PRH2 (proline rich protein HaeIII subfamily 2)

Gene: PRH2 (proline rich protein HaeIII subfamily 2) Homo sapiens

Analyze

Symbol:

PRH2

Name:

proline rich protein HaeIII subfamily 2

RGD ID:

1346350

HGNC Page

HGNC:9367

Description:

Predicted to be located in extracellular space.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

acidic salivary proline-rich protein, HaeIII type, 2; db-s; DKFZp686B01256; DKFZp686F14256; DKFZp686I11251; DKFZp686J06255; DKFZp686L01253; DKFZp686L16244; DKFZp686M04243; DKFZp686N24248; pa; parotid acidic protein; parotid double-band protein; parotid isoelectric focusing variant protein; parotid proline-rich protein 1/2; PIF-S; Pr; pr1/Pr2; PRH1; proline-rich protein HaeIII subfamily 2; protein C; PRP-1/PRP-2; salivary acidic proline-rich phosphoprotein 1/2

RGD Orthologs

Bonobo

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	10,929,236 - 10,934,845 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	10,929,236 - 10,934,845 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	11,081,835 - 11,087,444 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	10,973,101 - 10,977,668 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	10,973,100 - 10,977,663	NCBI
Celera	12	16,229,857 - 16,235,467 (+)	NCBI		Celera
Cytogenetic Map	12	p13.2	NCBI
HuRef	12	10,810,220 - 10,815,831 (+)	NCBI		HuRef
CHM1_1	12	11,051,143 - 11,056,753 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	10,782,594 - 10,807,884 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

acetylsalicylic acid (EXP)

aflatoxin B1 (EXP)

CGP 52608 (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

extracellular region (IEA)

extracellular space (TAS)

Molecular Function

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:438215	PMID:1849422	PMID:2993301	PMID:3009472	PMID:3196309	PMID:3687941	PMID:3710693	PMID:4053693	PMID:7228490	PMID:7380845	PMID:7390979	PMID:10627138
PMID:10858503	PMID:12477932	PMID:15489334	PMID:15693058	PMID:16203048	PMID:20879038	PMID:26091039	PMID:26375204	PMID:29191562	PMID:34445801	PMID:38364699

Genomics

Comparative Map Data

PRH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	10,929,236 - 10,934,845 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	10,929,236 - 10,934,845 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	11,081,835 - 11,087,444 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	10,973,101 - 10,977,668 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	10,973,100 - 10,977,663	NCBI
Celera	12	16,229,857 - 16,235,467 (+)	NCBI		Celera
Cytogenetic Map	12	p13.2	NCBI
HuRef	12	10,810,220 - 10,815,831 (+)	NCBI		HuRef
CHM1_1	12	11,051,143 - 11,056,753 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	10,782,594 - 10,807,884 (+)	NCBI		T2T-CHM13v2.0

PRH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	16,403,461 - 16,404,584 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	16,398,957 - 16,401,340 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	10,959,369 - 10,961,225 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	11,225,394 - 11,227,245 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

Variants

Variants in PRH2
9 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1	copy number loss	See cases [RCV000052776]	Chr12:121055..28415184 [GRCh38] Chr12:282465..28568117 [GRCh37] Chr12:100482..28459384 [NCBI36] Chr12:12p13.33-11.22	pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3	copy number gain	See cases [RCV000053662]	Chr12:80412..25470329 [GRCh38] Chr12:282465..25623263 [GRCh37] Chr12:59839..25514530 [NCBI36] Chr12:12p13.33-12.1	pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4	copy number gain	See cases [RCV000053666]	Chr12:212976..33926913 [GRCh38] Chr12:322142..34079848 [GRCh37] Chr12:192403..33971115 [NCBI36] Chr12:12p13.33-11.1	pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3	copy number gain	See cases [RCV000053660]	Chr12:77187..34380176 [GRCh38] Chr12:282465..34533111 [GRCh37] Chr12:56614..34424378 [NCBI36] Chr12:12p13.33-11.1	pathogenic
NM_001110213.1(PRH2):c.187G>A (p.Gly63Arg)	single nucleotide variant	Malignant melanoma [RCV000069813]	Chr12:10930748 [GRCh38] Chr12:11083347 [GRCh37] Chr12:10974614 [NCBI36] Chr12:12p13.2	not provided
NM_001110213.1(PRH2):c.188G>A (p.Gly63Glu)	single nucleotide variant	Malignant melanoma [RCV000069814]	Chr12:10930749 [GRCh38] Chr12:11083348 [GRCh37] Chr12:10974615 [NCBI36] Chr12:12p13.2	not provided
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3	copy number gain	See cases [RCV000136611]	Chr12:121255..34603274 [GRCh38] Chr12:282465..34756209 [GRCh37] Chr12:100682..34647476 [NCBI36] Chr12:12p13.33-11.1	pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3	copy number gain	See cases [RCV000137694]	Chr12:2871741..14987348 [GRCh38] Chr12:2980907..15140282 [GRCh37] Chr12:2851168..15031549 [NCBI36] Chr12:12p13.33-12.3	pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3	copy number gain	See cases [RCV000139052]	Chr12:121271..34603261 [GRCh38] Chr12:282465..34756196 [GRCh37] Chr12:100698..34647463 [NCBI36] Chr12:12p13.33-11.1	pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3	copy number gain	See cases [RCV000139555]	Chr12:121271..133196807 [GRCh38] Chr12:282465..133773393 [GRCh37] Chr12:100698..132283466 [NCBI36] Chr12:12p13.33-q24.33	pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4	copy number gain	See cases [RCV000139787]	Chr12:54427..34608071 [GRCh38] Chr12:282465..34761006 [GRCh37] Chr12:33854..34652273 [NCBI36] Chr12:12p13.33-11.1	pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3	copy number gain	See cases [RCV000141905]	Chr12:1258274..20657577 [GRCh38] Chr12:1367440..20810511 [GRCh37] Chr12:1237701..20701778 [NCBI36] Chr12:12p13.33-12.2	pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4	copy number gain	See cases [RCV000142149]	Chr12:64620..34682902 [GRCh38] Chr12:173786..34835837 [GRCh37] Chr12:44047..34727104 [NCBI36] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4	copy number gain	See cases [RCV000240164]	Chr12:148034..34178799 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3	copy number gain	See cases [RCV000258805]	Chr12:1..133851895 [GRCh37] Chr12:12p13.33-q24.33	pathogenic\|likely pathogenic
chr12:10074776-18800953 complex variant	complex	Breast ductal adenocarcinoma [RCV000207105]	Chr12:10074776..18800953 [GRCh37] Chr12:12p13.31-12.3	uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3	copy number gain	See cases [RCV000240487]	Chr12:89061..34178799 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.2-12.1(chr12:10853887-24103810)x1	copy number loss	not provided [RCV002292878]	Chr12:10853887..24103810 [GRCh37] Chr12:12p13.2-12.1	pathogenic
NM_001110213.1(PRH2):c.193C>A (p.Gln65Lys)	single nucleotide variant	Inborn genetic diseases [RCV003197180]	Chr12:10930754 [GRCh38] Chr12:11083353 [GRCh37] Chr12:12p13.2	uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3	copy number gain	See cases [RCV000449191]	Chr12:173786..37869301 [GRCh37] Chr12:12p13.33-q11	pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3	copy number gain	See cases [RCV000449287]	Chr12:173786..25286865 [GRCh37] Chr12:12p13.33-12.1	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3	copy number gain	See cases [RCV000447551]	Chr12:173786..34835837 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3	copy number gain	See cases [RCV000446050]	Chr12:173786..20026080 [GRCh37] Chr12:12p13.33-12.2	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150)	copy number gain	See cases [RCV000446017]	Chr12:189578..34756150 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.2(chr12:11047687-11751920)x4	copy number gain	See cases [RCV000510534]	Chr12:11047687..11751920 [GRCh37] Chr12:12p13.2	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3	copy number gain	See cases [RCV000510482]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)	copy number gain	See cases [RCV000511643]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3	copy number gain	See cases [RCV000511580]	Chr12:565369..34835837 [GRCh37] Chr12:12p13.33-11.1	likely pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3	copy number gain	See cases [RCV000510853]	Chr12:173786..11677456 [GRCh37] Chr12:12p13.33-13.2	pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3	copy number gain	See cases [RCV000510961]	Chr12:173786..28219229 [GRCh37] Chr12:12p13.33-11.22	pathogenic
GRCh37/hg19 12p13.2-13.1(chr12:10717428-14032860)x1	copy number loss	not provided [RCV000683470]	Chr12:10717428..14032860 [GRCh37] Chr12:12p13.2-13.1	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3	copy number gain	not provided [RCV000683478]	Chr12:173786..34835837 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.2(chr12:11043965-11260347)x4	copy number gain	not provided [RCV000683403]	Chr12:11043965..11260347 [GRCh37] Chr12:12p13.2	likely benign
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3	copy number gain	not provided [RCV000683480]	Chr12:173786..37869107 [GRCh37] Chr12:12p13.33-q11	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3	copy number gain	not provided [RCV000683479]	Chr12:173786..34835837 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3	copy number gain	not provided [RCV000750253]	Chr12:621220..133779118 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.2(chr12:10959031-11214383)x3	copy number gain	not provided [RCV000737773]	Chr12:10959031..11214383 [GRCh37] Chr12:12p13.2	benign
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3	copy number gain	not provided [RCV000750245]	Chr12:191619..31733044 [GRCh37] Chr12:12p13.33-11.21	pathogenic
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420)	copy number gain	not provided [RCV000767817]	Chr12:189216..15001420 [GRCh37] Chr12:12p13.33-12.3	pathogenic
GRCh37/hg19 12p13.2-13.1(chr12:10336209-13535349)	copy number loss	Multiple endocrine neoplasia type 4 [RCV000767604]	Chr12:10336209..13535349 [GRCh37] Chr12:12p13.2-13.1	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3	copy number gain	not provided [RCV000847209]	Chr12:173786..34496628 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4	copy number gain	not provided [RCV001006470]	Chr12:274676..37869301 [GRCh37] Chr12:12p13.33-q11	pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)	copy number gain	not specified [RCV002052958]	Chr12:173786..37869301 [GRCh37] Chr12:12p13.33-q11	pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)	copy number gain	not specified [RCV002052955]	Chr12:173786..25286865 [GRCh37] Chr12:12p13.33-12.1	pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)	copy number gain	not specified [RCV002052957]	Chr12:173786..34835837 [GRCh37] Chr12:12p13.33-11.1	pathogenic
NM_001110213.1(PRH2):c.295G>T (p.Gly99Cys)	single nucleotide variant	Inborn genetic diseases [RCV002969317]	Chr12:10930856 [GRCh38] Chr12:11083455 [GRCh37] Chr12:12p13.2	uncertain significance
NM_001110213.1(PRH2):c.248G>A (p.Gly83Asp)	single nucleotide variant	Inborn genetic diseases [RCV002906257]	Chr12:10930809 [GRCh38] Chr12:11083408 [GRCh37] Chr12:12p13.2	uncertain significance
NM_001110213.1(PRH2):c.365G>A (p.Arg122Gln)	single nucleotide variant	Inborn genetic diseases [RCV002764396]	Chr12:10930926 [GRCh38] Chr12:11083525 [GRCh37] Chr12:12p13.2	uncertain significance
NM_001110213.1(PRH2):c.356G>C (p.Arg119Pro)	single nucleotide variant	Inborn genetic diseases [RCV002787479]	Chr12:10930917 [GRCh38] Chr12:11083516 [GRCh37] Chr12:12p13.2	uncertain significance
NM_001110213.1(PRH2):c.265G>A (p.Gly89Arg)	single nucleotide variant	Inborn genetic diseases [RCV002792960]	Chr12:10930826 [GRCh38] Chr12:11083425 [GRCh37] Chr12:12p13.2	uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:176047-34179852)x4	copy number gain	Pallister-Killian syndrome [RCV003154827]	Chr12:176047..34179852 [GRCh37] Chr12:12p13.33-11.1	pathogenic
NM_001110213.1(PRH2):c.422C>T (p.Pro141Leu)	single nucleotide variant	Inborn genetic diseases [RCV003364615]	Chr12:10930983 [GRCh38] Chr12:11083582 [GRCh37] Chr12:12p13.2	uncertain significance
Single allele	duplication	not provided [RCV003448692]	Chr12:188053..34856694 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.2(chr12:10588512-11788901)x3	copy number gain	not provided [RCV003484864]	Chr12:10588512..11788901 [GRCh37] Chr12:12p13.2	uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835641)x3	copy number gain	not specified [RCV003986979]	Chr12:173786..34835641 [GRCh37] Chr12:12p13.33-11.1	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3	copy number gain	not provided [RCV000750246]	Chr12:191619..133777645 [GRCh37] Chr12:12p13.33-q24.33	pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	130
Count of miRNA genes:	129
Interacting mature miRNAs:	129
Transcripts:	ENST00000381847, ENST00000396400
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH103478

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	11,080,499 - 11,080,550	UniSTS	GRCh37
GRCh37	12	11,038,130 - 11,038,252	UniSTS	GRCh37
Build 36	12	10,929,397 - 10,929,519	RGD	NCBI36
Celera	12	16,186,388 - 16,186,510	RGD
Celera	12	16,228,522 - 16,228,573	UniSTS
Cytogenetic Map	12	p13.2	UniSTS
Cytogenetic Map	12	p13	UniSTS
HuRef	12	10,766,730 - 10,766,852	UniSTS
HuRef	12	10,808,885 - 10,808,936	UniSTS
GeneMap99-GB4 RH Map	12	58.21	UniSTS

SHGC-35333

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	11,083,729 - 11,083,942	UniSTS	GRCh37
Build 36	12	10,974,996 - 10,975,209	RGD	NCBI36
Celera	12	16,231,752 - 16,231,965	RGD
Cytogenetic Map	12	p13	UniSTS
Cytogenetic Map	12	p13.2	UniSTS
HuRef	12	10,812,115 - 10,812,328	UniSTS
Stanford-G3 RH Map	12	622.0	UniSTS
GeneMap99-GB4 RH Map	12	56.76	UniSTS
Whitehead-RH Map	12	109.2	UniSTS
NCBI RH Map	12	163.4	UniSTS
GeneMap99-G3 RH Map	12	622.0	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

High

Medium

Low

198

212

325

402

181

Below cutoff

1443

1583

1004

295

540

174

2322

1189

2349

536

836

121

737

1530

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001110213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047429101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054372462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054372463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC006518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC095488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC136499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC141916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX538206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX538207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX641094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX647085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX647155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX647156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX648436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX648656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX648871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX648901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR749583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	K03202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M13058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000381847 ⟹ ENSP00000371271

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	10,929,236 - 10,931,164 (+)	Ensembl

RefSeq Acc Id:

ENST00000396400 ⟹ ENSP00000379682

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	10,929,236 - 10,934,845 (+)	Ensembl

RefSeq Acc Id:

NM_001110213 ⟹ NP_001103683

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	10,929,236 - 10,934,845 (+)	NCBI
GRCh37	12	11,081,834 - 11,087,444 (+)	ENTREZGENE
HuRef	12	10,810,220 - 10,815,831 (+)	ENTREZGENE
CHM1_1	12	11,051,144 - 11,056,753 (+)	NCBI
T2T-CHM13v2.0	12	10,802,276 - 10,807,884 (+)	NCBI

Sequence:

show sequence

AGCATAAAGTTGGGAGTGACACCAGAGCCTTCTGCAAGATGCTTCTGATTCTGCTGTCAGTGGC
CCTGCTGGCCTTCAGCTCAGCTCAGGACTTAGATGAAGATGTCAGCCAAGAAGACGTTCCCTTG
GTAATATCAGATGGAGGAGACTCTGAGCAGTTCATAGATGAGGAGCGTCAGGGACCACCTTTGG
GAGGACAGCAATCTCAACCCTCTGCTGGTGATGGGAACCAGAATGATGGCCCTCAGCAGGGACC
ACCCCAACAAGGAGGCCAGCAGCAACAAGGTCCACCACCTCCTCAGGGAAAGCCACAAGGACCA
CCCCAACAGGGAGGCCATCCCCCTCCTCCTCAAGGAAGGCCACAAGGACCACCCCAACAGGGAG
GCCATCCCCGTCCTCCTCGAGGAAGGCCACAAGGACCACCCCAACAGGGAGGCCATCAGCAAGG
TCCTCCCCCACCTCCTCCTGGAAAGCCCCAGGGACCACCTCCCCAAGGGGGCCGCCCACAAGGA
CCTCCACAGGGGCAGTCTCCTCAGTAATCTAGGATTCAATGATAGGAAGTGAATAAGAAGATGA
CAGTGTTTCAAATGCCTTGAAACATAATGTGATCATGCTCTAACTTCAATATACCAATAAAATA
ATCAGCTTGCAATTTCTGATTATAGCATCTCCTTCTGAGTGTTTGGGACTCTGGAATCTGAGAC
CCATGTTCACATTGTAAGAACATCCAGGACCCCTTCTCCTTGATGTTTCCAGCAAGCTTCTTTC
CTCCTTATCCTTATTAAGTCATCTGCCTGGGGAAGGAGTTCCACTGTTTCTTTCCTTCTCTGTC
TTCTTAGCTCGAATTTAAATTGCACAATTATTTTCAGGTCATTTCCTGATAGTCTAGTCAGCTT
ATGAATGTAAGCAAAACAGGACCAATGAAAGAAAGTCCCAGAAGCTGAGAGAAACTTTAACAAG
TTTGAGAGTAACTTATTTTGTTTTCTAGGAAAGTGAGTATGGTTCTATGCCTGTATTCCCCAGA
AGCCACTAGACCTATTTTCCCCTATTTTATCACTGATCAGTTCTGTCCCTGCCTATGATTCTTA
CCATTCTTAAGAAAACCTGAATGGATTTCATCAAGGCGGCAGCATAATTTGAAGGGCAATTGCG
TGTGAAAATTGATGTGACTTGATTTACACAATAGTCAGAAAACATTTTAGAAATTGATGACTTT
ATAATGCAACCAGGAGTATTGAAAAAAAAGTAAGCAATGAGCTCAAATAATTAAAAAAGAGAGA
CAAAATACACTTGGGAGAACAGAAATAAGAATTAATGAAAATTTAAAAGATTAAATGAATGAGA
AGAAATGATTCATAAATTTTGAACTAACAGTAATAACTTCTTGAAAATCCAATAAAATTGGCAA
AAGATTGTGAAAATTCTGGAAGAATAAGGGAAACAGATAATCTTCAGAGTAATCAGGTAAAGCT
TAAACAAGTGTTTTAAAAGATGAGTTTTTCCTACATTCTGAAAAGCAAACATGAAAAACTGAAC
ACAGTTTTTACAGATATACAATATGGAGTGACTTATATACAAAATGACCTTAAAAATATATTAA
ACTCATTATAGTAGTTAATATCTAAGTAAAATATGATGAAATTTAATAGAGAATTCACTCCTCC
CAAAAGCACCTTCATGGAAGATTCCTCATTAACAGGCAGTCCTTTAGTATGCTGATTTATACAA
AATGCTGAAAAGAAGAGAAATACCCCAAGTTCTTGAAAAAAAATTTTTTGATATGACTACTCTA
ACAGTAATAACTATAAATCTCACTTTAAATAATTTAAAACAAATTAAAGTGATATATGAGTTAA
ATGACCAAGCAGACTTGATTCCAGGAATGTTAAGGAATGTTCATTATTTGTTTTGGATAATGAA
GTCAGCAGAGGAAAAAAAAATATGACCATCTCAAAAGATGCCAACGTTGTCTTTGATAATATTT
AATATATTTTTTAAAAAACAATTCTTGTAAAATACTTTTTTGATTAGCCTTCTGACCATGATTA
AAATGGTGTACCTCAAAGTAGCTGCTAACCTTATGTGTATCTGCAACACCCTGAAAAATTATCT
AATAAAAAGGCACAAAGAAAAAGCTTGTCAATGTTGTGGATAATTAGAAAGTGAATAATTTTAT
TTAATATTAGATAAACAAGCACATAACAGAGATACATATATTCAAATGGAAGGAGTAAAATTAC
CACCACATGCAGATCTGTTTTTCTGTCCAGAAAATAACAAGAGATTCTACTCAGGTAAAAAAGG
AAAGGAAGGAAAACCATTGTAATTAAAATAAAATTTAATACAATAGCCGTTTATTAATTCAACT
TCTAAAGAATCTTTGTGATTACACAATGACCAGCTAGTAAATATAATAAGAAAATGATTATTCA
CAAAGGAACCAAAAGGCCTAGTCTTCGAATTTTTAATGCCATTGTGATAGCAAGCATCTGATTA
TTTTACTCTAAGTTATTTCCACTTCTGATTTTAAGAACAGCTTCTTTCCCAGGGATGGGTTCCC
CCTAGTGATGTATTCTCTTCACCACAAGAGTTTGCAGCTCTGGCTTTCTTTCTGCTCATCTGTA
AAGATAACTACAGCTCCTCTATAAACCATCTCACCATTATTACCGAAATCAGACAAATTCTGGA
GATAGTCAAAGCTGTGAGGATTCGAAGATCTCTTTCACATCTTGACCCAGTCAATTCCGTTCAC
CAGTGTTATGAATCCATTCCCCAAAATTCCAATTAGGAATTATATATTTATTATTATAATGAGG
ATACTATACAAGGCATTTAGCATGGCTGCAAAGAGAGAGCTCCAATGTCTAAATGCAACGCTGA
CAATTTCTTCATCTATCACATGTACCTGTTATACATACTTATTAATTGGATGTGCAGTTAATTT
CTTCCTTTAAAAAAAAAACTATAGGCTCAATATGAAAGTAGAAAGCACTAAGGTGTACTAATGA
ATGGGCACATAGCTTTTTTCACAAAAAGATTATTTTGCCCCAGACAGCTATCTGCATTCTGATC
CAGATACTGTATGTTCTTAACATAAAGTGAAATTTCTCATACTTCATGATGAAAGAAAAAACTG
AATTCTCATTGTTAATAAACAAATAAAGACAATTCTCTGCA

hide sequence

RefSeq Acc Id:

XM_047429101 ⟹ XP_047285057

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	10,929,236 - 10,932,320 (+)	NCBI

RefSeq Acc Id:

XM_054372462 ⟹ XP_054228437

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	12	10,782,594 - 10,807,884 (+)	NCBI

RefSeq Acc Id:

XM_054372463 ⟹ XP_054228438

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	12	10,782,594 - 10,805,360 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001103683	(Get FASTA)	NCBI Sequence Viewer
	XP_047285057	(Get FASTA)	NCBI Sequence Viewer
	XP_054185595	(Get FASTA)	NCBI Sequence Viewer
	XP_054185596	(Get FASTA)	NCBI Sequence Viewer
	XP_054185963	(Get FASTA)	NCBI Sequence Viewer
	XP_054185964	(Get FASTA)	NCBI Sequence Viewer
	XP_054228437	(Get FASTA)	NCBI Sequence Viewer
	XP_054228438	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA60183	(Get FASTA)	NCBI Sequence Viewer
	AAA98808	(Get FASTA)	NCBI Sequence Viewer
	AAH95488	(Get FASTA)	NCBI Sequence Viewer
	AAI36500	(Get FASTA)	NCBI Sequence Viewer
	AAI41917	(Get FASTA)	NCBI Sequence Viewer
	CAE46044	(Get FASTA)	NCBI Sequence Viewer
	CAH18378	(Get FASTA)	NCBI Sequence Viewer
	EAW96219	(Get FASTA)	NCBI Sequence Viewer
	EAW96220	(Get FASTA)	NCBI Sequence Viewer
	EAW96221	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000371271
	ENSP00000371271.3
	ENSP00000379682
	ENSP00000379682.3
	ENSP00000458690.1
	ENSP00000461041.1
	ENSP00000481810.1
	ENSP00000483458.1
GenBank Protein	P02810	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001103683 ⟸ NM_001110213
- Peptide Label:	preproprotein
- UniProtKB:	Q53XA2 (UniProtKB/Swiss-Prot), Q4VBP2 (UniProtKB/Swiss-Prot), B2RMW2 (UniProtKB/Swiss-Prot), A5D902 (UniProtKB/Swiss-Prot), A3KN66 (UniProtKB/Swiss-Prot), A2VCM0 (UniProtKB/Swiss-Prot), Q6P2F6 (UniProtKB/Swiss-Prot), P02810 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLLILLSVALLAFSSAQDLDEDVSQEDVPLVISDGGDSEQFIDEERQGPPLGGQQSQPSAGDGN QNDGPQQGPPQQGGQQQQGPPPPQGKPQGPPQQGGHPPPPQGRPQGPPQQGGHPRPPRGRPQGP PQQGGHQQGPPPPPPGKPQGPPPQGGRPQGPPQGQSPQ hide sequence

RefSeq Acc Id:

ENSP00000371271 ⟸ ENST00000381847

RefSeq Acc Id:

ENSP00000379682 ⟸ ENST00000396400

RefSeq Acc Id:	XP_047285057 ⟸ XM_047429101
- Peptide Label:	isoform X1
- UniProtKB:	Q53XA2 (UniProtKB/Swiss-Prot), Q4VBP2 (UniProtKB/Swiss-Prot), P02810 (UniProtKB/Swiss-Prot), B2RMW2 (UniProtKB/Swiss-Prot), A5D902 (UniProtKB/Swiss-Prot), A3KN66 (UniProtKB/Swiss-Prot), A2VCM0 (UniProtKB/Swiss-Prot), Q6P2F6 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_054228437 ⟸ XM_054372462
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_054228438 ⟸ XM_054372463
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P02810-F1-model_v2	AlphaFold	P02810	1-166	view protein structure

Promoters

RGD ID:

7223199

Promoter ID:

EPDNEW_H17344

Type:

initiation region

Name:

PRH2_1

Description:

proline rich protein HaeIII subfamily 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	10,929,239 - 10,929,299	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:9367	AgrOrtholog
COSMIC	PRH2	COSMIC
Ensembl Genes	ENSG00000134551	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSG00000272803	UniProtKB/Swiss-Prot
	ENSG00000275679	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000381847	ENTREZGENE
	ENST00000381847.7	UniProtKB/Swiss-Prot
	ENST00000396400	ENTREZGENE
	ENST00000396400.4	UniProtKB/Swiss-Prot
	ENST00000572141.1	UniProtKB/Swiss-Prot
	ENST00000575657.5	UniProtKB/Swiss-Prot
	ENST00000622570.4	UniProtKB/Swiss-Prot
	ENST00000622848.2	UniProtKB/Swiss-Prot
GTEx	ENSG00000134551	GTEx
	ENSG00000272803	GTEx
	ENSG00000275679	GTEx
HGNC ID	HGNC:9367	ENTREZGENE
Human Proteome Map	PRH2	Human Proteome Map
InterPro	Pro-rich	UniProtKB/Swiss-Prot
KEGG Report	hsa:5554	UniProtKB/Swiss-Prot
	hsa:5555	UniProtKB/Swiss-Prot
NCBI Gene	5555	ENTREZGENE
OMIM	168790	OMIM
PANTHER	PTHR23203	UniProtKB/Swiss-Prot
	SALIVARY ACIDIC PROLINE-RICH PHOSPHOPROTEIN 1/2	UniProtKB/Swiss-Prot
Pfam	Pro-rich	UniProtKB/Swiss-Prot
PharmGKB	PA33738	PharmGKB
SMART	Pro-rich	UniProtKB/Swiss-Prot
UniProt	A2VCM0	ENTREZGENE
	A3KN66	ENTREZGENE
	A5D902	ENTREZGENE
	B2RMW2	ENTREZGENE
	P02810	ENTREZGENE, UniProtKB/Swiss-Prot
	Q4VBP2	ENTREZGENE
	Q53XA2	ENTREZGENE
	Q6P2F6	ENTREZGENE
UniProt Secondary	A2VCM0	UniProtKB/Swiss-Prot
	A3KN66	UniProtKB/Swiss-Prot
	A5D902	UniProtKB/Swiss-Prot
	B2RMW2	UniProtKB/Swiss-Prot
	Q4VBP2	UniProtKB/Swiss-Prot
	Q53XA2	UniProtKB/Swiss-Prot
	Q6P2F6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-14	PRH2	proline rich protein HaeIII subfamily 2		proline-rich protein HaeIII subfamily 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar