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Gene: MUC16 (mucin 16, cell surface associated) Homo sapiens
Symbol: MUC16
Name: mucin 16, cell surface associated
Description: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CA-125; CA125; CA125 ovarian cancer antigen; FLJ14303; MUC-16; mucin 16; mucin-16; mucin-16 long isoform; mucin-16 short isoform; ovarian cancer-related tumor marker CA125; ovarian carcinoma antigen CA125
Mus musculus (house mouse) : Muc16 (mucin 16)  MGI  Alliance
Rattus norvegicus (Norway rat) : Muc16 (mucin 16, cell surface associated)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Muc16 (mucin 16, cell surface associated)
Pan paniscus (bonobo/pygmy chimpanzee) : MUC16 (mucin 16, cell surface associated)
Canis lupus familiaris (dog) : LOC476718 (mucin-16)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Muc16 (mucin 16, cell surface associated)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38198,848,840 - 9,010,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37198,959,516 - 9,092,018 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,820,520 - 8,953,018 (-)NCBINCBI36hg18NCBI36
Build 34198,820,519 - 8,923,563NCBI
Cytogenetic Map19p13.2NCBI
HuRef198,536,945 - 8,584,059 (-)NCBIHuRef
HuRef198,584,670 - 8,673,562 (-)NCBIHuRef
CHM1_1198,959,010 - 9,091,710 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MUC16
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346263
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE