C>T single nucleotide variant Lung cancer [RCV000101791] Chr21:10598936 [GRCh38]
Chr21:10913521 [GRCh37]
Chr21:21p11.2		 uncertain significance
NM_199261.3(TPTE):c.1027+4484G>T single nucleotide variant Lung cancer [RCV000101792] Chr21:10583089 [GRCh38]
Chr21:10929368 [GRCh37]
Chr21:21p11.2		 uncertain significance
NM_199261.3(TPTE):c.796-990G>T single nucleotide variant Lung cancer [RCV000101793] Chr21:10576470 [GRCh38]
Chr21:10935987 [GRCh37]
Chr21:21p11.2		 uncertain significance
NM_199261.3(TPTE):c.-43-2442C>T single nucleotide variant Lung cancer [RCV000101794] Chr21:10536239 [GRCh38]
Chr21:10976218 [GRCh37]
Chr21:21p11.2		 uncertain significance
GRCh38/hg38 21q11.2-22.3(chr21:7749532-46649831)x3 copy number gain See cases [RCV000134509] Chr21:7749532..46649831 [GRCh38]
Chr21:14577835..48069743 [GRCh37]
Chr21:13499706..46894171 [NCBI36]
Chr21:21q11.2-22.3		 pathogenic
GRCh38/hg38 21q22.11-22.3(chr21:7749532-46670346)x3 copy number gain See cases [RCV000135310] Chr21:7749532..46670346 [GRCh38]
Chr21:34111831..48090258 [GRCh37]
Chr21:33033702..46914686 [NCBI36]
Chr21:21q22.11-22.3		 pathogenic
NM_199261.4(TPTE):c.1357-3_1357-2del deletion Autism spectrum disorder [RCV000172926] Chr21:10602054..10602055 [GRCh38]
Chr21:10910401..10910402 [GRCh37]
Chr21:21p11.2		 uncertain significance
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-42971047)x3 copy number gain See cases [RCV000133676] Chr21:7749532..42971047 [GRCh38]
Chr21:15499847..44391157 [GRCh37]
Chr21:14421718..43264226 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46653084)x3 copy number gain See cases [RCV000134727] Chr21:7749532..46653084 [GRCh38]
Chr21:15485038..48072996 [GRCh37]
Chr21:14406909..46897424 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46670440)x3 copy number gain See cases [RCV000134119] Chr21:7749532..46670440 [GRCh38]
Chr21:15485038..48090352 [GRCh37]
Chr21:14406909..46914780 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46664250)x3 copy number gain See cases [RCV000134836] Chr21:7749532..46664250 [GRCh38]
Chr21:15485038..48084162 [GRCh37]
Chr21:14406909..46908590 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46670440)x3 copy number gain See cases [RCV000134842] Chr21:7749532..46670440 [GRCh38]
Chr21:15513244..48090352 [GRCh37]
Chr21:14435115..46914780 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46660999)x3 copy number gain See cases [RCV000135448] Chr21:7749532..46660999 [GRCh38]
Chr21:15499847..48080911 [GRCh37]
Chr21:14421718..46905339 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2(chr21:10336174-10597374)x1 copy number loss See cases [RCV000136342] Chr21:10336174..10597374 [GRCh38]
Chr21:10915083..11176283 [GRCh37]
Chr21:9936954..10198154 [NCBI36]
Chr21:21p11.2		 benign
GRCh38/hg38 21p11.2(chr21:10478754-10648241)x1 copy number loss See cases [RCV000136399] Chr21:10478754..10648241 [GRCh38]
Chr21:10864216..11033703 [GRCh37]
Chr21:9886087..10055574 [NCBI36]
Chr21:21p11.2		 benign
GRCh38/hg38 21p11.2(chr21:10465006-10613466)x1 copy number loss See cases [RCV000136436] Chr21:10465006..10613466 [GRCh38]
Chr21:10898991..11047451 [GRCh37]
Chr21:9920862..10069322 [NCBI36]
Chr21:21p11.2		 benign
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46671060)x3 copy number gain See cases [RCV000137255] Chr21:7749532..46671060 [GRCh38]
Chr21:35319225..48090972 [GRCh37]
Chr21:34241095..46915400 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46671060)x3 copy number gain See cases [RCV000137337] Chr21:7749532..46671060 [GRCh38]
Chr21:10697897..48090972 [GRCh37]
Chr21:1..46915400 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.13(chr21:7749532-37653653)x1 copy number loss See cases [RCV000138095] Chr21:7749532..37653653 [GRCh38]
Chr21:15451032..39025955 [GRCh37]
Chr21:14372903..37947825 [NCBI36]
Chr21:21p11.2-q22.13		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46671060)x3 copy number gain See cases [RCV000138216] Chr21:7749532..46671060 [GRCh38]
Chr21:10944001..48090972 [GRCh37]
Chr21:9965872..46915400 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46671060)x3 copy number gain See cases [RCV000138436] Chr21:7749532..46671060 [GRCh38]
Chr21:15451032..48090972 [GRCh37]
Chr21:14372903..46915400 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 21p11.2-q22.3(chr21:7817158-46670440)x1 copy number loss See cases [RCV000142427] Chr21:7817158..46670440 [GRCh38]
Chr21:15485038..48090352 [GRCh37]
Chr21:14406909..46914780 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46670405)x3 copy number gain See cases [RCV000148131] Chr21:7749532..46670405 [GRCh38]
Chr21:15499847..48090317 [GRCh37]
Chr21:14421718..46914745 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46670405)x3 copy number gain See cases [RCV000050445] Chr21:7749532..46670405 [GRCh38]
Chr21:15499847..48090317 [GRCh37]
Chr21:14421718..46914745 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46670546)x3 copy number gain See cases [RCV000053045] Chr21:7749532..46670546 [GRCh38]
Chr21:15499647..48090458 [GRCh37]
Chr21:14421518..46914886 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46661140)x3 copy number gain See cases [RCV000053065] Chr21:7749532..46661140 [GRCh38]
Chr21:15499647..48081052 [GRCh37]
Chr21:14421518..46905480 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46661140)x3 copy number gain See cases [RCV000053067] Chr21:7749532..46661140 [GRCh38]
Chr21:15499847..48081052 [GRCh37]
Chr21:14421718..46905480 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46670405)x3 copy number gain See cases [RCV000053068] Chr21:7749532..46670405 [GRCh38]
Chr21:20655360..48090317 [GRCh37]
Chr21:19577231..46914745 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46670405)x3 copy number gain See cases [RCV000053069] Chr21:7749532..46670405 [GRCh38]
Chr21:34423268..48090317 [GRCh37]
Chr21:33345138..46914745 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46623792)x3 copy number gain See cases [RCV000053039] Chr21:7749532..46623792 [GRCh38]
Chr21:14524963..48043704 [GRCh37]
Chr21:13446834..46868132 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46653090)x3 copy number gain See cases [RCV000053040] Chr21:7749532..46653090 [GRCh38]
Chr21:14539679..48073002 [GRCh37]
Chr21:13461550..46897430 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46623792)x3 copy number gain See cases [RCV000053042] Chr21:7749532..46623792 [GRCh38]
Chr21:14595524..48043704 [GRCh37]
Chr21:13517395..46868132 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
GRCh38/hg38 21p11.2-q22.3(chr21:7749532-46623792)x3 copy number gain See cases [RCV000053043] Chr21:7749532..46623792 [GRCh38]
Chr21:14629063..48043704 [GRCh37]
Chr21:13550934..46868132 [NCBI36]
Chr21:21p11.2-q22.3		 pathogenic
Single allele deletion Large for gestational age [RCV000161893] Chr21:10599016..10684924 [GRCh38]
Chr21:10827533..10913441 [GRCh37]
Chr21:21p11.2		 not provided
GRCh38/hg38 21q11.2-22.3(chr21:7749532-46670346)x3 copy number gain See cases [RCV000140103] Chr21:7749532..46670346 [GRCh38]
Chr21:14577894..48090258 [GRCh37]
Chr21:13499765..46914686 [NCBI36]
Chr21:21q11.2-22.3		 pathogenic
GRCh38/hg38 21q11.2-22.3(chr21:7749532-46677460)x3 copy number gain See cases [RCV000143120] Chr21:7749532..46677460 [GRCh38]
Chr21:15006457..48097372 [GRCh37]
Chr21:13928328..46921800 [NCBI36]
Chr21:21q11.2-22.3		 pathogenic
GRCh38/hg38 21q11.2-22.3(chr21:7749532-46677460) copy number gain See cases [RCV000143160] Chr21:7749532..46677460 [GRCh38]
Chr21:14386013..48097372 [GRCh37]
Chr21:13307884..46921800 [NCBI36]
Chr21:21q11.2-22.3		 pathogenic
GRCh38/hg38 21q11.2-22.3(chr21:7749532-46677460)x3 copy number gain See cases [RCV000143376] Chr21:7749532..46677460 [GRCh38]
Chr21:15006458..48097372 [GRCh37]
Chr21:13928329..46921800 [NCBI36]
Chr21:21q11.2-22.3		 pathogenic
GRCh38/hg38 21q11.2-22.3(chr21:7749532-46698247)x3 copy number gain See cases [RCV000141346] Chr21:7749532..46698247 [GRCh38]
Chr21:14577835..48118159 [GRCh37]
Chr21:13499706..46942587 [NCBI36]
Chr21:21q11.2-22.3		 pathogenic
GRCh38/hg38 21q21.3-22.3(chr21:7749532-46677460)x3 copy number gain See cases [RCV000141827] Chr21:7749532..46677460 [GRCh38]
Chr21:28285299..48097372 [GRCh37]
Chr21:27207170..46921800 [NCBI36]
Chr21:21q21.3-22.3		 uncertain significance
GRCh38/hg38 21p11.2-q21.3(chr21:13048294-27532614) copy number loss Monosomy 21 [RCV000225452] Chr21:13048294..27532614 [GRCh38]
Chr21:21p11.2-q21.3		 pathogenic
GRCh37/hg19 21p11.2-q22.3(chr21:10824040-48090629)x3 copy number gain not provided [RCV000741418] Chr21:10824040..48090629 [GRCh37]
Chr21:21p11.2-q22.3		 pathogenic
GRCh37/hg19 21p11.2-q22.3(chr21:10827533-48100155)x3 copy number gain not provided [RCV000741419] Chr21:10827533..48100155 [GRCh37]
Chr21:21p11.2-q22.3		 pathogenic
GRCh37/hg19 21p11.2-11.1(chr21:10699330-10913441)x1 copy number loss not provided [RCV000741406] Chr21:10699330..10913441 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-11.1(chr21:10699330-10917770)x1 copy number loss not provided [RCV000741407] Chr21:10699330..10917770 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-11.1(chr21:10699330-10921513)x1 copy number loss not provided [RCV000741408] Chr21:10699330..10921513 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-11.1(chr21:10699330-10931039)x1 copy number loss not provided [RCV000741409] Chr21:10699330..10931039 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-11.1(chr21:10699330-10938138)x1 copy number loss not provided [RCV000741410] Chr21:10699330..10938138 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-11.1(chr21:10699330-11011760)x1 copy number loss not provided [RCV000741411] Chr21:10699330..11011760 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-11.1(chr21:10699330-11188004)x3 copy number gain not provided [RCV000741412] Chr21:10699330..11188004 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-q22.3(chr21:10699330-48117896)x3 copy number gain not provided [RCV000741413] Chr21:10699330..48117896 [GRCh37]
Chr21:21p11.2-q22.3		 pathogenic
GRCh37/hg19 21p11.2-11.1(chr21:10704198-11016737)x1 copy number loss not provided [RCV000741414] Chr21:10704198..11016737 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-q22.3(chr21:10704198-48117896)x3 copy number gain not provided [RCV000741415] Chr21:10704198..48117896 [GRCh37]
Chr21:21p11.2-q22.3		 pathogenic
GRCh37/hg19 21p11.2-11.1(chr21:10765264-11011760)x1 copy number loss not provided [RCV000741416] Chr21:10765264..11011760 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.2-11.1(chr21:10824040-11098723)x3 copy number gain not provided [RCV000741417] Chr21:10824040..11098723 [GRCh37]
Chr21:21p11.2-11.1		 benign
GRCh37/hg19 21p11.1-q21.2(chr21:10944001-25730963) copy number gain not provided [RCV000767670] Chr21:10944001..25730963 [GRCh37]
Chr21:21p11.1-q21.2		 pathogenic
NM_199261.4(TPTE):c.21G>T (p.Pro7=) single nucleotide variant not provided [RCV000886041] Chr21:10541121 [GRCh38]
Chr21:10971336 [GRCh37]
Chr21:21p11.2		 likely benign
NM_199261.4(TPTE):c.446+10A>G single nucleotide variant not provided [RCV000974662] Chr21:10561201 [GRCh38]
Chr21:10951256 [GRCh37]
Chr21:21p11.2		 benign
GRCh37/hg19 21p13-q22.3(chr21:1-48129895)x3 copy number gain See cases [RCV001780078] Chr21:1..48129895 [GRCh37]
Chr21:21p13-q22.3		 pathogenic
NM_199261.4(TPTE):c.212C>G (p.Ala71Gly) single nucleotide variant Inborn genetic diseases [RCV002984111] Chr21:10552695 [GRCh38]
Chr21:10959762 [GRCh37]
Chr21:21p11.2		 uncertain significance
NM_199261.4(TPTE):c.37G>C (p.Val13Leu) single nucleotide variant Inborn genetic diseases [RCV002935610] Chr21:10541137 [GRCh38]
Chr21:10971320 [GRCh37]
Chr21:21p11.2		 uncertain significance
NM_199261.4(TPTE):c.299T>C (p.Phe100Ser) single nucleotide variant Inborn genetic diseases [RCV002672608] Chr21:10561044 [GRCh38]
Chr21:10951413 [GRCh37]
Chr21:21p11.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:778
Count of miRNA genes:427
Interacting mature miRNAs:452
Transcripts:ENST00000298232, ENST00000328758, ENST00000342420, ENST00000361285, ENST00000415664, ENST00000447568
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D13S975  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37Y28,655,821 - 28,655,987UniSTSGRCh37
GRCh372110,972,146 - 10,972,312UniSTSGRCh37
Build 36219,994,017 - 9,994,183RGDNCBI36
CeleraY9,587,823 - 9,587,989RGD
Cytogenetic MapYq11.23UniSTS
Cytogenetic Map21p11UniSTS
HuRefY19,120,009 - 19,120,175UniSTS
PMC310823P6  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372110,937,912 - 10,938,056UniSTSGRCh37
Build 36219,959,783 - 9,959,927RGDNCBI36
Cytogenetic Map21p11UniSTS
PMC310823P1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map21p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 2 1 1 1 2 367 4
Low 32 2 29 7 30 7 41 15 31 4 25 60 2 8 1
Below cutoff 707 644 605 121 295 68 865 489 927 49 276 399 55 252 567 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_034032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC244111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC244144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF254982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF254983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF495908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI149736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI200912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL078471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL163201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY219886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY219887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY219888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB459772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC044491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000427445   ⟹   ENSP00000482488
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2110,521,575 - 10,605,716 (+)Ensembl
RefSeq Acc Id: ENST00000612746   ⟹   ENSP00000483087
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2110,521,575 - 10,605,716 (+)Ensembl
RefSeq Acc Id: ENST00000612957   ⟹   ENSP00000484064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2110,521,572 - 10,567,699 (+)Ensembl
RefSeq Acc Id: ENST00000618007   ⟹   ENSP00000484403
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2110,521,583 - 10,605,716 (+)Ensembl
RefSeq Acc Id: ENST00000622113   ⟹   ENSP00000482040
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2110,521,553 - 10,606,140 (+)Ensembl
RefSeq Acc Id: NM_001290224   ⟹   NP_001277153
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382110,521,583 - 10,605,716 (+)NCBI
CHM1_12110,639,867 - 10,724,310 (-)NCBI
T2T-CHM13v2.02110,521,020 - 10,605,159 (-)NCBI
Sequence:
RefSeq Acc Id: NM_199259   ⟹   NP_954868
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382110,521,583 - 10,605,716 (+)NCBI
GRCh372110,906,741 - 10,990,920 (-)RGD
Build 36219,928,612 - 10,012,791 (-)NCBI Archive
HuRef21136,639 - 139,791 (-)ENTREZGENE
HuRef2189,324 - 92,208 (-)NCBI
CHM1_12110,639,867 - 10,724,310 (-)NCBI
T2T-CHM13v2.02110,521,020 - 10,605,159 (-)NCBI
Sequence:
RefSeq Acc Id: NM_199260   ⟹   NP_954869
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382110,521,583 - 10,605,716 (+)NCBI
GRCh372110,906,741 - 10,990,920 (-)RGD
Build 36219,928,612 - 10,012,791 (-)NCBI Archive
HuRef21136,639 - 139,791 (-)ENTREZGENE
HuRef2189,324 - 92,208 (-)NCBI
CHM1_12110,639,867 - 10,724,310 (-)NCBI
T2T-CHM13v2.02110,521,020 - 10,605,159 (-)NCBI
Sequence:
RefSeq Acc Id: NM_199261   ⟹   NP_954870
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382110,521,583 - 10,605,716 (+)NCBI
GRCh372110,906,741 - 10,990,920 (-)RGD
Build 36219,928,612 - 10,012,791 (-)NCBI Archive
HuRef21136,639 - 139,791 (-)ENTREZGENE
HuRef2189,324 - 92,208 (-)NCBI
CHM1_12110,639,867 - 10,724,310 (-)NCBI
T2T-CHM13v2.02110,521,020 - 10,605,159 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_954870   ⟸   NM_199261
- Peptide Label: isoform alpha
- UniProtKB: Q71JA8 (UniProtKB/Swiss-Prot),   Q6XPS5 (UniProtKB/Swiss-Prot),   Q6XPS4 (UniProtKB/Swiss-Prot),   P56180 (UniProtKB/Swiss-Prot),   C9JKK8 (UniProtKB/Swiss-Prot),   C9J6D6 (UniProtKB/Swiss-Prot),   B2RAP7 (UniProtKB/Swiss-Prot),   Q8NCS8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_954868   ⟸   NM_199259
- Peptide Label: isoform beta
- Sequence:
RefSeq Acc Id: NP_954869   ⟸   NM_199260
- Peptide Label: isoform gamma
- Sequence:
RefSeq Acc Id: NP_001277153   ⟸   NM_001290224
- Peptide Label: isoform delta
- Sequence:
RefSeq Acc Id: ENSP00000482040   ⟸   ENST00000622113
RefSeq Acc Id: ENSP00000482488   ⟸   ENST00000427445
RefSeq Acc Id: ENSP00000484064   ⟸   ENST00000612957
RefSeq Acc Id: ENSP00000483087   ⟸   ENST00000612746
RefSeq Acc Id: ENSP00000484403   ⟸   ENST00000618007
Protein Domains
C2 tensin-type   Phosphatase tensin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56180-F1-model_v2 AlphaFold P56180 1-551 view protein structure

Promoters
RGD ID:13602494
Promoter ID:EPDNEW_H27432
Type:initiation region
Name:TPTE_1
Description:transmembrane phosphatase with tensin homology
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27433  EPDNEW_H27434  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382110,521,468 - 10,521,528EPDNEW
RGD ID:13602498
Promoter ID:EPDNEW_H27433
Type:initiation region
Name:TPTE_3
Description:transmembrane phosphatase with tensin homology
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27432  EPDNEW_H27434  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382110,521,583 - 10,521,643EPDNEW
RGD ID:13602500
Promoter ID:EPDNEW_H27434
Type:single initiation site
Name:TPTE_2
Description:transmembrane phosphatase with tensin homology
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27432  EPDNEW_H27433  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382110,543,949 - 10,544,009EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12023 AgrOrtholog
COSMIC TPTE COSMIC
Ensembl Genes ENSG00000274391 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000427445 ENTREZGENE
  ENST00000427445.6 UniProtKB/Swiss-Prot
  ENST00000612746 ENTREZGENE
  ENST00000612746.1 UniProtKB/Swiss-Prot
  ENST00000612957.4 UniProtKB/TrEMBL
  ENST00000618007 ENTREZGENE
  ENST00000618007.5 UniProtKB/Swiss-Prot
  ENST00000622113 ENTREZGENE
  ENST00000622113.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1110 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
GTEx ENSG00000274391 GTEx
HGNC ID HGNC:12023 ENTREZGENE
Human Proteome Map TPTE Human Proteome Map
InterPro C2_domain_sf UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTP_cat UniProtKB/Swiss-Prot
  PTP_VSP_TPTE UniProtKB/Swiss-Prot
  Tensin_C2-dom UniProtKB/Swiss-Prot
  Tensin_phosphatase UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7179 UniProtKB/Swiss-Prot
NCBI Gene 7179 ENTREZGENE
OMIM 604336 OMIM
PANTHER PHOSPHATASE WITH HOMOLOGY TO TENSIN UniProtKB/Swiss-Prot
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  PTEN_C2 UniProtKB/Swiss-Prot
  Y_phosphatase UniProtKB/Swiss-Prot
PharmGKB PA36702 PharmGKB
PROSITE C2_TENSIN UniProtKB/Swiss-Prot
  PPASE_TENSIN UniProtKB/Swiss-Prot
SMART PTEN_C2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
  SSF52799 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A087X1C4_HUMAN UniProtKB/TrEMBL
  B2RAP7 ENTREZGENE
  C9J6D6 ENTREZGENE
  C9JKK8 ENTREZGENE
  P56180 ENTREZGENE
  Q6XPS4 ENTREZGENE
  Q6XPS5 ENTREZGENE
  Q71JA8 ENTREZGENE
  Q8NCS8 ENTREZGENE
  TPTE_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2RAP7 UniProtKB/Swiss-Prot
  C9J6D6 UniProtKB/Swiss-Prot
  C9JKK8 UniProtKB/Swiss-Prot
  Q6XPS4 UniProtKB/Swiss-Prot
  Q6XPS5 UniProtKB/Swiss-Prot
  Q71JA8 UniProtKB/Swiss-Prot
  Q8NCS8 UniProtKB/Swiss-Prot