VN1R4 (vomeronasal 1 receptor 4) - Rat Genome Database

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Gene: VN1R4 (vomeronasal 1 receptor 4) Homo sapiens
Analyze
Symbol: VN1R4
Name: vomeronasal 1 receptor 4
RGD ID: 1347041
HGNC Page HGNC:19871
Description: Predicted to enable pheromone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; response to pheromone; and sensory perception of chemical stimulus. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CTD-2245F17.9; G-protein coupled receptor GPCR27; hGPCR27; pheromone receptor; V1R-like 4; V1r-like receptor 4; V1RL4; vomeronasal type-1 receptor 4
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Related Pseudogenes: VN1R101P   VN1R103P   VN1R108P   VN1R11P   VN1R15P   VN1R18P   VN1R20P   VN1R21P   VN1R22P   VN1R25P   VN1R28P   VN1R30P   VN1R33P   VN1R34P   VN1R35P   VN1R37P   VN1R38P   VN1R40P   VN1R46P   VN1R57P   VN1R59P   VN1R64P   VN1R65P   VN1R67P   VN1R68P   VN1R69P   VN1R6P   VN1R70P   VN1R76P   VN1R77P   VN1R79P   VN1R7P   VN1R80P   VN1R81P   VN1R84P   VN1R92P   VN1R97P   VN1R9P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,266,676 - 53,267,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,266,676 - 53,267,723 (-)EnsemblGRCh38hg38GRCh38
GRCh371953,769,929 - 53,770,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,461,825 - 58,462,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 341958,461,824 - 58,462,730NCBI
Celera1950,811,899 - 50,812,804 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,090,647 - 50,091,552 (-)NCBIHuRef
CHM1_11953,771,924 - 53,772,829 (-)NCBICHM1_1
T2T-CHM13v2.01956,346,170 - 56,347,217 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12044878   PMID:12123587   PMID:12477932   PMID:12826614   PMID:15489334   PMID:18029348   PMID:19952141   PMID:21873635  


Genomics

Comparative Map Data
VN1R4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,266,676 - 53,267,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,266,676 - 53,267,723 (-)EnsemblGRCh38hg38GRCh38
GRCh371953,769,929 - 53,770,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,461,825 - 58,462,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 341958,461,824 - 58,462,730NCBI
Celera1950,811,899 - 50,812,804 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,090,647 - 50,091,552 (-)NCBIHuRef
CHM1_11953,771,924 - 53,772,829 (-)NCBICHM1_1
T2T-CHM13v2.01956,346,170 - 56,347,217 (-)NCBIT2T-CHM13v2.0
Vmn1r237
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391721,534,279 - 21,535,148 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1721,532,127 - 21,535,174 (+)EnsemblGRCm39 Ensembl
GRCm381721,314,017 - 21,314,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1721,311,865 - 21,314,912 (+)EnsemblGRCm38mm10GRCm38
MGSCv371721,450,981 - 21,451,850 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361721,018,714 - 21,019,583 (+)NCBIMGSCv36mm8
MGSCv361720,370,997 - 20,371,866 (+)NCBIMGSCv36mm8
Celera7145,993,369 - 145,994,238 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1711.4NCBI
Vom1r21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,636,830 - 69,637,753 (+)NCBIGRCr8
mRatBN7.2160,963,939 - 60,964,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl160,961,052 - 60,970,529 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01928,377,249 - 28,378,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1928,377,249 - 28,378,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01939,317,209 - 39,318,078 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4158,877,734 - 58,878,603 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1158,880,678 - 58,881,548 (+)NCBI
Celera157,082,890 - 57,083,759 (+)NCBICelera
Cytogenetic Map1q12NCBI
LOC100971599
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22059,294,074 - 59,294,981 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,212,480 - 61,213,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01950,185,819 - 50,186,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,066,520 - 59,067,427 (-)NCBIpanpan1.1PanPan1.1panPan2
VN1R4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,754,428 - 103,755,378 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,619,140 - 103,620,090 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01104,210,210 - 104,211,160 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11103,841,645 - 103,842,595 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,603,998 - 103,604,948 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01104,323,517 - 104,324,467 (+)NCBIUU_Cfam_GSD_1.0
LOC110261298
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1657,751,417 - 57,752,358 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in VN1R4
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.42(chr19:53159246-53289022)x3 copy number gain See cases [RCV000140192] Chr19:53159246..53289022 [GRCh38]
Chr19:53662499..53792275 [GRCh37]
Chr19:58354311..58484087 [NCBI36]
Chr19:19q13.42
likely benign
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3 copy number gain See cases [RCV000142008] Chr19:52143873..58445521 [GRCh38]
Chr19:52647126..58956888 [GRCh37]
Chr19:57338938..63648700 [NCBI36]
Chr19:19q13.41-13.43
pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3 copy number gain See cases [RCV000445925] Chr19:50489390..59095359 [GRCh37]
Chr19:19q13.33-13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q13.41-13.42(chr19:53184204-54346718)x3 copy number gain not provided [RCV000740221] Chr19:53184204..54346718 [GRCh37]
Chr19:19q13.41-13.42
uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3 copy number gain not provided [RCV000740208] Chr19:50740074..59097160 [GRCh37]
Chr19:19q13.33-13.43
pathogenic
NM_173857.3(VN1R4):c.658A>G (p.Asn220Asp) single nucleotide variant not provided [RCV000948489] Chr19:53267008 [GRCh38]
Chr19:53770261 [GRCh37]
Chr19:19q13.42
benign
GRCh37/hg19 19q13.42(chr19:53762536-53953261)x1 copy number loss not provided [RCV001007056] Chr19:53762536..53953261 [GRCh37]
Chr19:19q13.42
uncertain significance
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42
not provided
NM_173857.3(VN1R4):c.766A>G (p.Met256Val) single nucleotide variant Inborn genetic diseases [RCV003289690] Chr19:53266900 [GRCh38]
Chr19:53770153 [GRCh37]
Chr19:19q13.42
uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43
pathogenic
NM_173857.3(VN1R4):c.416T>C (p.Met139Thr) single nucleotide variant Inborn genetic diseases [RCV003277016] Chr19:53267250 [GRCh38]
Chr19:53770503 [GRCh37]
Chr19:19q13.42
uncertain significance
GRCh37/hg19 19q13.42(chr19:53723679-53787396)x1 copy number loss not provided [RCV002473759] Chr19:53723679..53787396 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.856A>C (p.Met286Leu) single nucleotide variant Inborn genetic diseases [RCV002777085] Chr19:53266810 [GRCh38]
Chr19:53770063 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.833C>T (p.Pro278Leu) single nucleotide variant Inborn genetic diseases [RCV002739676] Chr19:53266833 [GRCh38]
Chr19:53770086 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.605T>C (p.Met202Thr) single nucleotide variant Inborn genetic diseases [RCV002997896] Chr19:53267061 [GRCh38]
Chr19:53770314 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.254A>G (p.Tyr85Cys) single nucleotide variant Inborn genetic diseases [RCV002950522] Chr19:53267412 [GRCh38]
Chr19:53770665 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.604A>G (p.Met202Val) single nucleotide variant Inborn genetic diseases [RCV002701910] Chr19:53267062 [GRCh38]
Chr19:53770315 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.377A>G (p.His126Arg) single nucleotide variant Inborn genetic diseases [RCV003003782] Chr19:53267289 [GRCh38]
Chr19:53770542 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.46G>A (p.Val16Met) single nucleotide variant Inborn genetic diseases [RCV002765187] Chr19:53267620 [GRCh38]
Chr19:53770873 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.202G>A (p.Ala68Thr) single nucleotide variant Inborn genetic diseases [RCV002964618] Chr19:53267464 [GRCh38]
Chr19:53770717 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.425A>G (p.Asn142Ser) single nucleotide variant Inborn genetic diseases [RCV002965568] Chr19:53267241 [GRCh38]
Chr19:53770494 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.191A>T (p.Gln64Leu) single nucleotide variant Inborn genetic diseases [RCV002964081] Chr19:53267475 [GRCh38]
Chr19:53770728 [GRCh37]
Chr19:19q13.42
uncertain significance
NM_173857.3(VN1R4):c.11G>A (p.Arg4Gln) single nucleotide variant Inborn genetic diseases [RCV003344576] Chr19:53267655 [GRCh38]
Chr19:53770908 [GRCh37]
Chr19:19q13.42
uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3 copy number gain not provided [RCV003485200] Chr19:49625130..57647352 [GRCh37]
Chr19:19q13.33-13.43
likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:84
Interacting mature miRNAs:85
Transcripts:ENST00000311170
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D19S921  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371953,817,876 - 53,818,069UniSTSGRCh37
GRCh371953,771,240 - 53,771,473UniSTSGRCh37
Build 361958,463,052 - 58,463,285RGDNCBI36
Celera1950,813,126 - 50,813,355RGD
Celera1950,859,560 - 50,859,753UniSTS
Cytogenetic Map19q13.42UniSTS
HuRef1950,091,874 - 50,092,111UniSTS
Marshfield Genetic Map1987.66UniSTS
Marshfield Genetic Map1987.66RGD
Genethon Genetic Map1991.7UniSTS
TNG Radiation Hybrid Map1921223.0UniSTS
deCODE Assembly Map1994.56UniSTS
Whitehead-YAC Contig Map19 UniSTS
UniSTS:485589  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371953,769,929 - 53,770,976UniSTSGRCh37
Celera1950,811,815 - 50,812,862UniSTS
HuRef1950,090,563 - 50,091,610UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 224 5
Below cutoff 128 203 89 10 122 4 268 116 200 5 206 91 6 103 182

Sequence


RefSeq Acc Id: ENST00000311170   ⟹   ENSP00000310856
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1953,266,676 - 53,267,723 (-)Ensembl
RefSeq Acc Id: NM_173857   ⟹   NP_776256
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381953,266,676 - 53,267,723 (-)NCBI
GRCh371953,770,013 - 53,770,918 (-)RGD
Build 361958,461,825 - 58,462,730 (-)NCBI Archive
Celera1950,811,899 - 50,812,804 (-)RGD
HuRef1950,090,647 - 50,091,552 (-)ENTREZGENE
CHM1_11953,771,924 - 53,772,829 (-)NCBI
T2T-CHM13v2.01956,346,170 - 56,347,217 (-)NCBI
Sequence:
RefSeq Acc Id: NP_776256   ⟸   NM_173857
- UniProtKB: Q8TDU2 (UniProtKB/Swiss-Prot),   Q7Z5H7 (UniProtKB/Swiss-Prot),   Q7Z5H6 (UniProtKB/Swiss-Prot),   Q2M3E2 (UniProtKB/Swiss-Prot),   Q7Z5H5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000310856   ⟸   ENST00000311170

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7Z5H5-F1-model_v2 AlphaFold Q7Z5H5 1-301 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19871 AgrOrtholog
COSMIC VN1R4 COSMIC
Ensembl Genes ENSG00000228567 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000311170 ENTREZGENE
  ENST00000311170.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
GTEx ENSG00000228567 GTEx
HGNC ID HGNC:19871 ENTREZGENE
Human Proteome Map VN1R4 Human Proteome Map
InterPro GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Vmron_rcpt_1 UniProtKB/Swiss-Prot
KEGG Report hsa:317703 UniProtKB/Swiss-Prot
NCBI Gene 317703 ENTREZGENE
PANTHER PTHR24062 UniProtKB/Swiss-Prot
  VOMERONASAL TYPE-1 RECEPTOR 4 UniProtKB/Swiss-Prot
Pfam V1R UniProtKB/Swiss-Prot
PharmGKB PA134985458 PharmGKB
PRINTS VOMERONASL1R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt Q2M3E2 ENTREZGENE
  Q7Z5H5 ENTREZGENE
  Q7Z5H6 ENTREZGENE
  Q7Z5H7 ENTREZGENE
  Q8TDU2 ENTREZGENE
  VN1R4_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q2M3E2 UniProtKB/Swiss-Prot
  Q7Z5H6 UniProtKB/Swiss-Prot
  Q7Z5H7 UniProtKB/Swiss-Prot
  Q8TDU2 UniProtKB/Swiss-Prot