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Gene: EPCAM (epithelial cell adhesion molecule) Homo sapiens
Symbol: EPCAM
Name: epithelial cell adhesion molecule
Description: Predicted to have cadherin binding activity involved in cell-cell adhesion. Involved in several processes, including negative regulation of cell-cell adhesion mediated by cadherin; positive regulation of stem cell proliferation; and regulation of gene expression. Localizes to several cellular components, including basolateral plasma membrane; bicellular tight junction; and lateral plasma membrane. Implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenocarcinoma-associated antigen; cell surface glycoprotein Trop-1; CO-17A; CO17-1A; DIAR5; EGP; EGP-2; EGP314; EGP34; EGP40; Ep-CAM; epithelial glycoprotein 314; ESA; GA733-2; hEGP-2; HNPCC8; human epithelial glycoprotein-2; KS1/4; KSA; M4S1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; TACST-1; TACSTD1; TROP1; trophoblast cell surface antigen 1; tumor-associated calcium signal transducer 1
Mus musculus (house mouse) : Epcam (epithelial cell adhesion molecule)  MGI  Alliance
Rattus norvegicus (Norway rat) : Epcam (epithelial cell adhesion molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epcam (epithelial cell adhesion molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : EPCAM (epithelial cell adhesion molecule)
Canis lupus familiaris (dog) : EPCAM (epithelial cell adhesion molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epcam (epithelial cell adhesion molecule)
Sus scrofa (pig) : EPCAM (epithelial cell adhesion molecule)
Chlorocebus sabaeus (African green monkey) : EPCAM (epithelial cell adhesion molecule)
Heterocephalus glaber (naked mole-rat) : Epcam (epithelial cell adhesion molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl247,345,158 - 47,387,601 (+)EnsemblGRCh38hg38GRCh38
GRCh38247,369,311 - 47,387,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37247,596,287 - 47,614,167 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,449,971 - 47,467,661 (+)NCBINCBI36hg18NCBI36
Build 34247,508,117 - 47,525,808NCBI
Celera247,435,038 - 47,452,920 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef247,332,819 - 47,350,813 (+)NCBIHuRef
CHM1_1247,526,380 - 47,544,227 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EPCAM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345999
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.