MIR134 (microRNA 134) - Rat Genome Database

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Gene: MIR134 (microRNA 134) Homo sapiens
Analyze
Symbol: MIR134
Name: microRNA 134
RGD ID: 1347046
HGNC Page HGNC
Description: Predicted to act upstream of or within several processes, including cell aging; cellular response to amino acid stimulus; and long-term synaptic potentiation. Predicted to be located in postsynaptic density.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-134; MIRN134
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14101,054,687 - 101,054,759 (+)EnsemblGRCh38hg38GRCh38
GRCh3814101,054,687 - 101,054,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714101,521,024 - 101,521,096 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,590,776 - 100,590,848 (+)NCBINCBI36hg18NCBI36
Celera1481,577,085 - 81,577,157 (+)NCBI
Cytogenetic Map14q32.31NCBI
HuRef1481,704,397 - 81,704,469 (+)NCBIHuRef
CHM1_114101,460,046 - 101,460,118 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Additional References at PubMed
PMID:12007417   PMID:15183728   PMID:15891114   PMID:16381832   PMID:16421561   PMID:17604727   PMID:18320040   PMID:20546789   PMID:21037258   PMID:21943159   PMID:22259016   PMID:22683779  
PMID:23010597   PMID:23034410   PMID:23467648   PMID:23824713   PMID:24135056   PMID:24258346   PMID:24440911   PMID:24498348   PMID:24833470   PMID:25156495   PMID:25447206   PMID:25528443  
PMID:25564273   PMID:25811077   PMID:26166818   PMID:26363097   PMID:26365938   PMID:26416415   PMID:26512644   PMID:26546816   PMID:26642897   PMID:26646931   PMID:26799933   PMID:26823765  
PMID:26897940   PMID:26939053   PMID:27012554   PMID:27095166   PMID:27166267   PMID:27241841   PMID:27558843   PMID:27685628   PMID:28043921   PMID:28075475   PMID:28206956   PMID:28260021  
PMID:28646209   PMID:28728844   PMID:28978937   PMID:29038169   PMID:29130100   PMID:29275424   PMID:29432532   PMID:29762819   PMID:29971778   PMID:30158376   PMID:30514242   PMID:30521500  
PMID:30569124   PMID:30645141   PMID:30953817   PMID:30977909   PMID:31383552   PMID:31721211   PMID:31983121   PMID:32039495   PMID:32106369   PMID:32170146   PMID:32238141   PMID:32314378  
PMID:32568182   PMID:32749739   PMID:32875345   PMID:33116466   PMID:33155208   PMID:33331954   PMID:33362712   PMID:33467738   PMID:33621196   PMID:33728743  


Genomics

Comparative Map Data
MIR134
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14101,054,687 - 101,054,759 (+)EnsemblGRCh38hg38GRCh38
GRCh3814101,054,687 - 101,054,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714101,521,024 - 101,521,096 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,590,776 - 100,590,848 (+)NCBINCBI36hg18NCBI36
Celera1481,577,085 - 81,577,157 (+)NCBI
Cytogenetic Map14q32.31NCBI
HuRef1481,704,397 - 81,704,469 (+)NCBIHuRef
CHM1_114101,460,046 - 101,460,118 (+)NCBICHM1_1
Mir134
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,700,573 - 109,700,643 (+)NCBIGRCm39mm39
GRCm39 Ensembl12109,700,573 - 109,700,643 (+)Ensembl
GRCm3812109,734,139 - 109,734,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,734,139 - 109,734,209 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,972,349 - 110,972,419 (+)NCBIGRCm37mm9NCBIm37
Celera12110,931,370 - 110,931,440 (+)NCBICelera
Cytogenetic Map12F1NCBI
Mir134
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26128,748,908 - 128,748,980 (+)NCBImRatBN7.2
Rnor_6.06133,884,547 - 133,884,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,884,531 - 133,884,633 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,046,904 - 143,046,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,333,287 - 126,333,359 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR134
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,283,496 - 69,283,568 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,801,642 - 68,801,714 (+)NCBI
ROS_Cfam_1.0869,565,142 - 69,565,214 (+)NCBI
UMICH_Zoey_3.1869,228,685 - 69,228,757 (+)NCBI
UNSW_CanFamBas_1.0869,294,783 - 69,294,855 (+)NCBI
UU_Cfam_GSD_1.0869,692,783 - 69,692,855 (+)NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
VEGFAhsa-miR-134-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayFunctional MTI18320040
ABCC1hsa-miR-134-5pMirtarbaseexternal_infoqRT-PCR//Western blot//Northern blotFunctional MTI20371173
FOXM1hsa-miR-134-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI23010597
FOXM1hsa-miR-134-5pOncomiRDBexternal_infoNANA23010597
DPYDhsa-miR-134-5pOncomiRDBexternal_infoNANA22306127

Predicted Targets
Summary Value
Count of predictions:38571
Count of gene targets:13745
Count of transcripts:29363
Interacting mature miRNAs:hsa-miR-134-3p, hsa-miR-134-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 2 2 3 2 2
Low 6 1 9 3 9 3 10 8 29 2 12 13 1 1 2
Below cutoff 3 1 1 5 3 8 11 3 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385258
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl14101,054,687 - 101,054,759 (+)Ensembl
RefSeq Acc Id: NR_029698
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,054,687 - 101,054,759 (+)NCBI
GRCh3714101,521,024 - 101,521,096 (+)RGD
Celera1481,577,085 - 81,577,157 (+)RGD
HuRef1481,704,397 - 81,704,469 (+)ENTREZGENE
CHM1_114101,460,046 - 101,460,118 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
NC_000014.9:g.100806482_101281031del474550 deletion Paternal uniparental disomy of chromosome 14 [RCV000149429] Chr14:100806482..101281031 [GRCh38]
Chr14:101272819..101747368 [GRCh37]
Chr14:14q32.2-32.31
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:100575917-107281934) copy number gain not provided [RCV000767752] Chr14:100575917..107281934 [GRCh37]
Chr14:14q32.2-32.33
pathogenic
GRCh37/hg19 14q32.31(chr14:101468366-101979522)x3 copy number gain See cases [RCV000449250] Chr14:101468366..101979522 [GRCh37]
Chr14:14q32.31
uncertain significance
GRCh37/hg19 14q32.2-32.33(chr14:98051841-107285437)x3 copy number gain See cases [RCV000446497] Chr14:98051841..107285437 [GRCh37]
Chr14:14q32.2-32.33
likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:100661319-107285437)x1 copy number loss See cases [RCV000511171] Chr14:100661319..107285437 [GRCh37]
Chr14:14q32.2-32.33
pathogenic
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33
pathogenic
GRCh37/hg19 14q32.12-32.33(chr14:91969028-107285437)x3 copy number gain not provided [RCV000848687] Chr14:91969028..107285437 [GRCh37]
Chr14:14q32.12-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q32.2-32.31(chr14:99737888-101847855) copy number gain not provided [RCV000767823] Chr14:99737888..101847855 [GRCh37]
Chr14:14q32.2-32.31
likely pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:99794230-107285437)x3 copy number gain not provided [RCV000849272] Chr14:99794230..107285437 [GRCh37]
Chr14:14q32.2-32.33
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:96829290-107287663)x1 copy number loss See cases [RCV001195078] Chr14:96829290..107287663 [GRCh37]
Chr14:14q32.2-32.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31519 AgrOrtholog
COSMIC MIR134 COSMIC
Ensembl Genes ENSG00000207993 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385258 ENTREZGENE
GTEx ENSG00000207993 GTEx
HGNC ID HGNC:31519 ENTREZGENE
Human Proteome Map MIR134 Human Proteome Map
miRBase MI0000474 ENTREZGENE
NCBI Gene 406924 ENTREZGENE
OMIM 610164 OMIM
PharmGKB PA164722480 PharmGKB
RNAcentral URS0000272A92 RNACentral
  URS0000589AA3 RNACentral
  URS000075CBC9 RNACentral