CYP17A1-AS1 (CYP17A1 antisense RNA 1) - Rat Genome Database

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Gene: CYP17A1-AS1 (CYP17A1 antisense RNA 1) Homo sapiens
Analyze
No known orthologs.
Symbol: CYP17A1-AS1 (Ensembl: WBP1L)
Name: CYP17A1 antisense RNA 1 (Ensembl:WW domain binding protein 1 like)
RGD ID: 1346128
HGNC Page HGNC:31671
Description: ASSOCIATED WITH 17,20-Lyase Deficiency, Isolated; breast cancer; Congenital adrenal hyperplasia; INTERACTS WITH propofol
Type: ncrna (Ensembl: protein-coding)
RefSeq Status: MODEL
Previously known as: bA753C18.3; CYP17A1OS; cytochrome P450, family 17, subfamily A, polypeptide 1 opposite strand
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,832,676 - 102,834,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,743,948 - 102,834,516 (+)EnsemblGRCh38hg38GRCh38
GRCh3710104,590,493 - 104,594,273 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map10q24.32NCBI
HuRef1098,227,200 - 98,229,045 (+)NCBIHuRef
CHM1_110104,875,651 - 104,877,496 (+)NCBICHM1_1
T2T-CHM13v2.010103,718,461 - 103,720,297 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
propofol  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16344560   PMID:19430479   PMID:19915575  


Genomics

Variants

.
Variants in CYP17A1-AS1
76 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000102.4(CYP17A1):c.715C>T (p.Arg239Ter) single nucleotide variant 17-alpha-hydroxylase/17,20-lyase deficiency, combined partial [RCV000001854]|Breast cancer, susceptibility to [RCV000001855]|Deficiency of steroid 17-alpha-monooxygenase [RCV000709946]|not provided [RCV000497599] Chr10:102834074 [GRCh38]
Chr10:104593831 [GRCh37]
Chr10:10q24.32		 pathogenic|risk factor|not provided
GRCh38/hg38 10q24.32-24.33(chr10:102710547-103110626)x1 copy number loss See cases [RCV000138062] Chr10:102710547..103110626 [GRCh38]
Chr10:104470304..104870383 [GRCh37]
Chr10:104460294..104860373 [NCBI36]
Chr10:10q24.32-24.33		 uncertain significance
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh38/hg38 10q24.32-25.3(chr10:102732173-114085105)x1 copy number loss See cases [RCV000143371] Chr10:102732173..114085105 [GRCh38]
Chr10:104491930..115844864 [GRCh37]
Chr10:104481920..115834854 [NCBI36]
Chr10:10q24.32-25.3		 pathogenic
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3		 pathogenic
GRCh38/hg38 10q24.32-24.33(chr10:102243341-103929730)x1 copy number loss See cases [RCV000052568] Chr10:102243341..103929730 [GRCh38]
Chr10:104003098..105689488 [GRCh37]
Chr10:103993088..105679478 [NCBI36]
Chr10:10q24.32-24.33		 pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3		 pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
NM_000102.4(CYP17A1):c.847G>C (p.Asp283His) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV000352347] Chr10:102833115 [GRCh38]
Chr10:104592872 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_000102.4(CYP17A1):c.754-251del deletion not provided [RCV001645431] Chr10:102833459 [GRCh38]
Chr10:104593216 [GRCh37]
Chr10:10q24.32		 benign
NM_000102.4(CYP17A1):c.678C>T (p.Asn226=) single nucleotide variant not provided [RCV000943615] Chr10:102834111 [GRCh38]
Chr10:104593868 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.932_939del (p.Val311fs) deletion not provided [RCV001041548] Chr10:102833023..102833030 [GRCh38]
Chr10:104592780..104592787 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.869del (p.Asn290fs) deletion Deficiency of steroid 17-alpha-monooxygenase [RCV002501117]|not provided [RCV000815207] Chr10:102833093 [GRCh38]
Chr10:104592850 [GRCh37]
Chr10:10q24.32		 pathogenic|likely pathogenic
NM_000102.4(CYP17A1):c.754-266dup duplication not provided [RCV001577705] Chr10:102833458..102833459 [GRCh38]
Chr10:104593215..104593216 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.702C>T (p.Ser234=) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV001275793]|not provided [RCV000932753] Chr10:102834087 [GRCh38]
Chr10:104593844 [GRCh37]
Chr10:10q24.32		 likely benign|uncertain significance
NM_000102.4(CYP17A1):c.753+155G>T single nucleotide variant not provided [RCV001555585] Chr10:102833881 [GRCh38]
Chr10:104593638 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+75C>G single nucleotide variant not provided [RCV001657448] Chr10:102832918 [GRCh38]
Chr10:104592675 [GRCh37]
Chr10:10q24.32		 benign
NM_000102.4(CYP17A1):c.671T>C (p.Phe224Ser) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV001106934] Chr10:102834118 [GRCh38]
Chr10:104593875 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_000102.4(CYP17A1):c.675dup (p.Asn226fs) duplication CYP17A1-related condition [RCV003906153]|Deficiency of steroid 17-alpha-monooxygenase [RCV003467722]|not provided [RCV001040537] Chr10:102834113..102834114 [GRCh38]
Chr10:104593870..104593871 [GRCh37]
Chr10:10q24.32		 pathogenic|likely pathogenic
NM_000102.4(CYP17A1):c.753+13G>A single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV001106933]|not provided [RCV002556094] Chr10:102834023 [GRCh38]
Chr10:104593780 [GRCh37]
Chr10:10q24.32		 likely benign|uncertain significance
NM_000102.4(CYP17A1):c.754-12_754-3dup duplication not provided [RCV001396797] Chr10:102833210..102833211 [GRCh38]
Chr10:104592967..104592968 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.777C>T (p.Ile259=) single nucleotide variant not provided [RCV001396325] Chr10:102833185 [GRCh38]
Chr10:104592942 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.954G>T (p.Leu318=) single nucleotide variant not provided [RCV001494636] Chr10:102833008 [GRCh38]
Chr10:104592765 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.750C>T (p.Tyr250=) single nucleotide variant not provided [RCV001473104] Chr10:102834039 [GRCh38]
Chr10:104593796 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.909C>T (p.Gly303=) single nucleotide variant CYP17A1-related condition [RCV003980432]|not provided [RCV001495427] Chr10:102833053 [GRCh38]
Chr10:104592810 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.691A>T (p.Lys231Ter) single nucleotide variant not provided [RCV001384809] Chr10:102834098 [GRCh38]
Chr10:104593855 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.924C>T (p.Thr308=) single nucleotide variant not provided [RCV001475596] Chr10:102833038 [GRCh38]
Chr10:104592795 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.753+1G>A single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV003469620]|not provided [RCV001376809] Chr10:102834035 [GRCh38]
Chr10:104593792 [GRCh37]
Chr10:10q24.32		 pathogenic|likely pathogenic
NM_000102.4(CYP17A1):c.831T>C (p.Asn277=) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV002488269]|not provided [RCV001467586] Chr10:102833131 [GRCh38]
Chr10:104592888 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.943C>T (p.Leu315=) single nucleotide variant not provided [RCV001441058] Chr10:102833019 [GRCh38]
Chr10:104592776 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.970-4T>G single nucleotide variant not provided [RCV001409512] Chr10:102832684 [GRCh38]
Chr10:104592441 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.796C>T (p.Leu266=) single nucleotide variant not provided [RCV001445429] Chr10:102833166 [GRCh38]
Chr10:104592923 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.802C>T (p.Gln268Ter) single nucleotide variant not provided [RCV001384138] Chr10:102833160 [GRCh38]
Chr10:104592917 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.705T>C (p.His235=) single nucleotide variant not provided [RCV001425901] Chr10:102834084 [GRCh38]
Chr10:104593841 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.727C>T (p.Leu243=) single nucleotide variant not provided [RCV001429868] Chr10:102834062 [GRCh38]
Chr10:104593819 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.741T>C (p.Leu247=) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV002476784]|not provided [RCV001473918] Chr10:102834048 [GRCh38]
Chr10:104593805 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.816C>T (p.Asn272=) single nucleotide variant not provided [RCV001461897] Chr10:102833146 [GRCh38]
Chr10:104592903 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.875T>G (p.Ile292Ser) single nucleotide variant not provided [RCV001774360] Chr10:102833087 [GRCh38]
Chr10:104592844 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_000102.4(CYP17A1):c.776T>C (p.Ile259Thr) single nucleotide variant not specified [RCV001844441] Chr10:102833186 [GRCh38]
Chr10:104592943 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_000102.4(CYP17A1):c.752del (p.Lys251fs) deletion not provided [RCV001943275] Chr10:102834037 [GRCh38]
Chr10:104593794 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.667-13_667-10del deletion 17-alpha-hydroxylase/17,20-lyase deficiency, combined complete [RCV002266080]|Congenital adrenal hyperplasia [RCV002282672]|Deficiency of steroid 17-alpha-monooxygenase [RCV003471223]|not provided [RCV002018992] Chr10:102834132..102834135 [GRCh38]
Chr10:104593889..104593892 [GRCh37]
Chr10:10q24.32		 pathogenic|likely pathogenic
NM_000102.4(CYP17A1):c.849del (p.Ser284fs) deletion not provided [RCV001938366] Chr10:102833113 [GRCh38]
Chr10:104592870 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.967C>T (p.Gln323Ter) single nucleotide variant not provided [RCV001939563] Chr10:102832995 [GRCh38]
Chr10:104592752 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.909C>A (p.Gly303=) single nucleotide variant not provided [RCV002089210] Chr10:102833053 [GRCh38]
Chr10:104592810 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.970-18A>G single nucleotide variant not provided [RCV002125015] Chr10:102832698 [GRCh38]
Chr10:104592455 [GRCh37]
Chr10:10q24.32		 benign
NM_000102.4(CYP17A1):c.764G>A (p.Arg255Gln) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV003445048]|not provided [RCV002094530] Chr10:102833198 [GRCh38]
Chr10:104592955 [GRCh37]
Chr10:10q24.32		 likely benign|uncertain significance
NM_000102.4(CYP17A1):c.667-10T>C single nucleotide variant not provided [RCV002076496] Chr10:102834132 [GRCh38]
Chr10:104593889 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.834T>C (p.Ala278=) single nucleotide variant not provided [RCV002101804] Chr10:102833128 [GRCh38]
Chr10:104592885 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.754-11A>C single nucleotide variant not provided [RCV002176181] Chr10:102833219 [GRCh38]
Chr10:104592976 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.754-10C>T single nucleotide variant not provided [RCV002203533] Chr10:102833218 [GRCh38]
Chr10:104592975 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.970-8G>T single nucleotide variant not provided [RCV002219663] Chr10:102832688 [GRCh38]
Chr10:104592445 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.873C>T (p.His291=) single nucleotide variant not provided [RCV002751468] Chr10:102833089 [GRCh38]
Chr10:104592846 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.962A>G (p.Asn321Ser) single nucleotide variant Inborn genetic diseases [RCV002883757] Chr10:102833000 [GRCh38]
Chr10:104592757 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_000102.4(CYP17A1):c.753+9T>C single nucleotide variant not provided [RCV002614344] Chr10:102834027 [GRCh38]
Chr10:104593784 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.684C>G (p.Thr228=) single nucleotide variant not provided [RCV002851768] Chr10:102834105 [GRCh38]
Chr10:104593862 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.930G>A (p.Val310=) single nucleotide variant not provided [RCV002575745] Chr10:102833032 [GRCh38]
Chr10:104592789 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.966T>C (p.Pro322=) single nucleotide variant not provided [RCV003022195] Chr10:102832996 [GRCh38]
Chr10:104592753 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.742G>A (p.Glu248Lys) single nucleotide variant Inborn genetic diseases [RCV002714702] Chr10:102834047 [GRCh38]
Chr10:104593804 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_000102.4(CYP17A1):c.754-10_754-9insAA insertion CYP17A1-related condition [RCV003898637]|not provided [RCV002966343] Chr10:102833217..102833218 [GRCh38]
Chr10:104592974..104592975 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.846A>G (p.Gln282=) single nucleotide variant not provided [RCV003046723] Chr10:102833116 [GRCh38]
Chr10:104592873 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.716G>A (p.Arg239Gln) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV003143879] Chr10:102834073 [GRCh38]
Chr10:104593830 [GRCh37]
Chr10:10q24.32		 likely pathogenic
NM_000102.4(CYP17A1):c.806_810del (p.Ala269fs) deletion Deficiency of steroid 17-alpha-monooxygenase [RCV003468648] Chr10:102833152..102833156 [GRCh38]
Chr10:104592909..104592913 [GRCh37]
Chr10:10q24.32		 likely pathogenic
NM_000102.4(CYP17A1):c.887T>C (p.Ile296Thr) single nucleotide variant Deficiency of steroid 17-alpha-monooxygenase [RCV003468638]|not provided [RCV003738477] Chr10:102833075 [GRCh38]
Chr10:104592832 [GRCh37]
Chr10:10q24.32		 likely pathogenic
NM_000102.4(CYP17A1):c.671del (p.Phe224fs) deletion Deficiency of steroid 17-alpha-monooxygenase [RCV003468653] Chr10:102834118 [GRCh38]
Chr10:104593875 [GRCh37]
Chr10:10q24.32		 likely pathogenic
NM_000102.4(CYP17A1):c.667-16_680del deletion Deficiency of steroid 17-alpha-monooxygenase [RCV003468645]|not provided [RCV003779172] Chr10:102834109..102834138 [GRCh38]
Chr10:104593866..104593895 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.946dup (p.Ala316fs) duplication Deficiency of steroid 17-alpha-monooxygenase [RCV003468634] Chr10:102833015..102833016 [GRCh38]
Chr10:104592772..104592773 [GRCh37]
Chr10:10q24.32		 likely pathogenic
NM_000102.4(CYP17A1):c.970-4T>A single nucleotide variant not provided [RCV003571899] Chr10:102832684 [GRCh38]
Chr10:104592441 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.861T>A (p.Leu287=) single nucleotide variant not provided [RCV003691961] Chr10:102833101 [GRCh38]
Chr10:104592858 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+13C>G single nucleotide variant not provided [RCV003544536] Chr10:102832980 [GRCh38]
Chr10:104592737 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+13dup duplication not provided [RCV003693595] Chr10:102832979..102832980 [GRCh38]
Chr10:104592736..104592737 [GRCh37]
Chr10:10q24.32		 benign
NM_000102.4(CYP17A1):c.969+15C>T single nucleotide variant not provided [RCV003740097] Chr10:102832978 [GRCh38]
Chr10:104592735 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.753+15A>C single nucleotide variant not provided [RCV003544801] Chr10:102834021 [GRCh38]
Chr10:104593778 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.917C>A (p.Thr306Asn) single nucleotide variant not provided [RCV003572459] Chr10:102833045 [GRCh38]
Chr10:104592802 [GRCh37]
Chr10:10q24.32		 likely pathogenic
NM_000102.4(CYP17A1):c.891G>A (p.Gly297=) single nucleotide variant not provided [RCV003716491] Chr10:102833071 [GRCh38]
Chr10:104592828 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.782dup (p.Asn261fs) duplication not provided [RCV003716516] Chr10:102833179..102833180 [GRCh38]
Chr10:104592936..104592937 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.783C>T (p.Asn261=) single nucleotide variant not provided [RCV003577379] Chr10:102833179 [GRCh38]
Chr10:104592936 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.973A>T (p.Lys325Ter) single nucleotide variant not provided [RCV003579012] Chr10:102832677 [GRCh38]
Chr10:104592434 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.667-20C>T single nucleotide variant not provided [RCV003690588] Chr10:102834142 [GRCh38]
Chr10:104593899 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.754-19C>T single nucleotide variant not provided [RCV003580055] Chr10:102833227 [GRCh38]
Chr10:104592984 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.970-13C>T single nucleotide variant not provided [RCV003717522] Chr10:102832693 [GRCh38]
Chr10:104592450 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.667-19A>G single nucleotide variant not provided [RCV003812180] Chr10:102834141 [GRCh38]
Chr10:104593898 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+12C>G single nucleotide variant not provided [RCV003673210] Chr10:102832981 [GRCh38]
Chr10:104592738 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.970-1G>C single nucleotide variant not provided [RCV003579965] Chr10:102832681 [GRCh38]
Chr10:104592438 [GRCh37]
Chr10:10q24.32		 pathogenic
NM_000102.4(CYP17A1):c.861T>G (p.Leu287=) single nucleotide variant not provided [RCV003702134] Chr10:102833101 [GRCh38]
Chr10:104592858 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.732T>C (p.Asn244=) single nucleotide variant not provided [RCV003725553] Chr10:102834057 [GRCh38]
Chr10:104593814 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.970-17C>T single nucleotide variant not provided [RCV003579938] Chr10:102832697 [GRCh38]
Chr10:104592454 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.754-15C>A single nucleotide variant not provided [RCV003823303] Chr10:102833223 [GRCh38]
Chr10:104592980 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+11C>G single nucleotide variant not provided [RCV003731338] Chr10:102832982 [GRCh38]
Chr10:104592739 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.754-9C>T single nucleotide variant not provided [RCV003675380] Chr10:102833217 [GRCh38]
Chr10:104592974 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+18T>C single nucleotide variant not provided [RCV003563233] Chr10:102832975 [GRCh38]
Chr10:104592732 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+12C>T single nucleotide variant not provided [RCV003733295] Chr10:102832981 [GRCh38]
Chr10:104592738 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+13C>A single nucleotide variant not provided [RCV003720170] Chr10:102832980 [GRCh38]
Chr10:104592737 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.969+9C>T single nucleotide variant not provided [RCV003871918] Chr10:102832984 [GRCh38]
Chr10:104592741 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.753+12_753+13del microsatellite not provided [RCV003824285] Chr10:102834023..102834024 [GRCh38]
Chr10:104593780..104593781 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.667-15C>A single nucleotide variant not provided [RCV003720488] Chr10:102834137 [GRCh38]
Chr10:104593894 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.852A>G (p.Ser284=) single nucleotide variant not provided [RCV003552313] Chr10:102833110 [GRCh38]
Chr10:104592867 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.858G>A (p.Leu286=) single nucleotide variant not provided [RCV003727402] Chr10:102833104 [GRCh38]
Chr10:104592861 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.754-14C>A single nucleotide variant not provided [RCV003552767] Chr10:102833222 [GRCh38]
Chr10:104592979 [GRCh37]
Chr10:10q24.32		 likely benign
NM_000102.4(CYP17A1):c.918C>A (p.Thr306=) single nucleotide variant not provided [RCV003551033] Chr10:102833044 [GRCh38]
Chr10:104592801 [GRCh37]
Chr10:10q24.32		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:51
Interacting mature miRNAs:51
Transcripts:ENST00000369884
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2425 2502 1693 593 1658 435 4342 2001 3338 406 1447 1591 171 1204 2776 4
Low 11 489 32 31 291 30 14 195 379 13 13 21 4 1 12 1 2
Below cutoff 1 1 15 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000369884
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10102,832,721 - 102,834,516 (+)Ensembl
RefSeq Acc Id: ENST00000369889   ⟹   ENSP00000358905
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10102,776,249 - 102,816,267 (+)Ensembl
RefSeq Acc Id: ENST00000448841   ⟹   ENSP00000414721
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10102,743,948 - 102,816,262 (+)Ensembl
RefSeq Acc Id: ENST00000647664   ⟹   ENSP00000498131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10102,743,982 - 102,833,848 (+)Ensembl
RefSeq Acc Id: XR_007081289
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.010103,718,461 - 103,720,297 (+)NCBI
RefSeq Acc Id: XR_428804
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810102,832,676 - 102,834,504 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC CYP17A1-AS1 COSMIC
Ensembl Genes ENSG00000166272 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000369884 ENTREZGENE
GTEx ENSG00000166272 GTEx
HGNC ID HGNC:31671 ENTREZGENE
Human Proteome Map CYP17A1-AS1 Human Proteome Map
NCBI Gene CYP17A1-AS1 ENTREZGENE
PharmGKB PA134973774 PharmGKB


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-21 CYP17A1-AS1  CYP17A1 antisense RNA 1  CYP17A1-AS1  CYP17A1 antisense RNA 1 (non-protein coding)  Symbol and/or name change 5135510 APPROVED
2011-09-13 CYP17A1-AS1  CYP17A1 antisense RNA 1 (non-protein coding)  CYP17A1OS  cytochrome P450, family 17, subfamily A, polypeptide 1 opposite strand  Symbol and/or name change 5135510 APPROVED