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Gene: UPF3B (UPF3B regulator of nonsense mediated mRNA decay) Homo sapiens
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Symbol: UPF3B
Name: UPF3B regulator of nonsense mediated mRNA decay
Description: Exhibits mRNA binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of translation. Localizes to the centriolar satellite; cytosol; and nucleus. Implicated in syndromic X-linked intellectual disability 14.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HUPF3B; hUpf3p-X; mental retardation, X-linked 62; MRX62; MRX82; MRXS14; nonsense mRNA reducing factor 3B; regulator of nonsense transcripts 3B; RENT3B; up-frameshift suppressor 3 homolog B; up-frameshift suppressor 3 homolog on chromosome X; UPF3 regulator of nonsense transcripts homolog B; UPF3 regulator of nonsense transcripts homolog B (yeast); UPF3B pseudogene 1; UPF3B pseudogene 2; UPF3B pseudogene 3; UPF3B, regulator of nonsense mediated mRNA decay; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X; UPF3X
Orthologs:
Mus musculus (house mouse) : Upf3b (UPF3 regulator of nonsense transcripts homolog B (yeast))  MGI  Alliance
Rattus norvegicus (Norway rat) : Upf3b (UPF3B, regulator of nonsense mediated mRNA decay)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Upf3b (UPF3B regulator of nonsense mediated mRNA decay)
Pan paniscus (bonobo/pygmy chimpanzee) : UPF3B (UPF3B regulator of nonsense mediated mRNA decay)
Canis lupus familiaris (dog) : UPF3B (UPF3B regulator of nonsense mediated mRNA decay)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Upf3b (UPF3B regulator of nonsense mediated mRNA decay)
Sus scrofa (pig) : UPF3B (UPF3B regulator of nonsense mediated mRNA decay)
Chlorocebus sabaeus (green monkey) : UPF3B (UPF3B regulator of nonsense mediated mRNA decay)
Heterocephalus glaber (naked mole-rat) : Upf3b (UPF3B regulator of nonsense mediated mRNA decay)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX119,805,311 - 119,852,998 (-)Ensembl
GRCh38X119,805,311 - 119,853,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X118,941,115 - 118,986,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,852,017 - 118,870,996 (-)NCBINCBI36hg18NCBI36
Build 34X118,749,870 - 118,768,850NCBI
CeleraX119,422,616 - 119,441,635 (-)NCBI
Cytogenetic MapXq24NCBI
HuRefX108,461,263 - 108,479,939 (-)NCBIHuRef
CHM1_1X118,879,087 - 118,898,087 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on UPF3B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346078
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.