SULT1C4 (sulfotransferase family 1C member 4) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SULT1C4 (sulfotransferase family 1C member 4) Homo sapiens
Analyze
Symbol: SULT1C4
Name: sulfotransferase family 1C member 4
RGD ID: 1347018
HGNC Page HGNC
Description: Exhibits aryl sulfotransferase activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process; ethanol catabolic process; and sulfation. Localizes to cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC149521; MGC34422; ST1C4; sulfotransferase 1C2; sulfotransferase 1C4; sulfotransferase family, cytosolic, 1C, member 2; sulfotransferase family, cytosolic, 1C, member 4; sulfotransferase family, cytosolic, 1C, member C2; SULT1C; SULT1C#2; SULT1C2
RGD Orthologs
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2108,377,911 - 108,388,989 (+)EnsemblGRCh38hg38GRCh38
GRCh382108,377,954 - 108,388,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372108,994,413 - 109,004,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362108,360,853 - 108,370,702 (+)NCBINCBI36hg18NCBI36
Build 342108,452,938 - 108,462,788NCBI
Celera2103,302,687 - 103,312,533 (+)NCBI
Cytogenetic Map2q12.3NCBI
HuRef2102,593,594 - 102,603,444 (+)NCBIHuRef
CHM1_12108,998,638 - 109,009,695 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IDA,TAS)

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9034160   PMID:9852044   PMID:10720750   PMID:10783263   PMID:11154739   PMID:11535246   PMID:12477932   PMID:15815621   PMID:17425406   PMID:20056724   PMID:21873635   PMID:23207770  
PMID:24028175   PMID:24667918   PMID:26067475   PMID:26186194   PMID:26344197   PMID:26948952   PMID:28514442   PMID:30021884  


Genomics

Comparative Map Data
SULT1C4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2108,377,911 - 108,388,989 (+)EnsemblGRCh38hg38GRCh38
GRCh382108,377,954 - 108,388,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372108,994,413 - 109,004,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362108,360,853 - 108,370,702 (+)NCBINCBI36hg18NCBI36
Build 342108,452,938 - 108,462,788NCBI
Celera2103,302,687 - 103,312,533 (+)NCBI
Cytogenetic Map2q12.3NCBI
HuRef2102,593,594 - 102,603,444 (+)NCBIHuRef
CHM1_12108,998,638 - 109,009,695 (+)NCBICHM1_1
LOC100910235
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.094,323,997 - 4,328,175 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl94,324,211 - 4,327,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.093,362,858 - 3,366,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map9q11NCBI
SULT1C4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A109,612,337 - 109,623,365 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A109,572,466 - 109,622,211 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A94,508,492 - 94,519,963 (+)NCBIMhudiblu_PPA_v0panPan3
SULT1C4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1035,495,727 - 35,504,125 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11035,494,614 - 35,504,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC100623441
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1347,765,022 - 47,777,178 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,934,288 - 49,946,616 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103241211
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11411,860,065 - 11,882,111 (+)NCBI
ChlSab1.1 Ensembl1411,861,211 - 11,871,767 (+)Ensembl

Position Markers
SULT1C2_3157  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372109,003,785 - 109,004,249UniSTSGRCh37
Build 362108,370,217 - 108,370,681RGDNCBI36
Celera2103,312,048 - 103,312,512RGD
HuRef2102,602,959 - 102,603,423UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:526
Count of miRNA genes:362
Interacting mature miRNAs:392
Transcripts:ENST00000272452, ENST00000409309, ENST00000494122
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 83 91 154 28 12 29 167 14 728 176 396 466 136 141 1
Low 2108 2106 1386 455 474 311 3628 1918 2949 184 926 920 145 1 1068 2302 2 1
Below cutoff 203 572 177 136 916 118 525 248 43 46 101 157 27 345 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000272452   ⟹   ENSP00000272452
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2108,377,954 - 108,388,989 (+)Ensembl
RefSeq Acc Id: ENST00000409309   ⟹   ENSP00000387225
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2108,378,185 - 108,387,640 (+)Ensembl
RefSeq Acc Id: ENST00000494122
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2108,377,911 - 108,382,922 (+)Ensembl
RefSeq Acc Id: NM_001321770   ⟹   NP_001308699
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382108,377,954 - 108,388,989 (+)NCBI
CHM1_12108,998,638 - 109,009,695 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006588   ⟹   NP_006579
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382108,377,954 - 108,388,989 (+)NCBI
GRCh372108,994,413 - 109,004,296 (+)NCBI
Build 362108,360,853 - 108,370,702 (+)NCBI Archive
Celera2103,302,687 - 103,312,533 (+)RGD
HuRef2102,593,594 - 102,603,444 (+)RGD
CHM1_12108,998,638 - 109,009,695 (+)NCBI
Sequence:
RefSeq Acc Id: NR_135776
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382108,377,954 - 108,388,989 (+)NCBI
CHM1_12108,998,638 - 109,009,695 (+)NCBI
Sequence:
RefSeq Acc Id: NR_135779
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382108,377,954 - 108,388,989 (+)NCBI
CHM1_12108,998,638 - 109,009,695 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003807   ⟹   XP_016859296
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382108,378,419 - 108,388,989 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006579   ⟸   NM_006588
- Peptide Label: isoform 1
- UniProtKB: O75897 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308699   ⟸   NM_001321770
- Peptide Label: isoform 2
- UniProtKB: O75897 (UniProtKB/Swiss-Prot),   Q6PD90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859296   ⟸   XM_017003807
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000272452   ⟸   ENST00000272452
RefSeq Acc Id: ENSP00000387225   ⟸   ENST00000409309
Protein Domains
Sulfotransfer_1

Promoters
RGD ID:6861272
Promoter ID:EPDNEW_H3801
Type:initiation region
Name:SULT1C4_1
Description:sulfotransferase family 1C member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3802  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382108,377,970 - 108,378,030EPDNEW
RGD ID:6861274
Promoter ID:EPDNEW_H3802
Type:initiation region
Name:SULT1C4_2
Description:sulfotransferase family 1C member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3801  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382108,378,147 - 108,378,207EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q11.2-12.3(chr2:100378510-108472871)x3 copy number gain See cases [RCV000050836] Chr2:100378510..108472871 [GRCh38]
Chr2:100994972..109089327 [GRCh37]
Chr2:100361404..108455759 [NCBI36]
Chr2:2q11.2-12.3
pathogenic
GRCh38/hg38 2q12.2-13(chr2:106696282-110223328)x3 copy number gain See cases [RCV000053141] Chr2:106696282..110223328 [GRCh38]
Chr2:107312738..110980905 [GRCh37]
Chr2:106679170..110338194 [NCBI36]
Chr2:2q12.2-13
uncertain significance
GRCh38/hg38 2q11.2-13(chr2:97672522-110211318)x3 copy number gain See cases [RCV000052947] Chr2:97672522..110211318 [GRCh38]
Chr2:98288985..110968895 [GRCh37]
Chr2:97655417..110326184 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q12.3-13(chr2:107962353-109700179)x1 copy number loss See cases [RCV000134167] Chr2:107962353..109700179 [GRCh38]
Chr2:108578809..110457756 [GRCh37]
Chr2:107945241..109815045 [NCBI36]
Chr2:2q12.3-13
pathogenic|uncertain significance
GRCh38/hg38 2q12.3(chr2:107924122-108509089)x1 copy number loss See cases [RCV000137577] Chr2:107924122..108509089 [GRCh38]
Chr2:108540578..109125545 [GRCh37]
Chr2:107907010..108491977 [NCBI36]
Chr2:2q12.3
uncertain significance
GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3 copy number gain See cases [RCV000138645] Chr2:101710825..110791418 [GRCh38]
Chr2:102327287..111548995 [GRCh37]
Chr2:101693719..111265466 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q12.3(chr2:107924122-108472871)x3 copy number gain See cases [RCV000139122] Chr2:107924122..108472871 [GRCh38]
Chr2:108540578..109089327 [GRCh37]
Chr2:107907010..108455759 [NCBI36]
Chr2:2q12.3
uncertain significance
GRCh38/hg38 2q12.2-13(chr2:106516472-110576905)x3 copy number gain See cases [RCV000139569] Chr2:106516472..110576905 [GRCh38]
Chr2:107132928..111334482 [GRCh37]
Chr2:106499360..110857227 [NCBI36]
Chr2:2q12.2-13
uncertain significance
GRCh38/hg38 2q12.3(chr2:107901810-108472871)x3 copy number gain See cases [RCV000141241] Chr2:107901810..108472871 [GRCh38]
Chr2:108518266..109089327 [GRCh37]
Chr2:107884698..108455759 [NCBI36]
Chr2:2q12.3
uncertain significance
GRCh38/hg38 2q12.2-14.1(chr2:106428663-112379067)x3 copy number gain See cases [RCV000140834] Chr2:106428663..112379067 [GRCh38]
Chr2:107045119..113136644 [GRCh37]
Chr2:106411551..112853115 [NCBI36]
Chr2:2q12.2-14.1
uncertain significance
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3 copy number gain See cases [RCV000141075] Chr2:94678532..110602409 [GRCh38]
Chr2:95344257..111359986 [GRCh37]
Chr2:94707984..111076455 [NCBI36]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2q12.2-14.1(chr2:106423310-115054828)x1 copy number loss See cases [RCV000240053] Chr2:106423310..115054828 [GRCh37]
Chr2:2q12.2-14.1
pathogenic
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4 copy number gain See cases [RCV000446842] Chr2:95327499..111370025 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2q12.3-13(chr2:108526025-110876776)x3 copy number gain See cases [RCV000446992] Chr2:108526025..110876776 [GRCh37]
Chr2:2q12.3-13
uncertain significance
GRCh37/hg19 2q12.3(chr2:108513707-109127929)x1 copy number loss See cases [RCV000446455] Chr2:108513707..109127929 [GRCh37]
Chr2:2q12.3
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.3(chr2:108526025-109127929)x3 copy number gain See cases [RCV000511366] Chr2:108526025..109127929 [GRCh37]
Chr2:2q12.3
uncertain significance
GRCh37/hg19 2q12.3-13(chr2:108534030-110492791)x3 copy number gain See cases [RCV000510943] Chr2:108534030..110492791 [GRCh37]
Chr2:2q12.3-13
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele duplication Neuronopathy, distal hereditary motor, type viia [RCV000534213] Chr2:107988136..108963283 [GRCh38]
Chr2:2q12.3-13
uncertain significance
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss PARP Inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
Single allele duplication not provided [RCV000678012] Chr2:107096423..112235727 [GRCh37]
Chr2:2q12.2-13
likely pathogenic
GRCh37/hg19 2q12.3-13(chr2:108501887-110504318)x3 copy number gain not provided [RCV000682142] Chr2:108501887..110504318 [GRCh37]
Chr2:2q12.3-13
uncertain significance
GRCh37/hg19 2q12.2-13(chr2:107020782-111365996)x1 copy number loss not provided [RCV000682152] Chr2:107020782..111365996 [GRCh37]
Chr2:2q12.2-13
likely pathogenic
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NC_000002.12:g.(?_107988146)_(108963283_?)del deletion Neuronopathy, distal hereditary motor, type viia [RCV001031168] Chr2:108604602..109579739 [GRCh37]
Chr2:2q12.3
uncertain significance
NC_000002.12:g.(?_107988146)_(108963283_?)dup duplication Neuronopathy, distal hereditary motor, type viia [RCV001033739] Chr2:108604602..109579739 [GRCh37]
Chr2:2q12.3
uncertain significance
GRCh37/hg19 2q12.3-13(chr2:108499809-110504318)x1 copy number loss not provided [RCV001005304] Chr2:108499809..110504318 [GRCh37]
Chr2:2q12.3-13
likely pathogenic
GRCh37/hg19 2q12.2-13(chr2:107029680-113187742)x1 copy number loss not provided [RCV001259645] Chr2:107029680..113187742 [GRCh37]
Chr2:2q12.2-13
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11457 AgrOrtholog
COSMIC SULT1C4 COSMIC
Ensembl Genes ENSG00000198075 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000272452 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387225 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000272452 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409309 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000198075 GTEx
HGNC ID HGNC:11457 ENTREZGENE
Human Proteome Map SULT1C4 Human Proteome Map
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:27233 UniProtKB/Swiss-Prot
NCBI Gene 27233 ENTREZGENE
OMIM 608357 OMIM
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162405070 PharmGKB
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.312644 ENTREZGENE
UniProt O75897 ENTREZGENE
  Q6PD90 ENTREZGENE, UniProtKB/TrEMBL
  ST1C4_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q069I8 UniProtKB/Swiss-Prot
  Q08AS5 UniProtKB/Swiss-Prot
  Q53S63 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-10 SULT1C4  sulfotransferase family 1C member 4    sulfotransferase family, cytosolic, 1C, member 4  Symbol and/or name change 5135510 APPROVED