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Gene: CDKN2D (cyclin dependent kinase inhibitor 2D) Homo sapiens
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Symbol: CDKN2D
Name: cyclin dependent kinase inhibitor 2D
Description: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDK inhibitor p19INK4d; cell cycle inhibitor, Nur77 associating protein; cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase 4 inhibitor D p19; cyclin-dependent kinase inhibitor 2D; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); inhibitor of cyclin-dependent kinase 4d; INK4D; p19; p19-INK4D
Orthologs:
Mus musculus (house mouse) : Cdkn2d (cyclin dependent kinase inhibitor 2D)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn2d (cyclin dependent kinase inhibitor 2D)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN2D (cyclin dependent kinase inhibitor 2D)
Canis lupus familiaris (dog) : CDKN2D (cyclin dependent kinase inhibitor 2D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkn2d (cyclin dependent kinase inhibitor 2D)
Sus scrofa (pig) : CDKN2D (cyclin dependent kinase inhibitor 2D)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,566,460 - 10,568,979 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,677,138 - 10,679,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,538,138 - 10,540,655 (-)NCBINCBI36hg18NCBI36
Build 341910,538,138 - 10,540,655NCBI
Celera1910,571,882 - 10,574,399 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,255,057 - 10,257,571 (-)NCBIHuRef
CHM1_11910,677,886 - 10,680,400 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CDKN2D
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346352
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.